Nipponia nippon (crested ibis): 104011583 Help Entry 104011583         CDS       T05756                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism nni  Nipponia nippon (crested ibis) Pathway nni04020   Calcium signaling pathway nni04260   Cardiac muscle contraction nni04261   Adrenergic signaling in cardiomyocytes nni04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:nni00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     104011583 (RYR2)    04020 Calcium signaling pathway     104011583 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     104011583 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     104011583 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:nni04040]     104011583 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:nni04990]     104011583 (RYR2) Ion channels [BR:nni04040]  Voltage-gated cation channels   Ryanodine receptor    104011583 (RYR2) Domain-containing proteins not elsewhere classified [BR:nni04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    104011583 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  104011583 NCBI-ProteinID:  XP_009462130 LinkDB All DBs Position Unknown AA seq 4949 aa AA seqDB search MPDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLS VRALQEMLANTEEKAEGLVDVEKWKFMMKSAQGGGHRTLLYGHAILLRHSYSGMYLCCLS TSRSSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHL SYGNGSLHVDAAFQQTLWSVAPISSGSEVAQGYLIGGDVLRLLHGHMDECLTVPSGEHGE EQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHITTGKYLSLLDDKSL LLTDKEKADVKSTAFCFRSSKEKLDIGTRKEVDGMGAPEIKYGDSICFIQHVDTGLWLTY QSADAKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQNEESRTARVIRSTVFLFNRFIRGLD ALSKKVKSSTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGM INLVLECIDRLNVYSSAAHFADVAGKEAGEAWKSILNSLYELLAALIRGNRKNCAQFSGS LDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICLLDKHGRNHKVLDVL CSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGISEGSAQYRKWY YELMVDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAEWGGNGVGDDLYSYGFDGLHLWS GCVARTVNSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSF SAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVEHSREYKQDRSYTRDLLGPT ISLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQ HPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKKMKLPKNYQLLS GYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVP YALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHATRLDVCSGIMEKFRIFRTEKTY AVKAGKWYFEFEAVTAGDMRVGWTRPGCLPDQELGSDEEAFVFDGFKAQRWHQGNEHFGR SWLAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEVGDGFLPVCSLGPCQVGR MNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLPVPQNHEHIEVMRID GTIDSCPCLKVTQKSFGSQNSKTDVMFFRLSMPIECAEVFSRSAAGGLPGSGLFGPKNDL EDYDADSDFEVLMKTAHGHLVPDRTEREKDATKPELNNHKDYIQEKPSRLKQRFMLRRTK PDYSSSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYD TSFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCLVDAA SGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSE HKNPVSQCPPRLHVQFLTHVLWSRVPNHFLKVDVSRISERQGWMIQCLNPLQFMALHIPE ENRTIDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHAMCSHVDESQLLYAIENKYM PGLLRAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFPDENKKHGLPGIGLS