KEGG   Neogale vison (American mink): 122894172
Entry
122894172         CDS       T08764                                 
Symbol
AKT1
Name
(RefSeq) RAC-alpha serine/threonine-protein kinase
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
nvs  Neogale vison (American mink)
Pathway
nvs01521  EGFR tyrosine kinase inhibitor resistance
nvs01522  Endocrine resistance
nvs01524  Platinum drug resistance
nvs04010  MAPK signaling pathway
nvs04012  ErbB signaling pathway
nvs04014  Ras signaling pathway
nvs04015  Rap1 signaling pathway
nvs04022  cGMP-PKG signaling pathway
nvs04024  cAMP signaling pathway
nvs04062  Chemokine signaling pathway
nvs04066  HIF-1 signaling pathway
nvs04068  FoxO signaling pathway
nvs04071  Sphingolipid signaling pathway
nvs04072  Phospholipase D signaling pathway
nvs04140  Autophagy - animal
nvs04150  mTOR signaling pathway
nvs04151  PI3K-Akt signaling pathway
nvs04152  AMPK signaling pathway
nvs04210  Apoptosis
nvs04211  Longevity regulating pathway
nvs04213  Longevity regulating pathway - multiple species
nvs04218  Cellular senescence
nvs04261  Adrenergic signaling in cardiomyocytes
nvs04370  VEGF signaling pathway
nvs04371  Apelin signaling pathway
nvs04380  Osteoclast differentiation
nvs04510  Focal adhesion
nvs04517  IgSF CAM signaling
nvs04518  Integrin signaling
nvs04550  Signaling pathways regulating pluripotency of stem cells
nvs04611  Platelet activation
nvs04613  Neutrophil extracellular trap formation
nvs04620  Toll-like receptor signaling pathway
nvs04625  C-type lectin receptor signaling pathway
nvs04630  JAK-STAT signaling pathway
nvs04660  T cell receptor signaling pathway
nvs04662  B cell receptor signaling pathway
nvs04664  Fc epsilon RI signaling pathway
nvs04666  Fc gamma R-mediated phagosome formation
nvs04668  TNF signaling pathway
nvs04722  Neurotrophin signaling pathway
nvs04725  Cholinergic synapse
nvs04728  Dopaminergic synapse
nvs04810  Regulation of actin cytoskeleton
nvs04910  Insulin signaling pathway
nvs04914  Progesterone-mediated oocyte maturation
nvs04915  Estrogen signaling pathway
nvs04917  Prolactin signaling pathway
nvs04919  Thyroid hormone signaling pathway
nvs04920  Adipocytokine signaling pathway
nvs04922  Glucagon signaling pathway
nvs04923  Regulation of lipolysis in adipocytes
nvs04926  Relaxin signaling pathway
nvs04929  GnRH secretion
nvs04931  Insulin resistance
nvs04932  Non-alcoholic fatty liver disease
nvs04933  AGE-RAGE signaling pathway in diabetic complications
nvs04935  Growth hormone synthesis, secretion and action
nvs04936  Alcoholic liver disease
nvs04973  Carbohydrate digestion and absorption
nvs05010  Alzheimer disease
nvs05017  Spinocerebellar ataxia
nvs05132  Salmonella infection
nvs05135  Yersinia infection
nvs05142  Chagas disease
nvs05145  Toxoplasmosis
nvs05152  Tuberculosis
nvs05160  Hepatitis C
nvs05161  Hepatitis B
nvs05162  Measles
nvs05163  Human cytomegalovirus infection
nvs05164  Influenza A
nvs05165  Human papillomavirus infection
nvs05166  Human T-cell leukemia virus 1 infection
nvs05167  Kaposi sarcoma-associated herpesvirus infection
nvs05168  Herpes simplex virus 1 infection
nvs05169  Epstein-Barr virus infection
nvs05170  Human immunodeficiency virus 1 infection
nvs05200  Pathways in cancer
nvs05205  Proteoglycans in cancer
nvs05207  Chemical carcinogenesis - receptor activation
nvs05208  Chemical carcinogenesis - reactive oxygen species
nvs05210  Colorectal cancer
nvs05211  Renal cell carcinoma
nvs05212  Pancreatic cancer
nvs05213  Endometrial cancer
nvs05214  Glioma
nvs05215  Prostate cancer
nvs05218  Melanoma
nvs05220  Chronic myeloid leukemia
nvs05221  Acute myeloid leukemia
nvs05222  Small cell lung cancer
nvs05223  Non-small cell lung cancer
nvs05224  Breast cancer
nvs05225  Hepatocellular carcinoma
nvs05226  Gastric cancer
nvs05230  Central carbon metabolism in cancer
nvs05231  Choline metabolism in cancer
nvs05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
nvs05415  Diabetic cardiomyopathy
nvs05417  Lipid and atherosclerosis
nvs05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:nvs00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122894172 (AKT1)
   04012 ErbB signaling pathway
    122894172 (AKT1)
