Nyctereutes procyonoides (raccoon dog): 129499256 Help Entry 129499256         CDS       T09008                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism npo  Nyctereutes procyonoides (raccoon dog) Pathway npo04020   Calcium signaling pathway npo04024   cAMP signaling pathway npo04260   Cardiac muscle contraction npo04261   Adrenergic signaling in cardiomyocytes npo04371   Apelin signaling pathway npo04713   Circadian entrainment npo04911   Insulin secretion npo04921   Oxytocin signaling pathway npo04972   Pancreatic secretion npo05020   Prion disease npo05022   Pathways of neurodegeneration - multiple diseases npo05410   Hypertrophic cardiomyopathy npo05412   Arrhythmogenic right ventricular cardiomyopathy npo05414   Dilated cardiomyopathy npo05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:npo00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     129499256 (RYR2)    04020 Calcium signaling pathway     129499256 (RYR2)    04024 cAMP signaling pathway     129499256 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     129499256 (RYR2)    04921 Oxytocin signaling pathway     129499256 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     129499256 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     129499256 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     129499256 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     129499256 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     129499256 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     129499256 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     129499256 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     129499256 (RYR2)    05414 Dilated cardiomyopathy     129499256 (RYR2)    05415 Diabetic cardiomyopathy     129499256 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:npo04040]     129499256 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:npo04990]     129499256 (RYR2) Ion channels [BR:npo04040]  Voltage-gated cation channels   Ryanodine receptor    129499256 (RYR2) Domain-containing proteins not elsewhere classified [BR:npo04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    129499256 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  129499256 NCBI-ProteinID:  XP_055164967 LinkDB All DBs Position Unknown AA seq 4967 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKSLLLMDKENADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV CYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKVRASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLKTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEEK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDEHAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMTERTMMFTLNGEVLLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDIMFYRLSMPIECAEVFSKTVAG GLPGTGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNSEFIVPMTEETKSITLFP DENKKHGLPGIGLSTSLRPRIQFSSPSFVSINNECYQYSPEFPLDILKAKTIQMLTEAVK EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPDEE TEALEKEPCPEDSKSEGTGEEEAKGVKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLK KKQAEKPIESDSKKSSTLQQLISETMVRWAQESVIEDPDLVRAMFVLLHRQYDGIGGLVR ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQML VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG NGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLDTEEEEDDTIHMGNAIMTFYSALIDLLG RCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY KLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHG YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAK EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI LEFDGGGRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPIAFLETHLDKHNI YSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP MLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFT TLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSHNFKREEQNFV VQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNI CAPGDQELIALAKNRFSMKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTED TSDPEKTVERVLDIANVLFHLEQKSTCMRRRYYSLVEHPQRSKKAVWHKLLSKQRKRAVV ACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGADPPEEEESTKR VDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEME KQKLLYQQARLHDRGAAEMVLQTISASKGDTGPMVAATLKLGIAILNGGNSTVQQKMLDY LKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLF RFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDE QGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQ DSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMF LKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDY EEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMG SAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEM QLAAQISESDLNERSVSKEESEKEKPEEQGPRMGFFSILTVKSALLALRYNVLTLMRMLS LKSLKKQMKRVKKMTVKDMVMAAFSSYWNIFMSLLHFVASVSRGFFRIICSLLLGGSLVE GAKKIRVAELLANMPDPTQDEVRGDSEEGDRKPMEAALPSEDLTDLKELTEESDLLSDIF GLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPDVQEKFQEQKAKEEEKEEKEENKSEPE KAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFY NMRMLALFVAFAINFILLFYKVSTSSVVEGKELSTRSSSENAKVSSLDSGSPRIITVHYV LEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQ PSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFS DAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFFA AHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGD TPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLA IIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLF FLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14904 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgagggcgaggacgagatccagttcctgcgaactgatgatgaagtg gttctgcagtgtaccgcaaccatccacaaagaacaacagaagctgtgtttggcagcagaa ggctttggcaacagactttgtttcttggagtccacttcaaattccaagaatgttcctcca gacctctccatctgcacctttgtgctggaacagtctctctctgtccgggccctgcaagag atgctggctaacacggtggagaagtcagaagggcaagttgatgtggaaaaatggaaattc atgatgaagactgctcaaggtggtggtcatcgaacacttctctatggacatgccatattg ctacgccattcctacagtggtatgtatctgtgctgcctctccacctcccggtcttcaact gataaactggcctttgatgttggcttgcaagaggacacaacaggtgaggcttgctggtgg actattcaccctgcctctaagcagcggtcggaaggagaaaaggttcgagttggagatgac ctcatcttagtcagtgtgtcctctgagaggtacctgcacttgtcttatggcaacggcagc ttacacgtggatgctgctttccagcagactctttggagcgtggccccaatcagctcagga agcgaagcagcccaagggtatctaattggtggtgacgtcctcaggttgctgcatggacac atggatgaatgcctcactgtcccttcgggagagcacggtgaagagcagcggagaactgtt