Neogale vison (American mink): 122892606
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Entry
122892606 CDS
T08764
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
nvs
Neogale vison (American mink)
Pathway
nvs05012
Parkinson disease
nvs05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
nvs00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
122892606 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
122892606 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
nvs01001
]
122892606 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
nvs04131
]
122892606 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
nvs04147
]
122892606 (LRRK2)
Enzymes [BR:
nvs01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
122892606 (LRRK2)
Protein kinases [BR:
nvs01001
]
Serine/threonine kinases: TKL group
LRRK family
122892606 (LRRK2)
Membrane trafficking [BR:
nvs04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
122892606 (LRRK2)
Exosome [BR:
nvs04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
122892606 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
LRR_4
COR-B
Ras
COR-A
LRR_14
LRR_9
Beta-prop_RSE1_2nd
LRR_NXF1-5
Arf
LRR_13
Beta-prop_EML_2
AAA_22
T2SSE
nSTAND3
Ank_2
Kdo
PduV-EutP
ABC_tran
SRPRB
GTP_EFTU
MMR_HSR1
TniB
LRR_6
AAA_7
AAA_16
TsaE
NB-ARC
MobB
Septin
G-alpha
AAA_29
NACHT
WD40_WDHD1_1st
Beta-prop_THOC3
TrwB_AAD_bind
nSTAND_NTPase5
cobW
HHO5_N
AAA_SelU
FtsK_SpoIIIE
Motif
Other DBs
NCBI-GeneID:
122892606
NCBI-ProteinID:
XP_044085249
LinkDB
All DBs
Position
12:77246365..77385380
Genome browser
AA seq
2527 aa
AA seq
DB search
MASGSCQGCEEEDEETLKKLIVRLNNVQEGKQIETLVQILEDMLVFTYADHASKLFQGKK
VHVPVLIVLDLYMRVASVQQVGWSLLCKLIEICPNTMQSLMGPQDIGHDWEVLGVHQLIL
KMLTVHNANVNLLTIGLKALDLLLTSGKITLLILDEESDIFLLIFDAMRTFSANDEVQKL
GCKALHVLFERVSEEQLTEFVENKDYMILLNALKNFKDEEEIVLHVLHCLHSLAIPCNNV
EVLMSGNVRCYNIVVEAMKTFPVNEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAV
RRYSENATLQIAALSCLALLTETIFLNQDLEEKSENQENDDEEEDKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQSSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTTLDTM
AAVAPKIITVMKSHEASLSVQLEALRAVLHFIFPGMPEESGEDTEYQHKLNMIKRQCFKN
DIHKLVLAALNKFIGNPGIQKCGLKVISSIAHSPDALEVLSLGGAIDSVLHTLQMYPDDQ
EIQCLGLSLIGCLITKKNLCIGTEHLLAKILVSSLQRFKDMAEVQIKGFQTILAILELSV
SFSNLLVHHSFDSVIFHQMSSSIMEQKDQQFLNLCCKCFAKLVMDDELKSVLLERACDQN
NSIMVECLLLLGADANGTKEATSLICQVCEKASSPKLVELLLNGGSREQDVRKALAISIG
KGDSQIISLLLRRLALDLANNSICLGGFCIGKIEPSWLGPLFPDKTSNLRKETNIGSTLA
RMVLRYQMKTSLEEGAASGSNGNFPEGVLDKFDEWTFIPDSYVDSVFGQSDDLDSEGSEG
SFLVKRKSNSISVGEFYRERALQRCSPNLQRHSNSLGPIFDHEDLLKQKRKILSSDDSLR
SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKSCISGHLEHLEKLELHQ
NALTSFPQQLCETLKCLTHLDLHSNKFTSFPYYLLKMNCIANLDVSRNDISPSVVLDPAV
KCPTLKHFNLSYNQLSSFPENLDDVVEKLEQLILEGNKIPEICSPLSLKELKILNLSKNH
ITSLSEDFLKACPKVESFSARMNYLAAMPLLPSSLTSLKLSQNRFTCVPEVILNLPHLRS
