Numida meleagris (helmeted guineafowl): 110401310 Help Entry 110401310         CDS       T06015                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism nmel  Numida meleagris (helmeted guineafowl) Pathway nmel04020   Calcium signaling pathway nmel04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:nmel00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     110401310 (RYR3)    04020 Calcium signaling pathway     110401310 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:nmel04040]     110401310 (RYR3) Ion channels [BR:nmel04040]  Voltage-gated cation channels   Ryanodine receptor    110401310 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_6 EF-hand_1 EF-hand_8 TBK1_ULD Motif Other DBs NCBI-GeneID:  110401310 NCBI-ProteinID:  XP_021257938 LinkDB All DBs Position 6:complement(30806611..30965788) Genome browser AA seq 4848 aa AA seqDB search MPLGSLVDDEVVLQCVSSIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVPPDLCICNFVL EQSLSVRALQEMLTNTGDNASEGAAQGGHRTLLYGHAILLRHSFSEMYLTCLTSSRSQTD KLAFDVGLRENAAGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSMSNGSI QVDASFMQTLWNVHPTCSGSNITEGYLLGGHVVRFFHGHDECLTIPSTDQNDSQQKKVLY ETGGAGVRARSLWRVEPLRISWSGSNIRWGQPFRLRHITTGMYLGLNDDEGLVMLDREKS DTASSAFCFRASKELKEKQDSALKRDIDGMGVPEIKYGDSVCFIQHVASALWLTYKAPDA KSARLGPLKRKVILHQEGHMDDGLTLQRCQHEESQAARIIRNTTSLFSQFISGNNRTLSP IALPVEEMAQTLQDLIKYFQPPGEDLEHEDKQSKLRSLKNRQNLFKDEGMLALVLNCIDR LNDYNSAAHFAEIAREENGTAWKEILNLLYKLLAALIRGNRNNCTQFSSNLDWLISKLDR LESSSGILEVLHCILIESPEALNVIAEEHIKSIISLLDKHGRNFKVLDVLCSLCVCNGVA VRANQNLICDNLLPRRDLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKWYFELIIDQVDP FLTAEPTHLRVGWASTSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGRVPRAVASV NQHLLSSDDVVSCCLDLGVPSISFRINGQPVQGMFENFCTDGFFFPVVSLSAGVKARFLL GGRHGEFKFLPPAGYAPCYEALLPKEKMKLEPVKEYKRDSDGVRDLLGTTQFLSQASFIP CPIDTSQVALPFHLEKIRDKLAENIHELWGMNKIELGWTYGKIRDDNKRHHPCLVEFSKL PETEKNYNLQMSTETLKTLLALGCHIVHANPAAEEDLKKVKLPKNYIMSNGYKPAPLDLS EVKLLPSQEFLVDKLAENAHNVWAKDRIKQGWTYGIQQDIKNKRNPRLVPYALLDERTKK SNRDSLREAVRTFAGYGYNVEPPDQEIADQTVEKVSIDKIRFFRVEQSYAVKAGKWYFEF EAVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSKGQRWHQGSGFFGRSWQPGDVVGCM INLDDKSIIFTLNGELLITSKGSELAFADFGIESGFVPVCSLGLSQIGRMNLGMDASTFK YYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKNHPHIEIWRIDGTIESPPRLKV THKTFGTQNSNSDMIYCRLSMPIEFRSSFSFGVGVENASSDALQKRKHSQEFPASSTTYF YSLRIFAGQDPSSVWVGWVTPDYHFYSENFDINKNCTVTVTLGDERGRVHESVKRSNCYM VWGGDVTANSQRSGRSNVDLEIGCFVDLATGMLSFTANGKELGTCYQVEPNTKLFPAAFV QPTSKNLIQFELGKLKNTMPLSAAIFKSEERNPVPQCPPRLDVQTITPVLWSRMPNSFLK VETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMKFHYHTLKLYSSVC