Nanorana parkeri (Xizang Plateau frog): 108790127 Help Entry 108790127         CDS       T04897                                  Symbol SYNE1 Name (RefSeq) nesprin-1   KO K19326   nesprin-1 Organism npr  Nanorana parkeri (Xizang Plateau frog) Pathway npr04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:npr00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     108790127 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:npr03036]     108790127 (SYNE1) Chromosome and associated proteins [BR:npr03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     108790127 (SYNE1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 CH SYNE1 KASH Spectrin_SYNE1_2 SYNE3 DUF2990 Motif Other DBs NCBI-GeneID:  108790127 NCBI-ProteinID:  XP_018415837 LinkDB All DBs Position Unknown AA seq 8797 aa AA seqDB search MALYREVGTRKVTSVNLVTGFFQYLRDEQEAVQKRTFTKWINSHLAKRNPPLVINDLFID IKDGTKLLALLEVLSGQKLPCEQGRQLKRIHWVANIGAALKFLEGRRIKLVNINSTDIVD GKPTIVLGLIWTIILYFQIQELTSNLPQLHSLSSSTSSVDSVVSSETGSPPTKRKVVNKI QGSAKKALLRWVQYTAAKRLGIEIKDFGPSWRNGIAFHSMIYAIRPELVDLDKLKGRSNR ENLEEAFSIAENELGIPRLLDPEDVDVDKPDEKSIMTYIAQFLKHYPDLHSTAGGQQDDK EEGLLRDLKVWIEQFEREISRAQTVESSLQDKYQSFKQYRVQYEMKRKQVESVIKPWGKD GKLSLDQTMLKQAWDKVSARILDWHVQLDKSLPAPLGTIGSWLYRAEIALREEIIIQQSH DETANIIQRKLDQHKDILKNLDGYKKAFQEIHRSRSVNGVPVPIEQLEDMAERFSFVASS SQLHMIKLEFMELKYRLLALLVLAESKLKSWIIKYGRRESVELLLQNYIMFIDGSRFFEQ YEFTSQSLKQASEIYVKAEGSAEEAESVTKFLNETTIQWRNLSVEVRSVRSMLEEVISNW DKYSGTVASLQAWLEDAEKMLDQPEHAKKEFFRHLPHVIQQHTTMNDSGNFLIETCDDTV SKDIKQQLLLLNGRWRDLFMEVKHYARADDYDRAKREYAEGLIALAAFAEGGNERISIPL EVSFLNVKMFVQDLEDIKQKMPIIEAQYKSVTRMAQLLTKESPPSEASEMLAAVARIKEH LNRIRERYPPLLYESQQLLLPLGEFEGHMTIFYETLEKLTGIISMSDMDLQSTSVLKQKQ RELITYQENCKKALVIIEKNGQAVHKALTISKSLHHFDRSLLQKKITDAQSAFQTMVKKI SEWKKTVESNSSLMKKFEESRAELEKVLKTAETYLKEKGNPEELLKKHTDFFGQLDLKVL NAFLKACDELTDILPEQDQQPLQETVRKLHKQWKDYQSEAPYHLLHLKIELERNRILSSV EECRTELVRENKILAVDGSQKVLKEHRAFFGEKGCYQLCEKRLRLIEELCLKLQERDPIK GVYESSRVVLKDLKTQIDNTHLKLMEHPDKWKNFRIRLKDVSDWLAAKDNQLNQIKSGAK DITKYEQIKSSVQEIRQDVVKQEDNLRYLKDSLAALTEVSVEKEVRKQNIDLTRLSDSFK SFLDSLDETEKILNTVGDCVECKEAVKNVLSELVTSSKDVQSEAEKILNTESLEEAQELL IRYEQNVKKIRSKKQDVQLQITRAKQIQIEKGLPRDVHDEFMKMEAEMENVETTLVQQEE DLKDTINNWEKIETGKESIAHHLKQMGPTLERPLNFGTVDNLSLELQQTKEICKQSEDLS VQAENLVKKSSDIKLGEKSKRHLLEKTKTVNENAKQVKKYLSENITKMERLKDRWQNFNQ DFEMHATWISDQEKELSDLELSNISADIQVTHIQEILKELQGKSNAVADLEANSQSFAEF ISSPEMTRIRSRLSQMVKDWDGLKEHAQRLKESILGHAEQQQKFDESFHQVQTSLENIEA SLACPVKNCPSAAETYKVLNQHQDLCHDVESLKTRIHSLTAGARNLTNKDKAVQETSNLQ QRIETAWTQAKERHSLLEQLLAHWQRQEKEFSSFIIWLERNEALLSPPQELFPADKTKIG ADMQAVQALHADLAQSQRYTVLVQLSASLYPTSTESGIESMRSRLEDLLQRWNSLPEAVS