Nipponia nippon (crested ibis): 104011220 Help Entry 104011220         CDS       T05756                                  Symbol UBR4 Name (RefSeq) E3 ubiquitin-protein ligase UBR4   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism nni  Nipponia nippon (crested ibis) Brite KEGG Orthology (KO) [BR:nni00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:nni04121]     104011220 (UBR4) Enzymes [BR:nni01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      104011220 (UBR4) Ubiquitin system [BR:nni04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     104011220 (UBR4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  E3_UBR4_N E3_UbLigase_R4 UBR4 zf-UBR AP3D1 Motif Other DBs NCBI-GeneID:  104011220 NCBI-ProteinID:  XP_009461714 LinkDB All DBs Position Unknown AA seq 5155 aa AA seqDB search MVWLSAGNGRIGPLNYLAGLREEFERKVSLMFSYLLRESEILHHDKQYEPFYSSFVALST HYITTVCGLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSR LDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFN PRVSSSPSVTPETQVEGESEDQASTDQTSAAKTKSIFIAQNVASLQELGGSEKLLRVCLN LPYFLRYINRFQDAVSANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLT PTRLQDVTVLALSCLYAGVSVATCMAILHVGSTQQVRTGSTSSKEEDYENDAATIVQKCL EIYEMIGQAISNSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAAL RVRDIIARTKEGVGSPKLGPGKGHQGFGVLSVVLANHAIKLLSSLFQDLQVEALHKGWES DGPPAVLDIMAQSTSIQRIQRLIDSVPLTNLLLTLLSTSYRKACVLQRQRKGSMSSDASA STDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKVAPPPPPPPPPLESSPR VKSPNKQTAGENGNILASRKDPELFLSLASNILNFITSSMLNSRNNFIRNYLSVSLSEQH MATLASIIKEVDKDGLKGTSDEEFAAALYHFNHSLVTSDLQSPALQNTLLQQLGVAPFSE GPWPLYIHPQSLSVLSRLLLIWQHKATAQGDPDVPECLKVWERFVGTLKQNALQGTLPSD TEDLNVEHLQLLLLIFHNFSERGRRSIMMLCIQTIVELTVNMDTQQCSVPLIVARLLLVF DYLLHQYSKAPMYLFEQVQYNWLTPPIGWVSGSQDSSRRTSVPLYHAFKEVEENWTKHCS SDTVPQPRFYCILSLEASEDDLNRLDSTVCEVLFSRTMKYDELYAALTSLLAAGSQFDTL RRKENKNVTALEACALQYYFLILWRILGILPPSKNYMNQLAMNTPEMSECDILHTLRWSS RLRIASYVTWIKDHLTKQGMKADHAASLIELASSKCSSVKYDVEIAEEYFARQISSFCGV DCTTILQLHEVPSLQSIYTLDAAISKIQVSLDEHFSKLAAETDPHKSSEITKNLLPATLQ LIDTYATFTRSYLLRSLSEEGSTENKPSEEKLRGYAAVLAIGSSRCKSNTLGPTLVQNLP SAVQTLCESWNNIHTNEFPNIGSWRNAFANDTIPAESYISAVQAAHLGTLCSQSLPLAAS LKHTLLSLVRLTGDLVVWSDDLNPPQVIHSLLPLLLETSTESVAEISSNSLERILGPAES DEFLARVYEKLITGCYNILAHHSDPNSGLDESILEECLQHLEKQLESSQARKAMEEFFSE SGELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLRLCGSLAQLACVEPVR LQAWLTRMTTSPPKDSDQLDVVQENRQLLQLLTTYIVRENSQVGEGVCTVLLSTLIPMAT EMLANGDGTGFPELMVVMATLASAGQGAGHLQLHGAAVDWLGRCKKYLSQKNVVEKMNAN VMQGKHVTILECTCHIVSYLADVTNALSQTSGQGPSHLSVDGEERAIEVDSDWVEELAVE EEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHE ISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMKESAFQSEPRVPESVIRHASTSP AEKAKVTISEGKGPDEEKPKKSSLCRNVEGCREELQSQANFSFAPLVLEMLNFLMDAIQI NFQQASAMGSSSRAQQALNELHTLDKSVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQT IRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTR LASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIK AVWLPGSQTELAIVTADFVKIYDLSVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIM SSAGYIYTQLMEEASSAQHGPFYVTNVLEVNHEDLKDSNGQVAGGGVSVYYSHVLQMLFF SYCQGKSFAATISRANLEVQRLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTT GVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMA NVENTSYWLQPSLQPSSVISIMKPVRKRKAAAITTRTSSQVNFPIDFFEHNQQLTDVEFG GNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEVTNNNSTMVMTGMRIQIGTQAIERA PSYLEIFGRTMQLNMTRARWFDFPFTREEALQADKKLTIFIGASVDPAGVTMMDSIKIYG KTKEQFGWPDEPPEDFPSASVSNVCPPNLNQGNGTGDTESATPAAASGTVLERLVVSSLE ALESCFAVGPVNEKEKNKVAAQELATMLLSMPAPSSVQQQTKSLLASLHTSRSAYHNHKD QALLSKAIQYLSSSTKEGKDLDPEVFQRLVITARSIAIMRPNNLVHYTESKLPQLETENE EGQEAQKQAEGDGCTFITQLVNHFWKLHASKPKNAFLAPACLPGLTHVEATVNALVDIIH GYCTCELDCIHTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTP MGDKDDDDDDDAEDKLQSSGIANGEHIRQESQEQSEVDHGDFEMVSESMVLETSENVNNG NPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLSG QAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDSV AGEHSVSGRSSAYGDTTAEGHPAGPGSVSSSTGAISTTTGQQEGDGSEGEGEAEGDVHTS NRLHMVRLMLLERLLQNLPQLRNVGGVRAIPYMQVILMLTTDLDGDDEKDKGALDNLLSQ LIAELCMDKKDVSKKNERSPVNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATAA ALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVATSQLLKPHTTSSPPDMSPFFLRQYVKG HAADVFEAYTQLLTEMVLRLPYQIKKIADTNSRIPPPIFDHSWFYFLSEYLMIQQTPFVR RQVRKLLLFICGSKDKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSALQYD TLISLMEHLKACAEIATQRTVNWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCAL CGSKVLSVASSSGSSSTSSTSAPAASGSGQPATQSKSSTKKSKKEEKEKEREGESSGSQE DQLCTALVNQLNKFADKETLIQFLRCFLLESNSSSVRWQAHCLALHIYRNSNKSQQELLL DLMWSIWPELPAYGRKAAQFVDLLGYFSLKTQQTEKKLKEYSQKAVEILRTQNHILTNHP NSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGS HTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVK IDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCR SINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVTNINTLLDKADR VYHQLMGHRPQLENLLCKVNEAAPEKPQDESGSSGGISSTSASVNRYILQLAQEYCGDCK NSFDELSKIIQKVFASRKELLEYDLQQREAATKSSRTTVQPTFTASQYRALSVLGCGHTS STKCYGCASAVTEHCITLLRALATNSAIRHILVSQGLIRELFDYNLRRGAATMREEVRQL MCLLTRDNPEATQQMNDLIIGKVSAALKGHWANPDLASSLQYEMLLLTDSISKEDSCWEL RLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVDALTTVKPY SNEIHAQAQLWLKRDPKASYEAWKKCLPARGIDANGKSPSKAELHQLYLSEKYVWKWKQF MSRRGKRTCPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATIPSRKQQVLDLLTS YLDELSIAGECAAEYLALYQKLIKPAHWKVYLAARGVLPYIGSLITKEIARLLALEEATL STDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQ DMLLEMLEDMTTGTESETKAFMAVCIETAKRYSLDDYRTPVFIFERLCSIIYPEENEVTE FFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMEL