Numida meleagris (helmeted guineafowl): 110395962 Help Entry 110395962         CDS       T06015                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism nmel  Numida meleagris (helmeted guineafowl) Pathway nmel04020   Calcium signaling pathway nmel04260   Cardiac muscle contraction nmel04261   Adrenergic signaling in cardiomyocytes nmel04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:nmel00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     110395962 (RYR2)    04020 Calcium signaling pathway     110395962 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     110395962 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     110395962 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:nmel04040]     110395962 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:nmel04990]     110395962 (RYR2) Ion channels [BR:nmel04040]  Voltage-gated cation channels   Ryanodine receptor    110395962 (RYR2) Domain-containing proteins not elsewhere classified [BR:nmel04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    110395962 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  110395962 NCBI-ProteinID:  XP_021246745 LinkDB All DBs Position 3:complement(37322717..37687545) Genome browser AA seq 4955 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWKFMMKSAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEFAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHI TTGKYLSLLDDKSLLLTDKENADVKSTAFCFRSSKEKLDVGTRKEVDGMGAPEIKYGDSI CFIQHVDTGLWLSYQSADAKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKVKSSTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLNVYSSAAHFADVAGKEAGEAWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGISEGSAQYRKWYYELMVDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAEWGGNGVGD DLYSYGFDGLHLWSGCVARTVNSPNQHLLRTEDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVEHSREY KQDRSYTRDLLGPTLNLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADERAEEK VKKMKLPKNYQLLSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHATRLDVSNG IMERFRIFRTEKTYAVKSGKWYFEFEAVTAGDMRVGWTRPGCLPDQELGSDEEAFVFDGF KAQRWHQGNEHFGRSWLAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEVGDG FLPVCSLGPSQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLP VPQNHEHIEVMRIDGTIDTCPCLKVTQKSFGSQNSKTDVMFFRLSMPIECAEVFSRTAAG GLPGTGLYGPKNDLEDYDADSDFEVLMKTAHGHLAADRTEREKDATKPELNNHKDYVQEK PSRLKQRFMLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTSFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNNGLEIGCLVDAASGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVSQCPPRLHVQFLTHVLWSRVPNHFLKVDVSRISERQGWMIQ CLNPLQFMALHIPEENRTIDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHAMCSHV DESQLLYAIENKYMPGLLRAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFP DENKKHGLPGIGLSTSLRPRMQFSSPSFVSINSECFQFSPEFPLEILKAKTIEMLTEAVQ EGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNGDLKHILQLIEPRVFKEAASLEDE RDLSEKELSTGELKSEGEEETRGEQVPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRI EAIVAFSDDFVAKLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDD KTDCPCPEEIRDQLLDFHEDLMTHCGIELDEDGTMDGNSDLTIRGRLLYLMEKVTYLKKK QAEKPVDDDAKTSSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRAL PKTYTINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLM RALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLL ENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPLLIS KGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNG LLAAMEEAIQISEDPTRDGPSPNNGSSKTLEIEEQEDDTIHMGNAIMTFYAALIDLLGRC APEMHLIHAGKGEAIRIRSILRSLIPLEDLVGVISIPFHMPTIAKDGTVVEPDMSAGFCP DHKAAMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCT AVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLRP SMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSR KLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVNMMEKQSSMDSDGNFN PQPVDTSNITIPEKLEYFINKYAEHTHDKWSMEKFANGWTYGETYSESAKVQPLMKQYKL LSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQISVDAAHGYS PRAIDMSNVTLSRDVHAMAEMMAENYHNIWAKKKKMELEAKVGGGNHPLLVPYDTLTAKE KAKDREKAQDILKFLQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYIL EFDAGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLSSGGHASNKEK EMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKMALRAFL DNAAEDLEKTMENLKQGQFTHSRNQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDL ILEDVQVSCYRILASLYALGTSKSIYVERQRSALGECLAAFSGAFPVAFLETHLNKHNIY SIYNTKNARDRAVLNLPTSVEEVCPNIPSLVKLMEEIVELAESGIRYTQMPHIMEVILPM LCSYMSHWWEHGPENNPDKAEVCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAV FSQPIISKAKPQLLKTHFLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAELLILDEFTT LARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVV QNEINNMSFLISDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNIC APGDQDLIALAKNRFSMKDTEDEVRDIIRSNLHLQGKLEDPAIRWQMALYKDLPNRTEDS SDPEKTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPR HRAVNLFLQGYDKSWIETEEHYFEDKLIEDLAKPGEEPPEEDESLKRVDPLHQLILLFSR TALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEKQKLLYQQARLHD RGAAEMVLQTISASKGEMGPMVAATLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSL AGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHNSD FQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVA KQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMD LQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFK EYDPDGKGIISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKD IGFNVAVLLTNLSEHMPHDTRLQTFLELSESVLNYFQPFLGRIEIMGSAKRIERVYFEIS ESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNE RSANKEDNEKDKPEEQDPGMGFFSLVTMKSALVALKYNLMTLMKMLSMKSLKKQMKKVKK MTMKDMVMALFSSYWSILMGLLHFACSVFRGFFRIICSLLLGGSLVEGAKKIKVAELLAN MPDPTQDEVRGEGEEGERKPAETVLPTEDLTDLRTLSEENDLLSDIFGLDLKREGGQYKL IPHNPNAGLSDLLSTPSVAPMPEAQEKVQEQVKEDEKEEKEETKSEPEKAEGEDGEKEEK AKEDKAKQKLRQLHTHRYGEPEVQESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFA INFILLFYKVSTSAATEEKEVPVVSTGENMKLDSLESDNQRVIAVHYVLEESSGYMEPTL RILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDR LVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDS SLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKT LRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDMPDMKCDDMLTC YMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGE LRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETE HTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14868 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggcgagggcgaggacgagatccagttcctgcgaacagatgatgaagtg gttctgcagtgcactgcaactgttcacaaagagcaacagaaattgtgtcttgctgcagaa ggatttggcaacaggctttgctttttggaatccacatcaaattctaagaatgtgccacct gatttgtccatctgcacctttgtgcttgagcagtctctgtcagtacgagcccttcaggaa atgctggctaacacagaggagaaggcagaagggctagttgatgtggaaaaatggaaattt atgatgaagtctgcacaaggtggtggtcatcgaacactactctatgggcatgcaatcctg ctgcgccattcctacagtggcatgtatctatgctgcctctcaacatctcgatcttcaatg gataagctggcctttgatgtaggactgcaagaggacaccacaggtgaggcatgctggtgg actatccatcctgcttctaagcagcgatcagaaggagaaaaagtgcgtgttggagatgac cttattttagtcagtgtctcttctgaaaggtacttgcatctctcctatggcaatggtagc ttacatgttgatgcagctttccagcaaactctttggagtgtagcaccaatcagttcagga agtgaatttgcccaaggatatctgataggtggggatgttctgaggctgttgcatggtcac atggatgaatgcttgacagtcccttcgggtgaacatggggaagaacaaagaagaaccgta cattatgaaggtggtgctgtgtcaattcatgctcgttccctttggcgattagagactcta agagttgcgtggagtggcagccacataagatggggacagccattcaggctaagacatata acaacaggaaaatatttaagtctcctggatgacaagagtcttcttcttacggacaaagag aatgcagatgtaaaatctacagcgttctgttttcggtcttccaaggaaaaattggatgta ggtacgagaaaagaggtggatggaatgggagcacctgaaataaaatacggggattcgata tgcttcatacaacatgtagacacaggcttgtggctctcgtaccaatctgctgatgcgaag tctgtaagaatgggttctgtgcaacgcaaggcaataatgcaccatgaaggccacatggat gatggtttaacattgtccagatctcagcatgaagaatcccgtacagcacgtgtcatccgt agtacagtcttccttttcaacaggtttataaggggccttgatgctctcagcaaaaaagtg aagtcttccacagtagatttacctattgagtcagtcagtctgagccttcaagacctaatt ggctactttcaccctcccgatgaacatttagagcatgaagacaaacaaaacaggctccgt gcactgaagaatcgccagaacctcttccaggaagagggcatgatcaacctcgttcttgaa tgtattgatcgcttgaatgtatacagcagtgcagctcattttgcagatgtagctgggaag gaagctggagaagcatggaaatcaattctgaattccttatatgaattactcgcggctctt attcgagggaatcgtaaaaactgtgctcagttttctggatctcttgactggctgatcagc agattagaaagattagaagcttcttctggaatactagaggttttacactgcgtattggtg gaaagcccagaagctctgaacattattaaggaaggacatattaaatcaatcatttgtctt ttggacaaacatggaagaaatcataaggttttggatgtcttatgttctctctgtgtatgt catggagtagctgtgcggtctaatcaacatctaatctgtgataatctcctgccaggaaga gatctgctcttacagacacgccttgtcaaccacgtgagcagcatgcgacctaacattttc ttgggaattagtgaaggctctgcccagtacagaaaatggtactatgaacttatggtggac catctagagccttttgtgactgcagaatcaactcatctacgagtaggctgggcttcaaca gaaggctactcgccatatccagggggaggagcagaatggggaggaaatggtgttggtgat gacttgtattcttatggctttgatggtctgcatctgtggtcaggctgtgtagctcgaaca gtaaattctccaaaccaacatctgttacgaactgaagatgtaattagctgctgtttggat ctgagtgcccccagcatctcttttcggataaatggacagccagttcaaggaatgtttgag aatttcaacatagatggccttttcttcccggttgtcagcttctctgcaggaataaaggtg cgtttcttgcttgggggtcgccatggagaattcaagttccttcctccacctggatatgcc ccttgctttgaagctgttctaccaaaagagaaattgaaagtggaacatagccgagagtac aagcaggatcgaagctatacaagagacctgctgggtcccactctcaacctgtcgcaagca gctttcaccccagttcctgtagatactagtcagattgttttgcctccccacttggaaaga attagagaaaagttagcagagaacatccatgaactttgggttatgaataagattgaactt ggctggcagtatggaccagttagagatgacaacaaaagacaacacccatgcttagtggag ttctcaaaattgccggagcaggaaagaaattataacttgcaaatgtcacttgaaacactg aaaaccctgctggcattaggctgccatgttggaattgctgatgaacgtgctgaagaaaaa