KEGG   Neomonachus schauinslandi (Hawaiian monk seal): 110582352
Entry
110582352         CDS       T08474                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
nsu  Neomonachus schauinslandi (Hawaiian monk seal)
Pathway
nsu00562  Inositol phosphate metabolism
nsu01100  Metabolic pathways
nsu01521  EGFR tyrosine kinase inhibitor resistance
nsu01522  Endocrine resistance
nsu01524  Platinum drug resistance
nsu04012  ErbB signaling pathway
nsu04014  Ras signaling pathway
nsu04015  Rap1 signaling pathway
nsu04024  cAMP signaling pathway
nsu04062  Chemokine signaling pathway
nsu04066  HIF-1 signaling pathway
nsu04068  FoxO signaling pathway
nsu04070  Phosphatidylinositol signaling system
nsu04071  Sphingolipid signaling pathway
nsu04072  Phospholipase D signaling pathway
nsu04081  Hormone signaling
nsu04140  Autophagy - animal
nsu04145  Phagocytosis
nsu04150  mTOR signaling pathway
nsu04151  PI3K-Akt signaling pathway
nsu04152  AMPK signaling pathway
nsu04210  Apoptosis
nsu04211  Longevity regulating pathway
nsu04213  Longevity regulating pathway - multiple species
nsu04218  Cellular senescence
nsu04360  Axon guidance
nsu04370  VEGF signaling pathway
nsu04380  Osteoclast differentiation
nsu04510  Focal adhesion
nsu04517  IgSF CAM signaling
nsu04518  Integrin signaling
nsu04550  Signaling pathways regulating pluripotency of stem cells
nsu04611  Platelet activation
nsu04613  Neutrophil extracellular trap formation
nsu04620  Toll-like receptor signaling pathway
nsu04625  C-type lectin receptor signaling pathway
nsu04630  JAK-STAT signaling pathway
nsu04650  Natural killer cell mediated cytotoxicity
nsu04660  T cell receptor signaling pathway
nsu04662  B cell receptor signaling pathway
nsu04664  Fc epsilon RI signaling pathway
nsu04666  Fc gamma R-mediated phagosome formation
nsu04668  TNF signaling pathway
nsu04670  Leukocyte transendothelial migration
nsu04722  Neurotrophin signaling pathway
nsu04725  Cholinergic synapse
nsu04750  Inflammatory mediator regulation of TRP channels
nsu04810  Regulation of actin cytoskeleton
nsu04910  Insulin signaling pathway
nsu04914  Progesterone-mediated oocyte maturation
nsu04915  Estrogen signaling pathway
nsu04917  Prolactin signaling pathway
nsu04919  Thyroid hormone signaling pathway
nsu04923  Regulation of lipolysis in adipocytes
nsu04926  Relaxin signaling pathway
nsu04929  GnRH secretion
nsu04930  Type II diabetes mellitus
nsu04931  Insulin resistance
nsu04932  Non-alcoholic fatty liver disease
nsu04933  AGE-RAGE signaling pathway in diabetic complications
nsu04935  Growth hormone synthesis, secretion and action
nsu04960  Aldosterone-regulated sodium reabsorption
nsu04973  Carbohydrate digestion and absorption
nsu05010  Alzheimer disease
nsu05017  Spinocerebellar ataxia
nsu05020  Prion disease
nsu05100  Bacterial invasion of epithelial cells
nsu05132  Salmonella infection
nsu05135  Yersinia infection
nsu05142  Chagas disease
nsu05146  Amoebiasis
nsu05160  Hepatitis C
nsu05161  Hepatitis B
nsu05162  Measles
nsu05163  Human cytomegalovirus infection
nsu05164  Influenza A
nsu05165  Human papillomavirus infection
nsu05166  Human T-cell leukemia virus 1 infection
nsu05167  Kaposi sarcoma-associated herpesvirus infection
nsu05168  Herpes simplex virus 1 infection
nsu05169  Epstein-Barr virus infection
nsu05170  Human immunodeficiency virus 1 infection
nsu05171  Coronavirus disease
nsu05200  Pathways in cancer
nsu05203  Viral carcinogenesis
nsu05205  Proteoglycans in cancer
nsu05206  MicroRNAs in cancer
nsu05207  Chemical carcinogenesis - receptor activation
nsu05208  Chemical carcinogenesis - reactive oxygen species
nsu05210  Colorectal cancer
nsu05211  Renal cell carcinoma
nsu05212  Pancreatic cancer
nsu05213  Endometrial cancer
nsu05214  Glioma
nsu05215  Prostate cancer
nsu05218  Melanoma
nsu05220  Chronic myeloid leukemia
nsu05221  Acute myeloid leukemia
nsu05222  Small cell lung cancer
nsu05223  Non-small cell lung cancer
nsu05224  Breast cancer
nsu05225  Hepatocellular carcinoma
nsu05226  Gastric cancer
nsu05230  Central carbon metabolism in cancer
nsu05231  Choline metabolism in cancer
nsu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
nsu05415  Diabetic cardiomyopathy
nsu05417  Lipid and atherosclerosis
nsu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:nsu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    110582352 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    110582352 (PIK3CA)
