Nipponia nippon (crested ibis): 104020404 Help Entry 104020404         CDS       T05756                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism nni  Nipponia nippon (crested ibis) Pathway nni04020   Calcium signaling pathway nni04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:nni00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     104020404 (RYR3)    04020 Calcium signaling pathway     104020404 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:nni04040]     104020404 (RYR3) Ion channels [BR:nni04040]  Voltage-gated cation channels   Ryanodine receptor    104020404 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 TBK1_ULD Motif Other DBs NCBI-GeneID:  104020404 NCBI-ProteinID:  XP_009472111 LinkDB All DBs Position Unknown AA seq 4958 aa AA seqDB search MAASLAAPRSASRGPRRSLAVAQAGVGERGRSGAGGGVGTGRESRGKSPNTMETELEKRG KVLRRGSNRNKKDHKNKFQRGEDRNTFIVIVVVVAVVVCLQYSFQDDEVVLQCVASIHKE QRKFCLAAEGLGNRLCFLEPTSEAKYVPPDLCICNFVLEQSLSVRALQEMLANTGDNASE GAAQGGGHRTLLYGHAILLRHSFSEMYLTCLTSSRSQTDKLAFDVGLRENAAGEACWWTI HPASKQRSEGEKVRIGDDLILVSVSSERYLHLSMSNGSIQVDASFMQTLWNVHPTCSGSN ITEGYLLGGHVVRFFHGHDECLTIPSTDQNDSQHKKVLYETGGAGVRARSLWRVEPLRIS WSGSNIRWGQPFRLRHITTGKYLALNEDEGLAMLDREKSDTTSTAFCFRASKELKEKQDS SLKRDIDGMGVPEIKYGDSICFVQHVASALWLTYKAQDAKSARLGPLKRKVILHQEGHMD DGLTLQRCQHEESQAARIIRNTTSLFSQFISGNNRTLSPTALPIEEMAQTLQDLITYFQL PEEDLEHEDKQSKLRSLKNRQNLFKEEGMLALVLNCIDRLNDYNSTAHFAGIAREEHGTA WKEILNLLYKLLAALIRGNRNNCTQFSSNLDWLISKLDRLESSSGILEVLHCILIESPEA LNIIAEEHIKSIISLLDKHGRNYKVLDVLCSLCVCNGVAVRANQNLICDNLLPRRDLLLQ TRLINDVTSIRPNIFLGVAEGSAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASTSGYAP YPGGGEGWGGNGVGDDLYSYGFDGLHLWSGRVPRAVASVNQHLLASDDVVSCCLDLGVPS ISFRINGQPVQGMFENFSTEGFFFPVVSLSAGVKVRFLLGGRHGEFKFLPPAGYAPCYEA LLPKEKMKLEPVKEYKRDSDGVRDLLGTTQFLSQASFIPCPIDTSQIALPFHLEKIRDKL AENIHELWGMNKIELGWTYGKIRDDNKRHHPCLVEFSKLPETEKNYNLQMSTETLKTLLA LGCHIVHAHPAAEEDLKKVKLPKNYMMSNGYKPAPLDLSEVKLLPSQEFLVDKLAENAHN VWAKDRIKQGWTYGIQQDLKNKRNPRLVPYALLDERTKKSNRDSLREAVRTFAGYGYSIE PPDQEIADQTVEKVSIDKIRFFRVEQSYAVKSGKWYFEFEAVTGGDMRVGWARPGCRPDI ELGADDQAFVFEGSKGQRWHQGSGFFGRSWQPGDVVGCMINLDDKSIIFTLNGELLITSK GSELAFADFGIESGFVPICALGLSQIGRMNLGMDASTFKYYTMCGLQEGFEPFAVNMNRD VAMWFSKRLPTFVNVPKNHPHIEIWRIDGTIETPPRLKVTHKTFGTQNSNSDMIYCRLSM PIEFRSSFHFGMGMENASSDVFQKRKHSQETAAASTTYFYSLRIFAGQDPSSVWVGWVTP DYHFYSENFDLNKNCTVTVTLGDERGRVHESVKRSNCYMVWGGDVIANSQRSGRSNVDLE IGCFVDLATGMLSFTANGKELGTCYQVEPNTKLFPATFVQPTSTNLVQFELGKLKNTMPL SAAIFKSEERNPVPQCPPRLDVQTITPVLWSRMPNSFLKVETERVSERHGWVVQCLEPLQ MMALHIPEENRCVDILELCEQEDLMKFHYHTLKLYSSVSALGNTRVAYALCSHVDISQLF YTIDNQYLPGLLRSGFYDLLISIHLEHAKQAKLMMNNEFIIPVTDETRTIKLYPDETKKH GLPGVGLSTCLKPGFNFSTPCFIVTSEERQISSPEIPLDILKSKAISMLTEAVQCSGTHI