Neogale vison (American mink): 122903179 Help Entry 122903179         CDS       T08764                                  Symbol SYNE1 Name (RefSeq) nesprin-1 isoform X1   KO K19326   nesprin-1 Organism nvs  Neogale vison (American mink) Pathway nvs04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:nvs00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     122903179 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:nvs03036]     122903179 (SYNE1) Chromosome and associated proteins [BR:nvs03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     122903179 (SYNE1) SSDB OrthologParalogGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 SYNE1 CH KASH Spectrin_SYNE1_2 SR_desmoplakin_3 SYNE3 Motif Other DBs NCBI-GeneID:  122903179 NCBI-ProteinID:  XP_044099687 LinkDB All DBs Position 1:14128275..14607373 Genome browser AA seq 8833 aa AA seqDB search MAASRTASRSPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPLAVDDLFEDMKDG VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKSMYRGSPIKLVNINSTD IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSGSTSSVDSTVSAETASPPSKRKVA TKIQGNAKKALLKWVQYTVAKQTGIEVKDFGRSWRSGLAFHSIIHAIRPELVDLERVKGR PNRENLAEAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNTGTDGQ ETDEILPGFPSFANSIQIFKREDRLILKEAKVWIEQFERDLTRAQMTESNLQDKYQSFKH FRVQYELKRKQIEHLIQPVHRDGKLSLDQALVKQSWDRVSSRLFDWHIQLDKSLPAPLGT IGAWLYRAEVALREEITIQQVHEETANTIQRKREQHKDLLQNTDAHKRAFYEIYRTRSVN GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR ESVELLLQNYISFIENTKFFEQYEVTYQILKQTAEMYVQADGSVEEAENVMKFMNETTAQ WRNLSVEVRSVRSMLEEVIANWDRYGNTVASLQAWLEDAEKMLNQSEHAKKDFFRNLPHW IQQHAAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYARADEMDRMKKEY TDCVTALSDFATEALKKMSEPVEVSFLNVKLLIQDLEDIEQRVPVMDAQYKMITKTAHLI AKESSQEEANEMFATMSRLKEQLTKVKECHSPLLYESQQLLIPLEELEKQMTFFYDSLGK INEILTVLEHEAQSSALFKQKQQELSACQESCKKTMTQIEKGSQNVQKFVTLSSVLKHFD QTKLHRQIADTHGAFQNMVKKIGDWKKHVETNSRLMKKFEESRAELEKVLRTAQEGLEEK GNPEDLLKRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQG EAPYHLLHLKIGVEKNRFLASVEECRTELDRETKLVAQEGSEKIIKEHRIFFSDKGPHHL CEKRLQLIEELCLKLPVRDPVRNTPETCHATLRELRAAIDATYMKLVEDPDKWKDYTSRI SEFSSWISAKETQLKAFKSKPFDTANHGEVKRAVEEIRNGVTTKGETLNWLKSRLKILIE VSSENEAQKQGDELAKLSGSFKALAALLSEVEKMLSNFGDCVQYKEIVQSSLEDLISGSK EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPGQAREE LRKLESTLDHVEHSREKQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE SLSSELEQTKEFSKRTEGIAVQAENLVKEASEIPLGPKNKQLLQQQAKSIKEQVKKLEDT LEEDIKTMEMVKNKWDHFGNNFETLSDWITEKEKELNALETSSSAMDMQIHQIKVTIQEI ESKMSSITELEEAAQSFAQFVTTGESARIKAKLTQIRRYWEELREHAQCLEATILGHLSQ QQKFEENLRKIQKSVSEFEDKLADPLKICSSATETYKVLQEHMDLCQALEALSSVVATTS ASAQKVAKGGSSVQEAAALQQRYEETRTRAKERQTALETLLAHWQRLEKELSTFLTWLER CEEIASSPEMDISADRVKVESELQSIQALQNEVVSRASIYSSLLQLKESLFSVASKDDVK TMKVHLEQLDERWRDLPQIINKRITFLQSAVAEHQQFDELLLSFSVWIKLFLGELQTTSE ISITDQQAAFTRHKDHTAEVESKKGELHRLRDHLVKLGALGRAENLPVLQGRAEDCFQLF EEASQVVERRQLALSQLAEFLQSHASLSGVLHRLSHTVEATDRMSKKQTDLLEKDLNRAI QDAKALESAAISLDSVLAKAQYHLKSGNSEQRTSCRTTADHLCSELERIQNLLGMKQSEA DALAVLKKAFQDQKEELLRSIEDIEERTDKERLKELTRQALQQRLRVFNQLEDELNSHEH ELCWLKDKAKQMAQKDVAFACEVDREVNRLEVTWDDTKKLIHENQGQCCGLIDLMREYQN LKSAVSKVLENASNVIATRNTIKDQEDLRWALSKHETVKNEMCNKQKELDNFTSKGKQLL SELKKIHSSDFVLVKTDMESTVDRWLDMSEKIEENMDRLRVSLTIWADVLSSKEEIDGWS