KEGG   Neomonachus schauinslandi (Hawaiian monk seal): 110578303
Entry
110578303         CDS       T08474                                 
Symbol
MAPK11
Name
(RefSeq) mitogen-activated protein kinase 11 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
nsu  Neomonachus schauinslandi (Hawaiian monk seal)
Pathway
nsu01522  Endocrine resistance
nsu04010  MAPK signaling pathway
nsu04015  Rap1 signaling pathway
nsu04068  FoxO signaling pathway
nsu04071  Sphingolipid signaling pathway
nsu04114  Oocyte meiosis
nsu04148  Efferocytosis
nsu04218  Cellular senescence
nsu04261  Adrenergic signaling in cardiomyocytes
nsu04370  VEGF signaling pathway
nsu04380  Osteoclast differentiation
nsu04517  IgSF CAM signaling
nsu04550  Signaling pathways regulating pluripotency of stem cells
nsu04611  Platelet activation
nsu04613  Neutrophil extracellular trap formation
nsu04620  Toll-like receptor signaling pathway
nsu04621  NOD-like receptor signaling pathway
nsu04622  RIG-I-like receptor signaling pathway
nsu04625  C-type lectin receptor signaling pathway
nsu04657  IL-17 signaling pathway
nsu04658  Th1 and Th2 cell differentiation
nsu04659  Th17 cell differentiation
nsu04660  T cell receptor signaling pathway
nsu04664  Fc epsilon RI signaling pathway
nsu04668  TNF signaling pathway
nsu04670  Leukocyte transendothelial migration
nsu04714  Thermogenesis
nsu04722  Neurotrophin signaling pathway
nsu04723  Retrograde endocannabinoid signaling
nsu04728  Dopaminergic synapse
nsu04750  Inflammatory mediator regulation of TRP channels
nsu04912  GnRH signaling pathway
nsu04914  Progesterone-mediated oocyte maturation
nsu04917  Prolactin signaling pathway
nsu04926  Relaxin signaling pathway
nsu04932  Non-alcoholic fatty liver disease
nsu04933  AGE-RAGE signaling pathway in diabetic complications
nsu04935  Growth hormone synthesis, secretion and action
nsu04936  Alcoholic liver disease
nsu05014  Amyotrophic lateral sclerosis
nsu05020  Prion disease
nsu05022  Pathways of neurodegeneration - multiple diseases
nsu05132  Salmonella infection
nsu05133  Pertussis
nsu05135  Yersinia infection
nsu05140  Leishmaniasis
nsu05142  Chagas disease
nsu05145  Toxoplasmosis
nsu05152  Tuberculosis
nsu05161  Hepatitis B
nsu05163  Human cytomegalovirus infection
nsu05167  Kaposi sarcoma-associated herpesvirus infection
nsu05169  Epstein-Barr virus infection
nsu05170  Human immunodeficiency virus 1 infection
nsu05171  Coronavirus disease - COVID-19
nsu05205  Proteoglycans in cancer
nsu05208  Chemical carcinogenesis - reactive oxygen species
nsu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
nsu05415  Diabetic cardiomyopathy
nsu05417  Lipid and atherosclerosis
nsu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:nsu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    110578303 (MAPK11)
   04015 Rap1 signaling pathway
    110578303 (MAPK11)
   04370 VEGF signaling pathway
    110578303 (MAPK11)
   04668 TNF signaling pathway
    110578303 (MAPK11)
   04068 FoxO signaling pathway
    110578303 (MAPK11)
   04071 Sphingolipid signaling pathway
    110578303 (MAPK11)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    110578303 (MAPK11)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    110578303 (MAPK11)
  09143 Cell growth and death
   04114 Oocyte meiosis
    110578303 (MAPK11)
   04218 Cellular senescence
    110578303 (MAPK11)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    110578303 (MAPK11)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    110578303 (MAPK11)
   04613 Neutrophil extracellular trap formation
    110578303 (MAPK11)
   04620 Toll-like receptor signaling pathway
    110578303 (MAPK11)
   04621 NOD-like receptor signaling pathway
    110578303 (MAPK11)
   04622 RIG-I-like receptor signaling pathway
    110578303 (MAPK11)
   04625 C-type lectin receptor signaling pathway
    110578303 (MAPK11)
   04660 T cell receptor signaling pathway
    110578303 (MAPK11)
   04658 Th1 and Th2 cell differentiation
    110578303 (MAPK11)
   04659 Th17 cell differentiation
    110578303 (MAPK11)
   04657 IL-17 signaling pathway
    110578303 (MAPK11)
   04664 Fc epsilon RI signaling pathway
    110578303 (MAPK11)
   04670 Leukocyte transendothelial migration
    110578303 (MAPK11)
  09152 Endocrine system
   04912 GnRH signaling pathway
    110578303 (MAPK11)