KRIGILESVLGEHQKFDDMLLESSLWIKQFLRKLQETAEINTSNHEAAVTLNEKHIAEMK KQQEDVSHLNGQCAKLCTFTISEDHSLLQGRIRDCLQLYEEASQVTERRQESLSKLGDFL RIYMDSLGVIQILKETVVGAASLDKVKSDALGKDLNDVSQDIDKITALSTGLDTALTKAQ YNLKNSVTEQRTSCRSLCDNLNLELEKVQTLLGTKLSEAEVLGALWKSFIDCRERLLKTI EDIEEKADSEEMKEPTLQAIQQRLTFFNELEEEINAYQHERQWLMDKAKQIAQKDLSLAA EADKELNGLNITWEDTRTLITESQEQCQALIDLMKEYEQLKSAIMKVLENVENMITIKST LKDQEDIRRTIAKHESAKNEITENQKELEEFTNKGKRLLVELKRIHGCDSRPVKKDMDYY VDQWLDILERIDENLERLSVSLALWEDVLSINDEIDGWSTCSISQMNDSITNLSSSQHLK ACLADFQAEVTNKGQKLEEFHCKVYELKELTKSQEPPSELQFMEADLRQKLEHAKEVSQV AKGTLNDFSLQKMQLETFVDQMTNWLNKVEESILKYTNSQEPEDLKKLKEMQKEFQAQQS SIDATQENLNSLCRRYRSAELEAVGVALTALIKKYEATNQLCLRTQATLQETLEKQFNDA MYEFGEWFEEVKRGIQGSSDWSGDSKTLEAKIQHLQDVLDSVSQGQSKLDNATEKGERLY YCLPKALVLSIQEKISKAEKEFQGFKKQCLKDKQALEDCVSELGSFEDQHKKLSLWLHEL EERIRTETLGESKQHIPEKKSEMHKVEMFLEELLAARDSFEKLCQRGQTLHEDGRGDGQE VRQSSQLLTTYQNLVKTIKDKLRVCQVAVQEHQIFEEALQTTWLGLKDIQDKLSTTESTV GNKSTLEKRHLQVQEIILTKGEGEVKLNLAIGKGEQALKSSNMDGQMVIQMQLQTLKDVW GTVISTATRCLSVLEAVINQWNEHTERKNQMEHWLESVDHKLEQPLQPQNGLKEKFGVLD YIQAILSDVEDHSTTLHHLIEKTKELHQKTEDPSFSDIVQSDLKMHFNDIMTVAKEKMRN IEDIVKDHLLYLDAVHELTDWLHSAKEELHRWSDASGDSASIQKKATKIKELMDSRQTGA ERLSKVETLAPAVKKNTTASGCEQIDAEIQGLQTDWKQWEESVNQSKNTLETLSSQMAIS EQEFTSQVSKLEDAVQDFSVFLEKWAQKLMQAEGKNTDREIVEHWHRQKDALNALTEAEH ITDDLKTQLNDLCRFSKDLSVYSSKVSALIKEYNRVCLQASKACQSKEQTLQQRFRTAFR DFQQWLVNAKVMTAKCFDIHESITEASASLERIQECLSESESGQQKLQIVISRGELLCSI MPEENIKNIQQKVNTAKNDWKSFISSLHQKESALENLKVQMRDFEASAKPVQEWLSNTER IVQDSNNRLHDLPSKRKEQQKLQSILEEIACHEPQITRLKEKAQQLREGQSASKTCAHRV SQLSAQYLALNNLTKEKMSGMDRIVAEHQQFSQGLNELQDWIKDSIHLLQSYSHPTADKS VLDSRMFKLEALLLAKQEKEIPILMIITRGESVLRNTSPEGASAIQDQLQDLKDSWASLL SSCIQCKSQLEGALSKWTGYQDDVRQFSSWMDGIEDRMNDAERQYNDLRDKIAAQSKAKL LNEEVISHGSLLDTIEKKGSSMTEHYVTQLELQDLQERYKALQGKTKEAIFKVDKIVSDH KDYQKGLRVFDDWLQKEIEKLDCLELLDGNTEMYESTLRELQELQMRCAEGQALLNSALH IREEVIPWGIPHIEDRELESLRQDWQLYQQRLTETRGQINGALSKLKLMERKFQKTDEWL TSVEGNVNIRTGRQSDRATKEIQLQQMKKWHEEVLVYKEEVEEVGSLAQQVLEEGRSSSR MSSVATLLASRYQAVRLYILEQTQFLEEEIRSIEESDIAIKSYTDWFGEAQNNFKNVTSD MGVMDKTGLEKKMKKLELLLSDMDVGHRLLKSAREKGERVLNYLARAEAEQLEKDIHSHV ENLEDLASSIRKEHTALEKGLHLAKEFSDKYKVQAQWLAECQSILQADVEPKTELYEKKA QLAKYKSIQQTVLSHEPSIKLVIEKGEALFSLTRDATAGDKIQKLQKDYQGLCHMAKTSV ADLEEKVKEHEAYNSELQDVEKWLLHMSSRLVTPDLMESSNLETITQQLANHKAMMEDIA GFEERLNSLRLKGETLVLHCSEHLQGKFKQNIQAHLQGTRDSYSAICSTVQRVYLSLENE LQKHVSHQDTLLQCQAWLASMQKDIEPGTKAPLSLAEATKQAKHFRTLQEQANTYLDLLC TACDLSDGPVKNVAINIQRTKQTIEQRMMVAQDLANGWEEVKHLKAELQAYFQEAGQQIQ NMKRRRAELEIKLVQNMVSQLKEFNQKLQSQQDKITSFTEKVNRLTSGQESPEHADIGHL SNRWLDFCFQNNNLLQQREEDLQRTRDYHDRLSLVDVFLEKLTTEWDNLARSDTESTAAH