LDMSSNEIEYLPSPAHWKSLNLRELLFSFNQISILDLSEKAYVWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLTKTKKSDLGVQSATVGIDVKDWPIQI
RGKGKKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVKEN
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGYPK
HPKGIISRRDVEKFLSKKKRFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKGSLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAGIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLIKKCLKENPQERPTSAQVFDILNSAELICLMRHISIPKNFSVECMVATNH
NSKNASIWLGCGHRDKGQLLFLDLNTEKQTSEEVIDSRILCLALVPLPAEKESWIVCGTQ
SGMLLVINTEDGDKRHTLGKMTDSVTCLYCNPFPKQSKQKNFLLVGTADGNLAIFEDKTV
KCKGAAPLKILNIGNVSTPLMCLSESMNSAEKNIVWGGCGTKLFSFSDDFTIQKLIETKT
HQLFSYAAFSDSNIIAVVVDTALYVAKKNSPFVEVRDKKTEKLCELIDCVHFLKEEMVKV
NAESKHKLSYTGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRIIRIIQNFCDSVRVMMT
AQLGSLKNVMLVLGYIRKSTESSQHQKEIQSCLSVWDINLPHEVQNLEKHIEVRKELAEK
MRRVSVE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagctgtcaggggtgcgaggaggaggacgaggaaactctgaagaagttg
atagtcaggctgaacaatgtccaggaaggaaaacagatagagaccctggtccaaattctg
gaggatatgctggtgttcacgtacgccgaccacgcctccaagttatttcaaggcaaaaaa
gtccacgtgcctgtgttgatcgtcttggacttgtatatgagagtcgctagtgtgcagcag
gtgggttggtcacttctttgcaaattgatagaaatctgtccaaatacaatgcaaagctta
atgggacctcaggatattggacatgattgggaagtacttggggttcaccaactgattctt
aaaatgctaacagttcataatgccaacgtaaacctattaaccattgggctgaaggcctta
gatctccttctaacttcaggcaaaatcactttgctgatattggacgaagaaagtgatatt
ttcttgttaatttttgatgccatgcgcacgttttcagccaatgatgaagtccagaaactt
ggatgcaaagctttacatgtgctgtttgaaagagtttccgaggagcagctgaccgaattt
gttgagaataaagattatatgatcttgctcaatgcattaaaaaattttaaagatgaagag
gaaattgtgcttcatgtcctgcactgtttacattccctagcaattccttgcaataacgtt
gaagtcctcatgagtggcaacgtcaggtgttataatattgtggtagaagccatgaaaaca
ttccctgtcaatgaaaagattcaagaagtgagttgttgcttgctccatagacttacatta
ggtaatttttttaatattctggtgttaaacgaggtacatgagtttgtggtgaaagccgtg
cggcgatattcagagaacgccacattacagattgcagcactcagctgtttagcgctcctc
actgagaccattttcttaaatcaagacttagaggaaaagagtgagaatcaggagaatgat
gatgaggaagaggataaattgttctggttggaagcctgttacaaagcattgacatggcat
agaaagaacaagcatgtgcaggaggctgcatgctgggcccttaacaatctccttatgtac
caaagcagtttacatgagaagattggagatgaagatggccagttcccagctcatagggaa
gtgatgctttccatgctgatgcattcttcatcaaaagaagtcttccaggcatctgcaaat
gcattgtcaactctgttagaacaaaacgttaatttcagaaagatcctgttgtccaaagga
atatacctcaatgtactggagttaatgcagaagcatatacattctccagaagttgctgaa
agtggctgtaaaatgctaaatcatctctttgaaggaagcaacacgaccctggatacaatg
gcagcagtggcccccaaaataataacagttatgaaaagtcatgaggcatccttatcagtg
cagctggaggcactcagagctgttttacattttatatttccagggatgccagaagaatct
ggagaagatactgaatatcaacataagctaaatatgattaaaagacagtgtttcaagaat
gatattcataaactagtcctagcagctttgaacaagttcattggaaatcctgggattcag
aaatgtgggttgaaagtgatttcttctatagcacattctcctgatgcgctagaagtattg
tccttgggaggtgctattgattccgtgcttcacacgctgcagatgtatcccgatgaccaa
gaaattcaatgtctgggattaagtctgataggatgcttgattacaaagaagaatttatgc
ataggaactgagcatctgctggcaaaaattctggtttccagtttacaacgatttaaggat
atggccgaagtacagattaaaggatttcagacaatcttggcaatactggaattgtcagtg
