Neisseria meningitidis 510612 (serogroup A): NMA510612_1413
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Entry
NMA510612_1413 CDS
T03438
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
nmx
Neisseria meningitidis 510612 (serogroup A)
Pathway
nmx00290
Valine, leucine and isoleucine biosynthesis
nmx00620
Pyruvate metabolism
nmx01100
Metabolic pathways
nmx01110
Biosynthesis of secondary metabolites
nmx01210
2-Oxocarboxylic acid metabolism
nmx01230
Biosynthesis of amino acids
Module
nmx_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
nmx00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
NMA510612_1413 (leuA)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
NMA510612_1413 (leuA)
Enzymes [BR:
nmx01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
NMA510612_1413 (leuA)
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Gene cluster
GFIT
Motif
Pfam:
HMGL-like
LeuA_dimer
HCS_D2
P22_Cro
Motif
Other DBs
NCBI-ProteinID:
AHW75703
UniProt:
X5F946
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All DBs
Position
1204263..1206056
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AA seq
597 aa
AA seq
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MQLDIDRLVAYFGGVNALAEALKQHDPENAATTAAIYKWRTRGSLPLAQLQKLTALAESQ
GRPLDLNAFLQKNESLERTEMTQANRVIIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKL
GVDIIEAGFAAASPGDFEAVNAIAKTITKSTVCSLSRAIERDIRQAGEAVAPAPKKRIHT
FIATSPIHMEYKLKMKPKQVIEAAVKAVKIAREYTDDVEFSCEDALRSEIDFLAEICGAV
IEAGATTINIPDTVGYSIPYKTEEFFRELIVKTPNGGKVVWSAHCHNDLGLAVANSLAAL
KGGARQVECTVNGLGERAGNASVEEIVMALKVRHDLFGLETGIDTTQIVPSSKLVSTITG
YPVQPNKAIVGANAFSHESGIHQDGVLKHRETYEIMSAESVGWATNRLSLGKLSGRNAFK
TKLADLGIELESEEALNAAFARFKELADKKREIFDEDLHALVSDEMGSMNAESYKFISQK
ISTETGEEPRADIVFSIKGEEKRASATGSGPVDAIFKAIESVAQSGAALQIYSVNAVTQG
TESQGETSVRLARGNRVVNGQGADTDVLVATAKAYLSALSKLEFGSAKPKAQGSGTI
NT seq
1794 nt
NT seq
+upstream
nt +downstream
nt
atgcaattagatatagaccgcttggttgcttatttcggcggcgtgaacgcgcttgccgaa
gcgttgaaacagcacgatcccgaaaatgccgcgacgaccgccgccatctataaatggcgc
acgcgcgggtcgctgcctttggcgcaactgcaaaagctgaccgcgcttgccgaatcgcaa
ggcaggccgctggatttgaatgcttttttacaaaaaaacgaatctctggagagaacagaa
atgacacaggccaaccgcgttatcattttcgacaccaccctgcgcgacggcgaacaatcg
cccggcgccgctatgaccaaagaggaaaaaatccgcgtcgcccgccagctggaaaaattg
ggtgtggacatcatcgaagcgggttttgccgctgccagcccgggcgatttcgaggcggtc
aatgcgattgcgaaaaccattaccaaatcaacggtctgttcattgtcccgtgccatcgag
cgggacatccgtcaggcgggtgaggccgttgcgcccgcgccgaaaaaacgcatccacacc
ttcatcgccaccagccccatccatatggagtacaaattgaagatgaagccgaagcaggtg
attgaggcggcggtcaaagcggtgaaaatcgctcgtgaatacaccgacgatgtggaattt
tcctgcgaagacgcgttgcgttcggaaatcgatttccttgccgaaatctgcggcgcggta
attgaagcgggcgcgaccaccatcaatattcccgataccgtcggctattcaatcccgtac
aaaaccgaagaatttttccgcgaactgattgtcaaaacgcccaacggcggcaaagtcgtt
tggtcggcacactgccacaacgatttgggcttggcggttgccaattcgcttgccgcatta
aaaggcggtgcgcgtcaggtggaatgtactgtcaacggcttgggcgaacgtgcaggcaat
gcttcggttgaagaaatcgtgatggcgttgaaagtgcgccacgacttgttcggcttggaa
accggcatcgataccacgcaaatcgtgccttcgtccaaactggtgtccaccattacgggc
tatcccgtgcagcccaacaaagccattgtcggtgccaatgccttttcgcatgaatcgggc
atccatcaggacggggtgctgaaacaccgcgaaacttacgagattatgtccgccgaatcg
gtcggctgggcaacaaaccgtttgagcttgggcaaattgtccggccgcaacgccttcaaa
accaagctggcggatttgggcatcgagttggaaagcgaagaggcactgaacgccgcgttt
gcccgcttcaaagaactcgccgacaaaaaacgcgaaatcttcgatgaagacctgcacgca
ctggtatccgacgaaatgggcagcatgaatgccgagagctacaaattcatctcccaaaaa
atcagcaccgaaaccggcgaagagccgcgcgccgacatcgtgttcagcatcaaaggcgaa
gaaaaacgcgcttccgccacaggctccggccccgtggatgcgattttcaaagcgattgaa
agcgtggcgcaaagcggcgcggctttgcagatttattccgtcaacgccgtcacgcaaggt
acggaaagccagggcgaaaccagcgtccgtctggcgcgtggcaaccgcgttgtcaacggt
cagggtgcggataccgacgttttggtcgccactgccaaagcctacctctctgccttaagc
aaactggaatttggttctgccaaaccgaaagcgcaaggcagcggtacgatttga
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