ALGNTRVAYALCSHVDISQLFYTIDNQYLPGLLRSGFYDLLISIHLDHAKQAKLMMNNEF IIPVTEETRTIKLYPDETKKHGLPGVGLSTCLKPSFNFSTPCFIVTSEEHQTSSPEIPLD ILKSKAISMLTEAVQCSGSHIRDPVGGHIAFQFVPVLKLIATLLIMGVFDDDDVKQVLIL IDPNVFGDHKEETEERTEKEEVTQVEEKAVEAGEKAVKETKAPIKGLLQTRLPESVKLQM CHLLNYFCDCELQHRVEAIVSFADHYVSKLQYNQKYRYNELMQALNMSAALTAKKTKEFR SPPQEQINMLLNFQLGEDCPCPEEIRDELYDFHDDLLIHCGIPLEEEEEEEEDSSLTGKL RSLIYKIKGPPKPEKIEPREEEDKSPTTLKELISQTMVRWSQEDQIQDPELVRIMYTLLR RQYDSIGELLQALRKAYTISAASVKDTINLLAALGQIRSLLSVRMGKEEELLMINGLGDI MNNKVFYQHPNLMRVLGMHETVMDVMVNVLGGDKSQIAFPKMVASCCRFLCYFCRISRQN QKAMFEHLSYLLENSSVGLAFPSMRGSTPLDVAAASVMDNNELALALEEPDLDKVVTYLA GCGLQSCPVLLAKGYPDIGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPEC FGPELRGEGGNGLLAAMQEAIRISENPTRDLPSQGYKREGDEEEEEEEIVHMGNAIMSFY SALIDLLGRCAPEMHLIQSGKGEAIRIRSILRSLVPTEDLVGIISIPLKLSTVNKDGTVN EPDMSANFCPDHKAPMVLFLDRVYGIKDQSFLLHLLEVGFLPDLRASASLDTVSLSTTEA ALALNRYICSAVFPLLKRCAPLFSGTEHHASLVDSMLHTIYRLSKGRSLTKAQRDTIEEC LLAICHHLRPSMLQQLLRRLVFDVPLLNEYCKMPLKLLTNHYEQCWKYYCLPSGMGSYGI AAEDELHLTEKLFWGIFDSLSHKKYDPELFRMALPCLSAIAGALPPDYLDTRIRSTLEKQ TSVDPEGNFDPKPVNTANLVLPEKLEYIVSKYAEHSHDKWAFDKTNNGWKYGVSLDENTK THPLIRPFKTLTEKEKEIYRWPVRESLKTMLAMGWSLERTKEGGEAMLHQRENEKLRSIS QSSQGNGYNPAPLDLTNVVLSRELQGMVEVMAENYHNIWAKKKKMELESKGGGSHPLLVP YDTLTAKEKSRDREKAQELFKFLQVNGIIISRGLNDMDLDASSMEKRFAFKFLKKILKYV DSAQEFIAHLEAIVTSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHCLYFLSSPTKTLSS SGYASNKEKEMVASLFCKLAALVRHRISIFGSDSTTMVSCLHILAQSLDTRTVMKSGSEL VKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPVLTSIFEHI SQYHFGVDLLLGDVQVSCYRILCSLYALGTGKNIYVERQRPALGECLASLAAAIPVAFLE PSLNHYNPLSVFNTKSARERAILGMPETVEEMCPEIPQLDGLIKEINNLAESGARYTEMP HVIEVILPMLCNYLSYWWERGSESVPESAGPCCTMITSEHLSIILGNILKIINNNLGIDE ASWMKRIAVYAQPIISKARPDLLKTHFIPTLEKLKKKAIKIVMEEEQLRADSKSDTQEAE LLILDEFAVLCRDLYAFYPMLIRYVDNNRANWLKKPDADSDELFRMVAEVFILWCKSHNF KREEQNFVIQNEINNLAFLTGDTKSKMSKSGGQDQERKKSKRRGDLYSIQTSLIVAALKK MLPIGLNMCTPGDQELISLAKTRYSHRDTDEEVKEHIRNNLHLQEKSDDPAVKWQLNLYK DILKSDEPPDPEKNVERVQRISAALYHLDQVEQPLRSKKAVWHKLLSKQRKRAVVACFRM APLYNLPRHRSINLFLHGYQNYWIETEEYSFEEKLVQDLATSPKKEEEEEEDTEKEQPDP LHQIILYFSRNALTERSKLEDDPLYIAYAAMMAKSCQEEEEEEEEDKEKTFEEKEMEKQR TLYQQARLHDRGAAEMVLQMISASKGHTGPMVVETLKLGIAILNGGNTIVQQKMLDYLKE KKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTREKVLQHDEFTRDLFRFL QLLCEGHNNDFQNYLRTQMGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDVIDESGQ RNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSA QIELLKELLDLLKDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSSNVELILKFFDMFLKL KDLTNSDAFKEHDPDGKGIISKKDFQKSMEAQKQYIQSEIEFLLSCAEADENDMFNYIDF VDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLQSLLEPAESVLNYFEPYLGRIEIMGGAK KIERVYFEISESSRMQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLA SQISETDSAERPEEEEEEEPCYVVDIGDDEEEEKSLESPSAFAMACTAVKKNVANFFKMV TVKNLRKQYRKVRKMTVKEMVKVFFSFFWILFVGVFQLFFTVVWGIFQILWSTVFGGGLV EGAKNIKVTKILGDMPDPTQFGIHDDVTEAEKTEGAEHGIRDELVQFVKGEKGETDIISD IFGIPTKKEGGSKHGHDAGLGDIAEILGSDIQSSLENNVRKKKGLQIPETAKEAEAERKV EPEKADMEDGEKQDKAKEVQSEQPEEGKMKKKKRRHGQKVEKPEAVMANFFKALEIYQTK MLHCLARNFYNLRFLALFVAFAINFILLFYKVTEEPLDEVEEDSNLWNSFEEEEEEEGMV FFVLEESTGYMAPTLRALAVIHTIISFVCVIGYYCLKVPLVVFKREKEVARKLEFDGLYI TEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNAL DFSPVEESEPEAASLVSWLSSIDTKYHIWKLGVVFTDNSFLYLAWYTTMSILGHYNNFFF AAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDE DEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILL AIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYL FFLMYLINKDETEHTGQESFVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14547 nt NT seq  +upstreamnt  +downstreamnt atgcctcttggatctttagttgatgacgaagtagtacttcagtgtgtttccagtattcac aaagaacaaaggaagttttgcttggcagctgagggacttggaaatcgtctgtgctttttg gagccaacatcagaagctaaatatgttcctccagacctttgcatctgtaattttgtcctt gagcagtctctgtctgtcagagcccttcaagagatgctgaccaacacaggggataatgct agtgaaggggcagctcaaggtggtcacagaactctgctctatggccacgccatactactt cgacattcattcagtgaaatgtatttaacatgtttaacatcatcaagatcccagacagat aaacttgcatttgatgtgggactacgagaaaatgcagcaggtgaggcatgctggtggaca atacatcctgcttctaaacaaagatcagaaggagaaaaagttcgaataggtgatgatctt atcctggtcagtgtgtcctctgaaagatacctgcatctctccatgtcaaatggaagtatt caggtggacgcctcctttatgcagacactttggaatgtacatcctacatgctcaggaagc aatattacagaaggatatcttcttggtgggcatgttgtacgttttttccatggtcatgat gagtgtttgacaattccatctacagatcagaatgattcacagcagaagaaagtactttat gaaactggaggagccggtgttcgagcgaggtctttatggagagtagaaccccttcgaata agttggagtggaagtaacatcagatggggacagcctttccgccttcgacatataacaaca ggaatgtacttgggtttgaatgatgatgaaggtcttgtaatgttagacagagaaaagtcg gacacagcatcttctgctttttgtttcagagcatcaaaggaactaaaagaaaagcaggat tctgctcttaaacgtgacattgatggaatgggagtcccagaaataaagtacggtgattca gtctgttttattcaacatgtggccagtgccttatggttgacttataaagcaccagatgct aaatcagcacgcttaggtcctctgaaaagaaaggttatattacaccaagaaggccatatg gatgatggtctaaccttacaaagatgtcagcatgaagaatcccaggctgctcgaatcatt cgcaatactacaagcttattcagccagtttataagtgggaacaacagaacactatcaccc attgccctgcctgttgaggagatggctcagactctgcaagacctgatcaagtacttccag cctcccggagaagacctggaacatgaggataagcaaagcaagcttcggtccctcaaaaac cgacaaaatctattcaaagatgagggaatgctggcactagttttgaattgcattgatcgt ttaaatgactacaacagtgcagctcattttgcagaaattgcaagagaagaaaatggtaca gcatggaaagaaattttaaatctcctttacaaattgttagctgctctcattcgtggcaac agaaacaattgtactcagttttctagtaaccttgattggctaataagcaaactggacaga ttagaatcttcctcaggtattttggaagtgttgcactgtatcttgattgaaagcccagaa