Entry |
|
Symbol |
PLCB2
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
|
KO |
|
Organism |
nle Nomascus leucogenys (northern white-cheeked gibbon)
|
Pathway |
nle04070 | Phosphatidylinositol signaling system |
nle04072 | Phospholipase D signaling pathway |
nle04261 | Adrenergic signaling in cardiomyocytes |
nle04270 | Vascular smooth muscle contraction |
nle04613 | Neutrophil extracellular trap formation |
nle04621 | NOD-like receptor signaling pathway |
nle04723 | Retrograde endocannabinoid signaling |
nle04750 | Inflammatory mediator regulation of TRP channels |
nle04919 | Thyroid hormone signaling pathway |
nle04925 | Aldosterone synthesis and secretion |
nle04927 | Cortisol synthesis and secretion |
nle04928 | Parathyroid hormone synthesis, secretion and action |
nle04933 | AGE-RAGE signaling pathway in diabetic complications |
nle04935 | Growth hormone synthesis, secretion and action |
nle04961 | Endocrine and other factor-regulated calcium reabsorption |
nle04973 | Carbohydrate digestion and absorption |
nle05022 | Pathways of neurodegeneration - multiple diseases |
nle05163 | Human cytomegalovirus infection |
|
Module |
nle_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:nle00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
100606558 (PLCB2)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
100606558 (PLCB2)
04310 Wnt signaling pathway
100606558 (PLCB2)
04070 Phosphatidylinositol signaling system
100606558 (PLCB2)
04072 Phospholipase D signaling pathway
100606558 (PLCB2)
04071 Sphingolipid signaling pathway
100606558 (PLCB2)
04022 cGMP-PKG signaling pathway
100606558 (PLCB2)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
100606558 (PLCB2)
04081 Hormone signaling
100606558 (PLCB2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
100606558 (PLCB2)
04613 Neutrophil extracellular trap formation
100606558 (PLCB2)
04062 Chemokine signaling pathway
100606558 (PLCB2)
09152 Endocrine system
04911 Insulin secretion
100606558 (PLCB2)
04922 Glucagon signaling pathway
100606558 (PLCB2)
04929 GnRH secretion
100606558 (PLCB2)
04915 Estrogen signaling pathway
100606558 (PLCB2)
04921 Oxytocin signaling pathway
100606558 (PLCB2)
04926 Relaxin signaling pathway
100606558 (PLCB2)
04935 Growth hormone synthesis, secretion and action
100606558 (PLCB2)
04918 Thyroid hormone synthesis
100606558 (PLCB2)
04919 Thyroid hormone signaling pathway
100606558 (PLCB2)
04928 Parathyroid hormone synthesis, secretion and action
100606558 (PLCB2)
04924 Renin secretion
100606558 (PLCB2)
04925 Aldosterone synthesis and secretion
100606558 (PLCB2)
04927 Cortisol synthesis and secretion
100606558 (PLCB2)
09154 Digestive system
04970 Salivary secretion
100606558 (PLCB2)
04971 Gastric acid secretion
100606558 (PLCB2)
04972 Pancreatic secretion
100606558 (PLCB2)
04973 Carbohydrate digestion and absorption
100606558 (PLCB2)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
100606558 (PLCB2)
09156 Nervous system
04724 Glutamatergic synapse
100606558 (PLCB2)
04725 Cholinergic synapse
100606558 (PLCB2)
04728 Dopaminergic synapse
100606558 (PLCB2)
04726 Serotonergic synapse