NSSVPQLAESISHLNNSVRAEEVLKEFESEVKNKALRLEELHCKVNDLKELTKNPETPPD LQFIEADLRQKLEHAKEITEEAKGTLKDFTAQSTQVEKFINDMTSWLAKVEESLMNCAQA KTWEGLRKAKEIQKELQSQQSNISSTQENLNSLCRKYHSVELESLGSALTGLIKNHEAVS QLCSKTQATLQDFLEKHFSESMQQFQEWFSGIKAAAKESSDRTGDSKVLEAKLHELQNIL DSISDGQSKLDAVTQEGQTLYAHVSKQIVSSIQEQITKANEEFQAFLKQCLRDKQALQDC ALELGSFEDQHRKLNLWIHEMNERLSTENLGESKQHIPEKKNEVHKVELFLGELLAARES LDKLSQRGQLLSEEGHGAGKEGRLCSQLLTNYQNLLRTTKERLRSCQMALQEHEALEEAL QSMWSWVKGIQDRLAAAESTVGSKDTLEKRLLQIQDILLMKGEGEVKLNMAIGKGEQALR SSNKQGQKVIQTQLQTLKDVWADIMSSSVHAQSALEAVIGKWKDYLEWKHQLEQWLESVD QKVEQPLQLQPGLKEKFSLLDHFQSVVSEAEEHAGALQSLASKSRELYQKTEDDSFKEAA QEELKTQFNDIITVSKEKMRKVEEIVKDHLMYLDAVQEFTDWLHSAKEELHRWSDMSGDS SATQKKLSKIKELMDSREIGAGRLSRVESLAPAVKQNTSASGCELVDAEMQALRADWKQW EDSVLRTQTSLEDLVSQMALSEQEFSGQVAHLEQALGQFSALLTTWTQQLALLEGKNTDQ EIVECWQKGQEILDALQKSEPKTEDLKSQLNELCRFSRDLSTYSGRVSGLIKEYNCLCLQ ASKGCQNREQILQQRFRRAFKDFQQWLVNAKITTAKCFDIPQNISEVSASLQKIQEFLSE SENGQHKLNTMLSKGELLSTVLPKEKAEGIQAKVATAKEDWKNFHSNLHQKESALENLKI QMKDFEVSAEPVQDWLSKTEKLVQESSNRLYDLPAKRREQQKLQSVLEEINCYEPQLNRL REKAQQLWEGQAASKSFMHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHSQFSLGLKELQ DWMTDAVHMLESYCHPTSDKSVLDSRMLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP EGIPALQQQLQSVKDMWASLSSAAIRCKSQLEGALSKWTSYQDDVRQFSSWMDSVEAGLN ESERQYAELREKTTALGKAKLLSEEVLSYSSLLETIELKGAGMTEHYVTQLEFQDLQERY RAIKERAKEAVTRSEKLVRLHQEYQRDLKAFEVWLGQEQDKLDRHSVLEGDADSHETTLR HLQELQVRCAEGQALLNSVLHAREEVIPSGIPQTEDRALESLRQDWQAYQQRLSETRTQF NNVVNKLRLMEQKYQQVDEWLKTLESKVSVRTGRQASRAAKEMQLHQMKKWHEEVTAYKD EVEEVGARAQEVLDESHGSSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESELS LSSYSDWYSSTHKNFKNVATKIDRVDKAKMGKKMKMLEGLLKDMEKGHGLLKSAREKGER ALKYLEDGEAETLRKEIQEHMEQLKELTSAVRKEHLTLEKGLLLAKEFSDKYKALTQWIS EYQEILHAPEEPKMELYEKKAQLSKYKSLQQVVLSHEPSVRSVREKGEALLELVQDVTLK DEIDKLQGDYKDLCGAGKEHVCSLEAKVRDHEDYNSELQDVEKGLLQMSGRLVAPDLMET SSLETITQQLARHKAMMEEIAGFEDRLNNLKIKGDNLISQCADHLQAKLKQNVHAHLQGT RDSYSAICSTAQRVYQSLEHELQKHVSRQDTVQQCQAWLSAVQPDLQPSQHPPLSRAEAV KQVKHFRALQEQARTYLDLLCSMCDLSNPSVKATAKDIQQTEQMIEQRLAQAQNLTQGWG EIKHMKAELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQCKQASVTAIT ERVNKLTKNQESPEHKEISHLNDQWLDLCHQSDNLCLQREEDLQRTRDYHDCMNVVEVFL EKFTTEWDNLARSDAESTAVHLEALKKLALALQERKQAIEDLKDQKQKMIEHLNLDDKEL VKEQTSHLEQRWFQLEDLVKRKIQVSVTNLEELNVVRSRFQELMEWAEEQQPNVAEALKQ SPPPDTAQHLLMDHLSICSELEAKQMLLKSLIKDADRVMADLGLNERQIIQKALSEAQRH VNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQV KTCKSAQASLKTYQNEVTGLWAQGRELMKGVPEQEKSEVLGKLQELQSVYDTVLQKCSHR LQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESPELHTQLAKYQHILEQSP EYETVLLTLQRTGQAMLPSLNEVDHSYLNEKLNALPLQFNVVVALAKDKFYKVQEAILAR KEYGSLIELTTQSLSELEDQFLKMGKVPTDLRAEEAVSLQDGYRALLGEVVGLGEAVDEL NQKKESFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSFLEDTTSAYQEHEKMCHQLEKQ LEAVKTEQSRVNEETLPAEEKLKKYHSLAGNLQDLGIVLKRVTVHLEDLVPHLDPLAHEK AKQQIQSWQEELRRLTSAIGATVTECESRMVQSIDFQTELSRSLDWLRSVKAELRGPVCL DLRLQDIQEEIRKIQIHQEEVQSSLRILNALSNKEKEKFTKAKELISADLQHTLAELSEL DGDVQEALRTRQAVLTQIYSQCQRYYQVSQAANDWLEDAHEMLQLAGNGLDVESAEENLK SHKEFFSTEDQFHSHLEELQGLVASLDPLIKPTGKEDLAQKVASLEEKSRRIIQDSHAQL DLLQRCSAQWQDYQKAREEVIELMNDAEKKLSEFSLSKTSSSHEAEGKLSEHKSLVSLVN SFHEKVVALEDKTSQLEKTGNDASKAAISRSMTTVWQRWTRLRAVAQDQEKILEDAVEEW KSFNTKVTKASEMIDQLQDKLPDSSAEKASKAELFALLDHHETLVLELEQQHLALGLLRQ QALSMLQDGATPPPGGEPSIVQEITAMQDRCLNTQDKVKRNGKAVKQELEERDVVETQIN SVKSWIQETKEYLGNPTIEIEAQLEELQILLTEATNHRQNIEKMTEEQKNKYLGLYSILP SELSLQLAEVALELGTIHDQIQDKVKEVEQSKAMSQEFGRQIQNIAKDLTTILSKLRMKT DNITQAKTDQKVLGEELDGCNLQLVELDAAVQKFSEKNGQLGKPLAKKIGKLIELHQQTL RQAENRLSKLGQAASHLEEYNEMLDFILKWIEKAKVLLHGKITWNSAHQLREQYILHQSM LEESEEIHSHLEAMIEKLQYLASVYSTEKMSQQVAELGRESEELRQMIRIRMQNLHDAAK DMKKFETELKNLQVALEQAQTTLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVHAVQIC QSALRIPEDVVTNLPLCHAALHLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMQHLQE LIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHA TMLLTVTEVEGLAEGTEDLDRELLPATSAHPSVVMMTAGRCHTLLSPVTEESGEEGTSSE ISSPPACRSPSPVANTDASVNQDIAYYQALSPERLQTDAARIHPSSLPPQEFYEPGLEPS ATAKLDDLQRSWETLKNVISEKQRSLYEALERQQKYQDSLQSISTKMEAIEMKLSESLEP GRSPESQMAEHQSSPQALMDEILMLQDEISALQSSLAEELVSESPESDPAERLALQSTLT VLAERMSTIKMKASGKRQLLEEKLSEQLEEQRQEQALQRYRCEADELDHWLLSTKATLDT ALGTATEPMDMETQLVDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKEEAEQLAVK LRTLKGSLLELQRALHDKQLNIQQGTAQEKEESHADLTASQSPGVQDWLAQARTTWAHQR QSSLQQQKELEQELAEQKSLLRSVASRGEEILTQHSAAETSGSAGEKPDVLSQELGMEGE KSAAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDGQTQD RSAVTSLLDGLNQAFEEVSSQGGGTKRQNIHLEQKLYDGVSATSTWLDDVEERLFVATAL LPEETEACLFNQETLAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSL LDSVVNQRCHQMKERLQQILNFQNDLKVLCTSLADNKFIILQKLANVFEQPVAEQIEAIQ EAEDGLKELDAGIIELKKRGDKLQIEQPSMQELSKLQDMYDELMMTIGSRRSGLNQNLAL KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL FRKIISFAVPQETRFHAELMAQASAVLKQAHKRGVELEYILETWSHLDEDHQELSRQLEA VESSIPSVGLVEESEGRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLES QLNQLGEHWLNNTNKVSKELHRLETVLKHWTRYQSESAELTHWLQSAKDRLEFWTQQSVT VPQELEMVRDHLNAFLEFSKEVDAKSSLKSSVMSTGNQLLRLKKVDTAALRSELSHIESQ WTDLLTNIPVVQEKLHQLQMDKLPSRHAISEVMTWISLMENVIQKDEENIKNSIGYKAIH EYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQ GLVTEKIQMLEGLLESWSEYENDVQSLKTWYETQENRLKQQHRIGDQASVQNAMKDCQDL EDLIKAKEKEVEKIEQNGLALIQNKKEEVSGVVLNTLRELRQTWANLDRMVGQLKILLKS VFDQWNNHKVAFDEIHSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQEKNL QRFGSVTNQLLKECHPPVTETLTNTLKDVTMRWNNLLEEIAEQLHASKALLQLWQRYKDY SKQCASAVQQQDDRTNELLKAATNKDIADDEVATWIEDCNDLLKELGVVKDSLFVLRELG EQLKQQVDASAASALQSDQLSLSQHVCALEQALCKQQTMFQTGVLDYETFTKSLEVLEAW IVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSLAPDLDRLNELGYRLPLNDKEI KRMQSLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLIQTEQKLAVEISGNY QHLLEQQRAHELFQAEMFSRQQILHSIIIDGQHLLEQGQVDDRDEFNLKLTLLSSQWQGV IRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPVSALGSVPIPLQQARTLFDEV QFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELTEIQEKWRSASTHLEEQKKK LAFLLKDWEKCENGIANSLEKLRTFKKKLSQPLPDHHEELHAEQMRCKELENAAGSWTDD LAQLTLLKDTLCAYISADDISILNERMELLQRQWEELCHQLSLRRQQVSERLNEWAVFSE KNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAVAQENKIQLQQMGERLARAS HESKASEIEYKLGKVNDRWQHLLDLMAARVKKLKETLVAVQQLDKNMSNLRTWLAHIESE LAKPIVYESCDSDEIQKKLTEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECD SIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKISERTAAFPSS SGVLYTVAKEELKKFEAFQRQVHESLTQLELINKQYRRLARENRTDSSCRLKQMVHEGNQ RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIK QLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAVIEEELDELRRYCQEVFGRVERYH