LVNNKIISLDLPVAEVYKKVWCPTNEGEPMRIIYRMRGLLGDATEEFIESLDSTTDEEED EEEVYKMAGVMAQCGGLECMLNRLTGIKDFKQGRHLLTVLLKLFSYCVKVKINRQQLVKP EMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLT GDKDQLVMLLDQINSTFVRSNLSVLQGLLRIIPYLSFGEMEKMQILVDRFKPYCNFDKYD EEHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIPSAKNLDAD IWKKFLSRPALPFILRLLRGLATQHPATQVLIGTDSITNLHKLEQVSSDEGIGTLAENLL EALREHPEVNKKIDAARKETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQME ELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEFENKPRKQQGYSTVSHFNIVHY DCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTG QREPTYQLNVHDIKLLFLRFAMEQSFSVDTGGGGRESNIHLIPYIIHTVLYVLNTTRATS REEKNLQSFMEHPKEKWVESAYEVDGPHYYTVLALHISPPEKWKAMRVEILKRLLITSHA RVVSPGGASRLADKTVKEYATYRSGLLFWALVDLIYNMFKKVPTSNTEGGWSYSLAEFIR HNDMPIHEAADKALKTFQEEFMPVETFSEFLDVAGLLSEINDPDNFLKDLLNSIP NT seq 15468 nt NT seq  +upstreamnt  +downstreamnt atggtgtggctgtcggcgggaaacggccgcatcgggccactgaattacctcgcagggctg cgggaggaatttgaacgtaaagtctctctcatgttctcttatttattacgcgagtctgaa atcctgcaccatgacaaacagtatgagcctttttactcttccttcgttgcactttctacg cattacatcactactgtgtgtggtctaataccgagaaaccagttgcaatcagtggcagct gcttgtaaagtcctgattgaattctccctgctgcgtcttgagaacccagatgaagcatgt gctgtttcacagaaacacctcattctactgataaaggggctgtgcacgggctgcagccgc ctagatcgaactgaaattattaccttcacagcaatgatgaagtcggccaagctccctcag actgtcaaaaccctctctgatgtagaggaccagaaggagctggcctcgccggtgagccca gaactaagacagaaagaagtgcagatgaacttcctcaatcagttgacatcagtgtttaac cctagggtttcatcatcaccatctgtcacgccagagacacaggtggaaggagagagcgag gatcaagcttccacagatcagacctctgcagcaaagacaaaaagcatattcatcgctcag aatgtagccagcctgcaagaacttggtggctctgaaaaactgctgagggtgtgcctgaac ctcccatactttttgcgatacataaatcgatttcaggacgcagtgtcggccaactcattt tttattatgccagccacagttgcagatgccactgctgttcgcaatgggtttcattcgctg gtaatagatgtgaccatggcactggatacgctgtctctgcctgtactggagcccctgaca cccacgcgtctccaagatgtgactgttcttgctctcagctgtctctatgcaggtgtgagc gtggcaacttgcatggccatcctgcacgtgggtagcactcaacaggtacgaactgggtca acaagctccaaagaagaagattatgaaaatgatgctgctactattgtacagaaatgtctt gaaatctatgaaatgattggacaagccatcagcaattcacgccgtgcggggggtgagcat tatcagaacttccagctgctcggggcttggtgtttgctaaacagcctcttcctcatcttg aacctcagccctacggccttggctgataagggaaaggagaaagatccattggctgctctt cgcgtcagagacattattgcccgtactaaggagggcgttgggtctcccaaactaggacct gggaaagggcatcaagggtttggtgttctgtcagtggtgctagcaaatcatgctatcaaa ttgctgtcatcgctctttcaagatctgcaagtggaggcattgcacaagggctgggagagt gatggtccgccagcagtgctggatatcatggctcaaagcacatccatccagagaattcag cggctgatagattctgtgccgctcactaatttgctgctgactttgctatctacttcctac agaaaggcttgtgtcttgcagcgtcagaggaagggctccatgagcagcgacgcaagtgcc tccactgattcgaatacttactatgaggatgattttagcagcactgaggaggacagcagc caagatgacgacagtgaaccaatcctcgggcaatggtttgaagagacaatctccccaagc aaagagaaagtggccccaccaccaccccctccaccgccacctttggagagctcgcctaga gtgaaaagccctaacaaacagactgctggagagaacgggaacatcctggccagccgcaaa gatccagaattgtttttgagcctagcttcaaacattttgaactttatcacttcttctatg