gtgaaaaaaatgaaacttccaaagaactaccagttgttgagtggatataagcctgccccc atggatctgagttttatcaaactgaccccctctcaagaagctatggtggataaactagca gagaatgctcacaatgtatgggcaagggaccgtatcaggcaaggctggacctatggtatc cagcaggatgtgaaaaatcgacgaaatcctcgccttgtaccttatgcccttttggatgat cgaacgaagaagtcaaacaaagacagtcttcgggaagcagtccgcacccttctaggctat ggctacaatctggaagctcctgaccaagaccatgcaacaagactggacgtgagcaatggg ataatggaaagattccggatcttccgcacagagaaaacttatgcagtgaaatctggaaag tggtacttcgagtttgaggcagttacagcaggagacatgagagttggctggacaaggcct ggttgtctgccagatcaggaacttggctcagatgaagaagcttttgtttttgatggcttt aaggcacagcggtggcatcaaggtaatgagcattttggccgctcctggttggcaggagat gttgttggatgtatggttgacatgaatgagcacactatgatgttcaccttaaatggtgag atcctgcttgatgactcaggttcagaacttgcattcaaggattttgaggttggtgatgga tttctacctgtgtgcagcctgggtccatctcaagtgggaagaatgaactttggaaaagat gtcagcaccctaaaatatttcactatctgtggcttacaggaagggtatgaaccctttgct gttaatacaaacagagacattaccatttggctgagtaaaaggctccctcagtttctacca gtgccacaaaatcatgaacatattgaggtaatgagaattgatggaaccatagacacctgc ccttgcctgaaggtcacacagaagtcttttggttcacagaacagtaaaacagatgtcatg ttttttcgattaagtatgcccattgaatgtgctgaagtgttctccagaacagctgcagga gggttaccaggcactggtctttatggcccaaagaacgatttggaggattacgatgctgat tctgattttgaggttctaatgaaaactgctcatggtcatctagcagctgaccggacagaa agagaaaaagatgccacgaaaccagagttaaataaccataaagattatgttcaagaaaag ccttcacgtcttaaacaaagatttatgcttaggaggacaaagccagattatagcacaagc cattctgcaagacttactgaggatgtgctagcagatgatagggatgactatgattatttg atgcaaacttccacgtactattattcagtgagaatatttcctggtcaagaacctgctaat gtttgggtaggctggattacatctgacttccatcaatatgacacaagctttgacttggac agagtgcgtactgtcacagtaacactgggagatgaaaaggggaaggttcatgagagtata aaacgcagcaactgctacatggtatgcgcaggagagagcatgagccctgggcaaggacgt aataataacggtctggagattggttgcttagttgatgctgccagtggcctgctgaccttc acagctaatggcaaagaactgggcacatactatcaagttgaaccaagtacaaagttattt cctgctgtatttgctcaagctacaagccccaatgttttccagtttgaattgggtagaata aagaacgtaatgccattatctgctggtttattcaaaagtgaacacaaaaacccagtctcc cagtgtcctccacgtctccatgtccagtttctgactcatgtgctttggagcagagtgcca aaccacttcttgaaagttgatgtctctaggatcagtgaacgtcaaggctggatgatacag tgcctgaatcctttgcagttcatggcccttcatattcctgaagaaaacagaacaattgat attttagagctgacagaacaagaagaactgctgaaatttcactaccacactctccgattg tattcagctgtgtgtgctttagggaacaaccgagtggcccatgctatgtgtagccatgtg gatgaatctcagcttctatatgccattgagaataaatatatgccaggattattacgtgca gggtattatgacttactcatagacatccatctcaatacctatgcaactgccaggttaatg atgaataatgaatttattgttccaatgacagatgagaccaagagtattaccttgtttcct gatgaaaacaagaaacatggcctccctggtataggactcagcacttccttaaggccaaga atgcagttctcctcaccgagttttgtgagcattaacagtgaatgctttcagttcagtcct gaattcccactagaaatcttaaaggccaaaacaatagagatgctgactgaagctgttcag gagggcagcctccatgtcagagacccagttggaggttctacagaatttctgtttgtccct ctcatcaagctcttctacaccctcctaattatgggaatcttccacaatggggatctgaaa cacatcttgcagttgattgagccccgggttttcaaagaagctgcaagtctggaggatgaa agggatctctcagagaaggagctgagtacaggtgagctcaagtcagaaggagaggaagaa accagaggggaacaagtgccaaaggaaggactccttcagatgaaacttcctgaacctgtt aaactacagatgtgtcatctactccagtacctgtgtgattgccaggtacgacaccggata gaagccattgtagcattttcggatgattttgtggccaagcttcaagagaatcagcgcttc cggtataatgaagtgatgcaggccttgaacatgtctgctgccttgacagctagaaaaaca