   04914 Progesterone-mediated oocyte maturation
    110578303 (MAPK11)
   04917 Prolactin signaling pathway
    110578303 (MAPK11)
   04926 Relaxin signaling pathway
    110578303 (MAPK11)
   04935 Growth hormone synthesis, secretion and action
    110578303 (MAPK11)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    110578303 (MAPK11)
  09156 Nervous system
   04728 Dopaminergic synapse
    110578303 (MAPK11)
   04723 Retrograde endocannabinoid signaling
    110578303 (MAPK11)
   04722 Neurotrophin signaling pathway
    110578303 (MAPK11)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    110578303 (MAPK11)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    110578303 (MAPK11)
  09159 Environmental adaptation
   04714 Thermogenesis
    110578303 (MAPK11)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    110578303 (MAPK11)
   05208 Chemical carcinogenesis - reactive oxygen species
    110578303 (MAPK11)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    110578303 (MAPK11)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    110578303 (MAPK11)
   05161 Hepatitis B
    110578303 (MAPK11)
   05171 Coronavirus disease - COVID-19
    110578303 (MAPK11)
   05163 Human cytomegalovirus infection
    110578303 (MAPK11)
   05167 Kaposi sarcoma-associated herpesvirus infection
    110578303 (MAPK11)
   05169 Epstein-Barr virus infection
    110578303 (MAPK11)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    110578303 (MAPK11)
   05135 Yersinia infection
    110578303 (MAPK11)
   05133 Pertussis
    110578303 (MAPK11)
   05152 Tuberculosis
    110578303 (MAPK11)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    110578303 (MAPK11)
   05140 Leishmaniasis
    110578303 (MAPK11)
   05142 Chagas disease
    110578303 (MAPK11)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    110578303 (MAPK11)
   05020 Prion disease
    110578303 (MAPK11)
   05022 Pathways of neurodegeneration - multiple diseases
    110578303 (MAPK11)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    110578303 (MAPK11)
   05418 Fluid shear stress and atherosclerosis
    110578303 (MAPK11)
   05415 Diabetic cardiomyopathy
    110578303 (MAPK11)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    110578303 (MAPK11)
   04932 Non-alcoholic fatty liver disease
    110578303 (MAPK11)
   04933 AGE-RAGE signaling pathway in diabetic complications
    110578303 (MAPK11)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    110578303 (MAPK11)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:nsu01001]
    110578303 (MAPK11)
Enzymes [BR:nsu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     110578303 (MAPK11)
Protein kinases [BR:nsu01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   110578303 (MAPK11)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Kdo APH RIO1 Cas_CT1975
Other DBs
NCBI-GeneID: 110578303
NCBI-ProteinID: XP_021543505
UniProt: A0A2Y9H0E6
LinkDB
Position
5:625914..632150
AA seq 364 aa
MSGPRAGFYRLELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLRSIFHGANPLAVDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPDDEPEAEPYDESVEAKERTVEEWKELTYQEVLSFKPAEPPQSPSSL
QIEQ
NT seq 1095 nt   +upstreamnt  +downstreamnt
atgtcgggcccgcgtgcaggcttctaccggctggagctcaacaagacggtgtgggaggtg
ccgcagcggctgcaggggctgcgcccggtgggctccggcgcctacggctcggtctgctca
gcctatgacgcgcggctgcgccagaaggtggcggtgaagaagctgtcgcgacccttccag
tctctgatccacgcgcggagaacttaccgcgagctgcggctgctcaagcacctgaagcac
gagaacgtcatcgggctgctggacgtgttcacgccggccacctccattgaggacttcagc
gaagtgtacctggtgaccaccctgatgggcgcggacctgaacaacatcgtcaagtgccag
gcgctgagcgacgagcacgtccagttcctggtttaccagttgctgcgcgggctcaagtac
atccactctgcggggatcatccaccgggacctgaagcccagcaacgtggctgtgaacgag
gactgcgagcttaggatcctggacttcgggctagcccgccaggctgatgaggagatgact
ggctatgtggccactcggtggtaccgcgcacctgagatcatgctcaactggatgcactac
aaccagacagtggacatctggtctgtgggctgcatcatggctgagctgctccagggaaag
gccctctttccaggaaatgactacatcgaccagctgaagcgaatcatggaggtggtgggc
acacccagccctgaggttctagcaaagatatcctcagaacacgcccggacatacatccag
tccctgccccccatgccccagaaggacctcaggagcatcttccatggagccaaccccctg
gctgtggacctgctgggaaggatgctggtgctcgacagtgaccagagggtcagtgcggcc
gaggccctggcccatgcctacttcagccagtaccatgacccggacgatgagcctgaggct
gagccctatgatgagagcgttgaggccaaggaacgcacagtggaggagtggaaggagctc
acctaccaggaggtcctcagcttcaagcctgcagaaccaccgcagtctcccagcagcctg
cagattgagcagtga

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