LEALKTLASILQERRIALEDLKEQKQKITEHLNADDKELVKEQTNHFEQRWTQLEDLVKN KIQTCATTLEQLNLVNSRLQDLTEWAEDQQPSITEALKQSPPPELAQNLLMDHLTICSEV ETKQLLLKNLIKDADKIMGNLGLNERQQLQKALADSQKHVDCLSDLVNQRKRHLNKALSE RAQFLMAAYQALKQIQQHEKKVMFQEYISLHPDDVTKQIRTCRNAQAGLKAYQVDINCLW NQGRELMKEATEQEKVEVLGKLQELQNVFDSVLQKCGQRLIELEKSLVSRKHFKEDLDKA CHWIKHADVLTFPEINLMNDDSELYSQLSKYQQILEQAPEYENLLLSLQQNGQEILPSLN EVDHSYLDEKLNSLPLQCSYVVKLAREKLGKVQEAIIMRKEYVSLIDLTSKALKELEDHF LLMNKVPSSLLAQEALALQQNCSSLLNEVVTLGTAVNELNQKKEIFRSTGQPWLPEEMLQ VVSLFYKLKRMIEQKVSQLADITDAYRRYEDHCSKMNLKFETISKELEQVNVETLPAEDK LKSYRTMAAKLQDAGTLLRRITEQLEEMSSMLEPSACESADMQVQQWHEKLKLWNSVVKE KMGESENRFMQSIDFHTEICRILEWLRQMKVEINEPLLLDGKLESIQEEIRKLQIQQEEF VSSLRIINALFLREKQKYLKAKEFVPADLENSMAEVSELEKEINEGITGKQMTLDKMYIA SHRYHQAVQSAFDWLEEAQELLQQNENGVDIEIAEESLKVYTEFFSTESKFNGLLDELRT LVSELELCVQKSGQDHFKQAVASLKKKGKETKEQAQAQLDLLRRCTVQWNLYQEERHQVI ISLNEAEKKLSKFSVAKDASCHKTEEKLLAHKTLVTLVNSFHEKITALEEKASAMEKLGD NASKATISKSMTTVWQRWTRLRSTAREQERILEEALQEWKELSNKIQESTLAIDQLQERL PESCTEKAMKAELVELLENHETFSRELEQEFSAVSHLRQHALNGVLRDSATEPAAFEDLP VIQEMKAMLDRCSNMQQKVKKSKKFVEQELKEREDVEKELNAVKAWIKDTQDKMLDPASE MGMQIEDWQGLQEELNSHRRKVEKLSEEQQNKYLEMYAILPSEISLLLAEVALALASINE EIQTKQKEAQQNQVLYQELSQQAAEVEQELTVILEKLKEKASDVAQARKDHKILCEELDK CNIKLVELDAAVQDFSEQNHTLAKQLVDKVGVLTEVQLQASKEAEYKTGRVKQAAIQLEE YNEMLEFILRWIGKAKILVHGAIIWNSASQLRDQAMSHQAMLDESRDIRSDLEAMNEKID YLSSVHHTEGLCQQVSELGRETEELQQTIKQRLMSLYDAAEDMRTFESEVRALQTALAQA QSTLTSPELGHLSLKEQLSHRQHLLSKMESLKPKVQAVQVCQSALRIPEEVVTSLPICRT AIRLLEETSRLQHTAIQQCNIMQEAVVQYEQYEQEMRHLQHLIEEAHRELQDAKVTTNNI QELQIQIKRHEELAKKIKGYQDQIASLNSKCKMLTMKAKHATMLLTVTEVEGLTEGMEEL DAELLPAHSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDAS VNQDIAYYQALSAEQLQTDAAKIHPNRASPQEMYESGIETAANAKLDDLQRSWETLKNVI SEKQRTLYEALERQQRYQDSLQSISTKMEAVEVKLNESLEPSKTPESQMAEHQALMDEIL MLQEEISKLQASFADELVSESLDSEAADQLAVQSTLTVLAERMATIRMKASGKRQLLEEK LNEQLEEQRHEQALQRYRSEADELNHWVLGARSTLENVLRAFEEPMDMEAQLIDCQNMLL EIEQKVVALSELSVHSENLLIEGKAQTKEEAEQLAMKLRTLKGSLLELQRVLQDKQISIQ AKLAWGEMKAHKKAEHGTFHEKEESEAELSSSQSPSVQEWLVQTRTTRSLQKQNSLQKQK ELEQELAEQKKLLQSVASRGGEIINQQTATDRTNVSDGPDSLSRELGLEGVKPTSQDQMR MKWESLHQELSTKEKLIHSALQQEQEQPIFSKTNRIISGVPFYKGDKQVQDKSSVVNILD GLNQALEDVSSQTLVGEKKILPLEKKLYDAVSATSTWLDDVEERLFVQTALQPEEAEACL YHQETLAKDIKEMSEEMDKNKNLFLQAFTSTGDHQEIVEDTLYCLLGRLNSLESVVNHRC NQMKERLQDLLTFQNDLKMLFTSLADNKYIILHKLAEAVERPAKEQMQAILQAEDSLKEL DTEITELKKRGDRLQVDQQSVQELSKLQDTYDELIMIISSRRGGLNQNLALKSQCERALQ DLADLIETGEEKMSGGQKCIVSSREEVHNMLQKHKEYFQGLESHMILTETLYRKISSYAS HWETQQHSDLMTRASAVLKHAHKRGVELEYILETWMQLDEKYQDLSRQLESVESNIPIVG LVEESEERLKERIQLYQCFKSSLAEYQPRLYQVLDDGKRLLMSINCSELESSLNQVGEQW