KEGG   Nomascus leucogenys (northern white-cheeked gibbon): 100602081
Entry
100602081         CDS       T03265                                 
Symbol
MAPK10
Name
(RefSeq) mitogen-activated protein kinase 10 isoform X2
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
nle  Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle01522  Endocrine resistance
nle04010  MAPK signaling pathway
nle04012  ErbB signaling pathway
nle04014  Ras signaling pathway
nle04024  cAMP signaling pathway
nle04068  FoxO signaling pathway
nle04071  Sphingolipid signaling pathway
nle04137  Mitophagy - animal
nle04140  Autophagy - animal
nle04141  Protein processing in endoplasmic reticulum
nle04210  Apoptosis
nle04215  Apoptosis - multiple species
nle04217  Necroptosis
nle04310  Wnt signaling pathway
nle04380  Osteoclast differentiation
nle04510  Focal adhesion
nle04530  Tight junction
nle04620  Toll-like receptor signaling pathway
nle04621  NOD-like receptor signaling pathway
nle04622  RIG-I-like receptor signaling pathway
nle04625  C-type lectin receptor signaling pathway
nle04657  IL-17 signaling pathway
nle04658  Th1 and Th2 cell differentiation
nle04659  Th17 cell differentiation
nle04660  T cell receptor signaling pathway
nle04664  Fc epsilon RI signaling pathway
nle04668  TNF signaling pathway
nle04722  Neurotrophin signaling pathway
nle04723  Retrograde endocannabinoid signaling
nle04728  Dopaminergic synapse
nle04750  Inflammatory mediator regulation of TRP channels
nle04910  Insulin signaling pathway
nle04912  GnRH signaling pathway
nle04914  Progesterone-mediated oocyte maturation
nle04917  Prolactin signaling pathway
nle04920  Adipocytokine signaling pathway
nle04926  Relaxin signaling pathway
nle04930  Type II diabetes mellitus
nle04931  Insulin resistance
nle04932  Non-alcoholic fatty liver disease
nle04933  AGE-RAGE signaling pathway in diabetic complications
nle04935  Growth hormone synthesis, secretion and action
nle04936  Alcoholic liver disease
nle05010  Alzheimer disease
nle05012  Parkinson disease
nle05016  Huntington disease
nle05017  Spinocerebellar ataxia
nle05020  Prion disease
nle05022  Pathways of neurodegeneration - multiple diseases
nle05132  Salmonella infection
nle05133  Pertussis
nle05135  Yersinia infection
nle05142  Chagas disease
nle05145  Toxoplasmosis
nle05152  Tuberculosis
nle05161  Hepatitis B
nle05162  Measles
nle05166  Human T-cell leukemia virus 1 infection
nle05167  Kaposi sarcoma-associated herpesvirus infection
nle05169  Epstein-Barr virus infection
nle05170  Human immunodeficiency virus 1 infection
nle05171  Coronavirus disease - COVID-19
nle05200  Pathways in cancer
nle05208  Chemical carcinogenesis - reactive oxygen species
nle05210  Colorectal cancer
nle05212  Pancreatic cancer
nle05231  Choline metabolism in cancer
nle05415  Diabetic cardiomyopathy
nle05417  Lipid and atherosclerosis
nle05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:nle00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    100602081 (MAPK10)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100602081 (MAPK10)
   04310 Wnt signaling pathway
    100602081 (MAPK10)
   04668 TNF signaling pathway
    100602081 (MAPK10)
   04068 FoxO signaling pathway
    100602081 (MAPK10)
   04071 Sphingolipid signaling pathway
    100602081 (MAPK10)
   04024 cAMP signaling pathway
    100602081 (MAPK10)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100602081 (MAPK10)
   04137 Mitophagy - animal
    100602081 (MAPK10)
  09143 Cell growth and death
   04215 Apoptosis - multiple species
    100602081 (MAPK10)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100602081 (MAPK10)
   04660 T cell receptor signaling pathway
    100602081 (MAPK10)
   04658 Th1 and Th2 cell differentiation
    100602081 (MAPK10)
   04659 Th17 cell differentiation
    100602081 (MAPK10)
   04657 IL-17 signaling pathway
    100602081 (MAPK10)
   04664 Fc epsilon RI signaling pathway
    100602081 (MAPK10)
  09152 Endocrine system
   04917 Prolactin signaling pathway
    100602081 (MAPK10)
   04926 Relaxin signaling pathway
    100602081 (MAPK10)
   04935 Growth hormone synthesis, secretion and action
    100602081 (MAPK10)
  09156 Nervous system
   04728 Dopaminergic synapse
    100602081 (MAPK10)
   04723 Retrograde endocannabinoid signaling