tctttttccaacctgctggtgcatcattcctttgattctgtgatattccatcagatgtct
tctagtatcatggaacaaaaggatcaacagtttctaaacctttgttgcaagtgctttgca
aaattagttatggatgacgagttaaaaagtgtgctgctagagagagcatgtgatcagaat
aacagtatcatggttgaatgcttgcttctgttgggagcggacgccaatggaacaaaggag
gcaacgtctttaatttgtcaggtatgtgagaaagccagcagtcccaaattggtggaactg
ctactgaatggtggttcccgtgaacaagatgttcggaaggcgctggcgataagcattggg
aaaggtgacagccagatcattagcttgctcttaagaagacttgctctggatctggccaat
aatagcatttgccttggaggattttgtataggaaaaattgaaccttcatggcttggtcct
ttatttccagataagacatctaatttaagaaaagaaacaaatataggatccaccctagca
agaatggtgctcagatatcagatgaaaacttctttggaagaaggggcagcctcaggcagc
aatgggaactttcctgaaggagtacttgataaatttgatgaatggaccttcattccagac
tcctatgtggacagtgtttttggtcaaagtgatgacctggatagtgaaggaagtgaaggc
tcatttcttgtgaaaagaaaatccaattcaattagtgtaggagaattttaccgagagcgt
gccttgcagcgttgctcaccaaatttgcaaaggcattccaactcattgggacctattttc
gatcatgaagatttactgaagcaaaaaagaaaaatattgtcttcagatgactcactcagg
tcatcaaaacttcaatcccatatgaggcattcagacagcatttcttccctggcttctgag
agagaatatatcacatcattagacctttcagcaaatgaactaagagatattgatgccttg
agccagaaaagctgtatcagtggtcatttggagcatcttgaaaagctggagcttcatcag
aatgcactcacaagctttccacagcaactctgtgaaaccctgaagtgtttgacacatttg
gatttgcacagtaataaatttacatcatttccctattacttgttgaaaatgaattgtatt
gccaacctcgatgtctctcgaaacgacatcagcccttcagtagttttggatcctgcagtg
aagtgcccaaccttgaaacactttaacttgtcatataatcagctgtcttcttttcctgag
aaccttgatgatgtggtagagaaattggaacagctcattttagaaggaaataaaatacca
gaaatatgttccccattaagcctgaaggaactgaagattttaaaccttagtaaaaaccac
attacatcgctatcagaagacttccttaaggcatgtcctaaagtggagagtttcagtgcc
agaatgaattatcttgctgctatgcctcttttgccttcttccctgacaagcctaaaacta
tctcaaaacagatttacatgtgttccagaagtaattttaaatcttccacacttgcgatct
ttagatatgagcagcaatgaaattgagtatctgccgagtcctgcacactggaaatctttg
aacttaagggaactcttgttcagttttaatcagatcagcatcttggacttgagcgaaaaa
gcatatgtgtggtcaagagtagagaaactacatctttctcataataaactaaaagagatt
cctcctgagattggctgtctcgaaaacctgacctcccttgatgtcagttacaatttggag
ctgagatcctttcctaatgaaatggggaagttaagcaaaatatgggatcttcctttggat
gaactacggcttaattttgattttaaacatataggatgtaaagccaaagacatcataagg
tttctacaacagcggttaaaaaaggctgtgccctataaccgaatgaagcttatgattgtg
ggaaatactgggagtggtaaaaccaccttattgcagcaactgacaaaaaccaagaagtca
gatcttggggtgcagagcgccacagttggtatagatgtgaaagactggcctatccaaatt
agaggcaaagggaagaaggacctcattctgaatgtgtgggattttgcaggtcgtgaggaa
ttctacagtactcatccccacttcatgacccagcgagccctctaccttgctgtctatgac
cttagcaaagggcaggctgaagtggacgccatgaaaccttggctcttcaatataaaggct
cgtgcttcttcttcccctgtgattcttgttggcacacatttggatgtttctgatgaaaag
cagcgcaaagcctgcataagtaaaatcaccaaggaactcttgaacaagcgagggtttcct
gcaataagggattaccactttgtgaatgccactgaggaatctgatgctttggcaaagctt
cggaaaaccatcatcaatgagagtcttaatttcaagatccgagatcagcctgttgttggg
cagctgattccagactgctatgtagaacttgagaaaatcattttatcggagcgtaaaaat
gtgccaattgaatttcctgtaatcgaccggaaacgattattacaactcgtaaaagaaaat
cagctgcagttggatgaaaatgagcttcctcatgcagttcacttcctaaatgaatcaggg
gtccttcttcattttcaagacccagcattgcagttaagtgacttatattttgtggaaccc