TSLRPRMQFSSPSFVSISSECFQFSPEFPLEILKAKTIEMLTEAVQEGSLHVRDPVGGST EFLFVPLIKLFYTLLIMGIFHNGDLKHILQLIEPRVFKEAMSQEDEIEFSEKELSSDELK SEEGEEETRGEQVPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIEAIVAFSDDFVAK LQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKNDCPCPEEIRDQ LLDFHEDLMTHCGIELDEDGTLDGNSDLTIRGRLLYLMEKVTYLKKKQAEKPVDDDAKTS STLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGVGGLVRALPKTYTINSVSVED TINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVM VNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMR GSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPLLISKGYPDIGWNPVEG ERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIQISE DPTRDGPSPSNGSSKALEMEEQEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGE AIRIRSILRSLIPLEDLVGVISIPFHMPTIAKDGTVVEPDMSAGFCPDHKAAMVLFLDRV YGIEDQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLF AGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLRPSMMQHLLRRLVFD VPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQK KYEQELFKLALPCLSAVAGALPPDYMESNYVNMMEKQSSMDSDGNFNPQPVDTSNITIPE KLEYFINKYAEHSHDKWSMEKFANGWTYGETYSESAKVQPLMKQYKLLSEKEKEIYRWPI KESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQISVDTAHGYTPRAIDMSNVTLSR DLHAMAEMMAENYHNIWAKKKKMELEAKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKF LQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRGKGEHFP YEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLSSGGHASNKEKEMVTSLFCKLGVLV RHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLECVKMALRAFLDNAAEDLEKTMENL KQGQFTHSRNQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLILEDVQVSCYRILA SLYALGTSKSIYVERQRSALGECLAAFSGAFPVAFLETHLNKHNIYSIYNTKNARDRAVL NLPTSVEEVCPNIPSLVKLMEEIVELAESGIRYTQMPHIMEVVLPMLCSYMSHWWEHGPE NNPDKAEMCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISKAKPQLL KTHFLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAELLILDEFTTLARDLYAFYPLLIR FVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLISDT KSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELIALAKNR FSMKDTEDEVRDIIRSNLHLQGKLEDPAIRWQMALYKDLPNRTEDSSDPEKTVERVLDIA NVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYDKS WIEMEEHYFEDKLIEDLAKPGEEPPEEDESLKRVDPLHQLILLFSRTALTEKCKLEEDFL YMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEM VLQTISASKGEMGPMVAATLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQS CSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLR TQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNT LTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMV VMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDG KGIISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVA VLLTNLSEHMPHDTRLQTFLELSESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQ WEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKE ENEKDKPEEQDPRMGFFSLVTMKSALVALKYNLMTLMKMLSMKSLKKQMKKVKKMTMKDM VMALFYSYWSILMGLLHFACSVVRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQ DEVRGEGEEGERKPTEAALPTEDLTDLRTLSDESDLLSDIFGLDLKREGGQYKLIPHNPN AGLSDLLSTPSLAPMPEVQEKIQEQVKEDEKEEKEETKSEPEKAEGEDGEKEEKAKEDKG KQKLRQLHTHRYGEPEVQESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILL FYKVSTSAVTEEKEVPAVSAGESTKLNSLESDNQRVIAVHYVLEESSGYMEPTLRILAIL HTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQ SFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVL NSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILS SVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDMPDMKCDDMLTCYMFHMY VGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQE QVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQES YVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14850 nt NT seq  +upstreamnt  +downstreamnt atgcctgatgatgaagtggttctgcagtgcactgcaactgttcacaaggagcaacagaaa ttgtgtcttgctgcagaaggatttggcaacaggctttgctttttggaatccacatcaaat tctaagaatgttccaccggatttgtccatctgtacctttgtgctggagcagtctctgtca gtacgggccctccaggaaatgctggctaacacagaagaaaaggcagaagggctagttgat gtggaaaaatggaaatttatgatgaagtctgcacaaggtggtggtcatcgaacactgctc tatgggcatgcaatcctgctgcgccattcctacagtggcatgtatctatgctgcctctct acatctcgatcttcaatggataagctggcatttgatgtaggattgcaagaggacacaaca ggtgaggcatgctggtggaccatccatcctgcttccaagcaacgatcagaaggagaaaaa gtgcgtgttggagatgatctcattttagtcagtgtctcttcagaaagatatttgcatctc tcttatggcaatggtagcttacatgttgatgcagccttccagcagacgctctggagtgta gcaccaatcagttcaggaagtgaagttgcccaaggatatctgataggaggggatgttctg aggttattgcatggtcacatggatgaatgtttgacagtcccttcgggtgaacacggagaa gaacaaagaagaaccgtccactatgaaggtggtgctgtgtcaattcatgcgcgttccctt tggcgactagagactctaagagttgcgtggagtggcagccacattagatggggacagcca ttcagactaagacatataacaacaggaaaatatttaagtctcctggatgacaagagtctt cttcttacagacaaagagaaagcggatgtaaaatctacggcattctgttttcggtcttcc aaggaaaagttggacatagggacaagaaaagaggtggatggaatgggagcacctgaaata aaatacggggattcaatatgcttcatacaacatgtagatacaggcttatggctcacgtac cagtctgcggatgcaaagtctgtaagaatgggttccgtgcagcggaaggcaataatgcac catgaaggtcacatggatgatggtttaacattgtccagatctcagaatgaagaatcccgt acagcacgtgtcatccgtagtacagtcttccttttcaacaggtttataaggggccttgat gctctcagcaagaaagtgaagtcttccaccgtcgatttgcctattgagtcagtcagtctg agccttcaggacttgattggctactttcacccccccgatgaacatttggagcatgaagac aaacaaaacaggctccgagcgctgaagaatcgccagaacctcttccaggaagagggtatg atcaaccttgttcttgaatgtattgatcgcttgaatgtatacagcagtgcagctcatttt gcagatgtagctgggaaggaagctggagaagcatggaaatctattctgaattctttgtat gaattactagcggctctgattcgagggaatcgtaaaaactgtgctcaattttctggatct cttgattggttgatcagcagattagaaagactggaagcttcttctggaattctagaggtt ttacactgtgtgctggtagaaagcccggaagctctaaacattattaaggaaggacatatt aaatctatcatctgtcttttggacaaacatggaagaaaccataaggttttggatgttttg tgttctctctgtgtttgtcatggagtagctgtgcggtctaatcaacatctaatctgtgat aatctcctgccaggaagagatctgctcttacagacacggcttgtcaaccatgtgagcagc atgcgacccaacatcttcttggggattagtgaaggctctgcccaatacagaaagtggtac tatgaacttatggtggaccatctagagcccttcgtgaccgcagaatcaactcatctacga gtgggctgggcttcaacagagggctactcaccgtatccaggaggaggagcagaatgggga ggaaatggtgttggtgatgatttgtattcctatggctttgatggtctccatctgtggtca ggttgtgtagcacgaacagtaaattctcccaaccaacatctcttaagaaccgatgatgtt attagctgctgtttggacctgagtgcccccagcatctccttccggataaatggtcagcca gttcaaggaatgtttgagaatttcaacatagatggcctcttcttcccagttgtcagcttc tctgcaggaataaaggtacgtttcttgcttggaggtcgccatggggagttcaagttcctt cccccacctggatatgccccttgctttgaagctgtcctaccgaaagagaagcttaaagtg gagcatagccgagagtacaagcaggatcgtagctatacaagagacctactgggtcccact atctctctgtcacaagcagctttcactccagttcctgtagatactagtcagattgttttg