Neomonachus schauinslandi (Hawaiian monk seal): 110581342
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Entry
110581342 CDS
T08474
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X1
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
nsu
Neomonachus schauinslandi (Hawaiian monk seal)
Pathway
nsu00790
Folate biosynthesis
nsu01100
Metabolic pathways
nsu01240
Biosynthesis of cofactors
nsu01523
Antifolate resistance
nsu04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
nsu00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
110581342 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
110581342 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
110581342 (FPGS)
Enzymes [BR:
nsu01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
110581342 (FPGS)
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
110581342
NCBI-ProteinID:
XP_021546818
UniProt:
A0A2Y9H5A9
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Position
13:85918985..85929172
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AA seq
588 aa
AA seq
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MSQARCHLRAALFLAAVSPRGATTGVTARRGLSAWPAPQEPGMEYQDAVRTLNTLQTNAG
YLEQVKRQRGDPQTQLEAMKLYLARSGLQVEDLDQLNIIHVTGTKGKGSTCAFTERVLRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKHFWHLYHRLEETKDSSSCVSMPAYFR
FLTLMAFHIFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEEI
AWQKGGIFKRGVPAFTVLQPDGPLAVLRDRAQQISCPLYLCPPLEALEEGGPPLTLGLDG
EHQRFNAALALQLARCWLQQKGHQGLGELKVSRPSVLRQMPLAPVFQPTPHMRHGLRDTE
WLGRTQVLRRGPLTWYLDGAHTASSVQACVRWFHQALLRGHRPGRGPEVRILLFNSTGDR
DSAALLKLLQPCQFDYAVFCPNLTEVSSAGNADQQNFMVTLDQVLLRCLAHQQYWSHLAE
AQASPDLWSSPSLEPGEPTSSLLASHPPRTHSTSSLVFSCISHALQWISQGRDPVFQPPS
LPQGLLAHPVAGSGAGVLREAGAIHVLVTGSLHLVGGVLKLLEPALSQ
NT seq
1767 nt
NT seq
+upstream
nt +downstream
nt
atgtcgcaggcacgctgccacctgcgtgccgcgctcttcctggcagcagtttctccgcgc
ggtgcaacgaccggggtcacggcgcggcgagggttgagcgcgtggcccgcgccgcaggag
cccggcatggagtatcaggatgctgtgcgcacactgaacaccctgcagaccaatgctggc
tacctggagcaggtaaagcgccagcggggtgaccctcagacacagctggaagcgatgaag
ctgtacttggcccggagtgggctgcaggtggaagacttggaccagctgaacatcattcac
gtcactgggaccaaggggaagggttccacgtgtgccttcaccgaacgtgttctccgcagc
tatggcctgaagacgggattctttagctctccccacctggtgcaggtgcgggagcggatc
cgcatcaacgggcagcccataagccccgagctcttcaccaagcacttttggcacctctac
caccggctggaggagaccaaggacagcagcagctgcgtctccatgcctgcctacttccgc
ttcctcacactcatggccttccacatcttcctccaagagaaggtggacctggcagtggtg
gaagtgggcattggtggcgcttacgactgcaccaacatcatcaggaagcctgtggtgtgt
ggcgtctcctctcttggcatcgaccacaccagccttctgggggacacagtggaggagatc
gcatggcagaaagggggcatcttcaagcgtggcgtccctgccttcacggtgctccagcct
gacggtcccctggcggtgctgcgggaccgtgcccagcagatctcctgtcctctctacctg
tgcccaccactggaagccctggaggaaggggggccgccgctgaccctgggcctggatgga
gagcaccagcggttcaacgctgccttggccttgcagctggctcgctgctggctgcagcaa
aagggccaccagggcctcggggagctgaaggtgtctcggcccagcgtcttgcggcagatg
cccctggcacccgtgttccagcccacgccccacatgcggcatgggcttcgggacacggag
tggctgggccggacacaggtgctgcggcgcgggcccctcacctggtacctggacggcgcg
cacactgccagcagcgtgcaggcctgcgtgcgctggttccaccaggcgctgctccgaggc
cacaggcccggccgcggccctgaggtccgcatcttgctcttcaactccaccggggaccgg
gattccgcggccctgctgaagctgctgcagccctgtcagtttgactatgctgttttctgc
cctaacctgacagaggtgtcgtctgctggcaacgcagaccagcagaacttcatggtgacc
ctggaccaggtgctgctccgttgcctcgctcaccaacagtactggagccacctggccgag
gcgcaggccagcccagacctctggagctcccccagcctggagcctggtgagcccacatcc
tcgctgctggcttcccacccaccccgcacccatagcaccagctccctcgtcttcagctgc
atctcgcacgccctgcagtggatcagccaaggccgggaccctgtctttcagccacccagt
ctcccacagggcctccttgcccaccctgtggcaggcagcggggccggcgtgctccgcgag
gccggcgccatccatgtactggtcacgggcagcttgcacctggtgggcggtgtcctgaag
ctgctggagcctgccctgtcccagtag
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