ctgaactccaggaataacttcattcgcaactacctgagtgtctctctttcggagcagcac atggctacactggctagcatcatcaaagaagtggataaggacgggcttaaaggcacgtca gatgaggagtttgctgctgcgctgtatcacttcaaccattccttggtgacctcagatctt cagtcccctgccttgcagaacacacttcttcagcaactgggagttgcccctttttctgaa ggtccgtggcctctctacattcatcctcaaagtctgtcggtgctctcacgacttctcctg atttggcagcataaagccactgcccagggagatcctgacgttccagaatgccttaaagtt tgggaaaggtttgtgggcacattgaagcaaaacgccttgcaggggactcttcccagtgac acagaggatctgaatgttgaacatctccagctgctgctgcttatttttcacaatttctcc gagaggggccgcagatctatcatgatgctgtgtatccagacaattgtggagctgacagtg aacatggatacccagcagtgttctgtgccacttatcgtggcacgtctgctcttggtattt gactacctgctccatcagtattccaaggcccccatgtacctatttgaacaggtgcaatat aattggctgactccacccattggctgggtgagtggatcccaggacagtagcagacgaaca tctgtcccactttatcatgcgtttaaagaagtggaagaaaactggaccaaacactgttca tcagacacagttccacagcccagattctactgcatcctatctctggaagcttctgaagat gatctgaaccgtctggatagcacggtttgtgaggtccttttctctaggaccatgaagtat gacgagctctacgcagccctgacttcattacttgcagctgggtcacagtttgatacactc aggaggaaagagaacaaaaatgtcactgcactggaagcctgtgcacttcagtactacttc ttgatactgtggcggatactagggattttgcctccatccaaaaactacatgaatcaattg gctatgaacacaccagagatgagtgaatgtgatattttacacacgttgcgctggtcttct cgtctgcgcatcgcgtcttacgtcacgtggatcaaggatcaccttaccaagcagggcatg aaagctgaccatgctgcttctctcattgaattggcctccagcaagtgcagctcagtgaag tacgatgtggaaatagcagaggaatactttgctcgacagatatcttctttctgtggtgtt gattgcacaactattctccaactgcacgaagttcctagtttacagtccatttacaccctt gatgctgcaatttccaagattcaggtttctctagatgagcacttttccaagctagctgca gaaactgatccacacaagtcttcagagataaccaagaacctcctgcctgctacgctacag cttattgacacttacgctacgtttaccagatcttacttgctccggagcctctctgaagag ggctccactgagaacaaaccctctgaagagaagctacgaggttatgctgctgtcctggcc attggatccagccgttgcaaatctaatactctaggtccaacacttgttcagaacttgcca tcagctgtgcagactttatgtgaatcatggaacaacattcatacaaatgagtttccaaac attggctcatggcgcaacgcctttgcgaatgacacgatccctgcagaaagctacatcagc gcagttcaggccgcccacctcggtactctctgcagccaaagtctacctcttgcagcttcc ctaaaacacacccttctctccctggtcagactcactggggatctcgtggtctggtcagat gatttgaacccgccacaggtgattcattccctattgcccctccttttggagaccagcaca gagagcgtggcagagataagcagcaactccctagaaaggatcttgggccctgcagaatcg gatgaattcctggcgcgtgtttatgagaaactgatcacaggatgctataacatactggcc catcactctgatccaaacagtggcctggatgagtccatcttggaggaatgtttgcagcat ctggagaaacagctggagagcagccaggcccgaaaagccatggaggaattcttttcagaa agtggagaactggtccagatcatgatggcgacagccaatgaaaacctctcggcgaagttc tgcaacagggtgctgaaattcttcaccaagctcttccagctaactgagaagagtcccaac cccagcctgttgcggctttgtggttctttggctcagctggcttgtgtggagcctgtacgt ctccaggcctggttaaccaggatgaccacatccccacccaaagattcagatcaactggac gttgttcaagagaacaggcaactgctgcaactcttgacaacttacattgttcgggaaaac agccaagtcggagaaggcgtgtgcactgttctgctgagtactctgataccaatggcaaca gaaatgttggccaatggtgatggcacaggctttccagaactgatggtcgtgatggcaact ttggctagtgcaggacaaggcgcgggacacctccagcttcatggtgctgctgttgattgg