KEGG   Neomonachus schauinslandi (Hawaiian monk seal): 110589825
Entry
110589825         CDS       T08474                                 
Symbol
MAPK3
Name
(RefSeq) mitogen-activated protein kinase 3
  KO
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
nsu  Neomonachus schauinslandi (Hawaiian monk seal)
Pathway
nsu01521  EGFR tyrosine kinase inhibitor resistance
nsu01522  Endocrine resistance
nsu01524  Platinum drug resistance
nsu04010  MAPK signaling pathway
nsu04012  ErbB signaling pathway
nsu04014  Ras signaling pathway
nsu04015  Rap1 signaling pathway
nsu04022  cGMP-PKG signaling pathway
nsu04024  cAMP signaling pathway
nsu04062  Chemokine signaling pathway
nsu04066  HIF-1 signaling pathway
nsu04068  FoxO signaling pathway
nsu04071  Sphingolipid signaling pathway
nsu04072  Phospholipase D signaling pathway
nsu04114  Oocyte meiosis
nsu04140  Autophagy - animal
nsu04148  Efferocytosis
nsu04150  mTOR signaling pathway
nsu04151  PI3K-Akt signaling pathway
nsu04210  Apoptosis
nsu04218  Cellular senescence
nsu04261  Adrenergic signaling in cardiomyocytes
nsu04270  Vascular smooth muscle contraction
nsu04350  TGF-beta signaling pathway
nsu04360  Axon guidance
nsu04370  VEGF signaling pathway
nsu04371  Apelin signaling pathway
nsu04380  Osteoclast differentiation
nsu04510  Focal adhesion
nsu04517  IgSF CAM signaling
nsu04520  Adherens junction
nsu04540  Gap junction
nsu04550  Signaling pathways regulating pluripotency of stem cells
nsu04611  Platelet activation
nsu04613  Neutrophil extracellular trap formation
nsu04620  Toll-like receptor signaling pathway
nsu04621  NOD-like receptor signaling pathway
nsu04625  C-type lectin receptor signaling pathway
nsu04650  Natural killer cell mediated cytotoxicity
nsu04657  IL-17 signaling pathway
nsu04658  Th1 and Th2 cell differentiation
nsu04659  Th17 cell differentiation
nsu04660  T cell receptor signaling pathway
nsu04662  B cell receptor signaling pathway
nsu04664  Fc epsilon RI signaling pathway
nsu04666  Fc gamma R-mediated phagocytosis
nsu04668  TNF signaling pathway
nsu04713  Circadian entrainment
nsu04720  Long-term potentiation
nsu04722  Neurotrophin signaling pathway
nsu04723  Retrograde endocannabinoid signaling
nsu04724  Glutamatergic synapse
nsu04725  Cholinergic synapse
nsu04726  Serotonergic synapse
nsu04730  Long-term depression
nsu04810  Regulation of actin cytoskeleton
nsu04910  Insulin signaling pathway
nsu04912  GnRH signaling pathway
nsu04914  Progesterone-mediated oocyte maturation
nsu04915  Estrogen signaling pathway
nsu04916  Melanogenesis
nsu04917  Prolactin signaling pathway
nsu04919  Thyroid hormone signaling pathway
nsu04921  Oxytocin signaling pathway
nsu04926  Relaxin signaling pathway
nsu04928  Parathyroid hormone synthesis, secretion and action
nsu04929  GnRH secretion
nsu04930  Type II diabetes mellitus
nsu04933  AGE-RAGE signaling pathway in diabetic complications
nsu04934  Cushing syndrome
nsu04935  Growth hormone synthesis, secretion and action
nsu04960  Aldosterone-regulated sodium reabsorption
nsu05010  Alzheimer disease
nsu05020  Prion disease
nsu05022  Pathways of neurodegeneration - multiple diseases
nsu05034  Alcoholism
nsu05132  Salmonella infection
nsu05133  Pertussis
nsu05135  Yersinia infection
nsu05140  Leishmaniasis
nsu05142  Chagas disease
nsu05145  Toxoplasmosis
nsu05152  Tuberculosis
nsu05160  Hepatitis C
nsu05161  Hepatitis B
nsu05163  Human cytomegalovirus infection
nsu05164  Influenza A
nsu05165  Human papillomavirus infection