KKLIRLPLPDDEHDLSDRELELDDSAALSDLHWRDTSVDGVLSPQPSSNPSLSLAQPLRS ERSGRDTPASVDSIPLEWDHDYDLSRDLESAVSRTLPSEDEGGQDDKDFYLRGAVGLSDV MIPESPEAYVKLTESAIRNTSGAPSALESQIRQLDRALDESRFQMQQTENMIRSKTPTGP ELDSTYRGYMKLLSECSGSIDSVRRLERKLKEEEENFPGFVNLNTTETQTAGVIDRWELI QAQALSKELRMKQSLQKWQQFQADLHSVWTWLGEAEQELEQLRRVGLSTDIQAIELQIKK LKELQKAVDHRKAIILSINLCSPEFTQTGSEKSQDLQDRLCQMNGRWDRVCSLLEEWRGL LQDALMQCQDFHEMSHGLLLMLENIDRRKNEIVPIDSNLDADTLQDHHRQLSQIRNELLE SQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDMSS SQQDLSSWSSADELDTSGSVSPTSGRSTPNRQRTPRGKCSLSQPGPSVSSPHSRSIKGGS DSSLSEPQPARSGRAFWFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSF HPMLRYTNGPPPL NT seq 26502 nt NT seq  +upstreamnt  +downstreamnt atggcggcttctaggacggcctcacggtctcctcgggacattgccaacgtgatgcagaga ctgcaagatgagcaagagatagtacaaaaacgtactttcacaaaatggatcaattctcat ctggccaagcggaaacccccactggcggtagatgatctttttgaagacatgaaagatggt gttaagctgcttgctcttctggaggttctctctgggcaaaaactgccttgtgaacaagga cgccgtatgaagcgaatccatgctgtggccaatattggcacggcactcaagttccttgaa ggaaggaagtccatgtacagaggatcaccgattaaattagtcaacattaactccactgat atagctgacggccgaccatcaatagttctcggattgatgtggaccattattctatatttc cagattgaggagttgaccagcaacctgccacagctgcagtctttgtccggaagcacatcc tctgtggacagcacggttagtgcggagaccgccagccccccaagtaaacggaaggtggcc accaagatccaaggaaatgccaagaaggctctattaaagtgggttcagtacacagtagcc aagcagacaggaatcgaagtaaaagactttgggcggagctggaggagtggacttgccttt cattccatcatccacgccattcgaccggaattagtggacttggagagagtgaaagggaga cctaaccgggaaaacctggcggaggctttcactattgccgaaacagaactaggaatcccg agactgctggaccctgaagatgttgatgtggataaaccagatgagaagtctattatgact tacgtagcccagtttctgaaacattaccctgacatccacaatactggcactgatgggcaa gagactgatgaaatacttccaggttttccatcttttgcaaattctatccaaatttttaag agagaagacaggctaattttgaaggaagcaaaagtttggatagaacagtttgaaagagat ttgacaagggcacagatgacggaatcaaatttgcaagataaatatcagtcatttaagcac ttcagagttcaatatgaattaaaaaggaaacagattgaacatttaatacaacctgtacat agagacggtaaactgtcacttgaccaagcgttggtaaaacaatcctgggacagagtgtcc tccaggctctttgattggcatatacagcttgataaatctctccctgcacctctgggcacc ataggtgcttggctatacagagcagaggtggccttgagagaggaaattactattcagcag gtccatgaggaaacggccaacacaatacaacggaaacgtgagcaacacaaggatctgctt caaaacacagatgcccacaaaagagcattctatgaaatctaccggaccaggtctgttaac gggatcccagtgccacccgatcagttagaggacatggccgagaggtttcattttgtttcc tccacatcagagctgcacttaatgaaaatggaatttctagaattaaagtaccgtctgctt tcactgctggttcttgcagagtcaaagctgaaatcttggatcatcaagtatgggaggaga gagtcagtggagctgcttctgcaaaactacatctcttttatagaaaataccaagttcttt gaacagtatgaagtgacataccagatcttgaaacagacagcagagatgtacgtccaagct gatgggtcagtggaagaagccgagaatgtgatgaaattcatgaacgaaaccactgcccag tggcggaacctctcggtagaagtcagaagcgttcggagcatgctggaggaagtaattgct aactgggatcgatatggcaacactgtggccagtcttcaggcctggctagaggatgcagag aaaatgctaaatcagtcagagcatgccaaaaaggattttttccgaaatttgcctcactgg atacagcagcatgctgccatgaatgatgcgggcaatttcctaattgaaacgtgcgatgag atggtctcccgggatcttaaacagcagttactactgttgaatgggcgatggagggagctc ttcatggaagtcaagcaatatgctcgggctgatgagatggacagaatgaagaaggagtac acagactgtgtgaccgccctgtccgattttgcaactgaagcccttaagaaaatgtctgaa cccgtagaagtctcttttcttaatgtcaagttattaattcaagacttggaggacattgag cagagggtacctgtaatggacgcccagtacaagatgattaccaagactgcacacctcatt gccaaagagagctcccaagaagaagctaatgaaatgtttgcaaccatgtctaggctcaag gaacagctaaccaaggtcaaagaatgtcactctccgctcctttatgagtctcaacagctg