   04014 Ras signaling pathway
    110582352 (PIK3CA)
   04015 Rap1 signaling pathway
    110582352 (PIK3CA)
   04370 VEGF signaling pathway
    110582352 (PIK3CA)
   04630 JAK-STAT signaling pathway
    110582352 (PIK3CA)
   04668 TNF signaling pathway
    110582352 (PIK3CA)
   04066 HIF-1 signaling pathway
    110582352 (PIK3CA)
   04068 FoxO signaling pathway
    110582352 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    110582352 (PIK3CA)
   04072 Phospholipase D signaling pathway
    110582352 (PIK3CA)
   04071 Sphingolipid signaling pathway
    110582352 (PIK3CA)
   04024 cAMP signaling pathway
    110582352 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    110582352 (PIK3CA)
   04152 AMPK signaling pathway
    110582352 (PIK3CA)
   04150 mTOR signaling pathway
    110582352 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    110582352 (PIK3CA)
   04517 IgSF CAM signaling
    110582352 (PIK3CA)
   04518 Integrin signaling
    110582352 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    110582352 (PIK3CA)
   04140 Autophagy - animal
    110582352 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    110582352 (PIK3CA)
   04218 Cellular senescence
    110582352 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    110582352 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    110582352 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    110582352 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    110582352 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    110582352 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    110582352 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    110582352 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    110582352 (PIK3CA)
   04660 T cell receptor signaling pathway
    110582352 (PIK3CA)
   04662 B cell receptor signaling pathway
    110582352 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    110582352 (PIK3CA)
   04666 Fc gamma R-mediated phagosome formation
    110582352 (PIK3CA)
   04670 Leukocyte transendothelial migration
    110582352 (PIK3CA)
   04062 Chemokine signaling pathway
    110582352 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    110582352 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    110582352 (PIK3CA)
   04929 GnRH secretion
    110582352 (PIK3CA)
   04915 Estrogen signaling pathway
    110582352 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    110582352 (PIK3CA)
   04917 Prolactin signaling pathway
    110582352 (PIK3CA)
   04926 Relaxin signaling pathway
    110582352 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    110582352 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    110582352 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    110582352 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    110582352 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    110582352 (PIK3CA)
   04722 Neurotrophin signaling pathway
    110582352 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    110582352 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    110582352 (PIK3CA)
   04380 Osteoclast differentiation
    110582352 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    110582352 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    110582352 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110582352 (PIK3CA)
   05206 MicroRNAs in cancer
    110582352 (PIK3CA)
   05205 Proteoglycans in cancer
    110582352 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    110582352 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    110582352 (PIK3CA)
   05203 Viral carcinogenesis
    110582352 (PIK3CA)
   05230 Central carbon metabolism in cancer
    110582352 (PIK3CA)
   05231 Choline metabolism in cancer
    110582352 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    110582352 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    110582352 (PIK3CA)
   05212 Pancreatic cancer
    110582352 (PIK3CA)
   05225 Hepatocellular carcinoma
    110582352 (PIK3CA)
   05226 Gastric cancer
    110582352 (PIK3CA)
   05214 Glioma
    110582352 (PIK3CA)
   05221 Acute myeloid leukemia
    110582352 (PIK3CA)
   05220 Chronic myeloid leukemia
    110582352 (PIK3CA)
   05218 Melanoma
    110582352 (PIK3CA)
   05211 Renal cell carcinoma
    110582352 (PIK3CA)
   05215 Prostate cancer
    110582352 (PIK3CA)
   05213 Endometrial cancer
    110582352 (PIK3CA)
   05224 Breast cancer