gctttaaatgtaatagctgaggagcatataaaatctattatttcactgttggacaaacac gggcgcaatttcaaggttcttgatgtgctttgctctctttgtgtctgtaatggagttgca gttcgtgccaatcaaaacttgatctgtgacaatctactgccaagaagagacttacttttg caaacacgtttgattaatgatgtgacaagcatcaggccaaacatatttttgggtgttgct gagggctctgcgcaatacaagaagtggtactttgaattaataattgatcaggttgatcca ttcttgacggcagaacctacccatttacgggttggatgggcctctacttcaggttatgcc ccctatcctggaggtggagaaggatggggtggcaatggcgttggagatgacttatactct tatggttttgatggccttcatctgtggtctggtcgagtacccagagctgtggcgtctgtc aatcaacatttgttgtcatctgacgatgtagttagctgctgcttggatttaggtgtgccc agcatttcattccgcattaatggtcagcctgtacaaggaatgtttgagaacttctgtact gacgggtttttcttccctgttgtaagcttatcagcaggtgtaaaagctcgtttcttactg ggtggacgtcatggagagtttaaatttctacctcctgctggctatgctccctgttatgag gctttgctgccaaaagaaaagatgaaattagaaccagtgaaagaatataagagagattct gatggagtgagagatttgctgggtacaacacagttcctctcccaagcttcatttatacct tgtcctatagacaccagtcaggttgctcttccttttcatcttgaaaagatcagggataaa ctagcagaaaatatccatgaactgtggggaatgaataaaatagaactgggctggacatat ggcaagatacgggatgataataaaaggcatcatccttgtcttgtggaattctcaaaatta cctgagacagagaagaattataatctacaaatgtcaactgaaaccctcaaaacgcttttg gcccttggatgtcacattgttcatgctaatccagcagcagaggaagatcttaaaaaagtc aagcttcctaaaaattatatcatgtcaaatggttataaacctgcccctcttgatctttct gaagtgaaactgttaccttctcaagaatttctagttgacaaactagccgaaaatgcacat aatgtctgggcaaaagacagaataaagcaaggatggacctatggcattcagcaggatatt aagaacaaacgtaatcctcggctagtgccatatgcattactagatgaacgtaccaaaaaa tcaaatagagatagcctccgtgaagctgttaggacatttgcaggctatggttataatgtt gagccacctgaccaagaaatagctgaccaaacagtggaaaaagtcagcattgacaagata cgttttttcagagtagaacagtcttatgcagtgaaggctggaaagtggtactttgaattt gaagctgtaacaggtggagatatgcgtgttggctgggccaggccaggctgtcgacctgac attgaactgggagctgatgaccaagcatttgtttttgaaggaagcaaaggccagcgttgg catcaaggcagtggattctttggacgaagctggcaaccaggagatgtggttggttgcatg ataaacttggatgacaaatcaattatctttactctgaatggagagttgcttataaccagt aaaggttcagaacttgcatttgctgactttggaatagaaagtggttttgttccagtttgc tcactgggtctatctcagattggacgaatgaaccttggaatggatgccagtacattcaag tattataccatgtgtggccttcaagaaggttttgagccttttgcagtgaacatgaaccga gatgtcgctatgtggtttagtaaacgcttaccaacatttgttaatgtgccgaagaatcat cctcacatagagatatggagaattgatggaaccattgagagtccacctcggttaaaagtt actcacaaaacatttggtacacaaaacagcaattctgacatgatatattgccgtttgagc atgcccattgagttccgttcatcattcagctttggtgtgggtgtggaaaatgcctcatcg gatgctcttcaaaaacgaaaacacagccaagaatttcctgcttcttctaccacatatttt tattccttgcggatatttgctggccaagacccatcctctgtctgggttggttgggtaaca ccagactatcatttttacagtgagaattttgacataaataaaaactgtacagtgacggtt actttaggagatgagagaggcagggttcatgaaagtgtgaagcgcagtaattgctatatg gtttggggaggagatgtaactgctaattctcagagatcaggtcgcagtaatgttgattta gaaattggatgctttgttgacctggctactggaatgttgtcattcactgccaatggaaaa