ttgatcccattggaagaattagaaaagcagatgacattcttttatgactcacttgggaaa atcaatgaaatcttaacagttcttgagcatgaggcacaatctagtgctctttttaaacag aaacaacaggagctgtcagcttgtcaagaaagctgtaagaaaaccatgacacaaattgag aaaggcagtcaaaatgttcaaaaattcgtgaccttgagcagtgtgctaaagcattttgat cagacaaagctgcacagacagattgcagatacccatggtgctttccagaatatggtgaag aagattggagactggaagaaacatgtggaaaccaatagtcgcttgatgaagaaatttgag gagtctcgagcagagctggagaaggtgctgcggaccgcacaggagggtctggaggaaaag ggaaacccggaggacctcctgaagagacacaccgagtttttcagtcagctggatcagaga gtgctcaatgctttcctgaaagcttgcgacgagctcaccgacattctccctgagcaggag cagcagggtctgcaggaagccgttcgaaagctccataaacagtggaaggatcttcaagga gaagccccatatcatttgcttcatctgaagattggtgtggagaagaataggttcttagct tctgtagaagagtgcagaactgagctggatcgggagaccaagctggtggcccaggaaggc agtgaaaagatcattaaagaacacaggattttcttcagtgacaaaggtcctcatcatctt tgtgagaaaaggctacagcttattgaagaactgtgtctgaaactcccagtccgggacccg gtaaggaacacaccggaaacctgtcatgccactctgagagagctcagagctgccatcgat gccacctacatgaagctcgtggaagacccagacaagtggaaggactacactagcagaatt tccgagttctcatcttggatatctgcaaaggagacacagttgaaagcgtttaagagtaaa cccttcgatacggccaaccacggagaggttaaacgtgctgtagaggagatcaggaatggc gttaccacaaagggcgagactctcaactggctgaaatccaggcttaaaattttaattgaa gtttcttctgagaatgaagcccaaaagcaaggagacgagctggcaaaattatctggttct ttcaaggctctcgcagctttgttgtcagaggttgaaaagatgttaagcaactttggggac tgtgtccagtacaaagaaatagtgcaaagttcccttgaagacttaatttctggctctaaa gaagtccaggagcaggcggagaagatcctggacacggaaaacctgtttgaagcacagcag ttacttctccatcaccagcaaaagacaaagaggatttctgccaagaagcgagacgtgcag cagcagatagcgcaggctcagcagggagaaggcgggctgcccggccaggcccgggaggag ctgcggaagctggagagcaccctggaccacgtggagcacagcagggagaagcaggagcgc cgcattcaggtcacattaagaaaatgggagcgatttgaaacaaacaaagagacagtggtc agatacctttttcaaacaggttccagccatgagcgctttttgagttttagcagtttggaa agtttatcttcagaactggaacagacaaaggagttttctaaacgcacagaaggtattgca gtccaggctgaaaatcttgtgaaggaagcttctgagataccccttgggcccaagaataag cagctgcttcagcagcaggctaagtcaatcaaagagcaagtcaaaaaattagaagacaca cttgaagaagatattaaaaccatggaaatggtgaaaaacaagtgggatcattttggcaat aattttgagaccctgtccgactggataactgagaaagaaaaagaactcaatgccttggaa acttcgtcatctgccatggacatgcaaatccaccagatcaaggtcacaattcaggaaata gaaagcaagatgagcagcattacagaactagaagaagcagctcagtcttttgctcagttt 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gaggctcaacttgaagaacttcagattctcctaacggaagccacaaatcaccgacagaac attgagaaaatgactgaagagcagaagaataagtacctgggtctctactccatcttacct tctgaactgtccctccagttagccgaggtggcactggaattgggaactatccatgatcag atccaggacaaagtaaaagaagttgaacagagcaaagccatgagccaggaattcggccgg caaattcagaacatagccaaagatctcacaactattctaagtaagctgagaatgaagaca gataatataacacaagctaaaaccgaccaaaaggtgctaggagaagaattggatggctgt aatttacaattagtggaactagatgcagcagtacagaaattctcagaaaagaatggccaa ctgggtaaaccgctggctaagaagataggaaaactgattgaacttcatcagcagaccctt aggcaggctgagaaccggctctccaagctcggtcaggcagcatcccatttagaagaatac aatgaaatgcttgatttcattctgaagtggattgaaaaagctaaagtgttgctacatgga aagatcacatggaactcagcacatcaacttcgagaacaatacattttacatcagagcatg ctagaagaatctgaagagatccacagccatctggaagcaatgattgagaaattacagtac ctcgctagcgtgtactccacagaaaaaatgtctcagcaagtggcagaactggggcgggag tctgaggagctgcgacagatgatccgaattcgtatgcagaatctccacgatgctgccaag gatatgaaaaaatttgaaaccgagctaaaaaacttacaagttgctttggagcaagcccag acaaccttgacttctccagaagtcggacgtcttagtctcaaggagcaactttctcatcga cagcatttgttatctgagatggagtcactcaagccaaaggtccacgcggtgcagatctgc