    110582352 (PIK3CA)
   05222 Small cell lung cancer
    110582352 (PIK3CA)
   05223 Non-small cell lung cancer
    110582352 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    110582352 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    110582352 (PIK3CA)
   05161 Hepatitis B
    110582352 (PIK3CA)
   05160 Hepatitis C
    110582352 (PIK3CA)
   05171 Coronavirus disease
    110582352 (PIK3CA)
   05164 Influenza A
    110582352 (PIK3CA)
   05162 Measles
    110582352 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    110582352 (PIK3CA)
   05163 Human cytomegalovirus infection
    110582352 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    110582352 (PIK3CA)
   05169 Epstein-Barr virus infection
    110582352 (PIK3CA)
   05165 Human papillomavirus infection
    110582352 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    110582352 (PIK3CA)
   05135 Yersinia infection
    110582352 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    110582352 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    110582352 (PIK3CA)
   05142 Chagas disease
    110582352 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110582352 (PIK3CA)
   05017 Spinocerebellar ataxia
    110582352 (PIK3CA)
   05020 Prion disease
    110582352 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    110582352 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    110582352 (PIK3CA)
   05415 Diabetic cardiomyopathy
    110582352 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    110582352 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    110582352 (PIK3CA)
   04931 Insulin resistance
    110582352 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    110582352 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110582352 (PIK3CA)
   01524 Platinum drug resistance
    110582352 (PIK3CA)
   01522 Endocrine resistance
    110582352 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:nsu04131]
    110582352 (PIK3CA)
Enzymes [BR:nsu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     110582352 (PIK3CA)
Membrane trafficking [BR:nsu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    110582352 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 110582352
NCBI-ProteinID: XP_021548016
UniProt: A0A2Y9H8I3
LinkDB
Position
1:complement(85135198..85173413)
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagttgaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaagtaccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttactcaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgagaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccggaagtacaggacttccga
cgaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaactcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactagaagcatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttccttgaaaaatatcctctaagtcagtataagtacataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactcccaactgccaatggac
tgtttcacaatgccttcatattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaatcctttgt
gcgacctatgtgaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
tatcatggaggagaacccttatgcgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctaaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctctgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaaccccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaactggtcggtg
tctcgggaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aatgaattaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaactgcttctgtccgttaaatggaattctagagatgaagta
gcgcagatgtactgcttagtaaaagactggcctccaatcaaacctgaacaggctatggag
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatacttaacagatgacaagctttctcagtacctaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaactgtt
agtcagaggtttggccttcttttggagtcctattgtcgtgcatgtgggatgtatttgaag
cacctaaataggcaagttgaggctatggaaaagctcattaacttaactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcagatgcgg
cgaccagatttcatggatgctctacaaggtttcctatctcctctaaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaataattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
attggtgactgtgtgggacttattgaggtggtgcgaaattctcacacgattatgcagatt
cagtgcaaaggtggtctgaaaggcgctctgcagttcaatagccacacactccatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgttcacacgttca
tgtgctggttattgtgttgctaccttcattctgggcattggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgggaacgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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