KEGG   Neomonachus schauinslandi (Hawaiian monk seal): 110579316
Entry
110579316         CDS       T08474                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
nsu  Neomonachus schauinslandi (Hawaiian monk seal)
Pathway
nsu00562  Inositol phosphate metabolism
nsu01100  Metabolic pathways
nsu04015  Rap1 signaling pathway
nsu04020  Calcium signaling pathway
nsu04022  cGMP-PKG signaling pathway
nsu04062  Chemokine signaling pathway
nsu04070  Phosphatidylinositol signaling system
nsu04071  Sphingolipid signaling pathway
nsu04072  Phospholipase D signaling pathway
nsu04081  Hormone signaling
nsu04082  Neuroactive ligand signaling
nsu04261  Adrenergic signaling in cardiomyocytes
nsu04270  Vascular smooth muscle contraction
nsu04310  Wnt signaling pathway
nsu04371  Apelin signaling pathway
nsu04540  Gap junction
nsu04611  Platelet activation
nsu04613  Neutrophil extracellular trap formation
nsu04621  NOD-like receptor signaling pathway
nsu04713  Circadian entrainment
nsu04720  Long-term potentiation
nsu04723  Retrograde endocannabinoid signaling
nsu04724  Glutamatergic synapse
nsu04725  Cholinergic synapse
nsu04726  Serotonergic synapse
nsu04728  Dopaminergic synapse
nsu04730  Long-term depression
nsu04742  Taste transduction
nsu04750  Inflammatory mediator regulation of TRP channels
nsu04911  Insulin secretion
nsu04912  GnRH signaling pathway
nsu04915  Estrogen signaling pathway
nsu04916  Melanogenesis
nsu04918  Thyroid hormone synthesis
nsu04919  Thyroid hormone signaling pathway
nsu04921  Oxytocin signaling pathway
nsu04922  Glucagon signaling pathway
nsu04924  Renin secretion
nsu04925  Aldosterone synthesis and secretion
nsu04926  Relaxin signaling pathway
nsu04927  Cortisol synthesis and secretion
nsu04928  Parathyroid hormone synthesis, secretion and action
nsu04929  GnRH secretion
nsu04933  AGE-RAGE signaling pathway in diabetic complications
nsu04934  Cushing syndrome
nsu04935  Growth hormone synthesis, secretion and action
nsu04961  Endocrine and other factor-regulated calcium reabsorption
nsu04970  Salivary secretion
nsu04971  Gastric acid secretion
nsu04972  Pancreatic secretion
nsu04973  Carbohydrate digestion and absorption
nsu05010  Alzheimer disease
nsu05016  Huntington disease
nsu05017  Spinocerebellar ataxia
nsu05022  Pathways of neurodegeneration - multiple diseases
nsu05142  Chagas disease
nsu05143  African trypanosomiasis
nsu05146  Amoebiasis
nsu05163  Human cytomegalovirus infection
nsu05200  Pathways in cancer
nsu05415  Diabetic cardiomyopathy
nsu05417  Lipid and atherosclerosis
Module
nsu_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:nsu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    110579316 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    110579316 (PLCB1)
   04310 Wnt signaling pathway
    110579316 (PLCB1)
   04371 Apelin signaling pathway
    110579316 (PLCB1)
   04020 Calcium signaling pathway
    110579316 (PLCB1)
   04070 Phosphatidylinositol signaling system
    110579316 (PLCB1)
   04072 Phospholipase D signaling pathway
    110579316 (PLCB1)
   04071 Sphingolipid signaling pathway
    110579316 (PLCB1)
   04022 cGMP-PKG signaling pathway
    110579316 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    110579316 (PLCB1)
   04081 Hormone signaling
    110579316 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    110579316 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    110579316 (PLCB1)
   04613 Neutrophil extracellular trap formation
    110579316 (PLCB1)
   04621 NOD-like receptor signaling pathway
    110579316 (PLCB1)
   04062 Chemokine signaling pathway
    110579316 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    110579316 (PLCB1)
