KEGG   Nyctereutes procyonoides (raccoon dog): 129518309
Entry
129518309         CDS       T09008                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
npo  Nyctereutes procyonoides (raccoon dog)
Pathway
npo01521  EGFR tyrosine kinase inhibitor resistance
npo01522  Endocrine resistance
npo04010  MAPK signaling pathway
npo04012  ErbB signaling pathway
npo04068  FoxO signaling pathway
npo04270  Vascular smooth muscle contraction
npo04650  Natural killer cell mediated cytotoxicity
npo04720  Long-term potentiation
npo04726  Serotonergic synapse
npo04730  Long-term depression
npo04810  Regulation of actin cytoskeleton
npo04910  Insulin signaling pathway
npo04914  Progesterone-mediated oocyte maturation
npo04928  Parathyroid hormone synthesis, secretion and action
npo05010  Alzheimer disease
npo05022  Pathways of neurodegeneration - multiple diseases
npo05034  Alcoholism
npo05160  Hepatitis C
npo05161  Hepatitis B
npo05200  Pathways in cancer
npo05205  Proteoglycans in cancer
npo05208  Chemical carcinogenesis - reactive oxygen species
npo05210  Colorectal cancer
npo05211  Renal cell carcinoma
npo05212  Pancreatic cancer
npo05213  Endometrial cancer
npo05214  Glioma
npo05215  Prostate cancer
npo05218  Melanoma
npo05219  Bladder cancer
npo05220  Chronic myeloid leukemia
npo05221  Acute myeloid leukemia
npo05223  Non-small cell lung cancer
npo05224  Breast cancer
npo05225  Hepatocellular carcinoma
npo05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:npo00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    129518309 (ARAF)
   04012 ErbB signaling pathway
    129518309 (ARAF)
   04068 FoxO signaling pathway
    129518309 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    129518309 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    129518309 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    129518309 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    129518309 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    129518309 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    129518309 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    129518309 (ARAF)
   04720 Long-term potentiation
    129518309 (ARAF)
   04730 Long-term depression
    129518309 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129518309 (ARAF)
   05205 Proteoglycans in cancer
    129518309 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    129518309 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    129518309 (ARAF)
   05212 Pancreatic cancer
    129518309 (ARAF)
   05225 Hepatocellular carcinoma
    129518309 (ARAF)
   05226 Gastric cancer
    129518309 (ARAF)
   05214 Glioma
    129518309 (ARAF)
   05221 Acute myeloid leukemia
    129518309 (ARAF)
   05220 Chronic myeloid leukemia
    129518309 (ARAF)
   05218 Melanoma
    129518309 (ARAF)
   05211 Renal cell carcinoma
    129518309 (ARAF)
   05219 Bladder cancer
    129518309 (ARAF)
   05215 Prostate cancer
    129518309 (ARAF)
   05213 Endometrial cancer
    129518309 (ARAF)
   05224 Breast cancer
    129518309 (ARAF)
   05223 Non-small cell lung cancer
    129518309 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    129518309 (ARAF)
   05160 Hepatitis C
    129518309 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    129518309 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    129518309 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    129518309 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    129518309 (ARAF)
   01522 Endocrine resistance
    129518309 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:npo01001]
    129518309 (ARAF)
Enzymes [BR:npo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     129518309 (ARAF)
Protein kinases [BR:npo01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   129518309 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 Pkinase_fungal zf-RING-like TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 129518309
NCBI-ProteinID: XP_055194379
LinkDB
Position
Unknown
AA seq 606 aa
MEPPRGSPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIEGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNCRQFYHSVQDLSGGSRQHEAPSNRPLNEPL
TPQGPSSCTQHRDPEHFPFPAPANTPLQRIRSTSTPNVHMVSTTAPMDSSLIQLTAQSFS
TDAAGSRGGGDGAPRGSPSPASVSSGRKSPHSKSPSEQRERKSVADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILAAIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacggggctcccctgccaacggggccgagccgtcccgggcagtgggcact
gtcaaagtatacctgcccaacaagcaacgcactgtggtgactgtccgggatggcatgagt
gtctacgactctcttgacaaggccctcaaggtacggggtctcaatcaggattgctgtgtg
gtctaccggctcattgaggggcgaaagacagtcactgcttgggacacagccattgccccc
ctggatggagaggagctcattgtagaggtcctcgaagacgtcccactgaccatgcacaat
tttgtacggaagacgttcttcagcctggcattctgcgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaactgccgacagttttaccacagtgtccaagat
ttgtccggaggctccagacagcatgaagctccctcaaaccgccccctgaatgagccgcta
acccctcagggtcccagctcctgcacccagcaccgcgaccctgagcactttcccttccct
gcccctgccaacaccccactccagcgcatccgctccacatccactcccaacgtccatatg
gtcagcaccacagcccccatggactccagcctcatccagctcactgcccagagttttagc
accgatgctgctggtagtagaggtggtggtgacggagcccctcgggggagccccagcccg
gccagcgtgtcctcggggaggaagtccccacattccaagtccccgtcagagcagcgggag
cggaagtccgtggctgatgacaagaagaaagtgaagaatctggggtaccgggactccggc
tattactgggaggtgccacccagtgaggtgcagctgctgaagaggattgggacgggctcg
tttggcactgtgtttcgcgggcggtggcatggcgatgtggctgtgaaggtgctcaaggtg
gcccagcccacagctgagcaggcccaggccttcaagaatgagatgcaggtgctcaggaag
acacgtcatgtcaacatcttgctgttcatgggtttcatgacccggccaggatttgccatc
atcacacagtggtgtgagggctccagcctctaccaccacctgcatgtggccgacacacgc
ttcgacatggtccagctcattgatgtggcccgacagactgcccagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacaacatcttcctacatgagggg
ctcacagtgaagattggtgattttggcctggccacggtgaagacgcggtggagtggggcc
cagcccttggagcagccctcaggctctgtactgtggatggcagctgaggtgatccgtatg
caggacccgaacccctacagcttccaatcggatgtctacgcctatggggttgtgctctat
gagctcatgaccggctcactgccttacagccacattggcagccgtgaccagattatcttt
atggtgggccgtggttatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggaacgtcccctcttc
ccccagatcctggccgcgattgagctgttgcagcggtcactccccaagattgagcggagt
gcctccgaaccctccttgcaccgcacccaggctgatgagttgcccgcctgcctactcagc
gcagcccgccttgtgccttag

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