aaggaatttcgatccccacctcaggagcagattaacatgctgctgaactttaaagatgat aaaactgattgtccttgccctgaagaaattcgggatcagctcctggatttccatgaagac ctaatgacacactgtggaattgaactggatgaagatggaactatggatggaaacagtgat ttaaccattaggggtcgcctcctataccttatggaaaaagttacctatctgaagaagaag caagctgagaagccagtcgatgatgatgcaaagacatcctctactcttcagcaattgatt tcggatacaatggtgcgctgggcccaggaatcagtaatagaagacccggagttagtcagg gccatgtttgtactgctacatcgccaatatgatggtattggtggcttggttcgagccctg ccaaagacttacaccataaatagtgtgtccgtggaagatacaatcaatcttctggcatcc cttggccaaattcgttccttgctcagtgtcaggatggggaaggaggaagagaaacttatg attcgtggattaggagacataatgaataataaagtattttatcaacatccaaatctcatg agagctttaggcatgcatgagactgtcatggaagtgatggtaaatgtacttggtggagga gaatccaaggaaatcactttcccaaaaatggtggcaaactgctgtcgtttcctatgttat ttttgccgcattagtaggcagaatcaaaaagctatgtttgatcatcttagctatttattg gaaaatagcagtgttggccttgcctctccttctatgcgaggatcaactcctttagatgtt gcagcagcatctgtgatggataacaatgaacttgcgctagctttaagggagccggatctg gagaaggtcgttcgatacttggctggatgtggattgcagagttgtcctttgctgatttct aaagggtatccagacattggatggaatccagttgaaggagagcgatatttggattttctt cgttttgctgtattttgcaatggagagagtgtggaggagaatgctaatgttgtagtccga ctgcttattcgtcgaccagaatgttttggtccagctctaagaggagaaggaggcaatggt ctacttgctgccatggaggaagcaatacaaatatcagaagatccaacaagagatggacct tccccaaataatggatctagtaaaacccttgaaatagaagaacaagaagacgacactatt catatggggaatgcaatcatgaccttttatgctgctttgattgatctcttaggacgttgt gcccctgaaatgcatctaatacatgctggcaaaggagaggccataagaatcaggtcaatt ctgaggtctttgattccactggaagatttggtgggtgtaattagcattcctttccacatg ccaacgatagctaaagatggtactgtggtggaacctgacatgtctgcggggttttgccca gatcacaaggcagccatggttttgttccttgacagggtctatggaattgaggatcaggat tttcttctacatcttcttgaagttggctttctgccagatctccgtgctgctgcttcttta gatacagctgctttaagtgctacagatatggctttagctctgaatcgatacctttgcact gcagtcttgcctctgttgaccagatgcgctcctctttttgctggcacagagcaccatgct tcccttattgattccttattacatactgtgtacagactttcaaagggctgctctcttacc aaagctcagcgagattccattgaggagtgtttactgtctatctgtgggcagttgaggcct tctatgatgcagcatttgctgagaagattagtatttgatgttcctttattaaatgaacac gcaaagatgcctctcaagttgctgacaaatcattatgaaagatgctggaagtattattgt ttaccaggtggatggggtaactttggtgctgcctcagaagaagaacttcatttatccaga aagttgttctggggtatttttgatgctttgtctcagaagaagtatgaacaagaactgttc aaactggctttgccttgtttgagtgcagttgcaggggcattacctccagattatatggag tcaaattatgtcaatatgatggaaaaacagtcttcaatggattcagatgggaactttaat cctcaacctgttgatacttcaaacattacaatccctgaaaagctagaatatttcattaac aaatatgcggagcacactcatgataaatggtcgatggaaaagtttgccaatggatggaca tatggtgaaacatattctgaatctgcaaaagtgcaaccattaatgaaacagtataaatta ctctctgaaaaggagaaagaaatttatcgatggccaatcaaagaatcgctaaaaaccatg ctggcatggggatggcggattgaaaggacacgggagggagattccatggcattgtataat cgaacgcgtcgcatatctcagaccagtcaaatctctgtagatgcagcccatggttacagt cctcgagcaattgacatgagcaacgtcaccctctccagagatgtgcacgctatggcagag atgatggcagaaaactaccataacatatgggcaaagaaaaaaaaaatggagcttgaagca aaagtaggaggaggcaaccatcctcttcttgttccttatgatacactcacagccaaagaa aaagctaaggacagagaaaaagcgcaggatattctgaaatttctacagattaatggatat gtagtctccagaggacttaaggacttggaattagacacaccttccattgagaaacgcttt gcctacagtttccttcagcaacttataagatatgtagatgaagctcatcagtacattttg gaatttgatgctggcagcagaggcaaaggagagcatttcccatatgaacaagaaatcaag