cctccccacctggaaaggattagagaaaaattagcagagaacatccatgaactatgggtt atgaataagattgaacttggctggcagtatggaccagttagagatgacaacaaaagacaa cacccgtgcttagtggagttctcaaaattgccagagcaggaaagaaattataacttgcaa atgtcacttgaaacactgaaaaccctgctggcattaggctgccatgttggaattgctgat gaacatgctgaagaaaaagtgaaaaaaatgaaacttccaaagaactaccagttgttgagt ggatataagcctgctcctatggatctgagttttatcaaactgaccccgtctcaagaagct atggtggataaactagcagagaatgctcacaatgtgtgggcaagggaccgtataaggcaa ggctggacatatggtatccagcaggatgtgaaaaatcgacgaaatcctcgcctcgtacct tatgctcttttggatgatcggacaaagaagtcaaacaaagacagtcttcgagaagcagtc cgcacactgctaggctatggttacaacctggaagctcccgatcaagatcatgcgacgaga ctggacgtgtgcagtgggataatggaaaaattcaggatcttccgcacagaaaagacttat gcagtgaaggctgggaagtggtactttgagtttgaggcagttactgcaggagacatgaga gttggctggaccaggccgggttgtctgccagatcaggaacttggctcagatgaagaagct tttgtttttgatggctttaaggcacagcggtggcatcagggtaatgagcattttggccgc tcttggttggcaggagatgttgttggatgtatggttgacatgaatgagcacactatgatg ttcaccttaaatggtgaaatcctgcttgatgactcaggttcagaacttgcattcaaggac tttgaggttggtgatggatttctacctgtgtgcagcctgggcccatgtcaagtgggaaga atgaattttggaaaagatgtcagcactctaaaatatttcactatctgtggcctacaggaa gggtatgaaccctttgctgttaatacaaacagagatatcaccatttggctgagtaaaagg ctccctcagtttctgccagtgccacaaaatcatgaacatattgaggtgatgagaatcgat ggcaccatagacagctgtccctgcctgaaggtcacacagaagtcctttggttcacagaac agtaaaacagacgtcatgttttttcgattaagcatgcccattgaatgtgctgaggtgttc tccagatcagctgcaggagggttaccaggctctggtctttttggcccgaagaatgacttg gaggattatgatgctgattctgattttgaggttctaatgaaaactgctcatggtcatcta gttcctgaccggacagaaagagaaaaagatgccacaaaaccagagttaaacaaccataaa gattatattcaagaaaagccttcacgtcttaaacaaagatttatgctcaggaggacaaag ccagattatagctcgagtcactctgcacgacttactgaggatgtgctagcagatgatagg gatgactatgattatttgatgcaaacttccacgtactattattcagtgagaatatttcct ggtcaagaacctgctaatgtctgggtgggctggattacatctgactttcaccagtatgac acaagctttgacttggacagagtgcgtactgtcacagttacactgggagatgaaaaaggg aaggttcatgagagtataaaacgcagcaactgctatatggtgtgcgcaggagagagcatg agccctggacaaggacgtaataataatggtctggagattggttgcttggttgacgctgcc agtggcctgctgaccttcacagctaatggcaaggaactaggcacatactatcaggttgaa ccaagtacaaagttatttcctgctgtatttgctcaagctacaagccccaatgttttccag tttgaattgggaagaataaagaatgtaatgccattatctgctggcttattcaaaagtgaa cacaaaaacccagtctctcaatgtcctccacgtctccatgtccagtttctgactcatgtg ctttggagcagagtgccaaaccacttcttgaaggttgatgtctctcggattagtgaacgt caaggctggatgatacagtgcctgaatcctttgcagttcatggcccttcatattcccgaa gaaaacagaacaattgatattttagagttgacagaacaagaagaattgctgaaatttcac taccataccctccgattatattcagctgtttgtgctttaggcaacaaccgagtggcccat gctatgtgtagccacgtggatgaatctcagctcttgtatgctattgagaataaatatatg ccgggattattacgtgcaggatattatgacttactcattgacatccatctcaatacctat gcaactgccaggttaatgatgaataatgaatttatagttccaatgacagatgagaccaag agtattactttgtttcctgatgaaaacaaaaaacatggcctccctggtataggacttagc acttcattaaggccaagaatgcagttctcctctccaagttttgtaagcattagcagtgag tgctttcagttcagccctgaattccctctggaaattttgaaggccaaaaccatagagatg ctgactgaagctgttcaggaaggcagcctccatgtcagagatccagttggaggttctaca gaatttctctttgtccctctcatcaagctcttttatacccttctaattatgggaatcttc cacaatggggatctgaaacacatcttgcaattgattgagccccgggttttcaaagaagca atgagccaggaggatgaaattgaattctcagagaaggagctgagttcagatgagctcaag tcagaagagggagaggaagaaaccagaggggagcaagtgccaaaggaaggactccttcag