cagagcgccctccggatccccgaggatgtggtcaccaacttgccgctctgccatgcggcc ctgcacctgcaggaggaggccagccggctgcagcacacggccatccagcagtgcaacatc atgcaggaggctgtggtacaatatgaacagtatgagcaagaaatgcagcacctccaggag ctcatagaaggagcccacagagaaattgaggacaaacctgtggccaccagtaacatccag gagctgcaggcccagatttctcgacacgaggagctggctcagaaaatcaagggctaccag gagcagatcgcctctttgaactccaagtgcaagatgctgacgatgaaagccaagcacgcc accatgctgctgacggtgacggaggtggaggggctggccgaggggacggaggacctggac cgggagctcctccccgcgacctcggcccacccctcggtggtcatgatgactgcaggtcgc tgtcacactctgctgtcacctgtcactgaggagtctggggaggagggaaccagcagtgaa atttcctctccacctgcctgtcgctccccttcacctgtggctaataccgatgcttctgtt aaccaggacattgcttattaccaagcgctgtcccctgagaggttgcagaccgatgccgcc aggatacaccccagctcgctgccccctcaagagttctacgaaccagggctggagccctct gctactgctaaactagatgatttgcagcgttcttgggaaaccttaaaaaatgtgatcagt gaaaagcagcgcagtctctacgaggccttggaacgtcagcagaagtaccaggactccctc cagtccatctccacaaagatggaggccatcgagatgaaactcagtgagagtctggagccc ggcaggagcccggagagccagatggctgaacatcagtcttctccacaggccttgatggac gagatcctcatgcttcaagatgagatcagcgcgctccagtcatcgcttgcggaggagctg gtgtccgagtcccccgagtccgaccccgcagaacggctggccctacagtccacgctcacc gtcctggccgagcgcatgtccaccatcaagatgaaggcctcagggaagcgacagcttttg gaggagaagttaagtgagcagcttgaggaacagagacaggaacaggctctgcagaggtac cgctgtgaggccgacgagctggaccactggctcttgagcacgaaggctactctggacacg gcactgggcacagccacggagcctatggacatggagacccagctggtggactgccagaac atgctggtggaaatcgagcagaaggtggtggccttatcggaactctcagtccacaatgag aacctgctcctggagggcaaggctcacacgaaggaggaggctgagcagctggctgtaaag ctgaggaccctcaaggggagcctcctggagctgcagagagcgctgcacgacaaacagctc aacatccagcagggcacagcgcaagagaaggaggagagccatgcggacctaacggccagc cagagccctggggtccaggactggctggcccaagcccgaaccacgtgggcccaccagcga cagagcagcctccagcaacaaaaggagttggaacaggaattagccgagcagaagagcctc ctgcggtcagtagccagtcgtggagaggaaattctcacccaacactcagctgcagagacc tctggcagtgctggcgaaaaacctgatgtgttatcccaggagttggggatggaaggggag aaatcagctgctgaagaccagatgagaatgaaatgggaaagcctacatcaagaatttagt accaagcagaagctactacagaatgttctggaacaggaacaggagcaagtgctctacagc aggccgaatcgactcttgtctggtgtgccactatacaaaggagatggacagacccaagac agatctgcagtgacatctttgctggatggattgaaccaggcctttgaggaggtttcatct cagggtggggggacaaaaaggcagaacattcacttggaacagaagttgtatgatggggtc tcagctacgtctacatggttggatgatgttgaggaacgtttatttgttgccacagcactt ttaccagaagaaacggaagcttgcctcttcaaccaagagactcttgccaaagatattaaa gaaatgtctgaagaaatggataagaacaagaacttgttttctcaagcatttccagagaat ggtgataaccgggatgtcattgaagacactttgggttgtcttttgggcaggttgtccttg ctagactcagtagtaaatcagcgctgtcatcagatgaaggaaagacttcagcaaatactg aatttccagaatgatctgaaggtgctgtgcacgtcgctggctgacaacaagttcatcatt ctgcagaaactggcaaatgtgtttgaacagcctgtggcagagcaaatagaggcgatacaa gaggctgaagatgggctaaaggaattggatgcaggaatcattgaattaaaaaagcgtggg gacaagttgcagattgagcagccgtccatgcaggaactatccaaacttcaggacatgtac gatgaactgatgatgaccattggctcccggcggagcgggctgaaccagaatctcgcactt aagagtcagtacgaaagggccctacaagatctggctgacctgctggagactggacaggag aagatggcaggtgaccagaaaatcatcgtgtcctccaaagaggaaattcaacaactactt gataaacataaggaatactttcagggcctggaatctcatatgatcttgaccgaaacgctc ttcagaaagatcatcagctttgcagtcccacaggaaacacggttccacgcggaactgatg gcacaggcttccgcggtcctgaagcaggctcacaagaggggcgtggagttggagtacatt ctggagacatggtctcatttggatgaagaccaccaggagctcagcagacagctggaggcg gtggaaagcagcatcccgagcgtggggctggtggaggagagcgagggcaggctcatcgac