   04922 Glucagon signaling pathway
    110579316 (PLCB1)
   04929 GnRH secretion
    110579316 (PLCB1)
   04912 GnRH signaling pathway
    110579316 (PLCB1)
   04915 Estrogen signaling pathway
    110579316 (PLCB1)
   04921 Oxytocin signaling pathway
    110579316 (PLCB1)
   04926 Relaxin signaling pathway
    110579316 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    110579316 (PLCB1)
   04918 Thyroid hormone synthesis
    110579316 (PLCB1)
   04919 Thyroid hormone signaling pathway
    110579316 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    110579316 (PLCB1)
   04916 Melanogenesis
    110579316 (PLCB1)
   04924 Renin secretion
    110579316 (PLCB1)
   04925 Aldosterone synthesis and secretion
    110579316 (PLCB1)
   04927 Cortisol synthesis and secretion
    110579316 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    110579316 (PLCB1)
   04270 Vascular smooth muscle contraction
    110579316 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    110579316 (PLCB1)
   04971 Gastric acid secretion
    110579316 (PLCB1)
   04972 Pancreatic secretion
    110579316 (PLCB1)
   04973 Carbohydrate digestion and absorption
    110579316 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    110579316 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    110579316 (PLCB1)
   04725 Cholinergic synapse
    110579316 (PLCB1)
   04728 Dopaminergic synapse
    110579316 (PLCB1)
   04726 Serotonergic synapse
    110579316 (PLCB1)
   04720 Long-term potentiation
    110579316 (PLCB1)
   04730 Long-term depression
    110579316 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    110579316 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    110579316 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    110579316 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    110579316 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110579316 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    110579316 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    110579316 (PLCB1)
   05142 Chagas disease
    110579316 (PLCB1)
   05143 African trypanosomiasis
    110579316 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110579316 (PLCB1)
   05016 Huntington disease
    110579316 (PLCB1)
   05017 Spinocerebellar ataxia
    110579316 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    110579316 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    110579316 (PLCB1)
   05415 Diabetic cardiomyopathy
    110579316 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    110579316 (PLCB1)
   04934 Cushing syndrome
    110579316 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:nsu04131]
    110579316 (PLCB1)
Enzymes [BR:nsu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     110579316 (PLCB1)
Membrane trafficking [BR:nsu04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    110579316 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    110579316 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 110579316
NCBI-ProteinID: XP_021544589
UniProt: A0A2Y9H5N6
LinkDB
Position
10:complement(104142888..104822081)
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSAIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFESSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFETSKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
ETDPGETPSEVPNEARTTPAENGVNHTTSLAPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDSKKKSDPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQMDLEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPPSLASEPGKMNHKPPSS
EELEGDNPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggctcagcccggagtgcacgctttgcaactcaagcccgtgtgcgtgtccgac