ctaggcagatgcaagaaatacctgtctcaaaagaatgtggtagaaaaaatgaatgcaaac gtcatgcaagggaagcatgtgactatcctggagtgtacatgccatattgtctcttacctg gccgatgtcaccaatgcgctgagccagaccagtggccaaggaccaagtcatctttccgtt gatggagaggaacgggcgattgaggtggattcagactgggtggaagagttggcagtggag gaggaggactctcaagctgaggattcggatgaagattctctttgtaataaactctgtacc ttcaccatcacacagaaggaattcatgaatcaacactggtatcactgtcacacttgcaag atggttgatggggttggtgtttgcacggtttgtgctaaagtttgtcacaaggatcatgag atttcttatgccaaatacggatcgttcttctgtgactgtggagccaaggaagatggcagt tgcctggctttggtgaagagaactcccagcagtggtatgagctctaccatgaaagaatcc gccttccagagcgagcccagagtgcccgagagtgtcattcgacatgccagcacttctcct gcagagaaagccaaggtcaccatcagtgaggggaagggccctgacgaagaaaaacccaag aagagcagcctgtgtagaaacgttgagggctgtcgagaggaattgcagtcccaggccaac ttctcctttgcacctttggtgctggagatgctgaatttcctgatggatgccattcagata aacttccagcaagcttcggccatggggagcagcagtcgtgcacagcaagctctcaatgag ctacatactttggacaagtcagtagaaatgacggatcagttgatggtcccaactcttggc tctcaagaaggtgcttttgagaacgtccgcatgaactacagcggtgaccagggccagacg atccggcagctgatcagcgcccacgtgctgaggcgggtggcgatgtgcgtgctgtcgtcc ccgcatggacgtcggcagcacctggctgtgagtcacgaaaagggcaagattacagtcctt cagctctcagccttgctcaaacaagcagactccagcaaaagaaaattgacccttactcgc ctcgcgtccgcacccgttccgtttactgtactgagcctaactggaaatccctgcaaggag gactacctagccgtgtgtggactgaaagactgccatgtgctaacattcagcagctctgga tcagtctctgatcatctggtacttcatccccaactagccactgggaatttcatcattaaa gctgtgtggctgccaggatctcaaacagagcttgctattgtgactgcagactttgtgaag atttacgatctctctgtagatgccttgagtccaactttctatttccttctaccgagttcc aaaatcagggatgtcactttccttttcaacgaggaggggaagaacataatagtgatcatg tcctccgctgggtacatctatacgcagctcatggaagaggcgagcagtgcccagcatgga ccattctatgtcaccaatgtgcttgaagtcaatcacgaggacctaaaggacagtaatggc caggtagcaggaggcggtgtgtcagtgtattactcccatgtgctacagatgttgttcttc agttactgtcaaggcaaatccttcgcagccaccatcagccgggccaatctggaagtgcag cggctattcccgattaacataaagagttcaaacggtgggagtaagacttcaccggcactg tgtcagtggtctgaggtgatgaaccatcctggcttggtgtgctgtgttcagcaaaccaca ggtgtcccactggtggtgatggtgaagccggacacctttctcatccaggagattaaaacc ctgccagccaaagcaaagattcaggacatggtggccatccgtcacacagcctgcaatgag cagcagaggaccactatgatcctcctgtgtgaagacggcagcctgaggatctacatggcc aatgtagagaatacctcctactggctccagccctctctccagcctagcagcgtcatcagc atcatgaagccagttcgcaagcgcaaggcagctgctattacaactcgcacatccagccaa gtgaacttccctattgacttctttgaacacaaccagcagctcacagatgtagagtttgga ggcaacgacctgctgcaggtttacaatgctcagcagatcaagcaccggctcaattccact ggcatgtatgtggccaacacaaagcctgggggtttcaccattgaagtgacgaacaataac agcacgatggtgatgacaggcatgcggatccagattggcacacaagcgatagagagagcg ccctcgtacttggagatctttggccgcaccatgcagctgaacatgaccagggctcgttgg tttgacttccctttcactcgcgaggaagcattgcaggctgacaaaaaactaaccatcttc attggggcttccgtggatcctgctggagtcacaatgatggattccataaaaatttatggc aaaaccaaagagcagtttgggtggcctgatgagccccccgaggatttcccatctgcttca gtgagcaacgtttgtcccccaaacctgaatcaagggaatggcactggagacacggagtcg