cgcataacgctctaccagcatttgaaatccagccttaatgaataccagcccaaattatat caggtattagatgacgggaaacgactgctcatatccattagctgctcagatctagaaagc cagctaaatcaacttggagaacactggttaaataataccaacaaagtgtcaaaggagctt cacagattggaaacagtgttgaaacactggaccagatatcaaagtgaatctgcagaactt actcactggttacaatctgcaaaagacaggctagaattttggactcaacaatctgtgaca gtcccacaagaactggaaatggtccgtgatcatctcaatgctttcctggagttttccaaa gaagtagatgccaaatcgtccctgaaatcatctgttatgagcactggaaatcagcttctt cgattaaagaaagtggacacagctgccctacgttcagagctgtcacacattgagagccag tggactgacctgctgacaaatattcccgttgtacaggagaagctccaccagctccaaatg gataagctgccttcccgccatgccatttctgaagttatgacttggatttctctcatggaa aatgttattcaaaaggatgaagagaatataaaaaattcaataggttacaaggcaattcat gaataccttcagaaatataagggttttaagatagatattaactgtaaacagttgacagtt gattttgtgaatcagtccgtgctacagatcagtagtcaggatgtggaaagtaaacgcagt gataagactgattttgctgagcaactgggagccatgaacaaaagttggcaaatcctgcag ggtctcgtaactgagaagatccagatgttggaaggcttattggaatcttggtcagaatat gaaaatgatgtacaaagtctgaaaacttggtatgaaacccaggaaaacagactaaagcaa cagcatcgcattggggatcaggcttcagttcagaatgcaatgaaagactgtcaggatctg gaagatttgattaaagcaaaagaaaaagaggtggagaaaattgagcagaatggacttgct ttgattcagaacaagaaagaagaagtctctggtgttgtcctgaacacactgagggagctc aggcaaacatgggcaaatttagaccgcatggttggacaattaaagatactgctgaagtct gtgtttgaccaatggaataatcacaaggtagcctttgatgagatccacagctacctcatg gaggcgagatactctctgtcccgcttccgtctgctgactggttctttagaagctgtacaa gttcaggtagacaatcttcagaatcttcaagatgatctggaaaaacaggaaaagaactta cagaggtttggttctgtcaccaaccaactgttaaaagagtgtcacccacctgtgacagaa acgcttaccaatacattaaaagatgtcactatgagatggaataacttgctggaagagatc gctgagcagctgcacgccagcaaagccctacttcagctttggcagaggtacaaggactac tcgaagcagtgtgcctctgcggtacagcagcaggacgaccgaaccaacgagctcctgaag gcggccaccaacaaggacattgctgatgacgaggttgcgacgtggatcgaagattgcaat gatctcctcaaagaactgggggtagtgaaggattccctgtttgttctgcgtgagctggga gagcagctcaagcagcaagtggatgcttcagcggcatcagcccttcagtccgatcagctg tctttgagtcaacatgtgtgtgccctggagcaggctctttgcaagcagcagaccatgttc cagactggagttcttgactatgaaacctttaccaagagcttagaagtgttggaggcctgg atagtagaagctgaagaaatattacaagggcaggacccaagccactcatctgatctctca accatccaggaaaggatggaagaacttaaggggcagatgctaaaattcagcagcctggcc cctgacctagaccgtctgaatgagcttggatacaggctaccgctgaatgataaagaaatc aaaaggatgcagagtctgaaccgacactggtctctgatctcctctcagaccacagaaaga ttcagtaagttgcagtcatttttgctgcaacaccagactttcttggaaaaatgtgaaaca tggatggaattcctgattcaaacggaacaaaagttagcggtggagatttcaggcaactat cagcatcttttggagcagcagagagcgcatgagttgtttcaagcagagatgttcagtcgc cagcagattttgcactcaatcattattgacgggcagcatcttctagaacaaggtcaagtt gatgacagggatgaattcaacctgaaactgacacttctcagcagtcagtggcagggagtg attcgcagggcccagcagaggaggggtatcatcgacagccagattcgccagtggcagcgc tacagggagatggctgagaagctgcgtaaatggttggttgaagtgtcctatcttcccgtg agtgctctcggaagcgtccccataccactgcaacaggcaaggaccctctttgatgaagtg cagtttaaagaaaaagtgttcctgcgacagcaaggcagctacatccttacagtggaggcg ggcaagcagctcctgctctcggccgacagtggggctgaggccgcgttgcaggcagagctc actgagatccaggagaagtggagatcagccagcacgcatctggaggaacagaagaaaaaa ctggccttcttgctgaaagactgggaaaaatgtgagaacggaatagctaattctctggag aagctacgaacgttcaaaaagaagctttctcagcctctgccggatcaccatgaagagcta catgcagagcaaatgcgctgcaaggagttggaaaatgcagctgggagctggacagatgac ttggctcagctgaccctcttgaaggacaccctctgtgcctacatcagtgctgacgatatc tccatcctgaacgagcgcatggagcttctgcaaaggcagtgggaagaactctgccaccag ctctccctaaggcggcagcaagtaagtgagagattgaatgaatgggcggtcttcagtgaa