atgaaacttccagaacctgttaaattacagatgtgtcatctactccagtacctgtgtgat tgccaagtacgacaccgaatagaagccattgtagcattttcggatgattttgtggccaag cttcaagagaatcagcgcttccggtacaatgaagtgatgcaggccttgaacatgtctgct gccctgacagctagaaaaacaaaagaatttcgatccccacctcaggagcagattaacatg ctgctgaactttaaagatgataaaaatgattgtccttgccctgaagaaattcgggatcaa ctcctggatttccatgaagacctaatgacacactgtggaattgaactagatgaagatgga accttggatggaaacagtgatttaaccattaggggtcgcctcctataccttatggaaaaa gttacatatctgaagaagaagcaagctgagaagccagttgatgatgatgctaagacatcc tctactcttcagcagttgatttcagacacaatggtacgctgggcccaggaatcagtgata gaagacccggagttagtgagggccatgtttgtattgctgcatcgccaatatgatggtgtt ggtggcctggttcgagccctaccaaagacctacaccataaatagtgtgtctgtggaagac acaatcaatcttctggcatcccttggtcaaatccgttccttgcttagtgtcagaatgggg aaggaggaagagaaacttatgattcgtggattaggagacatcatgaataataaagtattt taccaacatccaaatctcatgagagctttaggcatgcatgaaactgtcatggaagtgatg gtaaatgtgcttggtggaggagaatccaaggaaatcactttcccaaagatggtggcaaac tgctgtcgttttctatgttatttttgccgcatcagcagacagaatcaaaaagctatgttt gatcatcttagctatttattggaaaacagcagtgttggccttgcctctccttccatgcga ggatcaactcctttagatgttgcagcagcctctgtgatggataacaatgaacttgcacta gctttaagggagcctgatctggagaaggttgttcgctacttggctggatgtggattgcag agttgtcctttgttgatttctaaaggctacccagacattggatggaatccagttgaagga gagcgatatttggattttcttcggtttgctgttttttgcaacggagagagtgtggaggag aatgctaatgttgtagtcagactgcttatccgtcgacctgaatgtttcggtccagctcta agaggagaaggaggcaatgggttacttgctgccatggaggaagcaatacaaatatcagaa gatccaacaagagatggaccttccccaagtaatggatctagtaaagcccttgaaatggaa gaacaagaagatgacactattcatatgggaaatgcaatcatgaccttttatgctgctttg attgatctcttaggacgttgtgcccccgaaatgcatctaatccatgctggtaaaggggaa gccattagaatcagatcaattctgcggtctttaattccactggaagatttggtgggagta attagtattcctttccacatgccaaccatagctaaagatggtactgtggtggaacctgac atgtctgcggggttttgcccagatcacaaggcagccatggttttgttccttgacagggtc tatggaattgaggaccaagattttcttctacaccttcttgaagttggctttctgccagat cttcgtgctgctgcttctttagatacggctgctttaagtgctacggatatggctttggct ctgaatcgatacctttgcacagcagtcttgcctctgttgaccagatgtgctcctcttttt gctggcacagagcaccatgcttccctcatcgattccttattacatactgtgtacagactc tcaaagggatgctctcttaccaaagctcagcgagattctattgaagagtgtttgctgtct atctgtgggcagttgcggccttccatgatgcagcatttgctgagaagattagtatttgat gttcctctcttaaatgaacatgcaaagatgcctctcaagttgctgacaaatcattatgaa agatgctggaagtactattgtttgccaggtggatggggtaactttggtgctgcctcagaa gaagaacttcatttatccagaaagttgttctggggtatttttgatgctttgtctcaaaag aagtatgaacaagaactgttcaaattggctttgccttgtttgagtgcagttgcaggggcc ttacctccagactatatggaatcaaattatgtcaatatgatggaaaaacagtcttcaatg gattcagatgggaactttaatcctcaacctgttgatacatcaaacattacaatccctgaa aagctagaatatttcattaacaaatatgcagagcactctcatgacaaatggtcaatggaa aagtttgccaatggatggacatacggtgaaacatattctgaatctgcaaaagtgcaacca ttaatgaaacaatataagttactatctgaaaaggagaaagaaatttatcgatggccaatc aaagaatcactgaaaactatgctggcatggggatggcgaattgaaagaacgcgggaggga gattccatggccctgtataatcggacacgtcgcatatctcaaaccagtcaaatctcggta gatacagcccatggttacactcctcgagcaattgacatgagcaatgtcaccctctccaga gacttacatgctatggctgagatgatggccgaaaactaccataacatatgggcaaagaaa aagaaaatggagcttgaagcaaaaggaggaggcaaccatcctcttcttgttccttatgat acactcacggccaaagaaaaagccaaggacagagaaaaagcacaggatattctgaaattt ctacagattaatggctatgttgtctccagaggacttaaggacctggagttagacacaccc tccattgagaaacgctttgcctacagtttccttcagcaacttataagatacgtggatgaa