cactatgaaggtggtgctgtatctgttcacgcacgttccctgtggaggctagagacacta agagttgcgtggagtggaagccacataagatggggccaacctttccgactacgccatgtc acaacaggaaaatacttgagtctcatggaagacaaaagccttctactcatggacaaagaa aacgcagatgtaaaatcaacagcatttaccttccgatcttccaaggaaaaattggatgtg ggtgtgagaaaagaagtagatggcatggggacatctgaaataaaatatggagactcagta tgctatatacaacatataaatacaggcctatggcttacctaccagtctgtggatgtaaaa tcagtgagaatgggatccatacaacgtaaggctattatgcatcatgaaggtcacatggat gatggcttaaatttatccagatctcagcatgaagaatcacggactgcacgagtcattcgg agcacagttttccttttcaatagatttataaggggcctagatgcgctcagcaagaaagtg agggcctccaccgtggacctccctatagagtctgtgagtctaagtctgcaagacttgatt ggctacttccaccccccggatgagcacttggagcatgaagacaagcagaacagattgcga gctctcaagaaccggcaaaacctcttccaggaagagggaatgatcaacctcgtgctcgag tgtatagacaggctgcatgtgtacagcagcgcggcacactttgctgatgttgctgggaga gaagcaggcgagtcctggaagtcgattctgaattctctctatgagttgctagcggcttta attagaggaaatcgtaaaaactgtgctcaattttctggctcccttgattggttgatcagc cgactagaaagactggaagcttcttctgggattcttgaagttttacactgtgtgttagta gaaagtccggaagctctaaatattatcaaggaaggacacattaaatccataatctcactt ttagacaagcatggaagaaaccacaaggttctggatgtcttgtgctctctctgtgtctgc catggagtagcagtgcgttctaaccagcacctcatctgtgacaatctgctgccaggaaga gatctcctattacagacgcgccttgtaaaccacgtcagcagcatgagacccaatattttt ctgggcgtcagtgaagggtccgctcagtataagaagtggtactatgagctgatggtggac cacacggagccatttgtgactgctgaagccacgcacctgcgggtgggctgggcttccacc gaagggtactctccctaccccggaggcggtgaggagtggggtggaaatggagtcggagat gatctcttttcctacggattcgatggccttcacctctggtcaggttgcattgctcgtact gtaagctcaccaaaccagcacttgctgaaaactgatgacgtcatcagttgctgtttagat ctgagtgccccaagcatctcattccgaattaacggacaacctgttcaaggaatgtttgag aatttcaacattgatggcctcttctttccagttgttagtttctctgcaggaataaaggta cgctttctgcttggggggagacatggagaatttaaattcctccctccacctgggtacgct ccttgttatgaagccgttctgccgaaagaaaagttgaaagtggagcacagccgagaatac aagcaggaaaggacttacacacgggacctgctgggccccacggtttccctgactcaggct gccttcacaccaattcctgtggacaccagccagattgtgttgcctcctcatctagagaga ataagagaaaaactggcagagaatatccatgaactttgggttatgaataaaatagagctt ggctggcagtatggtccggttagagatgacaataagagacaacacccctgtctggttgag ttctccaagctgcctgaacaagagcgcaattacaacttgcagatgtctctggagaccctg aagactttgctggcattaggatgtcatgtgggcatttcagatgaacatgctgaagaaaag gtgaaaaaaatgaagctgcccaagaattaccagctgacaagtgggtataagcctgcccca atggacctgagctttatcaaactcaccccatctcaggaagcaatggtggacaagttggca gaaaatgctcataatgtatgggcccgagatcgaatccggcagggctggacttacggcatc caacaggatgtaaagaacagaagaaaccctcgcctggttccctacactcttctagatgac cgcaccaagaaatccaataaagacagcctccgtgaagctgttcgcacgctgctggggtat ggctacaacctggaagcaccagatcaggatcatgctgccagagctgaagtgtgcagcggc acaggtgagagattcagaatcttccgtgctgagaaaacctacgctgtcaaggcaggaagg tggtattttgaatttgaggctgtcactgcaggcgacatgagagttggctggagcaggcca ggttgtcaacctgatcaagagcttggctccgacgaacatgcctttgcttttgatggcttc aaggctcagcggtggcaccagggcaatgagcattatgggcggtcatggcaagcgggagat gtcgtggggtgtatggtggacatgacagagcgtaccatgatgttcacgctcaatggcgaa gtccttctggacgattcgggctcagaactggcgttcaaggactttgatgttggtgatgga ttcattcctgtctgtagccttggagtggctcaagtgggcaggatgaactttggaaaggat gtcagcaccttgaaatatttcaccatctgtggcttacaagagggctatgaaccatttgct gttaacacaaacagggatattaccatgtggctaagcaagaggcttcctcagtttctccag gtcccatcaaatcatgagcatatcgaggtgaccagaatagatggcaccatagacagttct ccatgtttaaaggtcactcagaagtcctttggttctcagaacagcagcaccgatatcatg