100606558 (PLCB2)
04720 Long-term potentiation
100606558 (PLCB2)
04730 Long-term depression
100606558 (PLCB2)
04723 Retrograde endocannabinoid signaling
100606558 (PLCB2)
09157 Sensory system
04742 Taste transduction
100606558 (PLCB2)
04750 Inflammatory mediator regulation of TRP channels
100606558 (PLCB2)
09159 Environmental adaptation
04713 Circadian entrainment
100606558 (PLCB2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100606558 (PLCB2)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
100606558 (PLCB2)
09174 Infectious disease: parasitic
05146 Amoebiasis
100606558 (PLCB2)
05142 Chagas disease
100606558 (PLCB2)
05143 African trypanosomiasis
100606558 (PLCB2)
09164 Neurodegenerative disease
05010 Alzheimer disease
100606558 (PLCB2)
05016 Huntington disease
100606558 (PLCB2)
05017 Spinocerebellar ataxia
100606558 (PLCB2)
05022 Pathways of neurodegeneration - multiple diseases
100606558 (PLCB2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
100606558 (PLCB2)
05415 Diabetic cardiomyopathy
100606558 (PLCB2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
100606558 (PLCB2)
04934 Cushing syndrome
100606558 (PLCB2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:nle04131]
100606558 (PLCB2)
Enzymes [BR:nle01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
100606558 (PLCB2)
Membrane trafficking [BR:nle04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
100606558 (PLCB2)
Endocytosis
Macropinocytosis
Phospholipase C
100606558 (PLCB2)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
6:61115901..61136155
|
AA seq |
1185 aa
MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKMPKSQKLREVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKVWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGVSSAEMYRQVLLSGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKM
AEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDPGGE
AEGSGPPSAPAGEGTVWAGEEGTELEEEEVEEEEDEESGNLDEEEIKKMQSDEGTAGLEV
TAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQM
SRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEF
MRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRT
KLSPSTNSINPVWKEEPFIFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHL
CLHSESNMPLTMPALFIFLEMKDYVPGAWADLTVALANPIKFFSAHDKKSLKLKEAMGGL
PEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVK
LQRRHEKELQELERRGARRWEELLQRGAAQLAELGPPGAGGGGACKLGPGKGSRKKRSLP
CEESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHAAEQISKMMEL
AREKQAAELKALKETSESDTKEMKKKLETKRLERIQGMTKVTVNKMAQERLKREINNSHI
QEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKE
SVRACLRTCFPSEAKDKPERVCECPPELCEQDPLVAKADTQESRL |
NT seq |
3558 nt +upstreamnt +downstreamnt
atgtctctgctcaaccctgtcctgctgcctcccaaggtgaaggcctatctgagccaaggg
gagcgcttcatcaaatgggatgatgaaactacagttgcctctccagttatcctccgtgtg
gatcctaagggctactacttatactggacatatcaaagtaaggagatggagtttctggat
atcaccagcatccgggatactcgctttgggaagtttgccaagatgcccaagagtcagaag
ctccgggaggtcttcaacatggactttcctgacaacagcttcctgctgaagacactcaca
gtggtgtccggcccggacatggtggacctcaccttccacaacttcgtctcctacaaggag
aacgtgggcaaggtctgggctgaggacgtactggccctagtcaagcatccgctgacagcc
aacgcctctcgcagcaccttcctggacaagatccttgtgaagctcaagatgcagctcaat