LNSTSKVSKELNRLENILKHWTRYKNESAELVHWLRSAMDRLDFWTEQSVTVPQELETVR DHLNAFLEFSKEVDAKSSLKSSVLSTGNQLLRLKKVDTAALRSELAQIDNQWTELLTHIP VVQEKLHQLQMDKLPSRHAITEVMTWISLMENVIKEDEQNIRNVVGCEAIQEYLLKYKGF KIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEKLGAMNRRWQILQGLITEKIQL LDGLLESWTEYRNSVQSLKSWFEKQENKLQKYQSIGDQASVQNSLKDCQELEGLIKAKEK DVEKVGQTGLYLIHNKKEKVSAIIMDTLGELHQCWANLDCKVCQLKILLQSVLDQWSIYK EVYEDLNSYLMEARYSLSHFRLLTGSMEAVKVQVDNLQTLQEELEKQERLLNKFACVSNK LQNECYSTVAETLKSTLKEVTSRWNSLLEDISEQLHSSKTLLQLWQKYKDFCTQCFATVQ QQEDRTNQLLKTATNKDIGDDEIATWIQDCSVLLKNLDTANISLAGLCEIGEQLKQQVDS SAAATILSDHLSLSQRLSVLEQALQRQQDILQAGVLDYETFVSSLENLETWIVAAGEVLN GQDPNRSSDLSIIQERMEELKRQMLQFSSMGPGLDRLNELGYRLPLNDKEIKRMQCLNRD WTTVSSQTTERFSKLQSFLLHHQTFLEKCETWMEFLIQTEQKLAVEIPGNYQSLLEQQRA HELFQAEMFSRQQILHSIIVDGQRLLEQGQVDDRDEFNLKLTLLSNQWEGVIRRAQQRRG IIDSQIRQWQRYREMAEKLRKWLAQMSYQPVTGLGSIPIPLQQARNLLDEVQLRDRVLHR QQGSYILTVETGKQLLLSADGGAEASLQAELIDIQERWKATTVRLEEQKKQLAFLLKDWE KCEKGVADSLEKLRTFRKKLSQPLPVHHDELHTEQIRCKELENAVEGWVEDLVHLTELKD TFSPFISADDISILNERIELLQRQWEELCHQVSLRRQQVSERLNEWAIFNEKNKELCEWL TQMESKVSHNGDISIEEMIDKLRKDYQEEIAVFRENKIQLQQMGERLAKASHESKASEIE YKLSKVNDRWQHLLDLIGARVKKLKETLVAVQQLDKNMSSLRSWLGHIESELSKPIVYET SDSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACANDSECDSIQQATRSL DRRWRNICAMSMERRLKIEETWRLWQKFLEDFSRFEDWLKISEQTAALPSSSGVLYTVAK EELKKFEAFQRQVHESLTQLELINKQYRRLARENRTDSACKLKQMVHEGNQRWDNLQKRV TSILKRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEI ALNNSKIDQIITQGEQLLEKSEPLDAAVIEEELDELRRYCMEVFGRVERYHKKLIRLPLT DDEHDFSDREVDIDESMDLSDLQWHTKNSGGILSPLPSSNHSLSLIVPMRSERSGRDTPA SVDSIPLEWDHDYDLSRDLETAVSQALHSDDEDDKNYFLQGATGLTGSGLLESQIRQLDK ALDTSRFHLQQTENVIRSRTPTGPELDSSYTGYMKLLGECRGSIDTVRRVSGKLKEEEEK LSGFINLNSTETQSAGVIERWELIHAQALNKELRMKQKLQQWQQFMSDLNNIMDWLTETE EELEQLRRLDISTDIQTIEQRIKKLKELQKAVDSRKAIVLSINLCSSEFTQADTQESKEL QESLSQMNLRWDRVGSTLEDWRCSLQDALMQCQDFHEMSHGLLLWLENIDRRRGELLPIN PSLDSDTLQDHLKLLTQIKRELLESQLKVALLQDMSCHLMVNAEGKDCLEAKEKVHVIGN RLKVLLKEVTRHIKEIEKILDISSNQLELSSWSSADELDTSGSLSPVSGRSTPSRHRTPR GKCSVSQPGPSVNNPPSRSKDDGSGSYLSEANLAQKHQSFFLRVLRAALPLQLLLLLLIG LACLVPMSEEDYSCTLSNNFARSFHPMLRYTNGPPPI NT seq 26394 nt NT seq  +upstreamnt  +downstreamnt atggctttgtacagagaagttggtacccggaaggtcacttctgtgaatttggttaccggg ttttttcagtatctccgggatgaacaagaagcagtgcaaaagagaacctttacaaaatgg atcaattcacatttggctaagaggaatcctccgttagtaataaatgatctttttatagac ataaaagatggaactaagttacttgcattattggaagtcttgtctggacaaaaactgcca tgtgaacaaggaaggcaattgaagcgcattcactgggtagccaacattggcgcagcacta aagtttctggaaggcagacggattaaacttgtgaatatcaactcaacggacattgttgac gggaaacccaccattgtgcttggtttgatatggaccatcattctatatttccagattcaa