ttctatcgcctgagcatgcccatcgagtgtgcagaagttttttccaagacggtagcagga ggactcccaggcactggcctctttgggcctaagaatgatctggaggactacgatgcagat tctgactttgaggttctaatgaagaccgctcatggccatctcgtgccagatcgagttgac aaagacaaggaagccacaaaaccagagtttaataaccacaaagattatgctcaagaaaag ccttctcgtctgaaacaaagatttttgcttagaagaaccaagccagattacagcacgagc cattctgcaagactcactgaagatgtccttgcagacgatagggatgattacgattacttg atgcaaacgtccacgtactattactcagtgagaatctttcctggccaagaacctgcaaac gtctgggtaggctggattacatcagatttccatcaatatgatacaggctttgacttggac agagttcgtacagtaaccgttaccctaggagatgaaaagggaaaagtgcatgaaagcatc aaacgcagcaactgctatatggtatgtgcaggcgagagcatgagccctgggcaaggacgc aacaacaatggcctggagatcgggtgtgtggtggacgccgccagtgggctgctcacattc accgccaatggcaaggagctgagcacttactaccaggtggagccaagtacaaaattattt cctgcagtgtttgcacaagctacaagtcccaatgttttccagtttgagttgggaagaata aagaacgtgatgcctctgtcagcgggattgttcaagagtgagcacaaaaaccctgtgcca cagtgtcccccacgtctccacgtgcaatttctatcccacgtcctgtggagcagaatgccc aaccagttcttgaaggtagatgtctctcgaataagtgagcgccaaggctggctggtgcag tgtttggatcccctgcagttcatgtctcttcatatcccagaggagaacaggtcagtggac atactggaattgaccgagcaggaggagctgctgaagttccactatcacactctcaggctt tactccgctgtgtgcgcccttgggaaccaccgggtggcccatgccttgtgcagccacgtg gatgaacctcagctgctctacgccattgagaataaatacatgcctggcttgctgcgtgct ggctactacgacttgctcattgacatccacctcagctcctatgccactgccaggctcatg atgaacagtgagttcatcgtgcccatgacagaggagaccaagagcatcacccttttccct gatgagaacaaaaaacatggcctcccgggaattggcctcagcacttccctcaggccacgg atacaattttcctcccccagttttgtaagcattaataatgaatgttaccagtacagtcca gagttcccactggacatcctcaaggccaaaaccattcagatgctgacagaagctgtaaaa gagggcagccttcatgcccgggacccagttggggggacaactgagttcttgtttgtacct ctcatcaagcttttctatactctactcatcatggggatcttccacaatgaggacttgaaa cacatcttgcagttgatagagcccagcgtattcaaggaagctgccactccagatgaggag actgaggcactggagaaggaaccctgcccagaagactccaagtcagaaggaactggagaa gaagaagccaaaggggttaagaggcccaaggaaggcctgctccaaatgaaactgcctgag ccagttaaattgcagatgtgcctgctgcttcagtatctctgtgactgtcaggtccggcac cggatagaagccattgtggccttttcagatgactttgtagctaagctccaagataatcaa cgcttccgatacaatgaagttatgcaagccttaaacatgtcagctgcactcaccgccagg aaaacgaaggaatttagatcaccacctcaagaacagatcaatatgcttctcaattttaag gatgacaaaagtgaatgtccatgtcctgaggaaatccgtgaccaactcttagattttcat gaagatttgatgacacattgtggaattgagcttgatgaagatgggtctttggatggaaac agtgacttaacaattagaggacgcctgctgtccctggtagaaaaggtgacatacctgaag aagaaacaagctgaaaaaccaattgagagtgactccaagaagtcctccactcttcaacag ttgatttctgagaccatggtccgatgggcacaagagtctgtcattgaagaccctgacttg gtgagggctatgtttgtgttgctccatcgacagtatgatggcattgggggtctggtccgg gctctgccaaagacctacactataaatggtgtctccgtggaggataccatcaacctgctg gcatctcttggtcagattcgttctctgctgagtgtaagaatgggcaaagaagaagagaag cttatgattcgtggattaggggatatcatgaataataaagtgttttaccagcaccctaat ctcatgagggcacttgggatgcatgagacagtgatggaggtcatggtgaatgtccttggc ggtggagagtccaaggaaatcacttttcctaagatggtggccaactgttgccgtttcctc tgttacttctgtcgtataagtaggcagaatcaaaaagctatgttcgatcatctcagctat ttattggagaacagcagtgttggtcttgcctcaccagctatgagaggttcgacaccgctg gacgtagcagctgcctcggtgatggataataatgagctggccttagctctgcgtgagcca gatctggaaaaggtagttcgatatttggctgggtgtggactgcagagctgccagatgctg gtgtctaagggttatccagacattggatggaatccagttgaaggagagcgatatcttgac tttctcagatttgctgtcttctgtaatggggagagtgtggaagagaatgctaatgttgtg