gagcttggcacttgttatcaggttgaaccaaacacaaagctttttcctgcagcatttgta cagcctacgagcaagaacttaattcagtttgaacttggtaaattaaagaataccatgcct ttatcagcagcaatttttaaaagtgaggaaagaaatcctgttcctcagtgtccccctcgc cttgatgtgcaaacaattacacctgttttatggagtaggatgcctaacagctttctaaaa gtagaaacagagcgtgtcagtgaacgtcatggctgggttgtgcagtgtttggaacctctg cagatgatggcacttcatatcccagaggaaaacagatgcgttgatattttggaactgtgt gaacaagaagatttgatgaagtttcactatcacactttaaaactttatagctcagtttgt gctctaggtaacactagagttgcttatgcactttgtagccatgtagatatatctcagtta ttttacacaatagataatcagtatttacctggactcctacgttctggattttatgacttg ctcattagtattcatttggaccatgccaagcaagccaagctcatgatgaacaatgaattt atcattccagttacagaggaaactcgaactattaaattatatcctgatgagacaaagaag catggtttacctggagtagggcttagcacttgtctcaaaccaagctttaatttttctact ccttgctttattgtgacctctgaagaacatcagacatccagcccagaaattccccttgac atacttaaatccaaagctataagtatgctaacagaggcagtacagtgtagtggttctcat atacgagatcctgttggaggacacattgcattccagttcgttcctgttcttaaactcata gcaacattgcttataatgggagtttttgatgatgatgatgtgaagcaggtgttaatcctc attgatcccaatgtctttggagatcacaaggaagaaacagaagagaggacagagaaggaa gaagttacacaagttgaagaaaaagctgtagaagctggagaaaaggcagtaaaagaaacg aaggctcctataaagggcttattgcagacaagattaccagaatctgttaagcttcagatg tgccacttactcaattatttctgtgactgtgagctgcaacatagagtggaagcgattgta tcgtttgcagatcactatgtatcaaaattgcaatataatcagaagtacaggtacaatgaa ctcatgcaagccttgaacatgtctgctgctttgacagccaagaagactaaggaatttcga tctcctccacaagaacagattaatatgctgctgaattttcaactgggagaggattgtccc tgtccagaggagattcgggacgaactatatgacttccatgacgatcttctaattcactgt ggtattccactagaagaggaggaagaggaagaggaagattcctccttgactggcaaactt cgttcattaatatacaaaatcaaaggtccaccaaaaccagaaaaaatagagcccagggaa gaagaagataaatcacctactacactgaaggaactcatatcccagactatggtgcgctgg tcccaggaagatcagattcaagatccagaattggttcggattatgtacactctccttcgt aggcaatatgatagcattggtgagctacttcaagctctgaggaaagcatacactatcagt gctgcctctgtgaaggataccattaatttgcttgctgcactgggccagattcgctcgctt ctcagtgtcagaatgggaaaagaggaggaattgctaatgattaacggattaggggatata atgaacaacaaggttttttatcagcatcctaacttaatgagagtcttgggcatgcatgag acagttatggatgtgatggtgaatgtgcttggaggagataaatctcagatcgcttttcct aagatggtggcaagctgttgtcgattcctgtgctacttctgtcgaattagtcgtcaaaac caaaaagccatgtttgaacatctcagttacttgctggaaaacagcagcgttgggttggca tttccttcaatgagaggttcgacaccactagatgttgcagcagcctctgtcatggacaac aatgagcttgcactagcactggaagagccagatcttgataaagttgttacttacctggcg ggttgtggcctgcagagttgtccagtattgctagctaaaggatatccagacattgggtgg aatccaatagagggtgaacgttacctgtcattcctaagatttgcagtttttgttaacagt gaaagtgttgaagaaaatgcaagtgttgttgtaaagctccttattcgacgaccagagtgc tttggaccagagcttagaggagaaggaggaaacggtttgctggcagctatgcaagaagct atacggatctcagagaatcctactcgtgaccttccctcacaaggatataagagagaaggt gatgaagaggaggaggaggaggagattgtacacatgggcaatgcaattatgtcattttac