RDPVGGQVAFQFVPVLKLIATLLIMGVFDDDDVKQVLLLIDPNVFGDHKEETEERTEKEE VTQVEEKAVEAGEKAIKETKAPAKGLLQTKLPESVKLQMCHLLNYFCDCELQHRVEAIVS FADRYVSKLQYNQKYRYNELMQALNMSAALTAKKTKEFRSPPQEQINMLLNFQLGEDCPC PEEIRDELYEFHDDLLIHCGIPLEEEEEEEEDSSLTGKLCSLIYKIKGPPKAEKVEPKEE EEKSPTTLKELISQTMVRWSQEDQIQDPELVRIMYTLLRRQYDSIGELLQALRKAYTISA ASVKDTINLLAALGQIRSLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHET VMDVMVNVLGGDKSQIVFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLAF PSMRGSTPLDVAAASVMDNNELALALEEPDLDKVVTYLAGCGLQSCPVLLAKGYPDIGWN PIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPDLRGEGGNGLLAAMQEAI RISENPACDLPSQAYKREGDEEEEEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQSGK GEAIRIRSILRSLVPTEDLVGIISIPLKLSTVNKDGTVNEPDMSATFCPDHKAPMVLFLD RVYGIKDQSFLLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYICSAVFPLLKRCAP LFSGTEHHASLVDSMLHTIYRLSKGRSLTKAQRDTIEECLLAICHHLRPSMLQQLLRRLV FDVPLLNEYCKMPLKLLTNHYEQCWKYYCLPSGMGSYGIAAEEELHLTEKLFWGIFDSLS HKKYDPELFRMALPCLSAIAGALPPDYLDTRIRSTLEKQTSLDPEGNFDPKPVSTANLVL PEKLEYIVSKYAEHSHDKWAFDKTNSGWKYGVSLDENMKTHPLIRPFKTLTEKEKEIYRW PARESLKTMLAMGWSLERTKEGGEAIIHQRENEKLRSISQSSQGNGYSPAPLDLSNVVLS RELQGMVEVMAENYHNIWAKKKKMELESKGGGSHPLLVPYDTLTAKEKSRDREKAQELFK FLQVNGIIISRGLNELELDASSMEKRFAFKFLKKILKYVDSAQEFIAHLEAIVTSGKTEK SPHDQEIKFFAKVLLPLVDQYFTNHCLYFLSSPTKTLSSSGYASNKEKEMVASLFCKLAA LVRHRISLFGSDSATMVNCLHILAQSLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSE NLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSIFEHISQYQFGIDLLLGDVQVSCYRI LSSLYSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPSLNHYNPLSVFNTKSARERA ILGMPDRVEEMCPEIPQLDGLIKEINDLAESGARYTEMPHVIEVILPMLCNYLSYWWEKG SESVPQSAGPCCTMVTSEHLSVILGNILKIINNNLGIDEASWMKRIAVYAQPIISKARPD LLKTHFIPTLEKLKKKAIKIVMEEEQLRADSKTDTQEAELLILDEFAVLCRDLYAFYPML IRYVDNNRANWLKKPDADSDELFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTG DTKSKMSKAMQVKSGGQDQERKKSKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQEL ISLAKTRYSHRDTDDEVKEHLRNNLHLQEKSDDPAVKWQLNLYKDILKSDEPPDPEKNVE RVQRISAALYHLEQVEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFL HGYQNYWIETEEYSFEEKLVQDLATPPKKDEEEEEETEKKQPDPLHQIILYFSRSALTER SKLDDDPLYIAYSAMMAKSCQEEEEEEEEEKEKTFEEKEMEKQRTLYQQARLHDRGAAEM VLQMISASKGHTGPMVVETLKLGIAILNGGNTIVQQKMLDYLKEKKDAGFFQSLSGLMQS CSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVLQHDEFTRDLFRFLQLLCEGHNND FQNYLRTQMGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDVIDESGQRNFSKALAVT KQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSAQIELLKELLD LLKDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTNSDAFK EHDPDGKGIISKKEFQKSMEAQKQYRQSEXXXLLSCAEADENDMFNYVDFVERFHEPAKD IGFNVAVLLTNLSEHMPNDSRLQSLLEPAESVLNYFEPYLGRIEIMGGAKKIERVYFEIS ESSRMQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISETDSSE RPEEEEEAEPCYVVDIGDDEEEEKSLESASAFSMACVAVKKNVANFFKMITVKNLRKQYR KVRKMTVKEMVKVFFSFFWILFVGMFQLFFTIVWGIFQILWSTVFGGGLVEGAKNIKVTK ILGDMPDPTQFGIHDDVMEAEKAEGAEHGIRAELVQFVKGEKGETDIISDIFGIHTKKEG GSKHGHDAGLGDIAEILGTDIESSLENTVRKKKGLQISEIAKEAEAERKAEAEKADMEDG EKQDKAKEVQSEQLEEGKTKKKKRRHGQKIEKPEAVMANFFKALEIYQTKMLHYLARNFY NLRFLALFVAFAINFILLFYKVTEEPLDDVEEDSNLWNSFDEEEEDDGMVFFVLEESTGY MAPALRALAVIHTIISFVCVIGYYCLKVPLVVFKREKEVARKLEFDGLYITEQPSEDDIK GQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKSALDFSPVEESEP EEASLVSWLSSIDTKYHIWKLGVVFTDNSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMG FKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDM MTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDA FGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKD ETEHTGQESFVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14877 nt NT seq  +upstreamnt  +downstreamnt atggcggccagccttgcagcgcctcgctccgccagcaggggccctcggcgctccttggcc gtagcacaggccggggtaggggagagaggacgctccggagcaggtggcggtgttgggacg gggcgggagagtcgtggaaagtctccaaacacgatggaaactgaattagaaaagagaggg aaggtgctccgacgaggaagcaatcggaataagaaagaccataaaaacaaattccagaga ggagaggacaggaacactttcattgtcatcgttgttgtagtagcagtagtagtatgtctt cagtactcgtttcaagatgacgaagtagtacttcagtgtgttgccagtattcacaaagaa caaaggaagttttgcttggcagctgagggacttgggaatcgcctgtgctttttggaacca acatcagaagctaaatatgttcctccggacctttgcatctgtaatttcgtccttgaacag tccctatctgtcagagcccttcaagaaatgctggccaacacaggagataatgctagtgaa ggggcagctcaagggggtggtcacagaaccctgctgtatggccatgctatactacttcga cattcgttcagtgaaatgtatttgacatgtttaacatcatcaagatcccagacagataaa cttgcatttgatgtgggactacgagaaaatgcagcaggtgaggcatgctggtggacaata caccctgcttctaaacaaagatcagaaggagaaaaagttcgaataggtgatgatcttatc ctggtcagtgtgtcctctgaaagatacctgcatctctccatgtcaaatggaagtattcag gtggatgcctcctttatgcagacgctatggaatgtacatcctacatgctcaggaagcaat attacagaagggtatcttcttggtgggcatgtagtacgttttttccatggccatgatgag tgtttgacaattccatctacagatcagaatgattcacagcacaagaaagtactttatgaa actggaggagctggtgttcgagcaaggtctttgtggagagtagaaccgcttcgaataagc tggagtggaagtaacatcagatggggacagcctttccgtcttcgacatattacaacagga aagtacttggctctgaatgaagatgaaggacttgcaatgttagacagagagaagtcggac acaacatctactgccttctgttttagagcatcaaaggagctaaaagaaaagcaagattct agtcttaaacgtgacattgatggaatgggagtcccagaaataaagtacggtgattcaatc tgttttgtccaacatgtggccagtgccttatggttgacttacaaagcacaagatgctaaa tcagcacgtttaggtcccttgaaaagaaaggttatattacaccaagaaggccatatggat gatggtctaacgttacaaagatgtcagcacgaggaatcccaggctgctcgaatcattcgc aatactacaagcttattcagccagttcataagtggaaacaacagaacactatcacccact gccctgcctattgaggagatggctcagactctgcaagacctgataacttacttccagctt cccgaagaagacctggaacatgaagataagcaaagcaagcttcggtcactcaaaaacaga caaaatctattcaaagaagagggaatgctggcactagttttgaattgcattgatcgctta aatgactacaacagcacagctcattttgcaggaattgcaagagaagaacatggtacagca