KEGG   Neomonachus schauinslandi (Hawaiian monk seal): 110570410
Entry
110570410         CDS       T08474                                 
Symbol
PRKCA
Name
(RefSeq) protein kinase C alpha type
  KO
K02677  classical protein kinase C alpha type [EC:2.7.11.13]
Organism
nsu  Neomonachus schauinslandi (Hawaiian monk seal)
Pathway
nsu01521  EGFR tyrosine kinase inhibitor resistance
nsu04010  MAPK signaling pathway
nsu04012  ErbB signaling pathway
nsu04014  Ras signaling pathway
nsu04015  Rap1 signaling pathway
nsu04020  Calcium signaling pathway
nsu04066  HIF-1 signaling pathway
nsu04070  Phosphatidylinositol signaling system
nsu04071  Sphingolipid signaling pathway
nsu04072  Phospholipase D signaling pathway
nsu04082  Neuroactive ligand signaling
nsu04150  mTOR signaling pathway
nsu04151  PI3K-Akt signaling pathway
nsu04261  Adrenergic signaling in cardiomyocytes
nsu04270  Vascular smooth muscle contraction
nsu04310  Wnt signaling pathway
nsu04360  Axon guidance
nsu04370  VEGF signaling pathway
nsu04510  Focal adhesion
nsu04540  Gap junction
nsu04613  Neutrophil extracellular trap formation
nsu04650  Natural killer cell mediated cytotoxicity
nsu04664  Fc epsilon RI signaling pathway
nsu04666  Fc gamma R-mediated phagocytosis
nsu04670  Leukocyte transendothelial migration
nsu04713  Circadian entrainment
nsu04720  Long-term potentiation
nsu04723  Retrograde endocannabinoid signaling
nsu04724  Glutamatergic synapse
nsu04725  Cholinergic synapse
nsu04726  Serotonergic synapse
nsu04727  GABAergic synapse
nsu04728  Dopaminergic synapse
nsu04730  Long-term depression
nsu04750  Inflammatory mediator regulation of TRP channels
nsu04911  Insulin secretion
nsu04912  GnRH signaling pathway
nsu04916  Melanogenesis
nsu04918  Thyroid hormone synthesis
nsu04919  Thyroid hormone signaling pathway
nsu04921  Oxytocin signaling pathway
nsu04925  Aldosterone synthesis and secretion
nsu04926  Relaxin signaling pathway
nsu04928  Parathyroid hormone synthesis, secretion and action
nsu04929  GnRH secretion
nsu04933  AGE-RAGE signaling pathway in diabetic complications
nsu04935  Growth hormone synthesis, secretion and action
nsu04960  Aldosterone-regulated sodium reabsorption
nsu04961  Endocrine and other factor-regulated calcium reabsorption
nsu04970  Salivary secretion
nsu04971  Gastric acid secretion
nsu04972  Pancreatic secretion
nsu05017  Spinocerebellar ataxia
nsu05022  Pathways of neurodegeneration - multiple diseases
nsu05031  Amphetamine addiction
nsu05032  Morphine addiction
nsu05143  African trypanosomiasis
nsu05146  Amoebiasis
nsu05161  Hepatitis B
nsu05163  Human cytomegalovirus infection
nsu05164  Influenza A
nsu05170  Human immunodeficiency virus 1 infection
nsu05171  Coronavirus disease - COVID-19
nsu05200  Pathways in cancer
nsu05205  Proteoglycans in cancer
nsu05206  MicroRNAs in cancer
nsu05207  Chemical carcinogenesis - receptor activation
nsu05214  Glioma
nsu05223  Non-small cell lung cancer
nsu05225  Hepatocellular carcinoma
nsu05231  Choline metabolism in cancer
nsu05415  Diabetic cardiomyopathy
nsu05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:nsu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    110570410 (PRKCA)
   04012 ErbB signaling pathway
    110570410 (PRKCA)
   04014 Ras signaling pathway
    110570410 (PRKCA)
   04015 Rap1 signaling pathway
    110570410 (PRKCA)
   04310 Wnt signaling pathway
    110570410 (PRKCA)
   04370 VEGF signaling pathway
    110570410 (PRKCA)
   04066 HIF-1 signaling pathway
    110570410 (PRKCA)
   04020 Calcium signaling pathway
    110570410 (PRKCA)
   04070 Phosphatidylinositol signaling system
    110570410 (PRKCA)
