KEGG   Nyctereutes procyonoides (raccoon dog): 129506345
Entry
129506345         CDS       T09008                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
npo  Nyctereutes procyonoides (raccoon dog)
Pathway
npo01521  EGFR tyrosine kinase inhibitor resistance
npo01522  Endocrine resistance
npo04010  MAPK signaling pathway
npo04012  ErbB signaling pathway
npo04014  Ras signaling pathway
npo04015  Rap1 signaling pathway
npo04022  cGMP-PKG signaling pathway
npo04024  cAMP signaling pathway
npo04062  Chemokine signaling pathway
npo04066  HIF-1 signaling pathway
npo04068  FoxO signaling pathway
npo04071  Sphingolipid signaling pathway
npo04072  Phospholipase D signaling pathway
npo04114  Oocyte meiosis
npo04140  Autophagy - animal
npo04148  Efferocytosis
npo04150  mTOR signaling pathway
npo04151  PI3K-Akt signaling pathway
npo04210  Apoptosis
npo04218  Cellular senescence
npo04270  Vascular smooth muscle contraction
npo04370  VEGF signaling pathway
npo04371  Apelin signaling pathway
npo04380  Osteoclast differentiation
npo04510  Focal adhesion
npo04540  Gap junction
npo04550  Signaling pathways regulating pluripotency of stem cells
npo04613  Neutrophil extracellular trap formation
npo04620  Toll-like receptor signaling pathway
npo04650  Natural killer cell mediated cytotoxicity
npo04660  T cell receptor signaling pathway
npo04662  B cell receptor signaling pathway
npo04664  Fc epsilon RI signaling pathway
npo04666  Fc gamma R-mediated phagocytosis
npo04668  TNF signaling pathway
npo04720  Long-term potentiation
npo04722  Neurotrophin signaling pathway
npo04725  Cholinergic synapse
npo04726  Serotonergic synapse
npo04730  Long-term depression
npo04810  Regulation of actin cytoskeleton
npo04910  Insulin signaling pathway
npo04912  GnRH signaling pathway
npo04914  Progesterone-mediated oocyte maturation
npo04915  Estrogen signaling pathway
npo04916  Melanogenesis
npo04917  Prolactin signaling pathway
npo04919  Thyroid hormone signaling pathway
npo04921  Oxytocin signaling pathway
npo04926  Relaxin signaling pathway
npo04928  Parathyroid hormone synthesis, secretion and action
npo04929  GnRH secretion
npo04934  Cushing syndrome
npo04935  Growth hormone synthesis, secretion and action
npo05010  Alzheimer disease
npo05022  Pathways of neurodegeneration - multiple diseases
npo05034  Alcoholism
npo05132  Salmonella infection
npo05135  Yersinia infection
npo05160  Hepatitis C
npo05161  Hepatitis B
npo05163  Human cytomegalovirus infection
npo05164  Influenza A
npo05165  Human papillomavirus infection
npo05166  Human T-cell leukemia virus 1 infection
npo05167  Kaposi sarcoma-associated herpesvirus infection
npo05170  Human immunodeficiency virus 1 infection
npo05200  Pathways in cancer
npo05205  Proteoglycans in cancer
npo05206  MicroRNAs in cancer
npo05207  Chemical carcinogenesis - receptor activation
npo05208  Chemical carcinogenesis - reactive oxygen species
npo05210  Colorectal cancer
npo05211  Renal cell carcinoma
npo05212  Pancreatic cancer
npo05213  Endometrial cancer
npo05214  Glioma
npo05215  Prostate cancer
npo05216  Thyroid cancer
npo05218  Melanoma
npo05219  Bladder cancer
npo05220  Chronic myeloid leukemia
npo05221  Acute myeloid leukemia
npo05223  Non-small cell lung cancer
npo05224  Breast cancer
npo05225  Hepatocellular carcinoma
npo05226  Gastric cancer
npo05230  Central carbon metabolism in cancer
npo05231  Choline metabolism in cancer
npo05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:npo00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    129506345 (MAP2K1)
   04012 ErbB signaling pathway
    129506345 (MAP2K1)
   04014 Ras signaling pathway
    129506345 (MAP2K1)
   04015 Rap1 signaling pathway
    129506345 (MAP2K1)
   04370 VEGF signaling pathway
    129506345 (MAP2K1)
   04371 Apelin signaling pathway
    129506345 (MAP2K1)
   04668 TNF signaling pathway
    129506345 (MAP2K1)
   04066 HIF-1 signaling pathway
    129506345 (MAP2K1)
   04068 FoxO signaling pathway
    129506345 (MAP2K1)
   04072 Phospholipase D signaling pathway
    129506345 (MAP2K1)
   04071 Sphingolipid signaling pathway
    129506345 (MAP2K1)
   04024 cAMP signaling pathway
    129506345 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    129506345 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    129506345 (MAP2K1)
   04150 mTOR signaling pathway
    129506345 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    129506345 (MAP2K1)
   04148 Efferocytosis
    129506345 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    129506345 (MAP2K1)
   04210 Apoptosis
    129506345 (MAP2K1)
   04218 Cellular senescence
    129506345 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    129506345 (MAP2K1)
   04540 Gap junction
    129506345 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    129506345 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    129506345 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    129506345 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    129506345 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    129506345 (MAP2K1)
   04660 T cell receptor signaling pathway
    129506345 (MAP2K1)
   04662 B cell receptor signaling pathway