gtgaggttgctcatccggaggcccgagtgttttggtcctgctttgagaggggaaggtggg aatggtcttcttgcagccatggaggaagccataaaaatagctgaagatccttctcgagat ggcccctcaccaactagcggatccagtaaaacacttgatacagaagaggaggaagatgac actatccacatggggaatgccatcatgaccttttactcggctttgattgaccttttggga cgttgtgctcctgaaatgcatttgattcatgctggtaagggggaagccatcagaatccgg tcaattttgagatccctaattcccctgggagatttggtgggagtaatcagcattgctttt cagatgccaacaatagccaaagatgggaatgtggtggagcctgacatgtctgcggggttt tgcccagatcacaaggcagccatggttttgttccttgacagggtctatgggattgaggtt caagatttcctcctccatcttcttgaggttggctttctgccagatctccgggctgctgct tctttagatacggctgctttgagtgctacagacatggccctggccctcaatcggtacctt tgcacagctgtgttgcctttgttaacaagatgtgcccctctttttgctggcacagagcac cacgcttccctcattgactcattacttcacactgtgtacagactttctaagggctgctct cttaccaaagctcagcgggattccatagaagtttgtttactctctatttgtggccaattg agaccttctatgatgcagcacttactccgaagattagtatttgatgtcccattattaaat gaacatgcaaagatgccccttaagttgctgacaaatcattatgaaagatgctggaaatat tactgcctgcctggagggtgggggaactttggagctgcctcagaagaagagcttcattta tcgagaaagttgttttggggcatttttgacgccctatctcaaaagaaatatgagcaagaa cttttcaaactggcactgccttgcctgagtgcagttgcgggagctttgcctccagactac atggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaac tttaacccacaacctgttgatacctcaaatataacaattcctgagaagttggaatacttc attaacaaatatgcggaacattctcatgacaaatggtcaatggacaagttggcaaatgga tggatttatggagaaatatattcagactcatctaaagttcagccattaatgaagccatat aaactattatctgaaaaggaaaaagaaatttaccgctggccaatcaaagagtctctaaaa accatgcttgcgtggggttggagaattgagagaacacgggaaggagacagcatggccctc tataaccggactcgtcgcatttctcagacaagccaggtttctgtagatgctgcccatggt tatagccccagagccattgacatgagcaatgtcacactgtccagagacctgcatgctatg gcagaaatgatggctgaaaactaccataacatatgggcaaagaaaaagaaaatggaactg gagtccaaaggaggtggaaatcatccccttctggtaccttatgatacgctgacagccaaa gagaaagccaaggacagggaaaaagcacaggacatcctcaagttcttgcaaatcaatggc tatgctgtatccagggggtttaaggacctggaattggacacaccttccattgagaaacga tttgcctacagcttccttcagcaactcattcgctatgtggatgaagcccatcagtatatc ctggagtttgatggtggcggcagaagcaaaggagaacatttcccttatgaacaagaaatc aagttctttgctaaagtggttcttcctttaattgatcaatatttcaaaaaccatcgctta tacttcttatctgcagcaagcagacctctctgttctggaggacatgcatcaaacaaggag aaagaaatggtgacgagcctattctgcaaacttggagttcttgtcaggcataggatttca ctatttggaaatgatgccacatcaattgtcaactgtcttcatattttgggtcagactttg gatgccaggacagtgatgaagactggtctggaaagcgttaaaagtgccctccgagctttt ctagacaatgctgcggaggatctggagaagaccatggagaatctcaagcaaggccagttc acccacacccgaaaccaacccaaaggtgttactcagattatcaattataccacggtggct ctgttgccgatgctgtcatcattatttgagcatattggccagcatcaattcggagaagat ctaatattggaagatgtacaagtgtcatgttatagaattctgactagtttatatgctttg ggaaccagcaaaagtatttatgtggaaaggcaacgttctgcgttaggagaatgtctcgct 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tgtgcccctggggaccaggagctcatcgctctggccaaaaaccgattcagtatgaaagac actgaggatgaagtacgagatataattcgcagtaatattcatttacaaggcaagttggag gatcctgctatcagatggcaaatggctctttacaaagacttaccaaacaggactgaagat acatcagatccggaaaagaccgtagaaagagtattagatatagcaaatgtgctttttcat cttgagcagaagtctacatgtatgcgccggagatattacagtctggtggagcacccacag agatcgaagaaggctgtatggcacaaactgttatccaagcagaggaaaagagcagtggta gcctgtttccgaatggctcctttatacaatctgccaaggcatcgggctgtcaatctcttt cttcagggatatgaaaagtcttggattgaaacagaagaacactactttgaagataaatta atagaagatttagcaaagcctggagccgaccctccagaagaagaagaaagcacgaagaga