tggaaagaaattttgaatctactttacaaattattagctgctctcattcgtggcaacaga aacaattgtactcagttttccagtaacctggattggctaataagtaaattggacagatta gaatcttcctcaggtattttggaagtgttgcactgcatcttgattgaaagcccagaagct ttaaatataatagctgaggagcacatcaaatccattatttcattgttggataaacatggg cgcaattacaaggttctcgatgtgctttgctctctctgtgtctgtaatggtgttgcagtt cgtgccaatcaaaatttgatctgtgacaatctattgcctagaagagacttactcttgcaa acacgtttgattaatgatgtgacaagcataaggccaaacatatttttgggtgttgctgag ggctctgcacaatacaagaagtggtactttgagttaataattgatcaggttgatccattc ttgacggcagaacccacccatttacgagttggatgggcctctacttcaggttatgccccc tatcctggaggtggagaaggatggggaggcaatggtgttggcgatgacctgtactcttat ggttttgatggccttcatctgtggtctggtcgagtacccagagctgtagcatctgtcaat cagcatttattagcatctgatgatgtggttagctgctgcttggatttaggtgtacccagc atttcattccgcattaatggacagcctgtacaaggaatgtttgagaacttcagtacagaa gggtttttcttccctgttgtaagcttatcagcaggtgtgaaagttcgtttcttattgggt ggacgtcatggagagtttaaatttctgcctcctgctggctatgctccttgttatgaagca ttgcttccaaaagagaagatgaaacttgaaccagtgaaagaatataagagagattctgat ggagtgagggatttgctgggtacaacacagttcctctcccaagcttcctttatcccttgt ccaatagacaccagtcagattgctcttccttttcatcttgaaaagatcagggacaaacta gctgaaaatatccatgaactgtggggaatgaataaaatagaactgggctggacatatggc aagattcgggatgataataaaaggcatcatccttgtcttgtggaattctcaaaattacct gagacagagaagaattataatctacaaatgtcaactgaaaccctcaaaacccttttggcc cttggatgtcacattgttcatgctcatccagcagctgaggaagatcttaaaaaagtcaaa cttcctaaaaattacatgatgtcaaatggatataaacctgcccctcttgatctctctgaa gtgaaattgttaccctctcaagaatttctagttgacaaactagcagaaaatgcacataat gtctgggcaaaagacagaataaagcaaggatggacctatggcattcagcaggatcttaag aacaagcgtaatcctcggctagtgccatatgcattattagatgaacgtactaaaaaatca aacagagatagcctccgtgaagctgttagaacatttgcaggctatggttatagtattgag ccacctgaccaagagatagctgaccaaacagtggaaaaagtcagcatcgacaagatacga tttttcagagtagaacagtcttatgcagtgaagtctggaaagtggtactttgaatttgaa gctgtgacaggtggagatatgcgtgttggctgggcaaggccaggctgtcgacctgacata gagttgggagctgatgaccaagcatttgtatttgaaggaagcaaaggccagcgttggcat caaggcagtggattctttggacgaagctggcaaccaggagatgtggttggttgtatgata aacttggatgacaaatcaattatctttactctgaatggagagttgcttataaccagtaaa ggttcagaacttgcatttgctgactttggaatagaaagtggttttgttccaatttgtgca ctgggtctatctcagattggtcgtatgaaccttggaatggatgccagtacattcaagtat tatacaatgtgtggccttcaagaaggttttgaaccttttgctgtcaacatgaaccgagat gttgctatgtggtttagtaaacgcttaccaacatttgtcaatgtgccaaaaaatcatcct cacattgagatatggagaattgatggaaccattgagactccacctcggttaaaagttact cacaaaacatttggcacgcagaacagcaattcagacatgatatattgtcgtttgagtatg cccattgagttccgctcatcattccacttcggcatgggtatggaaaatgcctcatctgat gttttccaaaaaagaaagcatagccaagaaactgctgctgcttctacaacgtatttttat tcactacggatatttgctggccaagacccatcctctgtctgggttggctgggtaacacca gactatcatttttacagtgagaattttgacctaaataaaaattgtacagtgacagttact