   04072 Phospholipase D signaling pathway
    110570410 (PRKCA)
   04071 Sphingolipid signaling pathway
    110570410 (PRKCA)
   04151 PI3K-Akt signaling pathway
    110570410 (PRKCA)
   04150 mTOR signaling pathway
    110570410 (PRKCA)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    110570410 (PRKCA)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    110570410 (PRKCA)
   04540 Gap junction
    110570410 (PRKCA)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    110570410 (PRKCA)
   04650 Natural killer cell mediated cytotoxicity
    110570410 (PRKCA)
   04664 Fc epsilon RI signaling pathway
    110570410 (PRKCA)
   04666 Fc gamma R-mediated phagocytosis
    110570410 (PRKCA)
   04670 Leukocyte transendothelial migration
    110570410 (PRKCA)
  09152 Endocrine system
   04911 Insulin secretion
    110570410 (PRKCA)
   04929 GnRH secretion
    110570410 (PRKCA)
   04912 GnRH signaling pathway
    110570410 (PRKCA)
   04921 Oxytocin signaling pathway
    110570410 (PRKCA)
   04926 Relaxin signaling pathway
    110570410 (PRKCA)
   04935 Growth hormone synthesis, secretion and action
    110570410 (PRKCA)
   04918 Thyroid hormone synthesis
    110570410 (PRKCA)
   04919 Thyroid hormone signaling pathway
    110570410 (PRKCA)
   04928 Parathyroid hormone synthesis, secretion and action
    110570410 (PRKCA)
   04916 Melanogenesis
    110570410 (PRKCA)
   04925 Aldosterone synthesis and secretion
    110570410 (PRKCA)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    110570410 (PRKCA)
   04270 Vascular smooth muscle contraction
    110570410 (PRKCA)
  09154 Digestive system
   04970 Salivary secretion
    110570410 (PRKCA)
   04971 Gastric acid secretion
    110570410 (PRKCA)
   04972 Pancreatic secretion
    110570410 (PRKCA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    110570410 (PRKCA)
   04961 Endocrine and other factor-regulated calcium reabsorption
    110570410 (PRKCA)
  09156 Nervous system
   04724 Glutamatergic synapse
    110570410 (PRKCA)
   04727 GABAergic synapse
    110570410 (PRKCA)
   04725 Cholinergic synapse
    110570410 (PRKCA)
   04728 Dopaminergic synapse
    110570410 (PRKCA)
   04726 Serotonergic synapse
    110570410 (PRKCA)
   04720 Long-term potentiation
    110570410 (PRKCA)
   04730 Long-term depression
    110570410 (PRKCA)
   04723 Retrograde endocannabinoid signaling
    110570410 (PRKCA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    110570410 (PRKCA)
  09158 Development and regeneration
   04360 Axon guidance
    110570410 (PRKCA)
  09159 Environmental adaptation
   04713 Circadian entrainment
    110570410 (PRKCA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110570410 (PRKCA)
   05206 MicroRNAs in cancer
    110570410 (PRKCA)
   05205 Proteoglycans in cancer
    110570410 (PRKCA)
   05207 Chemical carcinogenesis - receptor activation
    110570410 (PRKCA)
   05231 Choline metabolism in cancer
    110570410 (PRKCA)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    110570410 (PRKCA)
   05214 Glioma
    110570410 (PRKCA)
   05223 Non-small cell lung cancer
    110570410 (PRKCA)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    110570410 (PRKCA)
   05161 Hepatitis B
    110570410 (PRKCA)
   05171 Coronavirus disease - COVID-19
    110570410 (PRKCA)
   05164 Influenza A
    110570410 (PRKCA)
   05163 Human cytomegalovirus infection
    110570410 (PRKCA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    110570410 (PRKCA)
   05143 African trypanosomiasis
    110570410 (PRKCA)
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    110570410 (PRKCA)