nsu05166  Human T-cell leukemia virus 1 infection
nsu05167  Kaposi sarcoma-associated herpesvirus infection
nsu05170  Human immunodeficiency virus 1 infection
nsu05171  Coronavirus disease - COVID-19
nsu05200  Pathways in cancer
nsu05203  Viral carcinogenesis
nsu05205  Proteoglycans in cancer
nsu05206  MicroRNAs in cancer
nsu05207  Chemical carcinogenesis - receptor activation
nsu05208  Chemical carcinogenesis - reactive oxygen species
nsu05210  Colorectal cancer
nsu05211  Renal cell carcinoma
nsu05212  Pancreatic cancer
nsu05213  Endometrial cancer
nsu05214  Glioma
nsu05215  Prostate cancer
nsu05216  Thyroid cancer
nsu05218  Melanoma
nsu05219  Bladder cancer
nsu05220  Chronic myeloid leukemia
nsu05221  Acute myeloid leukemia
nsu05223  Non-small cell lung cancer
nsu05224  Breast cancer
nsu05225  Hepatocellular carcinoma
nsu05226  Gastric cancer
nsu05230  Central carbon metabolism in cancer
nsu05231  Choline metabolism in cancer
nsu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
nsu05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:nsu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    110589825 (MAPK3)
   04012 ErbB signaling pathway
    110589825 (MAPK3)
   04014 Ras signaling pathway
    110589825 (MAPK3)
   04015 Rap1 signaling pathway
    110589825 (MAPK3)
   04350 TGF-beta signaling pathway
    110589825 (MAPK3)
   04370 VEGF signaling pathway
    110589825 (MAPK3)
   04371 Apelin signaling pathway
    110589825 (MAPK3)
   04668 TNF signaling pathway
    110589825 (MAPK3)
   04066 HIF-1 signaling pathway
    110589825 (MAPK3)
   04068 FoxO signaling pathway
    110589825 (MAPK3)
   04072 Phospholipase D signaling pathway
    110589825 (MAPK3)
   04071 Sphingolipid signaling pathway
    110589825 (MAPK3)
   04024 cAMP signaling pathway
    110589825 (MAPK3)
   04022 cGMP-PKG signaling pathway
    110589825 (MAPK3)
   04151 PI3K-Akt signaling pathway
    110589825 (MAPK3)
   04150 mTOR signaling pathway
    110589825 (MAPK3)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    110589825 (MAPK3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    110589825 (MAPK3)
   04148 Efferocytosis
    110589825 (MAPK3)
  09143 Cell growth and death
   04114 Oocyte meiosis
    110589825 (MAPK3)
   04210 Apoptosis
    110589825 (MAPK3)
   04218 Cellular senescence
    110589825 (MAPK3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    110589825 (MAPK3)
   04520 Adherens junction
    110589825 (MAPK3)
   04540 Gap junction
    110589825 (MAPK3)
   04550 Signaling pathways regulating pluripotency of stem cells
    110589825 (MAPK3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    110589825 (MAPK3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    110589825 (MAPK3)
   04613 Neutrophil extracellular trap formation
    110589825 (MAPK3)
   04620 Toll-like receptor signaling pathway
    110589825 (MAPK3)
   04621 NOD-like receptor signaling pathway
    110589825 (MAPK3)
   04625 C-type lectin receptor signaling pathway
    110589825 (MAPK3)
   04650 Natural killer cell mediated cytotoxicity
    110589825 (MAPK3)
   04660 T cell receptor signaling pathway
    110589825 (MAPK3)
   04658 Th1 and Th2 cell differentiation
    110589825 (MAPK3)
   04659 Th17 cell differentiation
    110589825 (MAPK3)
   04657 IL-17 signaling pathway
    110589825 (MAPK3)
   04662 B cell receptor signaling pathway
    110589825 (MAPK3)
   04664 Fc epsilon RI signaling pathway
    110589825 (MAPK3)