    129506345 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    129506345 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    129506345 (MAP2K1)
   04062 Chemokine signaling pathway
    129506345 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    129506345 (MAP2K1)
   04929 GnRH secretion
    129506345 (MAP2K1)
   04912 GnRH signaling pathway
    129506345 (MAP2K1)
   04915 Estrogen signaling pathway
    129506345 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    129506345 (MAP2K1)
   04917 Prolactin signaling pathway
    129506345 (MAP2K1)
   04921 Oxytocin signaling pathway
    129506345 (MAP2K1)
   04926 Relaxin signaling pathway
    129506345 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    129506345 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    129506345 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    129506345 (MAP2K1)
   04916 Melanogenesis
    129506345 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    129506345 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    129506345 (MAP2K1)
   04726 Serotonergic synapse
    129506345 (MAP2K1)
   04720 Long-term potentiation
    129506345 (MAP2K1)
   04730 Long-term depression
    129506345 (MAP2K1)
   04722 Neurotrophin signaling pathway
    129506345 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    129506345 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129506345 (MAP2K1)
   05206 MicroRNAs in cancer
    129506345 (MAP2K1)
   05205 Proteoglycans in cancer
    129506345 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    129506345 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    129506345 (MAP2K1)
   05230 Central carbon metabolism in cancer
    129506345 (MAP2K1)
   05231 Choline metabolism in cancer
    129506345 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    129506345 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    129506345 (MAP2K1)
   05212 Pancreatic cancer
    129506345 (MAP2K1)
   05225 Hepatocellular carcinoma
    129506345 (MAP2K1)
   05226 Gastric cancer
    129506345 (MAP2K1)
   05214 Glioma
    129506345 (MAP2K1)
   05216 Thyroid cancer
    129506345 (MAP2K1)
   05221 Acute myeloid leukemia
    129506345 (MAP2K1)
   05220 Chronic myeloid leukemia
    129506345 (MAP2K1)
   05218 Melanoma
    129506345 (MAP2K1)
   05211 Renal cell carcinoma
    129506345 (MAP2K1)
   05219 Bladder cancer
    129506345 (MAP2K1)
   05215 Prostate cancer
    129506345 (MAP2K1)
   05213 Endometrial cancer
    129506345 (MAP2K1)
   05224 Breast cancer
    129506345 (MAP2K1)
   05223 Non-small cell lung cancer
    129506345 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    129506345 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    129506345 (MAP2K1)
   05161 Hepatitis B
    129506345 (MAP2K1)
   05160 Hepatitis C
    129506345 (MAP2K1)
   05164 Influenza A
    129506345 (MAP2K1)
   05163 Human cytomegalovirus infection
    129506345 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    129506345 (MAP2K1)
   05165 Human papillomavirus infection
    129506345 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    129506345 (MAP2K1)
   05135 Yersinia infection
    129506345 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    129506345 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    129506345 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    129506345 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    129506345 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    129506345 (MAP2K1)
   01522 Endocrine resistance
    129506345 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:npo01001]
    129506345 (MAP2K1)
Enzymes [BR:npo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     129506345 (MAP2K1)
Protein kinases [BR:npo01001]
 Serine/threonine kinases: STE group
  STE7 family
   129506345 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 129506345
NCBI-ProteinID: XP_055175982
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDVAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDGEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctcggcggtg
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagcttgatgagcagcagcggaagcgccttgaggcctttctcacccagaagcagaaggtc
ggggaactgaaggatgacgacttcgagaagatcagtgagctgggtgctggcaacggtggc
gtggtgttcaaggtctcccacaagccgtccggcctagtcatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcataagggagctacaggttctacatgag
tgcaactccccatacatcgtgggcttctatggtgcattctacagcgatggcgagatcagt
atctgcatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattctaggaaaagttagcatcgctgtaataaaaggtctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccttccaacatcctcgtgaactcc
cgtggggagatcaagctctgtgattttggggtcagcgggcagctcattgactccatggcc
aactccttcgtgggcacaaggtcctatatgtcgccagaaagactccaggggactcattac
tccgtgcagtcggacatctggagcatggggctctctctggtggagatggcggttgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaagtggag
ggagacgtggcagagaccccacccagaccaaggaccccgggaagaccccttagctcttat
ggaatggacagccgaccgcccatggcaatttttgagctgttggattacatagtcaacgag
ccccctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaacccagcagaaagagcagatctgaagcaactcatggttcatgccttc
atcaagagatctgacggtgaagaagtggattttgcaggttggctctgctccaccattggc
cttaaccagcccagcacgccgacccacgcagctggcgtctaa

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