ttttttgccaaagttgtgctccctttgattgatcagtatttcaaaaatcatcgcttgtat ttcttatctgcagcaagtaggcctctcagcagcggaggccatgcctctaataaggagaaa gaaatggtgacaagcctgttctgcaaacttggagttcttgtcaggcataggatttcactg tttggaaatgatgcaacatcaatagtcaactgtcttcacatattgggccagaccttggat gccagaactgtgatgaaaactggtctggagtctgttaagatggcattgagagcatttttg gacaatgctgctgaggatctggagaaaacaatggaaaatcttaagcaaggccagtttaca cacagcagaaaccagcccaagggagttacacaaatcattaattataccacagtggctctc ctgccagtgctatcttcgttatttgagcatattggacagcaccagtttggggaagatttg atattggaagatgttcaagtgtcctgttacagaatattggccagtttgtatgctctggga accagcaaaagtatatatgtagagcggcaacgatcggcactaggagaatgcttggctgct ttctcgggtgcctttccagtggcttttttggaaactcatttgaacaaacataatatctac tcaatttacaataccaagaatgcaagagacagagcagttctcaatttgcctactagtgta gaagaggtttgcccaaatattccttccttggtgaagctaatggaagaaattgtggaactg gcggaatctggtattcgctacacacaaatgccacatataatggaagtgatactgcctatg ctgtgtagctacatgtcacactggtgggagcatgggccagaaaacaatcctgacaaagct gaagtgtgttgtacagccttgacatcagagcacatgaacactctgttgggtaacatattg aaaatcatctataacaaccttggtattgatgaaggagcctggatgaagaggctagcagtg ttttcccagcccatcataagcaaagcgaagccacagctcttaaagacacacttcctgcca ctgatggataagctaaagaaaaaagcagcagtggttgtatcggatgaagagcatctaaga gcagaaggcagaggtgacatgtcggaggctgaactgctcatcctagatgagttcaccact ttggcacgggacctctatgccttctaccctttgttgattagatttgtggactataacagg gcaaaatggctgaaagagcccaaccctgaagctgaagaattgttccgtatggtggctgaa gtctttatttactggtcaaagtctcataatttcaaaagagaagagcagaactttgtggta caaaatgaaatcaacaacatgtcattccttatcagtgacacaaaatctaagatgtccaag gcagcagtttctgaccaggagaggaagaagatgaagcggaaaggtgaccggtactctatg cagacctctcttattgtggcagcactgaagagattacttcctattggcctaaatatttgt gcccccggtgaccaagatctaattgcactggccaaaaaccgattcagcatgaaagatact gaggatgaggtacgagatatcattcgcagtaatcttcatctccagggcaagcttgaggat ccagccattagatggcagatggcactttacaaagatttaccaaacaggactgaagattca tcagatccagaaaagactgtggaaagagttcttgatatagctaatgtactgtttcatctg gaacaggttgaacatcctcagcggtccaaaaaagcagtctggcataagctactgtctaaa cagaggaaaagagcagtagttgcctgctttagaatggcaccattgtataatctgccaagg caccgagctgtcaatctctttcttcaaggatatgataaatcttggattgaaacagaagaa cactattttgaagacaaactgatagaagatttagcaaaacctggggaggaaccaccagaa gaggacgaaagtcttaaaagagtggatccgttacatcaacttattctgctattcagtcga acagccttaactgaaaaatgcaaattagaggaagattttctctatatggcttatgctgac attatggcaaagagttgccatgatgaagaagatgatgatggtgaagaagaagtgaagagc tttgaagaaaaagaaatggaaaagcaaaaacttctgtatcagcaagccagactgcatgac cggggtgctgctgagatggttcttcagacaatcagtgctagtaaaggtgagatggggcca atggttgcagctaccctaaagctagggattgccatcttaaatggagggaattctactgtt cagcagaaaatgcttgactacctcaaggataagaaagatgtgggtttctttcagagtctt gctggtcttatgcagtcctgtagtgttcttgacttaaatgcatttgaacgtcaaaacaaa gcagaaggccttggcatggtgactgaggagggatcaggagaaaaggtgatgcaggatgat gagttcacctgtgacctctttcgctttcttcaattgctttgtgaaggacacaattcagat tttcagaattacctgagaactcagactggtaacaacacaactgttaatattatcatttcc actgtggattacttattgagagtccaggagtccattagtgatttttattggtattattcc gggaaggatgttattgatgaacaaggacaacgaaatttttccaaagccatccaggttgca aaacaggttttcaatactctcacggagtatatccaggggccatgtactgggaatcagcaa agtctggcacacagcagactatgggatgctgtagttggttttcttcatgtatttgctcac atgcagatgaagctgtctcaggattccagtcaaattgaattactgaaagaattaatggat