tctgaagggaagattccggtgaagaactttttccagatgtttcctgctgaccgtaagcgg
gtggaagctgctctcagtgcctgccacctccccaaaggcaaaaatgacgccatcaatcct
gaggacttcccagaacctgtctacaagagtttcctcatgagcctctgtcctcggccagaa
atagatgagatcttcacttcttaccatgctaaggccaaaccctacatgacgaaggagcac
ctgaccaaattcatcaaccagaaacagcgggactcccggcttaactccctgctgttcccg
ccagcacggcctgaccaggtgcagggcctcatcgacaagtatgagcccagtggcatcaat
gtgcagaggggccagctgtcacctgaaggcatggtctggtttctttgtgggccagagaac
agcgtgctggcccaggacaagctgctgctccaccatgacatgacgcagccactcaatcat
tacttcatcaactcgtcccacaacacctacctgacagccggccagttctcaggcgtctcc
tcggctgagatgtaccgccaggtgctgctctctggctgccgttgtgtggagctagactgc
tggaaggggaaaccccctgacgaggagcccattatcacccatggcttcaccatgactaca
gacatcttcttcaaagaagcaattgaggctattgcagaaagtgcctttaagacctccccc
tatcccatcatcctgtcgtttgagaaccatgtggactcaccccgccagcaggctaagatg
gctgagtattgccggacgatctttggggatatgctgctcacagagcccctggaaaagttc
ccactgaaaccaggtgtccccctgcccagccctgaggatctcaggggcaagatcctcatc
aagaacaagaagaaccagttttctggccccacctcctccagtaaggatcctggtggggag
gctgagggcagcggcccacccagtgcccctgcaggtgagggcacagtgtgggctggcgag
gaagggactgagctggaggaggaggaggtggaagaggaagaggacgaggagtcaggaaac
ctggacgaagaagagattaagaagatgcagtcggatgagggcacagcgggcctggaagtg
acggcttatgaggagatgtccagcctagtcaattacatccagcccaccaagttcatctcc
tttgagttctctgcccaaaagaaccgaagttatgtcatctcatccttcacagagctcaag
gcatatgacctgctctccaaggcctcagtgcagtttgtggactacaacaagcgccagatg
agccgcatttaccccaagggaacccgcatggactcctcaaactacatgccccagatgttc
tggaatgctggatgccagatggttgccctcaacttccagacgatggacttgcccatgcag
cagaacatggcagtgtttgagttcaacgggcagagtggctacctcctcaagcacgagttc
atgcgccggccagacaagcagttcaaccccttctcagtggaccgcatcgacgtggtggtg
gccaccaccctttccatcacggtgatctctgggcagttcctgtcagaacgcagcgtgcgc
acctatgtggaagtggagctgtttggccttcctggggaccccaagaggcgctatcgaact
aagctgtcacctagtaccaactccatcaatcctgtctggaaggaggagccctttatcttt
gagaagatcttgatgcctgagctggcctccctcagggtggctgtgatggaggaaggcaac
aagtttcttggacaccgcatcatccccatcaatgccctaaattctgggtaccaccacctg
tgcctgcacagtgagagcaacatgcccctcaccatgcctgcgctcttcatcttcctggag
atgaaggactacgtacctggtgcttgggcagatctcactgtggccctcgccaaccccatt
aagttcttcagtgcccatgacaagaagtctctgaagctcaaggaggccatgggaggtctg
cctgagaagcccttcccactggcgagtccagttgccagccaggtcaatggggcgttggcc
ccaacgagcaatgggtcaccagcagccagggccggggccagggaagaggctatgaaagaa
gctgcggagccgcggaccgccagcctggaggagctccgggagctaaagggcgtcgtgaag
ctgcagcggcggcacgagaaggagctgcaggagttggagcggcgcggagcgcggcgctgg
gaggagctgctgcagcggggcgcggcgcagctggccgagctcgggccaccgggcgcgggg
ggcggcggggcctgcaagctcggtccgggcaagggctctcgcaagaagaggagcctgccc
tgcgaggagagcgccggagccgcgccgggcgagggccctgagggcgtggacgggcgcgtg
cgggagctgaaggacaggctggagctggagctgctgcggcagggcgaggagcagtacgag
tgcgttctgaagcgcaaggagcagcacgcggccgagcaaatctccaaaatgatggagctg
gctagagagaaacaggcggcagagctgaaggccctgaaggagacgtcggagagcgacacc
aaagagatgaagaaaaagctggagacgaagagactggagcggatccagggcatgaccaaa
gtcactgtaaacaagatggcccaggagaggttgaagagagagattaacaactcccacatc
caggaagtagtgcaggtgatcaagcagatgacggagaacttggagaggcaccaggagaag
ctggaagagaagcaggcggcttgcctggaacagatacgggagatggaaaagcagttccag
aaggaggcgctggcagagtacgaggccaggatgaagggtctggaggcagaggtgaaggag
tcggtgagggcctgcctcaggacctgctttccctctgaggccaaggacaagcctgagagg
gtctgcgagtgccccccagagctgtgtgagcaggacccactcgtagcaaaggcagatacc
caggagagccgcctctga |