KEGG   Neomonachus schauinslandi (Hawaiian monk seal): 110584045
Entry
110584045         CDS       T08474                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
nsu  Neomonachus schauinslandi (Hawaiian monk seal)
Pathway
nsu01521  EGFR tyrosine kinase inhibitor resistance
nsu01522  Endocrine resistance
nsu04010  MAPK signaling pathway
nsu04012  ErbB signaling pathway
nsu04014  Ras signaling pathway
nsu04015  Rap1 signaling pathway
nsu04022  cGMP-PKG signaling pathway
nsu04024  cAMP signaling pathway
nsu04062  Chemokine signaling pathway
nsu04066  HIF-1 signaling pathway
nsu04068  FoxO signaling pathway
nsu04071  Sphingolipid signaling pathway
nsu04072  Phospholipase D signaling pathway
nsu04114  Oocyte meiosis
nsu04140  Autophagy - animal
nsu04148  Efferocytosis
nsu04150  mTOR signaling pathway
nsu04151  PI3K-Akt signaling pathway
nsu04210  Apoptosis
nsu04218  Cellular senescence
nsu04270  Vascular smooth muscle contraction
nsu04370  VEGF signaling pathway
nsu04371  Apelin signaling pathway
nsu04380  Osteoclast differentiation
nsu04510  Focal adhesion
nsu04540  Gap junction
nsu04550  Signaling pathways regulating pluripotency of stem cells
nsu04613  Neutrophil extracellular trap formation
nsu04620  Toll-like receptor signaling pathway
nsu04650  Natural killer cell mediated cytotoxicity
nsu04660  T cell receptor signaling pathway
nsu04662  B cell receptor signaling pathway
nsu04664  Fc epsilon RI signaling pathway
nsu04666  Fc gamma R-mediated phagocytosis
nsu04668  TNF signaling pathway
nsu04720  Long-term potentiation
nsu04722  Neurotrophin signaling pathway
nsu04725  Cholinergic synapse
nsu04726  Serotonergic synapse
nsu04730  Long-term depression
nsu04810  Regulation of actin cytoskeleton
nsu04910  Insulin signaling pathway
nsu04912  GnRH signaling pathway
nsu04914  Progesterone-mediated oocyte maturation
nsu04915  Estrogen signaling pathway
nsu04916  Melanogenesis
nsu04917  Prolactin signaling pathway
nsu04919  Thyroid hormone signaling pathway
nsu04921  Oxytocin signaling pathway
nsu04926  Relaxin signaling pathway
nsu04928  Parathyroid hormone synthesis, secretion and action
nsu04929  GnRH secretion
nsu04934  Cushing syndrome
nsu04935  Growth hormone synthesis, secretion and action
nsu05010  Alzheimer disease
nsu05022  Pathways of neurodegeneration - multiple diseases
nsu05034  Alcoholism
nsu05132  Salmonella infection
nsu05135  Yersinia infection
nsu05160  Hepatitis C
nsu05161  Hepatitis B
nsu05163  Human cytomegalovirus infection
nsu05164  Influenza A
nsu05165  Human papillomavirus infection
nsu05166  Human T-cell leukemia virus 1 infection
nsu05167  Kaposi sarcoma-associated herpesvirus infection
nsu05170  Human immunodeficiency virus 1 infection
nsu05200  Pathways in cancer
nsu05205  Proteoglycans in cancer
nsu05206  MicroRNAs in cancer
nsu05207  Chemical carcinogenesis - receptor activation
nsu05208  Chemical carcinogenesis - reactive oxygen species
nsu05210  Colorectal cancer
nsu05211  Renal cell carcinoma
nsu05212  Pancreatic cancer
nsu05213  Endometrial cancer
nsu05214  Glioma
nsu05215  Prostate cancer
nsu05216  Thyroid cancer
nsu05218  Melanoma
nsu05219  Bladder cancer
nsu05220  Chronic myeloid leukemia
nsu05221  Acute myeloid leukemia
nsu05223  Non-small cell lung cancer
nsu05224  Breast cancer
nsu05225  Hepatocellular carcinoma
nsu05226  Gastric cancer
nsu05230  Central carbon metabolism in cancer
nsu05231  Choline metabolism in cancer
nsu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:nsu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    110584045 (MAP2K1)
   04012 ErbB signaling pathway
    110584045 (MAP2K1)
   04014 Ras signaling pathway
    110584045 (MAP2K1)
   04015 Rap1 signaling pathway
    110584045 (MAP2K1)
   04370 VEGF signaling pathway
    110584045 (MAP2K1)
   04371 Apelin signaling pathway
    110584045 (MAP2K1)
   04668 TNF signaling pathway
    110584045 (MAP2K1)
   04066 HIF-1 signaling pathway
    110584045 (MAP2K1)
   04068 FoxO signaling pathway
    110584045 (MAP2K1)
   04072 Phospholipase D signaling pathway
    110584045 (MAP2K1)
   04071 Sphingolipid signaling pathway
    110584045 (MAP2K1)
   04024 cAMP signaling pathway
    110584045 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    110584045 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    110584045 (MAP2K1)
   04150 mTOR signaling pathway
    110584045 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    110584045 (MAP2K1)
   04148 Efferocytosis
    110584045 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    110584045 (MAP2K1)
   04210 Apoptosis
    110584045 (MAP2K1)
   04218 Cellular senescence
    110584045 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    110584045 (MAP2K1)
   04540 Gap junction
    110584045 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    110584045 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    110584045 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    110584045 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    110584045 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    110584045 (MAP2K1)
   04660 T cell receptor signaling pathway
    110584045 (MAP2K1)
   04662 B cell receptor signaling pathway