ttaggtgatgagagaggcagggttcatgaaagtgtgaagcgcagcaattgctatatggtt tggggaggagatgtaattgctaattcccagagatcaggtcgcagtaatgttgatttagaa attggatgctttgttgacctggctactggaatgttgtcattcacagccaatgggaaagag cttggcacttgttatcaggttgaaccaaacacaaagctttttccagcaacttttgtacag cctacaagcactaacttggttcagtttgaacttggtaaattaaagaataccatgccctta tcagctgcaatttttaaaagtgaagaaagaaatcctgttcctcagtgtcctcctcgcctt gatgtgcaaacaattacacctgttctatggagcaggatgccaaacagctttctaaaagta gaaactgagcgtgtcagtgaacgtcatggctgggttgtgcagtgtttggaacctctgcag atgatggcacttcatatcccagaagaaaacagatgcgttgatattttggaactatgtgaa caagaagatttgatgaagtttcactaccacactttaaaactctatagctcagttagtgct ctgggtaacactagagttgcttatgcactttgtagccatgtggacatatctcagctattt tatacaatagataatcaatacttacctggactcctacgttctggattctatgacttgctt attagtattcatttggagcatgccaagcaagccaagctcatgatgaacaatgaatttatc attccagttacagatgaaactcgaactattaaattatatcctgatgaaacaaagaagcat ggtttacctggagtagggcttagcacttgtctaaaaccaggctttaatttttctactcca tgctttattgtgaccagtgaagaacgtcagatatccagcccagagataccccttgatata cttaaatccaaggccattagtatgttaacagaggcagtacagtgtagtggtactcatata cgagaccctgttggaggacaggttgcattccagttcgttcctgttcttaaactgatagca acattgctcataatgggcgtttttgatgacgatgatgtgaagcaggtgttactcctcatt gatcctaatgtgtttggagatcacaaggaagaaacagaagagaggacagagaaggaagaa gttacacaagttgaagaaaaagctgtggaagctggggagaaagcaataaaagaaacgaaa gctcctgcaaagggcttattgcagacaaaattaccagaatctgttaagcttcagatgtgt catttactcaattatttctgtgactgtgagctacaacatagagtggaagcaattgtatca tttgcagaccgttatgtatcaaaattgcaatacaatcagaagtacaggtacaatgaactc atgcaagccttgaacatgtcagctgctttgactgccaagaagactaaagaatttcggtct cctcctcaagaacagattaatatgttgctgaattttcaactgggagaggattgtccctgt ccagaggagattcgggatgagttatatgaatttcatgatgatcttctaattcactgtggt attccactagaagaggaggaagaggaagaggaagattcctcattgactggcaaactctgt tcattaatatacaaaatcaaaggtccaccaaaagcagaaaaagtagaacctaaggaggaa gaagagaaatctccaactacactgaaagaactcatatcccagactatggtgcgctggtcc caggaagatcagattcaagatccagaattagttcggattatgtacaccctccttcgtagg caatatgacagcattggtgagctactgcaagctctgaggaaagcatatactattagtgct gcctctgtgaaggataccattaatctgcttgcagcactgggccagattcgctcacttctc agtgtcaggatgggaaaagaggaggaattgctaatgattaatggattaggggatataatg aacaacaaggtgttttatcagcatcctaacttaatgagagtcttgggtatgcatgagact gttatggatgtgatggtgaatgtgcttggaggagacaaatctcagatcgtttttcctaag atggtggcaagctgttgtcgattcctgtgctacttctgccgaattagtcgtcaaaaccaa aaggccatgtttgagcatcttagttacttactggaaaacagcagtgttggactggcattt ccttcaatgagaggttcgacaccactagatgttgcagcagcctctgtaatggacaacaat gagcttgcactagcattggaggagccagatcttgataaggttgttacctacctggcgggt tgtggcctgcagagttgtccagtattgctggctaaaggatatccagacattggatggaat ccaatagagggtgaacgttacctgtcattcttaagatttgcagtttttgttaacagtgaa agtgttgaggaaaatgcaagtgttgttgtcaagctccttattcgacggccagagtgcttt gggccagaccttaggggagaaggaggaaatggtttgctggcagctatgcaggaagctatc