gttgatcccctccatcaactcatccttctgtttagtcgaacagctttaacagagaaatgc aaactggaagaagactttttatatatggcttatgcagatattatggcaaagagttgtcat gatgaggaagatgatgatggtgaagaagaagtgaagagttttgaagaaaaagaaatggaa aagcaaaagcttctataccaacaagccaggcttcatgaccgaggggctgcggagatggtg ctgcagaccatcagtgccagcaaaggtgatactggaccaatggtagctgcaactttgaaa cttggcattgctatcttaaatggcgggaactctacagtacagcagaaaatgcttgactac ctcaaggagaaaaaggatgtgggcttctttcagagccttgctggcctgatgcagtcatgt agtgtcctcgatctaaatgcatttgagcgacaaaacaaagctgaaggacttggaatggtg accgaggaaggatcaggagaaaaggttcttcaggatgacgagttcacttgtgacctcttc cgcttcctacaactgctttgtgagggacacaactcagattttcaaaattatctgagaacc cagactggcaacaacacaactgtcaacataatcatctctactgtagactacctcctgaga gtccaggaatccattagcgatttctattggtattactctgggaaagatgttattgatgaa caaggacaacggaatttttccaaagcaattcaagtagcaaagcaagtctttaacactctc acagagtatattcagggtccttgcactgggaatcagcagagcctggcccacagcaggctg tgggatgcagttgtgggctttcttcatgtatttgcccacatgcagatgaagctgtctcag gattccagtcaaattgagctattaaaagaattaatggatcttcagaaggatatggtggtc atgttgctgtccatgttagaaggtaatgtcgtcaatggaaccattggcaaacagatggtc gatatgcttgtggaatcttccaacaatgtggagatgattctcaagttttttgacatgttt ttaaaactaaaagatttgacgtcctcagacacatttaaggaatacgatcccgatggcaaa ggagtcatttccaagagggacttccataaagcgatggagagtcataagcactatacacag tcagaaaccgagtttcttctgtcctgtgcagagaccgatgaaaacgagactctcgactat gaagagtttgtcaaacgcttccatgagcccgcaaaggacataggcttcaacgttgccgtc ctcctgacaaacctgtctgaacacatgcccaatgacacccggctgcagacgtttctggag ttggcagagagtgtgctgaattacttccagccctttctgggccgcatcgagatcatggga agtgccaaacgcatcgagagggtctattttgaaatcagtgagtccagccgcacccagtgg gagaagccccaggtcaaggagtccaaacggcagttcatatttgacgttgtcaatgaaggg ggagaaaaggagaagatggaactttttgtgaacttctgtgaggacaccatatttgaaatg cagttggcggcacagatctcggagtcggatttgaatgagaggtcagtgagtaaggaggag agtgagaaggagaagcctgaagagcaggggcccaggatgggtttcttttccattctgaca gtcaagtcagccctgttggctctcaggtacaatgtcttgaccctcatgcgaatgctcagc ctgaagagcctgaagaagcagatgaaaagagtgaagaagatgactgtgaaggatatggtc atggctgccttttcatcctattggaatattttcatgagcctcctgcacttcgtggccagt gtttccagaggctttttccgtatcatttgcagcctgctgctggggggcagcctagtagaa ggggcaaagaagatcagggtggcagagctcttagccaacatgccggaccccacacaggat gaggtgagaggggatagtgaggagggggacaggaaacccatggaagctgccctgccctca gaagacctgacagacctaaaggagctgacagaggaaagtgaccttctttcggatatattc ggcttggacctgaagagagaaggaggacagtacaaactcattcctcataatcccaatgct ggcctcagcgacctcatgagcaacccggtccccatccctgatgtgcaggaaaaatttcag gaacagaaggccaaagaggaagaaaaggaggaaaaagaagaaaacaagtctgaacctgaa 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acgcacaatggcaaacagcttgtattaaccgttggcttattagctgttgttgtataccta tatactgttgtggcattcaattttttccgaaaattctacaataaaagtgaagatggtgat acaccagatatgaaatgtgatgatatgctaacgtgctatatgttccacatgtatgttggg gtacgtgctggagggggtattggtgatgaaattgaagacccagcaggcgatgaatatgag atctatcgaatcatctttgacatcaccttcttcttcttcgtgatcgtcatcctcttggct ataatacaaggtttaattattgatgcttttggagaactaagagaccaacaggagcaagtc aaagaagacatggagactaaatgcttcatctgtgggataggcaatgattactttgacaca gtgccacatggctttgaaacccacactttacaggaacacaacttggctaattacctgttt tttctgatgtatctcataaacaaggatgaaacagagcacacaggacaggaatcttatgtc tggaagatgtatcaagaaaggtgctgggaattcttcccagcaggggactgtttccggaaa cagtatgaggaccagctaaattaa

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