KEGG   Neogale vison (American mink): 122897579
Entry
122897579         CDS       T08764                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X1
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
nvs  Neogale vison (American mink)
Pathway
nvs01521  EGFR tyrosine kinase inhibitor resistance
nvs01522  Endocrine resistance
nvs04010  MAPK signaling pathway
nvs04012  ErbB signaling pathway
nvs04068  FoxO signaling pathway
nvs04270  Vascular smooth muscle contraction
nvs04650  Natural killer cell mediated cytotoxicity
nvs04720  Long-term potentiation
nvs04726  Serotonergic synapse
nvs04730  Long-term depression
nvs04810  Regulation of actin cytoskeleton
nvs04910  Insulin signaling pathway
nvs04914  Progesterone-mediated oocyte maturation
nvs04928  Parathyroid hormone synthesis, secretion and action
nvs05010  Alzheimer disease
nvs05022  Pathways of neurodegeneration - multiple diseases
nvs05034  Alcoholism
nvs05160  Hepatitis C
nvs05161  Hepatitis B
nvs05200  Pathways in cancer
nvs05205  Proteoglycans in cancer
nvs05208  Chemical carcinogenesis - reactive oxygen species
nvs05210  Colorectal cancer
nvs05211  Renal cell carcinoma
nvs05212  Pancreatic cancer
nvs05213  Endometrial cancer
nvs05214  Glioma
nvs05215  Prostate cancer
nvs05218  Melanoma
nvs05219  Bladder cancer
nvs05220  Chronic myeloid leukemia
nvs05221  Acute myeloid leukemia
nvs05223  Non-small cell lung cancer
nvs05224  Breast cancer
nvs05225  Hepatocellular carcinoma
nvs05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:nvs00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    122897579 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    122897579 (ARAF)
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    122897579 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    122897579 (ARAF)
   04720 Long-term potentiation
    122897579 (ARAF)
   04730 Long-term depression
    122897579 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122897579 (ARAF)
   05205 Proteoglycans in cancer
    122897579 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    122897579 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122897579 (ARAF)
   05212 Pancreatic cancer
    122897579 (ARAF)
   05225 Hepatocellular carcinoma
    122897579 (ARAF)
   05226 Gastric cancer
    122897579 (ARAF)
   05214 Glioma
    122897579 (ARAF)
   05221 Acute myeloid leukemia
    122897579 (ARAF)
   05220 Chronic myeloid leukemia
    122897579 (ARAF)
   05218 Melanoma
    122897579 (ARAF)
   05211 Renal cell carcinoma
    122897579 (ARAF)
   05219 Bladder cancer
    122897579 (ARAF)
   05215 Prostate cancer
    122897579 (ARAF)
   05213 Endometrial cancer
    122897579 (ARAF)
   05224 Breast cancer
    122897579 (ARAF)
   05223 Non-small cell lung cancer
    122897579 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    122897579 (ARAF)
   05160 Hepatitis C
    122897579 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122897579 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    122897579 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    122897579 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122897579 (ARAF)
   01522 Endocrine resistance
    122897579 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:nvs01001]
    122897579 (ARAF)
Enzymes [BR:nvs01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     122897579 (ARAF)
Protein kinases [BR:nvs01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   122897579 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 Pkinase_fungal zf-RING-like TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 122897579
NCBI-ProteinID: XP_044091789
LinkDB
Position
X:complement(90065645..90076707)
AA seq 606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIEGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNCRQFYHSVQDLSGGSRQHEVPSNRPLNEPL
TPQGPSSCAPHRDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAATDSSLIQLTTQSFG
TDAAGSRGGGDGAPRGSPSPASVPSGRKSPHSKSPSEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaacggggccgagccgtcccgggcagtgggcact
gtcaaagtatatttgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctcaaggtacggggtctcaatcaggattgctgtgtg
gtctaccggctcatcgaggggcgaaagacagtcaccgcctgggacacggccattgccccc
ctggatggagaggaactcattgtagaggtccttgaagatgttccactgaccatgcataat
tttgtacggaagacattcttcagcctggcattctgtgacttctgccttaagtttctgttc
cacggcttccgctgccaaacctgtggctacaagttccaccagcattgttcctctaaagtc
cccacagtctgtgttgacatgagcaccaactgccgacagttctaccacagtgtccaggat
ttgtccggaggctccagacagcacgaagttccctcgaaccgtcccctgaatgagccacta
acccctcagggtcccagctcctgcgccccgcaccgagaccccgagcactttcccttcccc
gcgccggccaatgccccgctccagcgcatccgctccacatccactcccaatgtccacatg
gtcagcaccacagccgccacggactccagcctcatccagctcactacccagagtttcggc
actgatgctgccggtagtagaggtggtggtgatggagccccccgggggagccccagccca
gccagcgtgccctcggggaggaagtccccccattccaagtccccgtcggagcagcgggag
cggaagtccttggccgatgacaagaagaaagtgaagaatctggggtaccgggactcgggc
tattactgggaggtaccgcccagcgaagtgcagctgctgaagaggatcgggacaggctcg
ttcggcaccgtgtttcgcgggcggtggcatggcgatgtggccgtgaaggtgctcaaggtg
gcccaacccacagctgagcaggcccaggctttcaagaatgagatgcaggtgctcaggaag
acccgtcacgtcaacatcttgctgttcatgggcttcatgacccggccgggatttgccatc
atcacgcagtggtgtgagggctccagcctctaccaccacctgcacgtggccgacactcgc
ttcgacatggtccagctcattgacgtggcccggcagactgcccagggcatggactacctc
cacgccaagaacatcattcatcgagatctcaagtctaacaacatcttcctacatgagggg
ctcacagtgaagattggtgactttggcctggccacagtgaagacacggtggagtggggcc
cagcccttggagcagccctcgggctccgtgctatggatggcggctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcggatgtctacgcctatggggttgtgctctat
gagctcatgaccggctcgctgccttacagccacattggcagccgtgaccagatcatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctatctgactgcctcaagttccagcgggaggaacgtcccctcttc
ccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgagcggagt
gcctctgaaccctccttgcaccgcacccaggctgatgagttgcctgcctgcctcctcagc
gcggcccgtctcgtgccttag

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