aggatctcagagaatcctgcttgtgaccttccctcccaggcatataaaagagaaggtgat gaggaggaggaggaggaagagattgtgcacatgggcaatgcaattatgtcattttactca gctctcatagatttacttggacgctgtgcaccagaaatgcatcttattcaaagtggaaaa ggggaagctattcgaatcagatcaatccttcgatctctagtgccaactgaagatttggtt gggattataagtataccactaaagctgtcaacagttaacaaagatggaacagtaaatgag ccagacatgtctgcaactttctgtcctgatcataaagcacccatggtactcttcttggac cgtgtctatggtattaaggaccaaagctttctccttcacctactggaagttggattttta ccagatttaagagcctctgcctctttggatacagtttctctaagtaccacagaggcagct ctcgcactaaatagatatatttgctcagctgtgtttccattactcaaaagatgtgctccc ctcttttctggaacagagcatcacgcctctctggttgactccatgcttcacacaatatat aggttatccaagggacgttcccttacaaaagcacaaagagacactattgaagaatgcctg cttgctatttgccaccacttacgtccctctatgctacaacagctgttgagaaggctggtt tttgatgtgcccctactcaatgaatactgtaaaatgcctctcaagcttctgacaaatcac tatgagcagtgctggaaatattattgtctgccttcaggaatgggaagctatggaattgca gcagaagaagaattacatttaactgaaaaacttttctggggaatatttgattccttgtct cataagaagtatgatccagagctctttcgaatggctttgccttgtctaagtgctatagct ggtgccttgccccctgattatttagatacacgaattaggtcaactttggaaaagcagact tcactggatccagaaggaaattttgatcccaaacctgtcagcacagcaaaccttgtactt cctgaaaagttggagtatattgtcagcaagtatgctgaacattcccatgataaatgggcc tttgataagactaatagtggatggaaatacggtgtttcactggatgaaaatatgaagact cacccattaataagaccttttaaaactttaactgaaaaggaaaaggaaatttatcgttgg cctgccagagaatcactgaaaaccatgttggccatgggatggagcctagaaaggaccaaa gaaggaggagaagcaataatacatcagcgtgaaaatgaaaagctccgcagcatatctcag tctagccagggaaatgggtatagcccagcaccacttgatctctctaatgtggtgctttct agggagcttcagggaatggttgaggtaatggcagaaaactaccataatatatgggccaaa aagaagaaaatggagttggaaagcaaaggtggaggtagtcatcctttattggtaccttac gacacattgacagccaaggagaaatcacgagaccgtgaaaaggcacaagagctgtttaaa ttccttcaagtcaatggtataatcatatctcggggtctgaatgagttggagttggatgct tcatccatggaaaagaggtttgcctttaagtttctgaagaaaattttaaaatacgttgat tctgctcaagagtttattgcgcatttggaagccattgtaaccagtggaaaaactgaaaaa tctccacatgaccaagaaataaagttctttgccaaagttcttttaccattagttgatcag tactttacaaatcactgcctctacttcctgtcttctccaacaaaaacactcagtagcagt ggatatgcatcaaataaggaaaaggaaatggtagcaagcctgttctgcaaactagctgct cttgttagacataggatctcactttttggtagtgattctgctacaatggtgaactgcctg cacatcttagctcagtctcttgacacacgaactgttatgaaatcaggatctgagcttgtt aaagctggattgcgtgccttttttgaaaatgcagctgaagacctggaaaaaacttcagaa aatcttaaacttggaaaatttacccattcacgaacacaaatcaaaggtgtttcacagaat atcaattatactacggtagcattgttaccgatcttgacatcaatttttgaacatatttca caatatcagtttggaattgatttactattgggtgatgtacaagtttcatgttacagaatt ctttctagcctctattcccttgggactgggaagaacatctatgttgaaaggcagcgtcct gcacttggtgagtgcttagcatctcttgcagcagccattccagtagcgttccttgaacct tctctcaaccattacaacccattgtctgtcttcaacacaaaaagtgcaagagaaagagca attttaggtatgcctgatagagtagaagagatgtgtccagagatccctcagttggatgga ctaataaaggaaattaatgatttagcagagtctggagcaaggtatactgaaatgcctcat