gaattgaccagcaatcttccacaacttcattcactgtctagtagcacatcttcagtagac agtgtggtgagctctgagaccggcagccccccaaccaaacgcaaagtggtcaataaaatc caaggaagtgccaagaaagcccttcttagatgggtacaatacactgcagccaaacgcctt ggaatagaaataaaagattttggaccaagttggagaaatggcattgccttccattcaatg atttatgcaattcgtccagaactggtggacttggacaaactaaaaggaagaagtaatcgg gaaaatctggaagaagctttttcaattgcagaaaatgagttgggaataccaagactttta gatcctgaagatgtagatgttgataagcctgatgaaaagtccatcatgacctacatcgct caattcctcaaacattatcctgatcttcacagcacagcaggaggccagcaagatgataag gaagaaggactgcttcgagacttaaaggtttggattgaacagtttgaacgggaaatcagc cgagcacaaacagtagaaagcagcttacaggacaaatatcagtcatttaaacaatataga gtccagtatgaaatgaaaaggaagcaagttgaaagtgttataaagccatggggcaaagat ggaaaattatcacttgatcagacaatgctgaagcaagcatgggataaagtttcagcaagg attcttgattggcatgtacaacttgataaatccctaccagctcctttgggaaccattggc tcctggttatatcgagcggagattgcactcagggaagaaattatcattcagcaatctcac gatgaaacagcaaatatcatacaaagaaaattagaccaacacaaggacatactgaagaat ctggatggttataaaaaggctttccaggagatccaccgctcacggtctgtcaacggagtc cccgtccctatagagcagttggaagacatggcagaaaggtttagttttgttgcatcttcc tcccagcttcatatgataaagttagaattcatggagttaaagtatcgccttttagctctt ttggtcctggcagaatctaaactcaagtcttggatcatcaaatatggaagaagagagtct gttgaactgcttctacaaaattacattatgtttattgacggcagcaggttctttgagcaa tatgaatttaccagccagtctcttaagcaagcatctgagatctatgttaaagctgaagga tcagctgaagaagctgagagtgtcacaaagtttttaaatgagactactatccagtggagg aacttatcggtggaagtcagaagtgtcagaagcatgcttgaggaagtcatttcaaactgg gataaatacagtggtacagtggccagtttacaagcttggttggaggatgctgaaaagatg ctggatcagccagagcatgccaaaaaggagttcttccgccacttgcctcacgtgatccag cagcacacgacaatgaacgactctggcaatttcctgattgaaacttgtgatgacacagtg tctaaagacatcaagcaacagctcctattgctgaatggccgttggagagacctattcatg gaagttaagcattatgccagagcagatgattatgaccgggcaaagagggaatatgcggag ggtttgatagcactggcagcatttgcagaaggaggcaacgaaagaatttccatcccgctg gaagtgtcctttttaaatgtcaagatgtttgttcaagatttagaggatatcaaacagaaa atgccaatcatagaagctcagtataagtcagtgacaaggatggctcagcttcttacaaag gaatcgccaccgtctgaagccagtgagatgttggcagcagtggcaagaattaaggaacat ctaaatcgaatacgggagcgatatcctcctctattgtatgaatcacaacaacttctattg ccacttggagagtttgagggtcacatgaccattttttatgagactcttgagaaactaact ggaattatctcaatgtcagacatggatttacagtcgacttctgttcttaaacagaagcag cgggagctaataacatatcaagagaactgtaaaaaagctttggtcatcattgagaagaat ggccaagctgttcacaaagcactgacaatcagcaaatcgttacaccattttgaccgatct cttctgcagaagaaaataacagatgctcagtctgcttttcagaccatggtaaagaaaata tctgagtggaaaaaaacagtagagtccaacagtagcctgatgaagaagtttgaagagtcc agagcagagcttgagaaagtattgaaaacggcagaaacatacctgaaagagaagggaaac ccagaggaattactaaagaagcacactgatttttttgggcagttagatctgaaggttctt aatgctttcctgaaagcttgtgatgagctgacagatatcctgccagagcaagaccagcag ccacttcaagaaactgtcaggaaattacataaacaatggaaggattatcagagtgaagct