   04666 Fc gamma R-mediated phagocytosis
    110589825 (MAPK3)
   04062 Chemokine signaling pathway
    110589825 (MAPK3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    110589825 (MAPK3)
   04929 GnRH secretion
    110589825 (MAPK3)
   04912 GnRH signaling pathway
    110589825 (MAPK3)
   04915 Estrogen signaling pathway
    110589825 (MAPK3)
   04914 Progesterone-mediated oocyte maturation
    110589825 (MAPK3)
   04917 Prolactin signaling pathway
    110589825 (MAPK3)
   04921 Oxytocin signaling pathway
    110589825 (MAPK3)
   04926 Relaxin signaling pathway
    110589825 (MAPK3)
   04935 Growth hormone synthesis, secretion and action
    110589825 (MAPK3)
   04919 Thyroid hormone signaling pathway
    110589825 (MAPK3)
   04928 Parathyroid hormone synthesis, secretion and action
    110589825 (MAPK3)
   04916 Melanogenesis
    110589825 (MAPK3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    110589825 (MAPK3)
   04270 Vascular smooth muscle contraction
    110589825 (MAPK3)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    110589825 (MAPK3)
  09156 Nervous system
   04724 Glutamatergic synapse
    110589825 (MAPK3)
   04725 Cholinergic synapse
    110589825 (MAPK3)
   04726 Serotonergic synapse
    110589825 (MAPK3)
   04720 Long-term potentiation
    110589825 (MAPK3)
   04730 Long-term depression
    110589825 (MAPK3)
   04723 Retrograde endocannabinoid signaling
    110589825 (MAPK3)
   04722 Neurotrophin signaling pathway
    110589825 (MAPK3)
  09158 Development and regeneration
   04360 Axon guidance
    110589825 (MAPK3)
   04380 Osteoclast differentiation
    110589825 (MAPK3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    110589825 (MAPK3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110589825 (MAPK3)
   05206 MicroRNAs in cancer
    110589825 (MAPK3)
   05205 Proteoglycans in cancer
    110589825 (MAPK3)
   05207 Chemical carcinogenesis - receptor activation
    110589825 (MAPK3)
   05208 Chemical carcinogenesis - reactive oxygen species
    110589825 (MAPK3)
   05203 Viral carcinogenesis
    110589825 (MAPK3)
   05230 Central carbon metabolism in cancer
    110589825 (MAPK3)
   05231 Choline metabolism in cancer
    110589825 (MAPK3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    110589825 (MAPK3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    110589825 (MAPK3)
   05212 Pancreatic cancer
    110589825 (MAPK3)
   05225 Hepatocellular carcinoma
    110589825 (MAPK3)
   05226 Gastric cancer
    110589825 (MAPK3)
   05214 Glioma
    110589825 (MAPK3)
   05216 Thyroid cancer
    110589825 (MAPK3)
   05221 Acute myeloid leukemia
    110589825 (MAPK3)
   05220 Chronic myeloid leukemia
    110589825 (MAPK3)
   05218 Melanoma
    110589825 (MAPK3)
   05211 Renal cell carcinoma
    110589825 (MAPK3)
   05219 Bladder cancer
    110589825 (MAPK3)
   05215 Prostate cancer
    110589825 (MAPK3)
   05213 Endometrial cancer
    110589825 (MAPK3)
   05224 Breast cancer
    110589825 (MAPK3)
   05223 Non-small cell lung cancer
    110589825 (MAPK3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    110589825 (MAPK3)
   05170 Human immunodeficiency virus 1 infection
    110589825 (MAPK3)
   05161 Hepatitis B
    110589825 (MAPK3)
   05160 Hepatitis C
    110589825 (MAPK3)
   05171 Coronavirus disease - COVID-19
    110589825 (MAPK3)
   05164 Influenza A
    110589825 (MAPK3)
   05163 Human cytomegalovirus infection