gtaattgaggttatcttacccatgctatgcaactatttgtcctactggtgggaaaaaggg tctgagagtgttcctcaaagtgctgggccttgctgtacaatggtaacatctgagcatctg agcgtcattcttggaaacattctgaaaatcattaacaacaatctgggaatagatgaagca tcttggatgaaaagaattgcagtttatgctcaacccatcatcagcaaagctaggcctgat ctgctcaaaactcactttattccaactctggagaaattgaagaagaaagctataaagatt gtgatggaagaggagcaactgagagcagatagtaaaactgacacccaagaagctgagcta ctcattctcgatgagtttgctgttctttgtagagacctttatgccttctatccaatgttg atacgttatgtagacaacaacagagccaactggctaaaaaaaccagatgcagattctgat gaactctttcgaatggtagctgaagtttttatcctgtggtgtaaatcacataatttcaaa agagaagaacaaaattttgtgattcagaatgaaatcaacaatttggcatttttaacagga gacaccaagagcaagatgtctaaagccatgcaagtaaagtctggaggacaagatcaagag agaaagaaatcaaaacgcagaggggatttgtactccatacaaacatccttgattgtagct gcacttaaaaagatgcttcctattggtttgaatatgtgtactcctggagatcaagagctc atctctttggctaagactagatatagccatagggacactgatgatgaagtcaaagaacat ttacgtaacaacttacatctgcaggaaaagtctgatgacccagctgtgaaatggcagtta aatctgtacaaagacattttgaagagtgatgaacctcctgaccctgagaaaaatgtggaa cgtgtgcagaggatatcagctgctctgtatcatctggaacaggttgaacaaccactgaga tcaaagaaggctgtttggcataaactcctgtcaaaacaacgcaaaagggctgttgttgca tgtttcagaatggcaccattatacaacctgccaaggcaccgttctattaacctcttcctc catggctatcagaactattggatagaaacagaggaatattcatttgaggagaaactagtt caggatttggctacacctccaaaaaaagatgaagaagaagaggaagagactgagaaaaaa cagcctgatccacttcatcagattatcctctattttagtcgcagtgctctcacagagaga agcaaactagatgatgatccgttatatattgcctattccgccatgatggcaaagagctgt caggaagaagaagaggaggaagaagaagaaaaagaaaagacatttgaggagaaagaaatg gaaaaacagagaactctctatcagcaagctcgcttacatgatcgtggagctgctgagatg gtccttcagatgattagtgcaagcaaaggtcatacaggacccatggttgttgaaacacta aaacttggtattgctattctaaatggtgggaataccatagttcaacagaaaatgctagac tacctgaaggagaaaaaggatgctggattttttcaaagtctctctggcttgatgcagtcc tgcagtgttcttgacttgaatgcgtttgagagacaaaataaagcagaaggcctgggaatg gttactgaagaaggaactctcatcgttcgtgagcgtggtgaaaaagtgttgcagcatgat gaatttactcgagatctatttagatttttacaactgctctgtgaagggcataacaatgat tttcaaaattatctacgtactcagatgggcaacaccacaacagtgaatattatcattagt acggttgactatctcttgcgtcttcaggaatcaatcagtgacttctattggtactattca ggaaaggatgtcattgatgaatcaggacaacgtaacttctctaaagctttggctgtcacc aaacaaatattcaattcccttacagaatatatccagggcccttgcataggtaatcaacag agtctggctcatagcaggctgtgggatgcagttgttggctttcttcatgtctttgccaat atgcagatgaagctttcacaggactctgctcagattgaattgcttaaagaactgctagat ctgctaaaggatatggtagtgatgctcttgtcactgcttgaaggtaacgttgtgaatgga actattggaaaacaaatggtagacacacttgtagaatcatctagcaacgtagaaatgatt ttgaagttctttgacatgttcctcaagttaaaagatctgactaactcagatgctttcaaa gagcatgacccagatggtaaaggcatcatttcaaagaaggaattccagaaatcaatggag gctcaaaaacaatacagacagtcagagnnnnnnnnnctgctgtcctgtgcagaagctgat gaaaatgacatgtttaactatgttgactttgtggaaaggttccatgaaccagccaaagac attggatttaatgtagcagtattgctaacaaacctttcagagcacatgcctaatgattca