ccctaccatttactacatctgaaaattgagttggagaggaataggattctatcttcagtt gaggaatgccgaacggagttggtacgggaaaacaaaatacttgcagtagatggcagtcag aaggttttgaaagaacacagggctttctttggtgagaaaggatgctaccagctgtgtgag aagaggctgagactgattgaagagctgtgtttaaaactacaggagagggaccccataaaa ggagtttatgaaagcagcagagtggtgctaaaagacctgaaaactcagattgataataca catctaaaactgatggagcatccggacaagtggaagaatttcaggatcagattaaaagat gtgtcggattggctggcagcaaaggacaaccagttaaatcaaattaaaagcggggctaaa gacattacaaaatatgaacaaataaaatcgtcagtgcaggaaattagacaagatgtggtt aaacaagaggataacctcaggtatttgaaagacagcctggctgcacttactgaagtatca gtggagaaggaagtaagaaagcaaaatattgatctaacaagactttctgacagcttcaaa tctttcttggactcgctagatgagactgagaagattttaaacacagttggggattgtgta gagtgcaaagaggcagtaaagaatgtgctcagcgaattagtgacaagctcaaaagatgtc caatcagaagcagagaagatcctcaacacagaaagccttgaggaggctcaggagctactt attcgttatgagcaaaatgtaaagaaaatacgttcaaagaaacaggacgttcagctccag attactcgtgccaaacagatacaaattgagaagggattgcccagagatgtccatgatgaa tttatgaagatggaagctgaaatggaaaatgtggagacaacattggttcaacaggaagaa gacctaaaggacacaataaataattgggagaaaatagaaactggaaaagagtccattgcc caccatttaaagcaaatgggacctacacttgaacgacccttgaactttggtacagtggac aatctatcactagaacttcaacaaacaaaggaaatttgcaaacagagtgaggatctgtca gttcaagctgagaacctggtgaagaagtcaagtgacataaagcttggagaaaagagcaag cgccacctactggagaaaactaagactgttaatgagaatgcaaagcaggttaaaaagtac ctatctgagaacattaccaaaatggaacggttaaaggacaggtggcagaattttaatcaa gattttgagatgcatgccacatggatttcagatcaagaaaaggaattaagtgaccttgaa ctgtcaaatatttcagcagacatccaagtcactcatatccaggaaatactaaaggaacta caggggaaaagcaatgcagtggcagatcttgaagccaacagccagtcttttgctgaattt attagctctcctgagatgactcggataagatccagactgtcacagatggtcaaggactgg gatggactcaaagaacatgctcaacggctgaaagagagcattctaggacatgccgaacag caacaaaaatttgatgagtcctttcatcaggttcaaacttctttggagaacattgaagct tctcttgcatgcccagttaagaactgtccttctgcagcagagacatacaaagtgttgaat caacatcaggatctttgtcatgatgttgaaagtttgaaaaccagaatccattctctgact gccggtgctcgtaatcttacaaataaggataaagcagtgcaagagacctcaaaccttcaa caacgaattgaaactgcctggacacaagccaaagagagacactccttgctagagcaatta ctagcacattggcagagacaagaaaaagagttttcttcttttattatctggctggagaga aacgaagcattgctcagtcctccacaagaactattccctgcagacaaaacaaaaattgga gctgatatgcaggcagtccaggctcttcatgctgacttagcacaatcccagaggtacact gttctggtccagctgtctgcatctttgtatccaacctccaccgaaagtggcatagagtca atgaggagccgcttagaggatctgttgcaaagatggaatagtctacctgaagctgtttct aaaaggatcggtattttggagtctgtcctgggtgaacatcagaaatttgatgacatgttg cttgaatcgtctctctggataaaacagttccttagaaaacttcaggaaaccgctgagatc aatacctctaatcatgaggctgctgtgactttaaatgagaaacatatagcagagatgaaa aaacaacaagaggatgtcagtcacctgaatggccagtgtgctaagttatgtaccttcacc atttcagaagatcattcccttttacaaggaaggatcagggactgtttacagctgtatgaa