    100602081 (MAPK10)
   04722 Neurotrophin signaling pathway
    100602081 (MAPK10)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100602081 (MAPK10)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100602081 (MAPK10)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100602081 (MAPK10)
   05208 Chemical carcinogenesis - reactive oxygen species
    100602081 (MAPK10)
   05231 Choline metabolism in cancer
    100602081 (MAPK10)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100602081 (MAPK10)
   05212 Pancreatic cancer
    100602081 (MAPK10)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100602081 (MAPK10)
   05170 Human immunodeficiency virus 1 infection
    100602081 (MAPK10)
   05161 Hepatitis B
    100602081 (MAPK10)
   05171 Coronavirus disease - COVID-19
    100602081 (MAPK10)
   05162 Measles
    100602081 (MAPK10)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100602081 (MAPK10)
   05169 Epstein-Barr virus infection
    100602081 (MAPK10)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100602081 (MAPK10)
   05133 Pertussis
    100602081 (MAPK10)
   05152 Tuberculosis
    100602081 (MAPK10)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100602081 (MAPK10)
   05142 Chagas disease
    100602081 (MAPK10)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100602081 (MAPK10)
   05012 Parkinson disease
    100602081 (MAPK10)
   05016 Huntington disease
    100602081 (MAPK10)
   05017 Spinocerebellar ataxia
    100602081 (MAPK10)
   05020 Prion disease
    100602081 (MAPK10)
   05022 Pathways of neurodegeneration - multiple diseases
    100602081 (MAPK10)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100602081 (MAPK10)
   05418 Fluid shear stress and atherosclerosis
    100602081 (MAPK10)
   05415 Diabetic cardiomyopathy
    100602081 (MAPK10)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100602081 (MAPK10)
   04936 Alcoholic liver disease
    100602081 (MAPK10)
   04932 Non-alcoholic fatty liver disease
    100602081 (MAPK10)
   04931 Insulin resistance
    100602081 (MAPK10)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100602081 (MAPK10)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    100602081 (MAPK10)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:nle01001]
    100602081 (MAPK10)
Enzymes [BR:nle01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     100602081 (MAPK10)
Protein kinases [BR:nle01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   100602081 (MAPK10)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like APH FTA2
Other DBs
NCBI-GeneID: 100602081
NCBI-ProteinID: XP_003265902
Ensembl: ENSNLEG00000009285
UniProt: G1RDP5
LinkDB
Position
9:complement(68857038..69185189)
AA seq 426 aa
MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK
MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV
MNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAG
PLGCCR
NT seq 1281 nt   +upstreamnt  +downstreamnt
atgagcaaaagcaaagttgacaaccagttctacagtgtggaagtgggagactcaaccttc
acagttctcaagcgctaccagaatctaaagcctattggctctggggctcagggcatagtt
tgtgccgcgtatgatgctgtccttgacagaaatgtggccattaagaagctcagcagaccc
tttcagaaccaaacacatgccaagagagcgtaccgggagctggtcctcatgaagtgtgtg
aaccataaaaacattattagtttattaaatgtcttcacaccccagaaaacgctggaggag
ttccaagatgtttacttagtaatggaactgatggatgccaacttatgtcaagtgattcag
atggaattagaccatgagcgaatgtcttacctgctgtaccaaatgttgtgtggcattaag
cacctccattctgctggaattattcacagggatttaaaaccaagtaacattgtagtcaag
tctgattgcacattgaaaatcctggactttggactggccaggacagcaggcacaagcttc
atgatgactccatatgtggtgacacgttattacagagcccctgaggtcatcctggggatg
ggctacaaggagaacgtggatatatggtctgtgggatgcattatgggagaaatggttcgc
cacaaaatcctctttccaggaagggactatattgaccagtggaacaaggtaattgaacaa
ctaggaacaccatgtccagaattcatgaagaaattgcaacccacagtaagaaactatgtg
gagaatcggcccaagtatgcgggactcaccttccccaagctcttcccagattccctcttc
ccagcggactccgagcacaataaactcaaagccagccaagccagggacttgttgtcaaag
atgctagtgattgacccagcaaaaagaatatcagtggacgatgccttacagcatccctac
atcaacgtctggtatgacccagccgaagtggaggcgcctccacctcagatatatgacaag
cagttggatgaaagagaacacacaatcgaagaatggaaagaacttatctacaaggaagta
atgaactcagaagaaaagactaaaaatggcgtagtaaaaggacagccttctccttcaggt
gcagcagtgaacagcagtgagagtctccctccatcctcgtctgtcaatgacatctcctcc
atgtccaccgaccagaccctggcatctgacactgacagcagcctggaagcctcggcagga
cccctgggttgttgcaggtga

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