gctacccctgctgctgccagtggcactgtcctggagaggctagtagtgagttctttagaa gcactggaaagctgctttgctgtaggaccagtcaacgagaaggagaagaataaggtggca gctcaggaactggctactatgctgctctccatgccagctccttccagtgtccagcagcag accaagagcctcttggctagcttgcacaccagccgctcagcataccataaccacaaggat caagcattgttaagtaaagccattcagtatttgagttcctcaaccaaagaaggaaaggac cttgatcctgaagtgtttcagaggctggtcatcaccgctcgatccattgctattatgaga cccaacaatctggtccattatacggaatcaaagctgccacagttggaaacagagaatgaa gaagggcaagaggcccagaaacaggctgaaggagatggctgcacatttattacccagctg gtcaaccacttctggaagctacatgcatcaaaacccaaaaacgccttccttgcccctgcc tgcttgccaggtctcactcatgttgaagccacagtcaatgctttggtggatattatccat ggatactgcacgtgtgaactggattgtatccatacagcatccaagatctatatgcagatg ttactttgcccggatcctgcagtgagcttttcttgcaaacaagctttgatcagagtgctg agaccaaggaacaagcggagacatgtcaccttgccatcctcccctcggagcaatactcct atgggagataaggatgatgatgatgatgacgacgcggaagacaagctgcagagttctggg atagcaaacggtgagcatatccgacaggaaagccaagagcaaagcgaagttgatcacggg gacttcgagatggtgtccgaatctatggttctggagacttctgaaaatgtgaataatggg aatccttctcccctggaggctcttctggctggagcagagggattccctcctatgctggat attcctccagatgcagatgatgaaacaatggtggaactggctattgccctgagcctgcaa caagatcagcaagggagcagcagtagtgcacttggacttcagagcttaggactgtctggc caagcacccagctcttcttctctcgatgccggaacgctctcagatacaacagcatcagct ccagcgtctgatgatgaaggcagcacagctgcaacagatggctcaactctgcggacttca cctgcagaccatggtgggagcgtgggctctgagagcggtggcagcgcggtggactccgta gctggtgagcacagcgtgtctggccgtagtagtgcctatggggacacgacagcggagggc caccctgctgggccaggcagcgtcagctcaagcacaggcgctatcagcactaccacaggc cagcaagagggagatggttcagaaggggaaggggaggcagagggagatgtccacaccagc aacaggctgcatatggtccgactgatgttgctggagaggctgctgcaaaacttacctcag ctgaggaatgttggaggagtccgggccattccttatatgcaggttattctgatgctcaca acagacctagatggagatgatgagaaagacaagggtgctttagataaccttctgtcccaa ctgattgcagaactgtgcatggacaaaaaggatgtgtctaagaaaaacgaacgctctcct gtgaatgaagtgcacttggtggtaatgaggctgcttagtgtgttcatgtccagaactaag tcaggatccaagtcttccatttgtgagtcttcctccctcatctctagtgccactgctgct gcgttgttgagctctggtgctgttgactactgtctgcatgtactgaagtctttgctggag tactggaaaagccagcagaatgacgaggagcctgtagccaccagccagctcctcaaacct cacactacttcttctccacctgacatgagcccttttttcctccgccagtatgtgaagggt catgctgcagatgttttcgaggcctacactcagctcctgacagagatggtgctgcggctg ccctatcagatcaagaagattgcagacacaaactcccgcatcccacctcccatctttgat cactcctggttttactttttgtctgagtacctgatgatccagcagaccccattcgtgcgc cgccaagtccgcaagcttttgctctttatctgtggatcaaaggataaataccgccagctc agggaccttcacaccttggactctcatgttcgtggaatcaaaaagctcctagaagagcaa ggtattttcctccgtgccagtgtggtcacagcaagttcaggctcggccctgcagtacgat acgttgatcagcttgatggaacatttaaaggcttgtgcagagatcgccacacagcgaaca gtaaactggcagaaattctgcattaaagacgactcggttctctatttcctccttcaagtc agcttcctggtagatgaaggagtgtcgccagttctcctgcagctgctgtcttgtgctctg tgtggcagtaaagtgctgtctgtggcttcatcctccggatcatcaagcacctcttccacc tctgctcctgcagcatcgggctctgggcagccagcaacacagagcaaatcctccactaaa aagagcaagaaagaagaaaaggaaaaggagcgagagggcgagagttcgggcagtcaggaa