tctgctctcatagatttacttggacgctgtgcaccagaaatgcaccttattcaaagcgga aaaggtgaagctattcgaatcagatcaatccttcgatctctagtgccaactgaagatttg gttgggattataagtattccgctaaagctgtcaacagttaacaaagatggcactgtaaac gagccggacatgtctgcaaatttctgtcctgatcataaagcgccaatggtactctttttg gaccgtgtgtatggtattaaggaccaaagcttcctccttcacctacttgaagttggattt ttaccagatttaagagcttctgcctctctggatacagtttctttaagtaccacagaggca gctcttgcactaaacagatatatttgctcagctgtgtttccattactcaaaagatgtgct cccctcttttctggaacagagcatcatgcctctcttgttgactccatgcttcacacaata tataggttatccaaaggacgttcacttacaaaagcacaacgagacactattgaagaatgc ctccttgctatctgccaccacttacgtccctctatgctgcaacagctattgagaaggcta gtttttgatgtgcccttacttaatgaatactgtaaaatgccactcaagcttctgacaaat cactatgaacagtgctggaaatattattgtctaccttcaggaatgggaagctatggaatt gcagcagaggatgaattacatttaactgaaaaactgttttggggaatatttgattccttg tctcataagaagtatgatccagagctctttagaatggccttgccctgtctaagtgctata gctggtgctttgcctcctgattatttagatacacgaattagatcaacactggaaaagcag acgtcagtggatccagaaggaaattttgatcccaaacctgtcaacacagcaaaccttgta cttcctgaaaagctggagtatatagtcagtaaatatgctgagcattctcatgataaatgg gcctttgataagactaataacggatggaaatacggtgtttcactggatgaaaatacaaag actcatccattaataagacctttcaaaactttaactgagaaggaaaaagaaatttatcgt tggcctgtgagagaatcactgaaaaccatgttggccatgggatggagcctagagaggacc aaggaaggaggagaagcaatgttacatcagcgtgaaaatgaaaagctccgcagtatatct cagtccagccagggaaatggatataacccagcaccacttgatctcacaaacgtggtactt tctagggaacttcagggaatggttgaggtaatggcagaaaactaccataatatatgggcc aaaaagaagaaaatggagttggaaagcaaaggtgggggcagtcatcctttattggtacct tatgacacattgacagccaaggagaaatcacgggaccgtgaaaaggcacaagagctattt aaattccttcaagtgaatggtataatcatatctcggggtctgaatgacatggatttggat gcttcatccatggagaagaggtttgcctttaagtttctgaagaaaattttaaaatacgtt gactctgctcaagagttcattgcacatttggaagccattgttaccagtggaaaaactgaa aaatctccacatgaccaagaaataaaattctttgccaaagttcttttaccattagttgat cagtactttacaaatcactgcttgtacttcctgtcttctccaacaaaaacactcagtagc agtggatatgcatcaaataaggaaaaggaaatggtagcgagcctgttctgcaaactagct gctcttgttagacataggatctcaatttttggtagtgattctacaacaatggtgagctgc ctgcacatcttagctcagtctctggacactcgaactgttatgaaatcaggatctgagcta gttaaagctggattgcgtgctttttttgaaaatgcagctgaagatctggaaaaaacttca gaaaatcttaaacttggaaaatttacccattcacgaacacaaatcaagggtgtttcacag aatatcaattatactacagtagcgttgttacctgtcttgacatcaatttttgagcatatt tcacagtatcattttggagttgatttacttttgggtgatgtacaagtttcatgttacaga attctttgtagcctctatgcccttgggactgggaagaacatctatgttgaaaggcaacgt cctgcacttggtgagtgcttagcatctcttgcagcagccattccagtagcgttccttgaa ccttctctcaaccattacaacccattgtctgtcttcaacacaaaaagtgcaagagaaaga gcaattttaggtatgcctgaaacagtagaggagatgtgtccagagatccctcagctggat ggactaataaaggaaattaataatttagcagagtctggagcaaggtacactgaaatgcct catgtaattgaggttatcttacccatgctatgcaactatttgtcctactggtgggaacga