aagtggctttgtaaagtcatggcacagattttgacagtgaaagtggaaggctatcctaaa
catcctaaaggaatcatttcacgtagagatgtggaaaaatttctttcaaagaaaaagaga
tttccgaagaactacatgtcacaatactttaaacttctagaaaaattccagattgccttg
ccaataggagaagaatatttgctggttccaagcagtttgtctgaccacaggcctgtgata
gagcttccgcattgtgagaactctgaaatcatcattcgactctatgaaatgccttatttt
ccaatgggattttggtccaggttaatcaatcgattacttgaaatttcaccttacatgctt
tcaggaagagaacgagcacttcgtccaaacagaatgtactggcgacaaggcatctacttg
aattggtctcctgaagcttattgtctggtaggatctgaagtcttagacaatcatcctgag
agtttcttaaaaattacagttccttcttgtagaaaaggctgtattcttctgggccaagtt
gtggaccacattgattctctcatggaagaatggtttcctggactactggagattgatatc
tgtggtgaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggtgaa
gagcatcaaaaaatcttacttgatgacttgatgaagaaagcagaagaaggagaccttcta
gtaaatccagatcaaccaaggctcaccattccaatatctcaaattgctcctgacttaatt
ttggctgacctgcctaggaatattatgttgaataatgatgaattggaatttgaacaagct
cctgagtttctcttaggtgatggcagttttggatctgtttatcgggcagcctatgaaggg
gaagaagtggctgtgaagattttcaataaacatacatcactgagactgttaagacaagag
ctggtggtcctttgccacctccaccaccccagcttaatatctttgctggcggctgggatt
cgccctcgcatgttggtgatggagttggcctccaagggttcgctggaccgcttgcttcag
caggacaaaggaagtcttaccagaaccctgcagcacaggattgcgctacacgtggctgat
ggcctgagatacctccactcggccatgattatatatcgtgacttaaagccccacaatgtg
ctgctcttcaccctgtatcccaatgctggcatcattgcgaagattgcggactatggaatt
gctcagtactgctgtaggatggggataaagacgtcagagggcacaccagggtttcgtgca
cctgaagttgctagaggaaatgttatttataaccaacaagctgatgtttattcatttggt
ttactactctatgacattttgacaactggaggtagaatagcagagggtttgaagtttcca
aatgagtttgatgaactggcaatacaaggaaaattacctgatccagttaaagaatatggc
tgtgccccatggcccatggttgagaagttaattaaaaaatgtttgaaggaaaatcctcag
gaaaggcctacttctgcccaggtctttgacattttgaattcagctgagttaatctgtctg
atgaggcatatatcaatacctaaaaactttagtgttgaatgcatggtcgctacaaatcat
aacagcaagaatgcaagcatctggctgggctgtgggcaccgtgacaaaggacagctctta
tttcttgacttaaatacagaaaaacagacttctgaggaagttattgatagtagaatactg
tgcctagctttggtgcctcttcctgcggaaaaggaaagctggatagtgtgtgggacacag
tctggcatgctcctggtcatcaataccgaagatggggataagagacatacccttggaaag
atgaccgattctgtgacttgcttgtattgcaatccctttcccaagcaaagcaagcaaaaa
aactttcttctggtgggaactgctgatggaaatttagccatttttgaagataaaactgtt
aagtgtaaaggagccgctcctttgaagatactaaatataggaaatgtcagtactccactg
atgtgtttgagtgagtccatgaattcagctgaaaaaaacatcgtgtggggaggatgtggc
acaaaacttttctcgttttctgatgacttcaccattcagaagctcattgagaccaagaca
catcagctgttttcttatgcagctttcagtgattccaacatcatagcagtggtggtagac
acggctctctacgttgctaagaaaaatagcccattcgtggaagtacgggataagaaaacc
gaaaaactctgtgaactaatagactgtgtgcactttttaaaggaggagatggtaaaagta
aatgcagaatcaaaacacaaactgtcttatactgggagggtgaaaaccctgtgcctccag
aagaacactgctctctggataggaaccggaggaggccatattttactccttgatctttca
actcgtcgaattatacgtataattcagaatttctgtgactctgtcagagtcatgatgaca
gcacagttaggaagccttaaaaatgtcatgctggttttggggtatatccggaaaagtact
gaaagttcacaacaccaaaaagaaatacaatcttgtttgtccgtttgggacatcaatctt
ccacatgaagtgcaaaacttagaaaaacatattgaagtgagaaaagaattagctgaaaaa
atgagaagagtatctgttgaataa
DBGET
integrated database retrieval system