   04014 Ras signaling pathway
    122894172 (AKT1)
   04015 Rap1 signaling pathway
    122894172 (AKT1)
   04370 VEGF signaling pathway
    122894172 (AKT1)
   04371 Apelin signaling pathway
    122894172 (AKT1)
   04630 JAK-STAT signaling pathway
    122894172 (AKT1)
   04668 TNF signaling pathway
    122894172 (AKT1)
   04066 HIF-1 signaling pathway
    122894172 (AKT1)
   04068 FoxO signaling pathway
    122894172 (AKT1)
   04072 Phospholipase D signaling pathway
    122894172 (AKT1)
   04071 Sphingolipid signaling pathway
    122894172 (AKT1)
   04024 cAMP signaling pathway
    122894172 (AKT1)
   04022 cGMP-PKG signaling pathway
    122894172 (AKT1)
   04151 PI3K-Akt signaling pathway
    122894172 (AKT1)
   04152 AMPK signaling pathway
    122894172 (AKT1)
   04150 mTOR signaling pathway
    122894172 (AKT1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    122894172 (AKT1)
   04518 Integrin signaling
    122894172 (AKT1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    122894172 (AKT1)
  09143 Cell growth and death
   04210 Apoptosis
    122894172 (AKT1)
   04218 Cellular senescence
    122894172 (AKT1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122894172 (AKT1)
   04550 Signaling pathways regulating pluripotency of stem cells
    122894172 (AKT1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122894172 (AKT1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122894172 (AKT1)
   04613 Neutrophil extracellular trap formation
    122894172 (AKT1)
   04620 Toll-like receptor signaling pathway
    122894172 (AKT1)
   04625 C-type lectin receptor signaling pathway
    122894172 (AKT1)
   04660 T cell receptor signaling pathway
    122894172 (AKT1)
   04662 B cell receptor signaling pathway
    122894172 (AKT1)
   04664 Fc epsilon RI signaling pathway
    122894172 (AKT1)
   04666 Fc gamma R-mediated phagosome formation
    122894172 (AKT1)
   04062 Chemokine signaling pathway
    122894172 (AKT1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122894172 (AKT1)
   04922 Glucagon signaling pathway
    122894172 (AKT1)
   04923 Regulation of lipolysis in adipocytes
    122894172 (AKT1)
   04920 Adipocytokine signaling pathway
    122894172 (AKT1)
   04929 GnRH secretion
    122894172 (AKT1)
   04915 Estrogen signaling pathway
    122894172 (AKT1)
   04914 Progesterone-mediated oocyte maturation
    122894172 (AKT1)
   04917 Prolactin signaling pathway
    122894172 (AKT1)
   04926 Relaxin signaling pathway
    122894172 (AKT1)
   04935 Growth hormone synthesis, secretion and action
    122894172 (AKT1)
   04919 Thyroid hormone signaling pathway
    122894172 (AKT1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    122894172 (AKT1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    122894172 (AKT1)
  09156 Nervous system
   04725 Cholinergic synapse
    122894172 (AKT1)
   04728 Dopaminergic synapse
    122894172 (AKT1)
   04722 Neurotrophin signaling pathway
    122894172 (AKT1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    122894172 (AKT1)
  09149 Aging
   04211 Longevity regulating pathway
    122894172 (AKT1)
   04213 Longevity regulating pathway - multiple species
    122894172 (AKT1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122894172 (AKT1)
   05205 Proteoglycans in cancer
    122894172 (AKT1)
   05207 Chemical carcinogenesis - receptor activation
    122894172 (AKT1)
   05208 Chemical carcinogenesis - reactive oxygen species
    122894172 (AKT1)
   05230 Central carbon metabolism in cancer
    122894172 (AKT1)
   05231 Choline metabolism in cancer
    122894172 (AKT1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122894172 (AKT1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122894172 (AKT1)
   05212 Pancreatic cancer
    122894172 (AKT1)
   05225 Hepatocellular carcinoma
    122894172 (AKT1)
   05226 Gastric cancer
    122894172 (AKT1)
   05214 Glioma
    122894172 (AKT1)
   05221 Acute myeloid leukemia
    122894172 (AKT1)
   05220 Chronic myeloid leukemia
    122894172 (AKT1)
   05218 Melanoma
    122894172 (AKT1)
   05211 Renal cell carcinoma
    122894172 (AKT1)
   05215 Prostate cancer
    122894172 (AKT1)
   05213 Endometrial cancer
    122894172 (AKT1)
   05224 Breast cancer