gatcagctgtgtacagctctggtgaaccagctgaacaagtttgctgataaggagaccctc attcagttcctgcgttgcttcttgctggagtccaactcgtcctccgtgaggtggcaggcc cactgcctcgcgctccacatctacaggaactcgaacaagtctcagcaagaattactgttg gatctcatgtggtccatctggccagaacttccagcctacggaagaaaggctgctcagttt gtagatctcctgggatacttctctctgaaaacacagcagaccgagaaaaagttgaaggaa tactcccaaaaggctgtggagatcctccggactcaaaaccacattcttaccaaccaccct aactccaacatttacaacacactgtctgggctggtggaatttgatggctattacctggag agcgatccttgcctcgtctgcaacaatccagaggtgcccttctgttacatcaagctttcc tccattaaagtggacacgcggtatactaccacccagcaagtggtgaaactaatcggcagc cacaccatcagcaaagtgacagtgaagataggagacctgaaacgaaccaaaatggtccga accatcaacctctattacaacaacaggacggtgcaagccatagtggagctgaaaaacaag ccggctcgttggcacaaagctaaaaaagtccagctgaccccaggccagacggaggtgaag attgatttgccgctgcccattgtggcttcgaacctgatgattgaatttgccgatttctat gagaattaccaggcctccacggagaccctgcagtgcccccgctgcagcgcgtccgtccca gccaacccgggggtgtgcgggaactgtggcgaaaatgtgtaccagtgccacaagtgcaga tccattaattacgatgagaaagatcccttcctttgcaatgcctgtgggttctgtaaatat gctcgctttgacttcatgttgtatgccaagccttgctgtgcagtggatcccatagagaac gaagaggatcgaaagaaggcagtaacaaatatcaacactctcctggacaaggctgacaga gtgtatcaccagctaatgggacaccgaccgcagctggaaaaccttctgtgtaaagtgaat gaggcggctccggaaaagccacaggatgaatctggtagtagcggagggataagttctacc tcagccagtgtgaatagatacatactccagttagcccaggagtattgcggtgactgcaag aactctttcgatgaactttccaaaatcatccagaaagtgtttgcctctcgaaaggagctg ctggaatacgatctccaacagagagaggcagcaacaaagtcctcgcgaaccactgtccag cccacatttactgccagccagtatcgtgccttgtctgttttaggctgcggccacacatca tcaacgaaatgctatggctgtgcctcagctgtcactgaacactgcataacgctgctccgg gctttggcgaccaactctgccatcaggcatatcctcgtgtcccagggccttatccgagag ctctttgactacaacttgcgccggggcgcagccactatgcgggaggaggtccgtcagctc atgtgccttctgaccagggacaatccagaggccacgcaacaaatgaatgacttaatcatt gggaaggtttctgcagctctgaagggacactgggcaaatccagacttggctagcagcctc cagtatgaaatgttgctgctaacagattccatctcgaaggaagacagctgctgggagctc cgactacgttgtgctctcagcctctttctgatggcagtgaacattaagactccagtggtt gttgaaaacatcaccctcatgtgcctgcgcattcttcaaaagctgatcaagccacctgct ccaaccagcaagaagaacaaggatgtgcctgtggatgctctcaccactgtgaagccttac agcaatgaaatccatgcacaagctcagctgtggctcaagagggaccccaaagcatcgtat gaagcttggaaaaagtgcctccctgccagaggtatagatgccaatgggaaatctcccagc aaagctgagcttcaccagctctacttgtcggaaaaatatgtctggaaatggaaacagttc atgagtcgccgcgggaagagaacttgccctctggatctcaagctgggacacaacaattgg ctgcgacaggtgctgtttactcctgccactcaagctgcacggcaagctgcgtgtactatt gtggaagctctggctaccatccccagccgcaaacagcaggtccttgacctcctgacaagc tacctggatgagctcagcattgctggcgaatgtgccgccgagtacctggcactgtaccag aaactcatcaaaccggcccactggaaggtctacctggcagcccggggcgttctgccctat attggcagcctcatcactaaggaaatagctcgtttacttgccttggaggaagcaacactc agcactgatttgcagcaaggatatgccttgaagagtctcacaggtcttctctcttccttc gtggaggtggagtccatcaaacggcacttcaaaagccgcctggtgggtaccgtcctgaat ggttacctgtgtttgaggaagttagtggtacagagaacaaagctgatcgatgaaacccag