gcccatcagtacattctggagtttgatggtggcagcagaggcaaaggagagcacttccca tatgaacaagaaatcaagttttttgccaaagttgtgctccctttgattgatcagtatttt aaaaatcatcgcctgtatttcttatctgcagcaagtaggcctctcagcagtggaggtcat gcctctaataaagagaaagaaatggtgacaagcctgttctgcaaacttggagttcttgtc aggcataggatttcactgtttggaaatgatgcaacatcaatagtcaactgtcttcacata ctgggccagaccttggatgcgaggactgtgatgaaaactggtctggaatgtgttaagatg gcattgagagcatttttggacaatgctgctgaggatctggagaaaacaatggaaaatctt aagcaaggccagtttacacacagcagaaaccagccaaagggagttacacaaatcattaat tataccacagttgctctcctgccagtgctatcttcgttatttgagcatattggacagcac cagtttggggaagatttgatattggaagatgttcaggtctcttgttacagaatattggcg agtttatatgctctgggaaccagcaagagtatctatgtagagcggcaacgatcagcacta ggagaatgcttggccgctttctcaggtgcctttccagtggcctttttggaaactcattta aacaaacataatatctactcaatttacaataccaagaatgcgagagacagagcagttctc aatttgcctactagtgtagaagaggtttgcccaaatattccttccttggtgaagctaatg gaggaaattgtggaactggcagagtctggtattcgttacacacaaatgccacatatcatg gaagtagtactgcctatgttatgtagttacatgtcacactggtgggagcatgggccagaa aacaaccctgacaaggctgaaatgtgttgcacagccttgacctcagagcacatgaacact ctgttgggtaacatactgaaaatcatctataataaccttggtattgatgaaggagcctgg atgaagagattagcagtgttttcccagcccatcataagcaaagcgaagccacagctgtta aagacacacttcctgccactgatggataagctaaagaaaaaagcagcagtggttgtatcg gatgaagaacacctaagagcagaaggcagaggtgacatgtcggaggctgaactgctcatc ctagatgagttcaccactttggcacgggacctctatgccttctaccctttattgattaga tttgtggactataacagggcaaaatggctgaaagagccaaaccctgaagcagaagaattg ttccgcatggtggctgaggtcttcatttactggtcaaagtctcataatttcaaaagggaa gagcagaactttgtggtacaaaatgaaatcaacaacatgtctttccttatcagtgacacc aaatctaagatgtccaaggcagcagtttctgaccaggagaggaagaagatgaagagaaaa ggtgaccggtactctatgcagacctctctcattgtggcagcactgaagagattacttccc attggcctaaacatttgtgctcctggagaccaagagctaattgcactggccaaaaatcga ttcagtatgaaagatactgaagatgaagtacgagatatcatccgcagtaatcttcatctc cagggcaagcttgaggatcccgccattaggtggcagatggcactttacaaagatttacca aacaggactgaagattcctcagatccagagaagactgtggaaagggtccttgatatagct aatgtactgtttcacctggaacaggttgagcatcctcagcggtccaaaaaagcagtgtgg cataagctcctgtctaaacagaggaaaagagcagtagttgcctgctttagaatggcacca ttgtataatctgccaaggcaccgagccgtcaatctctttcttcaaggctatgataaatct tggattgaaatggaagaacactattttgaagacaaactgatagaagatttagcaaaacct ggggaggaaccaccagaagaagatgaaagccttaaaagagttgatcctttacatcaactt attctgctattcagtcgaacagccttgactgaaaaatgcaaattggaagaagatttcctg tatatggcttatgctgacattatggcaaagagctgccatgatgaagaagatgatgatggt gaagaagaagtgaagagttttgaagtgacaggatcacaacgcagcaaggaaaaagaaatg gaaaagcaaaaacttctgtatcaacaagccagactgcatgaccggggtgctgctgagatg gttctgcagaccatcagtgctagtaaaggtgagatggggccaatggttgcagctacccta aagctagggattgctatcttaaatggaggaaattctaccgttcaacagaaaatgcttgac tacctcaaggataaaaaggatgtgggattctttcagagccttgctggtcttatgcagtcc tgtagtgttcttgacctaaatgcatttgaacgtcagaacaaagcagaaggccttggcatg gtgactgaagagggatcaggggaaaaggtgatgcaggatgatgagttcacctgtgacctc ttccgcttccttcagttgctttgtgaaggacataattcagattttcagaattacctgaga actcagactggtaacaacacaactgttaatattatcatttccactgtggattacctatta agagttcaggaatccattagtgatttctattggtattattctggaaaggatgttattgat gagcaaggacaacgaaatttttccaaagccatccaggttgcaaaacaagttttcaatact cttacggagtatatacagggcccatgtactgggaatcagcaaagtctggcacacagcagg ctatgggatgctgtagttggttttcttcatgtgtttgcccacatgcagatgaagctgtct