Neomonachus schauinslandi (Hawaiian monk seal): 110593311
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Entry
110593311 CDS
T08474
Symbol
TOP2A
Name
(RefSeq) DNA topoisomerase 2-alpha
KO
K03164
DNA topoisomerase II [EC:
5.6.2.2
]
Organism
nsu
Neomonachus schauinslandi (Hawaiian monk seal)
Pathway
nsu01524
Platinum drug resistance
Brite
KEGG Orthology (KO) [BR:
nsu00001
]
09160 Human Diseases
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
110593311 (TOP2A)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:
nsu03032
]
110593311 (TOP2A)
03036 Chromosome and associated proteins [BR:
nsu03036
]
110593311 (TOP2A)
Enzymes [BR:
nsu01000
]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.2 Enzymes altering nucleic acid conformation
5.6.2.2 DNA topoisomerase (ATP-hydrolysing)
110593311 (TOP2A)
DNA replication proteins [BR:
nsu03032
]
Eukaryotic type
DNA Topoisomerases
110593311 (TOP2A)
Chromosome and associated proteins [BR:
nsu03036
]
Eukaryotic type
Chromosome condensation proteins
Other regulators of chromosome condensation
110593311 (TOP2A)
Centrosome formation proteins
Centriole proteins
110593311 (TOP2A)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DNA_topoisoIV
TOPRIM_C
DNA_gyraseB
DTHCT
HATPase_c
Toprim
Microp_apicomplexa_20
Motif
Other DBs
NCBI-GeneID:
110593311
NCBI-ProteinID:
XP_021560252
UniProt:
A0A2Y9I8D9
LinkDB
All DBs
Position
15:complement(38744914..38774210)
Genome browser
AA seq
1535 aa
AA seq
DB search
MEVSPLQPVNENMQISKTKKNEDAKKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQ
MWVYDEDIGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKVDETGNPLKIIHEQVNPRWEVC
LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
WIFVNALIENPTFDSQTKENMTLQVKSFGSTCQLSEKFIKAATGCGIVESILNWVKFKAQ
VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSNECTLILTEGDSAKTLAVSGLGVVGRDK
YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
RKEWLTHFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLTRLLFPPKDDHTLKFLYDDNQRVEPEW
YIPIIPMVLINGAEGIGTGWSCKIPNFDIREVVNNIRRLMDGEEPLPMLPSYKNFRGTIE
ELAPNQYVISGEVAILNSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
GYDSDPVKAWKEAQLKVPDEEENEESDNENEAEKSDSVRDSGPTFNYLLDMPLWYLTKEK
KDELCKLRNEKEQELETLKRKSPSDLWKEDLAAFIEELEAVETKEKQEEQIGLPGKGGKA
KGKKTQMAEVLPSPSGKRVIPRVTVEMKAEAEKKIKKKIKNENTEGGSPPEDNIELEGLK
QRLEKKQKREPGTKTKKQTTLPFKPIKKGKKRNPWSDSESDMSSDESNFDVPPREIEPRR
AATKTKFTVDLDSDDGFSDFDEKTQDEDFVPSSDVSPLKTKASPKHTTKELKPQKSATSV
MDLDAGDAKDSVPFPAGSPAADFSADTEILNPVSKKKVAVKKTAAKSQSSTSSTGAKKRA
APKGPKTDPGWNADVPQKPDPPKTKIRRKRKPSTSDDSDSNFEKMISKAVTNKKSKGESE
DFHLDLDSAVAPRAKSGRAKKPIKYLEESDEDDLF
NT seq
4608 nt
NT seq
+upstream
nt +downstream
nt
atggaggtgtcaccattgcagcctgtaaatgaaaatatgcaaatcagcaaaacaaagaaa
aatgaagatgctaagaaaagactgtctattgaaagaatctatcaaaagaaaacccaactg
gaacatattttgctccgcccagacacctacattggctctgtggaattagtgacccagcaa
atgtgggtttacgatgaagatattggcattaactatagggaagtcacctttgtccctggg
ttgtacaaaatctttgatgagatcctagtcaatgctgcagacaacaaacaaagggaccca
aaaatgtcttgtattagagtcacaattgacccggaaaacaatttaattagtatatggaat
aatgggaaaggtattcctgttgttgaacacaaagttgagaagatgtatgtcccagctctc
atctttggacagctcctaacttctagtaactatgatgatgatgaaaagaaagtaacaggt
ggtcgaaatggctatggggccaaattgtgtaacatattcagtaccaaatttactgtggaa
acagccagtagagaatacaagaaaatgttcaaacagacatggatggataacatggggaga
gctggtgagatggaactcaaaccctttaatggggaagattatacatgtattaccttccag
cctgacttgtccaagtttaaaatgcaaagcctagataaagatattgttgcactaatggtt
agaagagcatatgatattgctggatccacgaaagatgtcaaagtctttctcaatggaaat
aagctgccagtaaaaggattccgtagctatgtagatatgtatttgaaggataaggtagat
gaaactggcaatccactgaaaattatccacgaacaagtaaaccccaggtgggaagtatgc
ttaacaatgagtgaaaaaggctttcagcaaattagctttgtcaacagcattgctacttcc
aagggtggcagacatgttgattatgtagctgatcagattgtgactaaacttgttgatgtt