agcctgaagaagggcaccaaattcgtcaagtgggatgatgactctgctattgtcactcca
attattttgaggactgaccctcagggatttttcttttactggactgatcaaaataaggag
acggagctgttagatctcagccttgtcaaggatgccagatgtgggaagcatgccaaagct
cccaaggaccccaaattacgtgaacttttggatgtggggaacatcgggcgcctggagcat
cgcatgataacagtggtatatgggcctgacttggttaacatctcccatttgaatctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaacatgtcaagagacgcatttctggaaaaagcctatactaagcttaag
ctgcaagtcactccagaagggcgcattcctctcaaaaacatataccgcttgttctcagca
gaccggaagcgagtcgaaactgctttagaggcttgtagtcttccatcttcaaggaacgat
tcaatacctcaagaagatttcactccagaagtgtacagagttttcctgaacaacctttgc
cctcgacctgaaattgataacatcttttccgaatttggtgccaaaagcaaaccatacctt
accgtcgatcagatgatggactttatcaaccttaagcagcgagatccccggctaaatgaa
atcctttacccacctttaaaacaagaacaagtccaagtattgattgagaagtatgaaccc
aacagtagcctcgccaaaaaaggacagatatcagtggatggctttatgcgctatctgagt
ggagaagaaaatggagttgtttcgcctgagaaactggatttgaatgaagatatgtctcag
cccctttctcactatttcatcaattcctcacacaacacctacctcacagctggccagttg
gctggaaactcctctgtcgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtg
gagttggactgctggaagggacggactgctgaagaggaaccagtcatcacccatgggttc
accatgacaactgaaatatccttcaaggaagtgatagaagcaattgctgagtgtgcattt
aagacgtcaccttttccaattctgctttcatttgagaaccacgtagattccccaaagcag
caagccaagatggcggagtattgccgactgatctttggagacgctcttctcatggaacca
ctggaaaaatacccactggaatctggagttcctcttccaagccctatggacttaatgtac
aaaattttggtgaaaaataagaagaaatcgcacaagtcgtcagaaggaagtggcaaaaag
aagctctcagaacaagcttccaacacgtacagcgactcctccagcgtgttcgagtcctca
tctccaggagctggggaagctgataccgagagtgacgacgacgatgatgatgatgactgt
aaaaaatcttcaatggatgaggggactgcagggagcgaggccatggccaccgaagagatg
tctaacctggtgaactatattcagccagtcaagtttgagtcatttgaaacttcaaaaaaa
agaaacagaagttttgaaatgtcttccttcgtggaaaccaaaggcctcgagcaactgacg
aagtctccagtggaatttgtagaatataacaaaatgcagcttagcaggatatatccaaaa
ggaacccgtgtggattcatctaactacatgcctcagctcttctggaatgcgggttgccaa
atggttgcacttaattttcaaactgtggacctggctatgcaaataaatatggggatgtac
gaatacaatgggaaaagtggctacagattaaagccagagttcatgaggagacctgacaag
cattttgatccattcaccgaaggcatcgtggatgggatagtagccaatactttatctgtc
aagattatatcaggtcagtttctttctgataagaaagtcgggacttacgtggaagtggat
atgtttggtttgcctgtggacacgaggaggaaggcatttaagaccaaaacatcacaagga
aatgctgtaaatcctgtctgggaagaagagcccattgtgttcaaaaaggtggttcttcct
tctctggcctgtttgaggatagcagtttatgaagaaggaggtaaattcatcggtcaccgg
atcttgccagtacaggcaattcggccaggctatcactacatctgtctgaggaatgagagg
aaccagcctctgatgctcccagctgtctttgtctacatagaggtgaaagactatgtccca
gatacatatgcagatgtgattgaagctttgtcaaatccaatacgatatgtgaatctgatg
gagcaaagagctaaacaattggctgcattgacactggaagatgaagaagaagtaaagaaa
gagactgatcctggggaaacaccatcggaagttccgaatgaagccaggacaactccagca
gaaaacggagtgaatcacactacatccttggcacccaaaccaccctcccaggctctccac
agccaaccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagt
gttttaacagaagtggaagcccagaccatcgaagagctaaagcagcagaaatcatttgtg
aaacttcaaaagaagcactacaaagaaatgaaagacctggttaaaagacaccacaagaaa
accactgacctaatcaaagaacacactacaaagtataatgagattcagaatgactacttg
agaaggagggcagctttggaaaagacagccaaaaaggacagtaaaaaaaagtcagatccc
agcagtcctgaccatggttcatcaacgattgagcaagatcttgctgccctagatgccgaa
atgacccaaaagttaatagacttgaaggacaaacaacagcagcagctgcttaatcttcga
caagagcagtattatagtgaaaaataccagaagcgagaacatattaaactgcttattcaa
aaattgacggatgttgctgaagaatgtcagaacaatcagctgaagaagctcaaagaaatc
tgtgagaaagagaagaaggaattaaagaagaaaatggacaaaaaaaggcaggagaagata
acagaagctaaatccaaagacaaaagtcaaatggaagaggaaaagacagagatgatccgg
tcatacatccaagaggtggtgcagtacatcaagaggttagaagaggcccaaagtaaacgg
caagaaaaacttgtagagaaacacaaggagatacgtcaacagatcctggacgaaaagccc
aagctgcagatggacctggagcaagagtaccaagacaagttcaaaagactgcccctggag
atcttggagttcgtgcaggaagccatgaaagggaagatcagcgaagacagcaatcacagt
tctgcccctccctccctggcctcggagcctggaaaaatgaaccacaagcctccctccagt
gaggagctagaaggagacaacccaggaaaagagtttgatactcctctgtga

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