gaagcaagccaagtcaccgaaagacgtcaagaatccctttccaaattaggagacttctta agaatatatatggactcactgggagttatacagatcttaaaagaaacagtagtgggagca gccagcttggataaagtcaaatcagacgcacttgggaaagacttaaatgatgtttcacag gacattgacaagataacagccttatccacaggtttagatactgcactaacaaaagcacag tataacctaaagaactcagttactgagcagagaacatcttgtagatcactgtgtgacaat ctcaatctagaactagaaaaagtacagacattacttggaacaaagctaagtgaggcagag gttcttggagctttgtggaaatcatttattgattgcagagagaggctgctcaagactatt gaagacattgaagaaaaggcagacagtgaggagatgaaagagccaaccctacaagcaatt caacaaaggttgacattttttaatgaactggaggaggaaattaacgcataccagcatgaa agacagtggctgatggacaaagcaaagcagattgctcagaaggatttatctctggcagct gaagcagacaaagaactcaatggactgaacattacttgggaagatactaggacgcttatc accgagagccaagagcagtgtcaagccctcattgatctaatgaaagagtacgagcaactt aaatctgctataatgaaggttttagaaaatgtggaaaatatgatcacgatcaaatccacg ttaaaagatcaagaggacatccgccgcaccatagcaaaacatgaatcagccaagaatgaa atcacagagaaccagaaagaacttgaagagttcaccaacaaaggaaaacgtttactggtg gaactgaagagaattcatggatgtgactcaagaccagtgaaaaaagacatggactactat 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gagttccagggtttcaagaagcagtgtctgaaagacaagcaggctttagaggactgtgtc tctgagcttggaagctttgaggatcaacataaaaagttaagcttgtggcttcatgagctg gaggagcggattaggacagagacccttggagaaagcaagcagcacattccagagaagaaa agtgagatgcataaagtggaaatgttcttggaggaattactggctgcacgagattcattt gagaaactttgccagcgaggtcagaccctccatgaagatggccgaggtgatggtcaagaa gttcgtcagtcttcccagcttctcacaacctatcagaacttggtaaaaacaatcaaggac aagcttcgtgtctgccaggtggctgtacaagagcatcagatttttgaagaagcattgcaa accacatggttagggctgaaagatattcaagacaaactctccactacagaaagcacagtg ggaaacaaaagcacacttgaaaaacgtcatctgcaagttcaggaaatcatactaactaag ggcgaaggtgaagtcaaactgaacttagctattgggaaaggtgaacaggctcttaagagt agtaacatggatggacagatggtaatccaaatgcagctgcagacactgaaggatgtatgg gggactgtcatcagcaccgccactaggtgtctcagtgttttagaggccgtgatcaatcaa tggaatgagcacactgagaggaaaaatcaaatggaacattggctggagtccgtggatcat aaattggaacaacctctccagcctcaaaacggcctgaaggagaagtttggtgtattagat tacattcaagctatcttatcggatgtagaagatcactccactacgctgcatcatctcatt gaaaagacaaaggaactacaccagaaaactgaggacccttccttctctgacattgtccag 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atgcctgaggagaacataaaaaatatccagcaaaaggtcaatacagcaaaaaatgattgg aagagcttcatctcctctctacatcagaaggaatctgctttagagaatttaaaggtacag atgagagactttgaagcaagtgctaagccagttcaggagtggctcagcaatactgaacga atagttcaagacagtaataaccgcctccatgacctgccctctaaaagaaaggaacagcaa aagctgcagtctatcctggaagaaatagcctgtcatgagccacaaatcaccagactaaaa gaaaaagctcagcagctaagggaaggacagtctgccagcaaaacctgtgcgcacagggtg tctcagctgtctgctcaatacctagctttaaacaatctaaccaaggaaaaaatgtctggg atggaccgaattgttgcagaacatcaacagttttcgcagggcctgaatgagcttcaggac