gtgaagaagaagaacaagggtggtgttgcagtaaaagcacatcaggtgaaaaatcacatg
tggatttttgtgaatgccttaattgaaaacccaacctttgactctcagacaaaagaaaac
atgactttacaagtcaagagctttggatcaacatgccaattaagtgaaaaattcatcaaa
gctgcaactggctgtggtattgtggaaagcatactaaactgggtgaagtttaaggcccaa
gtccaattaaacaagaagtgttcagctgtaaaacataacagaatcaagggaattcccaaa
ctcgatgatgccaatgatgcagggggtcgaaactccaatgagtgtacacttatcctgact
gagggagactcagctaaaactttggctgtttcaggccttggtgtagttgggagagacaaa
tatggggttttcccacttagaggaaaaatactcaatgttcgagaagcttctcataaacag
atcatggaaaatgccgaaattaacaatatcatcaagattgtgggtcttcagtacaagaaa
aactatgaagatgaagattcattgaagactcttcgttatggaaagataatgattatgacc
gatcaggaccaagatggttcccatatcaaaggcctgctgattaattttatccatcacaac
tggccctctcttctacggcatcgttttctggaagaatttatcactcccattgtaaaggtg
tctaaaaacaaacaagaaatggcattctatagccttcctgaatttgaagaatggaagagt
tctactccaaatcataaaaaatggaaagtcaagtactacaaaggtttgggcaccagcaca
tcaaaagaagctaaagaatactttgcagatatgaaaagacatcgtattcaattcaaatat
tctggtcctgaagatgatgctgccatcagcctggcctttagcaagaaacagatcgatgat
cgaaaggaatggttaactcatttcatggaggatagaaggcaacggaagttacttggcctt
cctgaggattacttgtatggacaaactaccacatatctgacatacaatgacttcataaat
aaggaacttattctgttctcaaattctgataacgagagatctatcccatctatggtggat
ggcttgaaaccaggtcaaagaaaggttttgtttacctgtttcaaacggaatgacaagcga
gaggtgaaagttgcccagttagctgggtcagtagctgagatgtcctcttatcatcatggt
gagatgtcactaatgatgaccattatcaatttggctcagaattttgtgggtagcaataat
ctgaacctcttgcagcccattggtcagtttggtactaggctgcatggtggcaaggattct
gctagtcctcgatacatcttcacaatgctcagccctttgactcggttgttatttccacca
aaagatgatcatacattgaagtttttatatgatgacaatcaacgtgttgaacccgaatgg
tacattcctattatacccatggtgctgataaatggtgctgaaggaatcggtactgggtgg
tcctgcaaaatccccaactttgatattcgtgaggttgtaaataatatcaggcgtttgatg
gatggagaagaacctttgccaatgcttccaagttacaagaacttcaggggtactattgaa
gagctggctccaaatcaatatgtgattagtggtgaagtggctattcttaattccacaacc
attgaaatctcagagcttcctatcagaacatggactcagacatataaagaacaggttcta
gaacctatgttgaatggaactgagaagacaccacctctcataacagattatagggaatac
catacagacactactgtgaagtttgttgtgaaaatgactgaagagaaactggcagaggca
gagagagtgggactacacaaagtattcaaactccaaactagtctcacatgcaactctatg
gtgctttttgatcatgtaggatgtttaaagaaatacgacacagtgttggatattctaaga
gacttctttgaactcaggcttaaatattatggattaagaaaagaatggcttctaggaatg
cttggtgctgaatctgctaaactgaacaatcaggctcgctttatcttagagaaaatagat
ggcaaaataatcattgaaaataagcctaagaaagaattaattaaagttctgattcagagg
ggatatgattcagatcccgtgaaggcttggaaagaagcccagctaaaggtaccagatgaa
gaagagaatgaagagagtgacaatgaaaatgaagctgaaaagagtgactctgtaagagac
tctggaccaaccttcaactaccttcttgatatgcctctttggtatctcaccaaggagaag
aaggatgaactgtgcaagctgagaaatgaaaaagagcaagagctagaaacattaaagaga
aagagtccatcagatttgtggaaagaagacttggctgcttttattgaagagctggaggct
gttgaaacaaaggaaaaacaagaagaacaaataggacttcctgggaaaggggggaaagca
aaggggaaaaaaacacaaatggctgaagttttgccttctccgtccggtaaaagagtcatc
ccccgagtgaccgtagagatgaaagcagaggcagaaaagaaaattaaaaagaaaattaag
aatgaaaacactgaaggggggagccctccagaagacaatatcgaactagaaggtctgaaa
caaaggttggagaaaaaacagaaaagagaaccaggtaccaagacaaagaagcaaactaca
ttgccatttaaaccaatcaaaaaaggaaagaagagaaacccctggtctgattcagaatca
gatatgagcagtgacgaaagtaactttgatgtccctccacgagagatagagccacggaga
gcagcaacaaaaaccaaattcacagtggatttggattcagatgacggtttctcagatttt
gatgaaaaaactcaagatgaggattttgtcccatcatcagatgttagtccacttaagacc
aaagcttccccaaaacatactaccaaagaactgaagccgcagaaaagtgccacgtcagta
atggaccttgatgctggtgatgccaaggacagtgtaccatttcctgcaggttctcctgct
gctgatttctcagctgacactgaaatcctaaaccctgtttctaaaaagaaggtggcagtg
aagaagacggcagcaaaaagtcagtcttccacctccagtacaggtgccaaaaaaagggct
gcaccaaaaggacccaaaacggatccaggctggaatgctgatgtaccccagaagcctgat
ccccccaaaaccaaaattcgccgcaaaaggaagccatccacgtctgatgattccgactct
aattttgagaaaatgatttctaaagccgtcacaaacaagaaatccaagggggagagtgaa
gacttccatctggacttagactcagctgtggctcctcgggccaaatctggacgggcaaag
aaacctataaagtacctcgaagaatcggacgaagatgatctgttctaa
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