gggtctgagagtgttcctgaaagtgctgggccttgctgtacgatgataacatctgagcat ctgagcatcattctgggaaatattctgaaaatcattaacaacaatctgggaatagatgaa gcatcttggatgaaaagaattgcagtttatgctcaacctatcatcagcaaagccagacca gatctgctgaaaactcactttattccaacactggagaaattgaagaagaaagctataaag attgtgatggaagaggagcaactgagagcggacagtaaaagtgacactcaagaagctgag ctacttattcttgatgagtttgctgttctttgtagagacctctatgccttctatccaatg ctgatacgttatgtagacaacaacagagccaactggctaaagaaaccagatgcagattct gatgagctctttcgaatggtagctgaagtttttatcctgtggtgcaaatcacataatttc aaaagagaagaacaaaattttgtcattcagaatgaaatcaacaatttggcatttttaaca ggagataccaagagcaagatgtctaaatctggaggacaagatcaagagagaaagaaatca aaacgcagaggggatttgtactccatacaaacatccttgattgtagctgcacttaaaaag atgcttcctatcggcttgaatatgtgcactccaggagatcaagagctcatctccttggca aagactagatatagccatagggacactgatgaagaagtcaaagagcatatacgtaacaac ttacatttgcaggaaaagtctgatgatccagctgtgaaatggcagttaaatctatataaa gacattttgaagagtgatgagcctcctgaccctgagaaaaatgtggaacgtgtgcagagg atatcagctgctctgtatcatctggatcaggttgaacaaccactgagatcaaagaaagct gtttggcacaaacttctgtcaaaacaacgcaaaagagctgttgttgcttgttttagaatg gcaccgttatacaacctacccaggcaccgttctattaacctcttcctccatggctatcag aactattggatagaaacagaggaatattcatttgaggagaaactagttcaggatttggct acatctccaaaaaaagaggaagaagaagaggaagatacagagaaagaacaacctgatcca cttcatcagattatcctctattttagtcgcaatgctctcacagagagaagcaaactagaa gatgatcccttatatatcgcctatgctgccatgatggcaaagagctgtcaggaagaagaa gaggaggaagaagaagacaaagagaagacatttgaggagaaagaaatggaaaagcagaga actctttatcagcaagctcgcttacatgatcgtggagctgcggagatggtccttcagatg atcagtgcaagcaaaggtcacacaggacccatggttgttgagacactgaaacttggtatt gctattctaaatggtgggaatacaatagttcaacagaaaatgctagactacttgaaggaa aaaaaggatgctggattctttcagagtctttctggtttgatgcagtcctgcagtgtcctt gacttgaatgcgtttgagagacaaaataaagcagaaggcctgggaatggttactgaagaa ggaactcgtgaaaaagtgttgcagcatgatgaatttacacgagatctatttagattttta caactgctctgtgaagggcataacaatgattttcaaaattacctacgtactcagatgggc aacaccacaacagtgaatattatcattagtacggttgactacctcttgcgtcttcaggaa tcaatcagtgacttctattggtactattccggaaaagatgttattgacgaatcaggacaa cgcaacttctctaaagctttggctgtcaccaaacaaatattcaactcccttaccgaatat atacaggggccttgcattggtaaccaacagagtctggctcatagtaggctgtgggatgca gttgttggatttcttcatgtctttgccaatatgcagatgaaactttcacaggactctgct cagattgaactgcttaaagaactgctagatctgctaaaggatatggtagtgatgttgttg tcactacttgaaggtaacgtcgtaaatggaacaattggaaaacaaatggtcgatacactt gtagaatcatctagcaacgtagaattgatcttgaagttttttgacatgtttctgaaatta aaagatttaactaactcagatgctttcaaagagcatgacccagatggtaaaggcatcatt tcaaagaaggatttccagaagtcaatggaggctcaaaaacaatacatacaatcagagatt gaattcctgctgtcatgtgcagaagctgatgaaaatgatatgtttaactacattgatttt gtggacagattccatgaaccagccaaagatattggctttaacgtagcagttttgctcacc aacctttcagagcatatgcctaatgattcacgccttcagagcttacttgagcctgcagaa