   05022 Pathways of neurodegeneration - multiple diseases
    110570410 (PRKCA)
  09165 Substance dependence
   05031 Amphetamine addiction
    110570410 (PRKCA)
   05032 Morphine addiction
    110570410 (PRKCA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    110570410 (PRKCA)
   05415 Diabetic cardiomyopathy
    110570410 (PRKCA)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    110570410 (PRKCA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110570410 (PRKCA)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:nsu01001]
    110570410 (PRKCA)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:nsu04131]
    110570410 (PRKCA)
Enzymes [BR:nsu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     110570410 (PRKCA)
Protein kinases [BR:nsu01001]
 Serine/threonine kinases: AGC group
  PKC family [OT]
   110570410 (PRKCA)
Membrane trafficking [BR:nsu04131]
 Endocytosis
  Lipid raft mediated endocytosis
   Caveolin-mediated endocytosis
    110570410 (PRKCA)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr C1_1 C2 Pkinase_C C1_2 ABC1
Other DBs
NCBI-GeneID: 110570410
NCBI-ProteinID: XP_021534100
UniProt: A0A2Y9G7H4
LinkDB
Position
15:complement(46921046..47306481)
AA seq 672 aa
MADVFPANDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTRTIRSTLNPQWNESFTFKLKPSDKDRRL
SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVE
LRQKFEKAKLGPAGNKVISPSEDRRPPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPGKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV
NT seq 2019 nt   +upstreamnt  +downstreamnt
atggctgacgttttcccggccaacgactccacggcgtctcaggacgtggccaaccgcttc
gcccgcaaaggggcgctgagacagaagaacgtgcacgaggtgaaggaccacaaattcatc
gcccgcttcttcaagcagcccaccttctgcagccactgcaccgacttcatctgggggttt
gggaaacaaggcttccagtgccaagtttgctgttttgtggttcacaagaggtgccatgaa
tttgtcactttttcttgtccgggtgcggataagggacccgacaccgatgaccccagaagc
aagcacaagtttaaaatccacacctacggaagccccaccttttgtgatcactgtgggtcc
ttgctgtatggacttatccatcaagggatgaaatgtgacacctgtgacatgaacgtgcac
aagcagtgtgtgataaacgtgcccagcctctgcgggatggaccacacggagaagcggggc
cgcatctacctgaaggcagaggtcaccgacgagaagctccatgtcactgtacgagatgca
aaaaatctaattcctatggatccaaatgggctttcagatccttatgtgaagctgaaactt
attcctgatccaaagaatgaaagcaaacagaaaaccagaaccatccgctccacactaaac
ccccaatggaatgagtcctttacattcaaattaaaaccttcggataaagaccgacggctg
tccgtagaaatctgggactgggatcgaacaacaaggaatgatttcatgggatccctttcc
tttggagtctcggagctgatgaagatgccggccagtggatggtacaagctgcttaaccaa
gaggaaggtgagtactacaacgtacccattccagaaggggatgaagaaggcaacgtggag
ctcaggcagaaattcgagaaagccaagcttggccctgctggtaacaaagtaatcagtcct
tcagaagacaggagaccaccttccaacaacctggacagagtgaaactcaccgacttcaat
ttcctcatggtgctggggaaagggagttttggaaaggtgatgcttgctgaccggaagggc
acagaggaactgtatgctatcaaaatcctgaagaaggatgtggtgattcaagatgacgac
gtggagtgcaccatggtggagaagcgagtcctagccctgttggacaagcccccgttcctg
acacagctacactcctgcttccagacagtggaccggctgtatttcgtcatggaatacgtc
aatggcggggacctcatgtaccacattcagcaagtaggaaaatttaaggaaccacaagca
gtattttatgcagcagagatttccattggattgttctttcttcataaaagaggaatcatt
tacagggatctgaagttagataatgtcatgctggattcggaagggcatatcaagattgcc
gattttgggatgtgcaaggaacacatgatggatggagtcacaaccaggaccttctgtggg
acaccagattacatcgccccagagataatcgcatatcagccatatggaaaatccgtggac
tggtgggcctatggcgtcctattatatgaaatgctagccgggcagcctccctttgatggc
gaagatgaagacgagctgtttcagtccataatggagcataacgtttcttatcccaaatcc
ttgtccaaggaggccgtttccatctgcaaaggactgatgaccaaacacccaggcaagcgg
ctgggttgcgggccggagggggagagagacgtgcgggaacatgccttcttccgaaggatc
gactgggagaagctggagaacagggagatccagccgcccttcaagcccaaagtgtgtggc
aaaggtgcagaaaactttgacaagttcttcacgcgagggcagcctgtcttaacaccacct
gatcagctggtcattgctaacatagaccagtctgatttcgaggggttctcgtatgtcaac
ccccaatttgtgcaccccatcttgcagagcgcagtatga

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