cttcagaaggatatggttgttatgttgctgtctatgctggaaggtaatgttgtgaatgga actattggcaagcaaatggttgatatgcttgtggaatcgtcaaacaatgtggagatgatt ctgaagttttttgatatgttcttaaaactgaaggatttgacttcctctgatgcattcaaa gagtatgatcctgatggcaaaggcataatttcaaaaagggatttccacaaggcaatggaa agccataagcattacacccaatctgaaactgaatttctgctatcatgtgctgaaacagat gagaatgagactctggactatgaagagtttgtgaaacgattccatgagcctgccaaagac attggtttcaacgtcgctgttctcctgaccaacctttccgagcacatgccccacgatact cgcttgcaaacttttcttgaactgtcagaaagtgtgctgaactactttcagcctttcctt ggacgtatagaaatcatgggcagtgcaaagcgcattgaacgagtgtattttgaaataagt gagtcaagtcggactcagtgggaaaaacctcaggtaaaagagtcaaagagacaatttata tttgatgttgtaaatgaaggtggggagaaagaaaagatggagctttttgttaatttctgt gaagataccatctttgaaatgcaactggctgctcaaatctctgagtcagatctgaatgaa aggtcagcaaataaagaggacaatgagaaagataagcctgaggaacaggatcctggaatg ggtttcttctcacttgtaactatgaagtcagcattagtggcactcaagtacaatttaatg actcttatgaaaatgctcagcatgaagagcctaaagaaacagatgaaaaaagtgaagaaa atgaccatgaaggatatggttatggctttattttcttcctattggagcattttaatgggt ttactgcattttgcctgtagtgtcttccgtggcttctttcgcatcatatgcagtttgctg cttggaggaagtctagtagaaggagcaaagaaaatcaaggtggctgagctattagctaat atgccagatcccactcaggatgaggtgcgtggggaaggagaagagggggagaggaagcca gcagaaactgtattgcctactgaagacttgactgatttgagaactttatcagaggagaat gatctactctcagatatatttggtttggatttgaaacgagaaggtggacagtataaattg atccctcacaacccaaatgctggtttgagtgatttactgagcactccttccgtagctcca atgcctgaggcacaggaaaaagtccaggaacaggtgaaagaagatgaaaaggaagagaag gaagaaacaaaatctgaacctgaaaaagcagaaggagaggatggagaaaaagaagagaaa gcaaaggaagataaagcaaaacagaaattaagacagcttcatactcacagatatggagaa ccagaagttcaggaatcagctttctggaagaaaatcattgcatatcaacagaagcttctt aactattttgctcgaaacttttataacatgaggatgttggcgttgtttgttgcctttgcc atcaacttcatcctgcttttttataaggtctccacctctgctgcgacagaagaaaaggaa gttcccgtggtgtctactggagaaaatatgaagttggacagcttggagagcgacaaccag agagtcattgcagtgcattatgtcctggaagaaagcagtggctacatggagcccacactg cggattttggccatcttacacacagtcatctccttcttctgcatcattgggtattactgc ttgaaagttccgctggtaatttttaagagagaaaaggaagtagcaaggaaattggaattt gatgggctatatatcactgaacagccctcagaagatgatattaaagggcagtgggataga cttgtaatcaacacacagtcttttccaaacaactattgggacaaatttgtgaaaagaaag gtcatggataaatatggtgagttctatggccgtgacagaatcagtgagttattaggaatg gacaaagctgctcttgattttagtgatgctagagaaaagaagaaaccaaagaaggatagc tccttgtctgctgtgctaaactccattgatgttaagtatcagatgtggaaattaggagtt gttttcactgataattctttcctttacctagcttggtacatgaccatgtcagtccttggc cattacaacaattttttctttgctgctcatctccttgacattgcaatgggattcaagaca ttacgaactatactgtcatcagtgacccacaatggcaaacagcttgtcctaacggtgggg ttactggcagtagtggtatacttgtacacagtagtggcattcaattttttccgaaagttc tacaacaaaagcgaagatggtgatatgccagacatgaaatgcgatgatatgctaacatgc tacatgtttcacatgtatgttggagtacgtgcaggtggaggcattggtgatgaaatagag gatccagcaggagatgaatatgaaatctatcggattatctttgacatcactttcttcttc tttgtgattgtcattctgcttgccattattcaagggttaattattgatgcttttggtgag ttaagagatcagcaagaacaagttaaggaagacatggagacaaagtgctttatctgtgga ataggaaatgactactttgatacagtgccccatggctttgaaactcacacactgcaggag cacaacttggccaattatttgttttttctgatgtatcttattaacaaagatgagacggag catacaggacaggaatcctatgtatggaaaatgtatcaagaacgatgctgggagtttttt cctgctggtgattgtttccgaaaacagtatgaagaccagctcaactaa

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