    110584045 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    110584045 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    110584045 (MAP2K1)
   04062 Chemokine signaling pathway
    110584045 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    110584045 (MAP2K1)
   04929 GnRH secretion
    110584045 (MAP2K1)
   04912 GnRH signaling pathway
    110584045 (MAP2K1)
   04915 Estrogen signaling pathway
    110584045 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    110584045 (MAP2K1)
   04917 Prolactin signaling pathway
    110584045 (MAP2K1)
   04921 Oxytocin signaling pathway
    110584045 (MAP2K1)
   04926 Relaxin signaling pathway
    110584045 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    110584045 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    110584045 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    110584045 (MAP2K1)
   04916 Melanogenesis
    110584045 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    110584045 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    110584045 (MAP2K1)
   04726 Serotonergic synapse
    110584045 (MAP2K1)
   04720 Long-term potentiation
    110584045 (MAP2K1)
   04730 Long-term depression
    110584045 (MAP2K1)
   04722 Neurotrophin signaling pathway
    110584045 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    110584045 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110584045 (MAP2K1)
   05206 MicroRNAs in cancer
    110584045 (MAP2K1)
   05205 Proteoglycans in cancer
    110584045 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    110584045 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    110584045 (MAP2K1)
   05230 Central carbon metabolism in cancer
    110584045 (MAP2K1)
   05231 Choline metabolism in cancer
    110584045 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    110584045 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    110584045 (MAP2K1)
   05212 Pancreatic cancer
    110584045 (MAP2K1)
   05225 Hepatocellular carcinoma
    110584045 (MAP2K1)
   05226 Gastric cancer
    110584045 (MAP2K1)
   05214 Glioma
    110584045 (MAP2K1)
   05216 Thyroid cancer
    110584045 (MAP2K1)
   05221 Acute myeloid leukemia
    110584045 (MAP2K1)
   05220 Chronic myeloid leukemia
    110584045 (MAP2K1)
   05218 Melanoma
    110584045 (MAP2K1)
   05211 Renal cell carcinoma
    110584045 (MAP2K1)
   05219 Bladder cancer
    110584045 (MAP2K1)
   05215 Prostate cancer
    110584045 (MAP2K1)
   05213 Endometrial cancer
    110584045 (MAP2K1)
   05224 Breast cancer
    110584045 (MAP2K1)
   05223 Non-small cell lung cancer
    110584045 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    110584045 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    110584045 (MAP2K1)
   05161 Hepatitis B
    110584045 (MAP2K1)
   05160 Hepatitis C
    110584045 (MAP2K1)
   05164 Influenza A
    110584045 (MAP2K1)
   05163 Human cytomegalovirus infection
    110584045 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    110584045 (MAP2K1)
   05165 Human papillomavirus infection
    110584045 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    110584045 (MAP2K1)
   05135 Yersinia infection
    110584045 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110584045 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    110584045 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    110584045 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    110584045 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110584045 (MAP2K1)
   01522 Endocrine resistance
    110584045 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:nsu01001]
    110584045 (MAP2K1)
Enzymes [BR:nsu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     110584045 (MAP2K1)
Protein kinases [BR:nsu01001]
 Serine/threonine kinases: STE group
  STE7 family
   110584045 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 110584045
NCBI-ProteinID: XP_021549763
UniProt: A0A2Y9HDF9
LinkDB
Position
9:104768871..104850340
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDGEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggctcccgacggctccgcggtt
aacgggaccagctcggcagagaccaacctggaggccttgcagaagaagctggaggagttg
gagcttgatgagcagcagcggaagcgccttgaggcctttctcacccagaagcagaaggtc
ggggaattgaaggatgacgacttcgagaagatcagtgagctgggcgccggcaacggtggt
gtggtgttcaaggtctcgcacaagccctccggcctggtcatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcatacgggagctacaggttctacatgag
tgcaactccccctacatcgtgggcttctatggtgcgttctacagcgatggcgagatcagt
atctgcatggagcacatggatggtggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggtctgacatacctg
agggagaagcacaagataatgcacagagatgtcaagccttccaacatcctcgtgaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcattgactccatggcc
aactccttcgtgggcacacggtcctacatgtcgccagaaagactccaggggactcattac
tcggtgcagtcggacatctggagcatggggctctctctggttgagatggcggttgggagg
tatcccatccctcctccagatgctaaggagctggagctgatgtttgggtgccaagtggag
ggagatgcggctgagacgccacccagaccaaggacccctggaaggcccctcagctcttat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagttaacgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataag
tgcttaataaaaaacccagcagagagagcagatctgaagcaactcatggttcatgccttt
atcaagagatcggacggggaggaagtggattttgcaggttggctctgctccaccattggc
cttaaccagcccagcacaccgacccacgcagccggcgtctaa

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