aagaacaaggagctttgtgaatggctgacccagatggaaagcaaagtttctcaaaatgga gacatcctcattgaagaaatgatagagaagctcaagaaggattatcaagaggaaattgct gttgcccaagagaacaaaatacagctccagcaaatgggagaacgccttgctcgcgccagc catgaaagcaaagcctctgagattgaatacaagctcggaaaggtcaacgaccggtggcag catcttttggatctcatggcagccagggtgaagaagctaaaggagaccctggtggctgtg cagcagctagacaagaacatgagcaacctgaggacgtggttggctcacatcgagtcagag ctggccaagcccatagtctacgagtcctgtgactcggatgaaatacagaagaagctcact gagcagcaggagcttcagagagacatcgagaaacacagcacaggcgtggcgtccgtgctc aacctgtgtgaggtcctgctgcatgactgtgacgcctgtgccacagacgcagagtgtgac tccatccagcaggcgacgcgaaacctggaccggcggtggaggaacatctgtgccatgtcc atggaaagaaggctcaaaatcgaagagacgtggcgactgtggcagaagtttctggatgat tattcgcgttttgaagattggctcaagatttcagagaggacagctgccttccccagctcc tccggggtgctctatacggttgccaaggaggaactaaagaaatttgaggctttccagcga caggtacacgagagcctgacccagctggagctgatcaacaagcagtaccgtcgcctggcc agagagaaccgcaccgattcctcctgccgcctaaagcagatggttcacgaaggcaaccag cgatgggacaacctgcaaaaacgtgtcacctccatcttgcgcagactcaagcatttcatt ggccagcgtgaggagtttgagaccgcgcgggacagcattctggtgtggctgacggagatg gatctacagctcacgaatatcgagcatttttctgagtgtgacgttcaagctaaaataaag caactcaaggcctttcagcaggaaatttcactgaaccacaataagatcgagcagataatt gcccaaggagagcagctcatagagaagagcgagccgttggatgccgcagtcattgaggag gagctggatgaactccgacgttattgtcaggaggtcttcgggcgcgtggagagataccat aagaaactgattcgcctacctctcccagatgatgagcatgacctctctgaccgggagctg gagctggatgactccgcagctctctccgacctccactggcgtgacacctctgtggacggc gtgctttccccccagccttcctccaacccctccctctcactcgcccagcccctgcggagc gagcggtcgggacgagacacccctgccagtgtggactccatccccctggagtgggaccat gactatgacctcagtcgtgacctggagtctgctgtgtccagaacgctgccctctgaggac gaagggggtcaggatgataaggatttctacctcaggggagctgttggcttatcagatgta atgatccccgaaagtcctgaggcctatgtaaaactcacagaaagtgcaatcagaaatacc tctggagctcccagtgccttagagtcacagatccgacaactggacagagccttggatgag agccgttttcagatgcagcaaactgaaaatatgatccgcagcaaaactcccacaggacca gagctagactccacctacaggggctacatgaaactgctgagtgaatgcagcggcagtatc gactccgtgaggagactagaacgcaaactgaaggaggaagaagagaatttccccggcttc gttaacctgaatactacggaaacccaaacggctggtgtgatcgaccggtgggaactcatc caggcccaggccctgagcaaggagctgagaatgaaacagagtctccagaagtggcagcag ttccaggcggacctgcacagcgtctggacgtggctgggggaggcggagcaggagctggag cagctgcggcgcgtggggctcagcaccgacatccaggctatcgagctccaaatcaaaaag ctcaaggagctccagaaagccgtggaccaccgcaaagccatcatcctctccatcaacctg tgcagccccgagttcacccagaccggcagtgagaagagccaggatctgcaagaccgcttg tgccagatgaacgggcgctgggaccgggtgtgctcgctgctggaggagtggcggggcctg ctccaggacgcactgatgcagtgtcaggatttccatgaaatgagtcatggtttgcttctt atgctggagaacatcgacagaaggaaaaatgaaattgtccctattgattctaacctggat gcagacacacttcaagaccatcacaggcagctctcgcaaataaggaatgagctcttggaa tcccagctcagagtggcctcactgcaagacatgtcttgccaactcctggtgaacgctgaa ggcacagactgtttggaagccaaagaaaaagttcacgtaattgggaatcggctcaaactt ctcttgaaggaggtcagtcgtcacatcaaggagctggagaagctattagacatgtcaagc agtcagcaggatttgtcttcctggtcttcagctgatgagctggacacttcgggatctgtg agtcctacttccggaagaagcaccccaaacagacaaagaacgccacgaggcaaatgtagt ctctcacagcctggaccctctgtcagcagtccacatagcaggtccataaaaggtggctcc gattcctccctttctgagcctcagcccgctcggtccggccgagccttctggttcagagtc ctccgagcggctcttccgcttcagcttctcctgctgctcctcatcgggctcgcctgcctc gtaccgatgtcagaggaggactacagctgtgccctctccaacaactttgcccgatcattc caccccatgctccgatacacaaacggccctcctccgctctga

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