    122894172 (AKT1)
   05222 Small cell lung cancer
    122894172 (AKT1)
   05223 Non-small cell lung cancer
    122894172 (AKT1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    122894172 (AKT1)
   05170 Human immunodeficiency virus 1 infection
    122894172 (AKT1)
   05161 Hepatitis B
    122894172 (AKT1)
   05160 Hepatitis C
    122894172 (AKT1)
   05164 Influenza A
    122894172 (AKT1)
   05162 Measles
    122894172 (AKT1)
   05168 Herpes simplex virus 1 infection
    122894172 (AKT1)
   05163 Human cytomegalovirus infection
    122894172 (AKT1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122894172 (AKT1)
   05169 Epstein-Barr virus infection
    122894172 (AKT1)
   05165 Human papillomavirus infection
    122894172 (AKT1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122894172 (AKT1)
   05135 Yersinia infection
    122894172 (AKT1)
   05152 Tuberculosis
    122894172 (AKT1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    122894172 (AKT1)
   05142 Chagas disease
    122894172 (AKT1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122894172 (AKT1)
   05017 Spinocerebellar ataxia
    122894172 (AKT1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122894172 (AKT1)
   05418 Fluid shear stress and atherosclerosis
    122894172 (AKT1)
   05415 Diabetic cardiomyopathy
    122894172 (AKT1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    122894172 (AKT1)
   04932 Non-alcoholic fatty liver disease
    122894172 (AKT1)
   04931 Insulin resistance
    122894172 (AKT1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    122894172 (AKT1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122894172 (AKT1)
   01524 Platinum drug resistance
    122894172 (AKT1)
   01522 Endocrine resistance
    122894172 (AKT1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:nvs01001]
    122894172 (AKT1)
Enzymes [BR:nvs01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     122894172 (AKT1)
Protein kinases [BR:nvs01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   122894172 (AKT1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 PH_11 Seadorna_VP7 Pkinase_fungal
Other DBs
NCBI-GeneID: 122894172
NCBI-ProteinID: XP_044087570
LinkDB
Position
13:1707376..1726938
AA seq 480 aa
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVEQRESPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEEMMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFPEDRARFYGAEIVSALHYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMLCGRLPFYNQDHEKLFEL
ILMEELRFPRTLSPEAKSLLSGLLRKDPKQRLGGGPEDAKEIMQHRFFASIVWQDVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQGDTMEGEDSERRPHFPQFSYSASGTA
NT seq 1443 nt   +upstreamnt  +downstreamnt
atgaacgacgtggccatcgtgaaggagggctggctgcacaagagaggggagtacatcaaa
acctggcggccgaggtacttcctgctcaagaacgacggcaccttcatcggctacaaggag
cggccccaggatgtggagcagcgggagtcccctctgaacaacttctccgtggctcaatgc
cagctgatgaagacggagcggccccggcccaacactttcatcatccgctgcctgcagtgg
accacggtgatcgagcggaccttccacgtggagacccctgaggagcgggaggagtggacg
accgccatccagacggtggccgatgggctcaagaggcaggaggaggagatgatggacttc
aggtcgggctcgcccagtgacaactcgggggccgaggagatggaggtgtccctggccaag
cccaagcaccgtgtgaccatgaatgagtttgagtacctgaagctgctggggaagggcacg
ttcgggaaggtgatcctggtgaaggagaaggccacgggccgctactatgccatgaaaatc
ctgaagaaggaggtcatcgtggctaaggacgaggtcgcccacacgctcacggagaaccgt
gttctccagaactcgaggcatccgttcctgacagccctgaagtactccttccagacccac
gaccgcctctgcttcgtcatggagtacgccaacgggggcgagctcttcttccacctgtcc
cgggagcgcgtgttccccgaggaccgggcccgcttctacggcgccgagatcgtgtccgcc
ctgcactacctgcactcagagaagaacgtcgtctaccgcgacctcaagctggagaacctc
atgctggacaaggacgggcacattaagatcaccgacttcggcctgtgcaaggagggcatc
aaggacggggccaccatgaagaccttctgcgggacgcccgagtacctggcccccgaggtg
ctggaggacaacgactacggccgggcggtcgactggtgggggctgggcgtggtcatgtat
gagatgctgtgcggccgcctgcccttctacaaccaggaccacgagaagctcttcgagctc
atcctcatggaggagctccgcttcccgcgcacgctcagccccgaggccaagtccctgctg
tcggggctgctccggaaggacccgaagcagaggcttggagggggcccggaggacgccaag
gagatcatgcagcaccgtttcttcgctagcatcgtgtggcaggacgtgtatgagaagaag
ctcagtccgcccttcaagccccaggtcacgtcggagacggacacccggtactttgacgag
gagttcacggcgcagatgatcaccatcacgccacccgaccaaggtgacaccatggagggc
gaggacagcgagcggaggccccacttcccacagttctcctactcggccagcggcacggcc
tga

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