tggataaaggattctattcacctgctgcaatcctacagtcacccgacagcagataaaagt gtccttgacagcagaatgttcaagctggaggctctgctactagcgaagcaggagaaggaa atcccgattctgatgataataacccgaggagaatcagttctgagaaacacgtcaccagaa ggagcctctgccattcaggaccagcttcaagacctgaaggactcctgggcctccctatta tcctcctgtatacagtgtaaaagccaacttgaaggggctctgtctaagtggactggctat caggatgatgtacgtcagttctccagctggatggatgggattgaggatagaatgaatgat gctgaaaggcagtacaatgatctgagggacaaaattgcagcacagagcaaagctaaatta ttgaatgaagaggtcataagtcatgggtctttgttggacaccatagaaaagaaggggtcc 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caaaagaaagaaattttccgtagcacaggacaaccatggcttcctgaagaaatgctgcaa gttgtaagcctgttttataagttaaaaagaatgatagagcagaaagttagccagttggca gacattacagatgcctataggaggtacgaagatcattgttcaaagatgaatttaaagttt gagacaataagtaaggagctagagcaagttaatgtggagacacttccagctgaggataag ctgaaaagttaccgtacaatggcagccaagctacaggatgctggaactcttcttaggcgc attacagaacagttagaggagatgtcctcaatgctggaaccttcagcgtgtgaatctgcc gatatgcaagtacaacagtggcatgaaaagctaaagttatggaactctgtagtgaaggag aaaatgggagaaagtgagaacagatttatgcaaagtatagactttcatactgagatctgt cgtattctagagtggcttagacaaatgaaggtggagatcaatgaacctttgctattggat gggaaacttgaaagcatccaagaagaaattagaaagttacaaattcaacaggaggaattt gtgtcaagtttaagaataataaatgcactttttctcagagaaaaacagaagtatctgaag gcaaaggagtttgttccagctgatctggaaaacagcatggctgaggtgtctgaacttgaa aaggaaatcaatgaaggaatcacaggaaagcagatgactcttgacaagatgtatattgca agtcaccggtaccaccaagcagtgcagtctgcttttgactggcttgaagaagcgcaggaa ctactccagcaaaatgaaaatggtgtggatattgaaatagctgaagaaagtcttaaagtc tatacagagttctttagcacagaaagcaaattcaatggacttttagatgaactgcgcact 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aaagtggagaaattgtctgaagagcagcagaacaagtatttggagatgtatgccattctg ccatctgaaatctcattactgcttgctgaagtggcattagcactggccagtataaatgag gagattcaaacgaagcagaaagaagcacagcagaatcaagtgctgtaccaggagctgagt cagcaagctgcagaagttgaacaagagttgactgtcattttggaaaaactcaaagagaaa gcaagcgatgtggctcaagctagaaaagatcacaagatcttatgtgaggagttagacaag tgcaatataaagcttgtagaactggatgcagctgtgcaagactttagtgagcaaaatcac acactggcaaagcagttggtggacaaagtaggcgtactaactgaagtgcaactgcaagcc agcaaggaggctgaatacaagacaggcagagtaaaacaggctgcaattcaactagaagaa tacaatgaaatgctagaatttattttgcgttggatagggaaggcaaaaatattagtacac ggtgcaatcatctggaattcagcaagccagcttcgtgatcaggcaatgtctcatcaggct atgttggatgagtctagagatatccgcagtgatctggaagctatgaatgagaagatagac tacttatcaagtgtgcaccatactgaaggattgtgtcagcaagtatcagaacttggacga gagactgaagaactgcaacaaacaatcaaacaacgcctgatgagcctttatgatgcagca gaagatatgagaacgtttgagagtgaagtgagagctttacaaacagcactggcacaagct cagtctacacttacttctccagaacttggacacctgagtcttaaggagcaactatcacat cgacagcatctgctttccaaaatggagtctctgaagccaaaagtacaagctgttcaggtt 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