caggattccagtcaaattgaattactgaaggaattaatggatcttcagaaggatatggtt gtcatgttgctgtctatgctggaaggtaatgttgtgaatggaactattggcaagcagatg gtcgatatgcttgtggaatcgtccaacaatgtggagatgattctgaagttttttgatatg ttcttgaaattgaaggatttgacttcctctgatgcattcaaagaatacgaccctgatggt aaagggataatttcaaagagggattttcacaaggcaatggaaagccataagcattacacc cagtctgaaactgagtttctgctgtcatgtgctgaaacagatgagaatgagactctggac tatgaggagtttgtgaaacgattccatgaacctgccaaagacattggtttcaatgtcgct gttctcctgaccaacctgtcagaacacatgccccatgatacccgcttgcaaacttttctt gaactgtcagagagtgtgctgaattactttcaacctttcctcggacgcatagaaatcatg ggcagcgcgaagcgcattgaacgagtttattttgaaataagtgagtcaagtcggactcag tgggagaaacctcaggtaaaagagtcaaagagacaatttatatttgatgttgtaaatgaa ggcggggagaaagaaaagatggagctttttgttaatttctgtgaggataccatctttgaa atgcaactggctgcccagatctctgagtcagatctgaatgaaaggtcagcaaataaagag gagaatgagaaagataagcctgaagaacaggatcctagaatgggtttcttctctctcgtg accatgaagtcagcattagtagctctcaagtataatttaatgactcttatgaaaatgctt agcatgaagagcctaaagaaacagatgaaaaaagtgaagaaaatgaccatgaaggacatg gtcatggctttgttttattcctattggagcattttgatgggcttactacattttgcttgt agtgtcgttcggggcttctttcgcatcatatgcagtttgctgcttgggggaagcctcgta gaaggagcaaagaaaatcaaagtggctgaactgttagctaatatgccagatcccactcag gatgaggtgcgtggggaaggagaagaaggggagaggaagccaacagaagctgcattgcct acagaagacttgacagatctgagaactttatcagatgagagtgatctactctcagatata tttggtttggatttgaaacgagaaggtggacagtataaattgatccctcacaatccaaat gctggtttgagtgatttactgagcaccccctccttagctccaatgcctgaggtgcaggaa aaaatccaggagcaggtgaaagaagacgaaaaggaagagaaggaggaaacaaaatctgaa cctgagaaagcagaaggagaagatggagaaaaagaagagaaagccaaggaagacaaaggg aaacagaaattaagacaacttcatactcacagatatggggaaccagaagttcaggaatca gctttctggaagaaaatcattgcataccaacagaagcttcttaattattttgcgcgaaac ttttacaacatgaggatgttggcgttgtttgttgcttttgccatcaacttcatcctgctt ttctataaggtctccacctctgctgtgacagaagaaaaggaagttcctgcggtatctgct ggtgaaagtaccaagttgaacagcctggaaagcgacaaccagagggtcattgcagtgcat tacgtcctggaagaaagcagtggctacatggagcccacactgcggattttggccatccta cacacagtcatctcattcttctgcatcatagggtattactgtttgaaagttccactggtt atttttaagagagaaaaggaagtggcaaggaaattggaatttgatgggctgtatataact gaacagccatcagaagatgatattaagggacagtgggatagacttgtaatcaacacacag tcttttccaaataactattgggacaaatttgtgaaaagaaaggtcatggataaatatggt gagttctatggccgtgacaggatcagtgaattactaggaatggacaaagccgctctcgat tttagtgatgctcgagaaaagaagaaaccaaagaaggatagctccttgtctgctgtgcta aattccattgatgttaagtatcagatgtggaaattaggagttgttttcactgataattct ttcctttacctagcgtggtacatgaccatgtcagtccttggccattacaacaattttttc tttgctgctcatctccttgacattgcaatgggattcaagacattgcgaactatcctgtca tcagtgacccacaatggcaaacagcttgtcctaacagtgggattactggcagtagtagta tacttgtatacagtagtggcattcaattttttccgcaagttctacaacaagagtgaagat ggtgatatgccagacatgaaatgtgatgatatgctaacatgctacatgtttcacatgtac gttggagtacgtgcgggtggaggcattggtgacgaaatagaggatccagcaggagatgaa tatgaaatctatcggattatctttgacatcacttttttcttctttgtgattgtcatcctg cttgcaattattcaaggtttaattattgatgcttttggtgagttaagagatcagcaagag caagttaaggaagacatggagacaaagtgctttatctgtggaataggaaatgactacttt gatacagtgccccatggctttgaaacacacacactacaggagcacaacttggccaattat ttgttttttctgatgtatcttattaataaagatgaaacagagcatacaggacaggaatcc tatgtatggaaaatgtaccaagaacggtgctgggagtttttccctgccggtgattgcttc cgaaaacaatatgaagaccagctcaactaa

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