cgccttcagagcttacttgaacctgcggaaagtgttcttaattactttgaaccatacctt ggccgtattgaaataatgggtggagccaagaaaatagaaagagtttactttgaaatcagt gaatccagtagaatgcagtgggagaagccacaggtgaaggaatccaaaaggcagttcata tttgatgttgtaaatgaaggtggagagcaagaaaaaatggaactctttgtgaatttctgt gaagacacgatctttgaaatgcagttagcatcccagatctctgaaacagattcatctgag aggcctgaggaagaggaagaggcagagccttgttacgtagtggatattggagatgatgag gaagaagaaaagtccctggaatctgcttcagctttttcaatggcctgtgttgcagtgaag aagaatgttgcaaacttttttaaaatgatcactgtgaagaacctaaggaaacaatacagg aaagttagaaagatgacagtaaaagagatggtgaaagtgtttttctcctttttctggatc ctatttgtagggatgttccaactgttctttactatagtgtggggaattttccagattctt tggagcactgtatttgggggtggcctggttgaaggagccaaaaacattaaagttactaaa atattaggggacatgcctgacccaacacagtttggaatccatgatgatgttatggaagca gaaaaagctgaaggtgctgagcatggcatcagagctgaacttgtgcagtttgtgaagggt gaaaagggagaaactgacataatctcagacatttttggcattcatacaaagaaagaaggt ggctcaaaacatggtcacgatgctggacttggagatattgcagaaatccttggtactgat atcgagtcgtctttggaaaacacagttcgtaagaaaaaaggattacagatatctgaaatt gcaaaagaagctgaagcagaaagaaaagcagaagctgagaaggctgacatggaagatggt gagaaacaagataaagcaaaggaagtacaatctgagcagctagaagagggaaaaacgaag aaaaagaagagaaggcatggacaaaaaattgagaaaccagaggctgttatggctaacttc ttcaaagctttggaaatttatcaaacaaaaatgcttcactacttggcaagaaatttttat aacttaaggtttcttgctctatttgttgcatttgccatcaactttattcttctgttttac aaggtgacagaagagccacttgatgatgtagaggaagactctaatctctggaactctttt gatgaagaggaagaggacgacggcatggtgttttttgttttagaagaaagtacaggttac atggcacctgctctcagagcattggcagttattcacactatcatctcctttgtctgtgtg attggatactattgcttaaaggtccctctggttgtattcaaaagagaaaaggaggtagct agaaagctggaatttgatggactatacataactgaacagccatctgaagatgatattaaa ggacaatgggatcgcctggttatcaatactccgtcctttcctaacaattactgggacaaa tttgtaaaacggaaggttattaacaagtacggagacttatatggagcagagcgcatagca gaacttttgggtttggacaaaagtgcccttgattttagtccagtggaagagagcgaacca gaagaggcatctcttgtatcatggttaagctccattgatacaaagtaccacatttggaag ctcggagttgttttcactgataattcgtttttatacttagcgtggtacacgactatgtct atccttgggcactacaacaacttcttctttgctgctcatctgctggatattgctatgggt ttcaagacattgcgaaccattttgtcttcagtcactcacaatggcaaacagcttgtgctt actgtaggactcctcgctgtagtagtatatctttacactgttgtggcgttcaacttcttc cgcaaattctacaacaaaagtgaagatgaagatgaaccagacatgaaatgtgatgacatg atgacgtgttacctgttccacatgtatgtgggtgttagagctggtggtggcattggagat gaaattgaggatcctgctggagacccttatgaaatgtatcgaattgtttttgacatcaca tttttcttcttcgtcattgttatcctgctggccattattcaaggtcttattattgatgct tttggcgaattaagagaccagcaagaacaagtgagagaagatatggagaccaaatgtttt atttgtggaatcggcaatgactattttgacacaacccctcatggctttgaaacacatact ttgcaagaacacaacttggcaaactatctgttctttttaatgtatctcattaacaaggat gaaactgagcatactggccaggagtcatttgtgtggaagatgtaccaagaaagatgttgg gattttttcccagcaggggactgcttccggaaacagtatgaggatcaacttggctaa

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