    110589825 (MAPK3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    110589825 (MAPK3)
   05165 Human papillomavirus infection
    110589825 (MAPK3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    110589825 (MAPK3)
   05135 Yersinia infection
    110589825 (MAPK3)
   05133 Pertussis
    110589825 (MAPK3)
   05152 Tuberculosis
    110589825 (MAPK3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    110589825 (MAPK3)
   05140 Leishmaniasis
    110589825 (MAPK3)
   05142 Chagas disease
    110589825 (MAPK3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110589825 (MAPK3)
   05020 Prion disease
    110589825 (MAPK3)
   05022 Pathways of neurodegeneration - multiple diseases
    110589825 (MAPK3)
  09165 Substance dependence
   05034 Alcoholism
    110589825 (MAPK3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    110589825 (MAPK3)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    110589825 (MAPK3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    110589825 (MAPK3)
   04934 Cushing syndrome
    110589825 (MAPK3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110589825 (MAPK3)
   01524 Platinum drug resistance
    110589825 (MAPK3)
   01522 Endocrine resistance
    110589825 (MAPK3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:nsu01001]
    110589825 (MAPK3)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:nsu03036]
    110589825 (MAPK3)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:nsu04147]
    110589825 (MAPK3)
Enzymes [BR:nsu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     110589825 (MAPK3)
Protein kinases [BR:nsu01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   110589825 (MAPK3)
Chromosome and associated proteins [BR:nsu03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     110589825 (MAPK3)
Exosome [BR:nsu04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   110589825 (MAPK3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Haspin_kinase FTA2 Kdo
Other DBs
NCBI-GeneID: 110589825
NCBI-ProteinID: XP_021556116
UniProt: A0A2Y9HX44
LinkDB
Position
5:159228212..159234957
AA seq 379 aa
MAAAAAQGGGGGEPRGADGVGPGVSGEVEVVKGQPFDVGPRYTELHYIGEGAYGMVSSAY
DHVRKIRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERL
KELIFQETARFQPGALEAP
NT seq 1140 nt   +upstreamnt  +downstreamnt
atggcggcggcggcggctcaggggggcgggggcggggagccccggggagctgatggggtc
ggcccgggggtctcgggggaggtggaggtagtgaaggggcagccgttcgacgtgggcccc
cgctacacggagctgcattacatcggcgagggcgcgtacggcatggtcagctcagcttac
gaccacgtgcgcaagatccgcgtggccatcaagaaaatcagccccttcgagcatcagacc
tactgccagcgcacactgcgcgagatccagatcttgctgcgcttccgccacgagaacgtc
atcggcattcgggacattctgcgggcacccaccctggaagccatgagggatgtctacatc
gtgcaggacctgatggagacagacctctacaagttgctgaaaagccagcagctgagcaac
gaccatgtttgctacttcctctaccagatcttgcggggcctcaagtatatccactcagcc
aacgtgctccaccgggatttaaagccctctaacctgctcatcaacaccacctgcgacctt
aagatctgcgattttggcctggcccggattgccgatcctgagcatgaccacactggcttc
ctgacagaatatgtggccacacgctggtaccgggctccagaaatcatgcttaactctaag
ggctacaccaagtccatcgacatctggtctgtgggctgcattctggctgagatgctctcc
aaccggcccatcttccctggcaagcactacctggaccagctcaaccacattctgggtatc
ctgggctctccatcccaggaggacttgaattgtatcatcaatatgaaggcccgaaactac
ctgcagtctctgccctccaagaccaaggtggcctgggccaagctttttcccaagtcagac
tccaaagcccttgacctgctagaccggatgttgacctttaaccccaacaaacggatcaca
gtggaagaagcactggctcacccctacttggagcagtactacgacccaacagatgagcca
gtggctgaggagcctttcaccttcgacatggagctggatgatctacccaaggaacggctg
aaggagctcatcttccaggagacagcccgcttccagcctggggcactggaggccccctaa

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