gacatgctgctggagatgctggaagatatgacaacaggcacagaatctgaaaccaaagcc tttatggcagtgtgtatagagactgcaaaacgttacagccttgatgactacaggactcca gtcttcatctttgagagactatgcagtattatctatcctgaagagaatgaagtgaccgag ttctttgtaactctggagaaagatccccagcaggaagacttcttacagggcagaatgcca ggaaatccctacagcagtaacgagcctggcattgggccactcatgagggacatcaagaac aaaatctgtcaggactgtgacctggtagctctgctggaggatgacagtggaatggagctt ttggtgaacaataagatcatcagtttggatctgcctgtggctgaggtctacaagaaggtg tggtgtcccactaatgagggggagccgatgaggatcatttaccgcatgcgagggttacta ggagatgcaactgaggaattcattgagtctctcgactccactactgatgaagaggaggat gaggaagaagtgtataagatggcaggtgtcatggcccagtgtggaggcttggagtgcatg ctcaacagactgactggaatcaaggacttcaaacaaggccggcacctcttaaccgtgctg ttaaaactgtttagttactgtgtgaaggtgaaaataaatcgtcagcagttggtcaagccg gagatgaacactttgaatgtcatgctgggaactcttaacttggctctggtggctgagcag gaaagtaaggacagcggaggagcggccgtggcagaacaagtgcttagtataatggagatc atactggatgaatccaacgcagaacctctgagcgaggacaagggtaacctcctcctaact ggtgacaaagatcagctggtaatgttgctcgatcagattaacagcacttttgtccgttcc aatctcagcgtcttgcaaggcctgttacgcatcatcccttacctgtcctttggggaaatg gagaaaatgcagattctggttgatcgattcaagccctactgtaactttgataagtatgat gaggagcacagtggagatgataaagttttcctagactgcttctgtaaaatagcagcggga ataaagaacaacagcaacggccatcagctgaaagatctcatccttcagaagggaattacg cagaatgcccttgactacatgaaaaagcacattcccagtgcaaagaatttggatgcagac atatggaagaaattcttatctcgacctgcacttccttttatcctccgcctgctccgagga cttgccacgcagcaccctgctacgcaggtgctaataggtacagactcgattaccaacctg cacaaactggagcaggtgtctagcgatgaagggatcgggacgctagcagagaatcttctg gaggcactaagggaacatccagaggtgaacaagaagattgatgctgcccggaaggagaca cgtgcagagaagaagcgtatggccatggcaatgagacagaaggccttgggcactctgggg atgacgacgaatgagaagggtcaggtagtgaccaagactgcgctgctcaaacagatggag gaacttatagaagaaccaggtctgacttgctgcatctgccgggaaggatacaagtttcag cctacgaaagtcctaggtatttatactttcaccaaacgtgttgcactagaggagtttgag aacaagccccgaaaacaacagggatacagcacagtctctcacttcaacattgtccactac gactgtcacctggcagctgtgagacttgctcgcggccgtgaagaatgggagagtgcagcc ctacaaaatgccaacaccaagtgtaatgggctcctgccagtctggggacctcatgtgcca gagtctgctttcgctacttgcttagcgcgacacaacacgtacctccaggaatgcacaggc cagcgggaacccacctaccagctcaatgtccatgacattaaactgctatttctccgtttt gcgatggagcaatcattcagcgtagatactggaggaggaggaagggagagcaacatacac ctcattccatacataatccacacggtgctctacgtcctcaacacaactcgagcaacttcg agggaagagaaaaacctccagagcttcatggagcaccccaaagagaagtgggtggagagt gcctacgaggtggacgggccccattactacaccgtgctggcgctgcacatctcgcccccc gagaagtggaaagccatgcgcgtggagatcctcaagaggctcctcatcacctcccacgca cgagtggtgtcaccagggggagccagcagactggcagataagacagtgaaggaatacgca acgtaccgctctggccttctcttctgggccctagtagatcttatttacaacatgttcaag aaggtgcctaccagtaacacagaggggggctggtcctactctcttgctgaattcatacga cacaatgacatgccaatacatgaagctgcagacaaggccctgaaaaccttccaggaggag ttcatgccagttgaaacattttccgagtttttggatgtggctggactcttatcagaaatc aatgatcccgacaacttcctcaaggatcttttgaattccatcccctga

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