agtgttcttaattactttgaaccataccttggccgtattgaaataatgggtggagccaag aaaatagaaagagtttactttgaaatcagtgaatccagtcgaatgcagtgggagaagcca caagtgaaggaatccaaaaggcaattcatatttgatgttgtaaatgaaggtggagagcaa gaaaaaatggagctcttcgtgaatttctgtgaagacacaatctttgaaatgcagttagca tcccaaatctctgagactgattcagctgagagacctgaggaagaggaagaagaagagcct tgctatgttgtggatattggagatgatgaggaggaagaaaagtccctggaatctccttca gcttttgcaatggcctgtactgcagtcaagaagaacgttgccaacttttttaaaatggtc actgtgaagaacctaagaaaacagtacaggaaagttagaaagatgacagtaaaagagatg gtgaaagtgtttttctcttttttctggatcctattcgtaggggtgttccaactgttcttt acagtagtgtggggaattttccagattctttggagcactgtatttgggggtggactggtt gaaggagccaaaaacattaaagttacgaaaatattaggggacatgcctgacccaacacag tttggaatccatgatgatgttacggaagcagaaaaaactgaaggtgctgagcatggcatt agagatgaacttgtgcagtttgtaaagggtgaaaagggagaaactgacataatctcagat atttttggcattcctactaagaaagaaggcggttcaaaacatggtcatgatgctggactt ggagatattgcagaaatacttggttctgatatccagtcgtctttagaaaacaatgttcgt aagaaaaaaggattacagatacctgaaactgcaaaagaagctgaagcagaaagaaaagtg gaacctgagaaggctgacatggaagatggtgagaaacaggataaagcaaaggaagtacag tctgagcagcctgaagagggaaaaatgaagaaaaagaagcgaaggcatggacaaaaagtt gagaaacctgaggctgttatggctaatttcttcaaagctttggaaatatatcaaacaaaa atgcttcactgcctggcaaggaatttttataacttgcggtttcttgctttatttgttgca tttgccatcaactttattctgctattttacaaggtgacagaagagccacttgatgaagta gaggaagactctaatctctggaactcttttgaggaagaggaagaggaggaaggaatggta ttttttgttttggaagaaagtacaggttacatggcacccactctccgagcactggcagtt attcatactatcatctcctttgtctgtgtgattggatactattgcttaaaggtccctttg gttgtattcaagagagaaaaggaggtagctaggaagctcgaatttgatggattatacata actgaacaaccatctgaagatgatattaaaggacaatgggatcgcctggttataaacaca ccgtcctttcctaacaattactgggataaatttgtaaaacgaaaggttattaacaagtat ggagacttgtacggagcagagcgtatagcagaacttctgggtttggacaaaaacgccctt gattttagtccagtggaagagagtgaaccagaagcagcatctcttgtatcatggttaagt tccattgacacaaagtaccacatttggaagctcggtgttgttttcactgataactcattt ttgtatttagcttggtacacaactatgtctatccttgggcactacaacaacttctttttt gctgctcatctgctggatattgctatgggtttcaagacattgcgaaccattttgtcctca gtcactcacaatggcaaacagcttgtgcttactgtaggactcctggctgtagtagtgtat ctttacactgttgtggcgttcaacttcttccgcaaattctacaataaaagtgaagatgaa gatgaaccagatatgaaatgtgatgacatgatgacgtgttacctattccacatgtacgtg ggtgtaagagctggtggtggcattggggatgaaattgaggatcctgctggagacccttat gaaatgtatcgaattgtcttcgacatcacgtttttcttctttgtcattgttatcctactg gccattattcaaggtctgattattgatgcttttggtgaattaagagaccagcaagaacaa gtgagagaagatatggagaccaaatgctttatttgtggaattggcaacgactattttgac acaaccccacatggctttgaaacacatactctgcaggaacacaacttggcaaactacctg ttcttcttaatgtacctcattaacaaggatgaaactgagcatactggccaggagtcattt gtgtggaagatgtaccaagaaagatgttgggatttcttcccagcaggagactgcttccgg aaacagtatgaggatcaacttggctaa

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