KEGG   Neogale vison (American mink): 122905138
Entry
122905138         CDS       T08764                                 
Symbol
BRAF
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X1
  KO
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
nvs  Neogale vison (American mink)
Pathway
nvs01521  EGFR tyrosine kinase inhibitor resistance
nvs01522  Endocrine resistance
nvs04010  MAPK signaling pathway
nvs04012  ErbB signaling pathway
nvs04015  Rap1 signaling pathway
nvs04024  cAMP signaling pathway
nvs04062  Chemokine signaling pathway
nvs04068  FoxO signaling pathway
nvs04150  mTOR signaling pathway
nvs04270  Vascular smooth muscle contraction
nvs04510  Focal adhesion
nvs04650  Natural killer cell mediated cytotoxicity
nvs04720  Long-term potentiation
nvs04722  Neurotrophin signaling pathway
nvs04726  Serotonergic synapse
nvs04730  Long-term depression
nvs04810  Regulation of actin cytoskeleton
nvs04910  Insulin signaling pathway
nvs04914  Progesterone-mediated oocyte maturation
nvs04928  Parathyroid hormone synthesis, secretion and action
nvs04934  Cushing syndrome
nvs05010  Alzheimer disease
nvs05022  Pathways of neurodegeneration - multiple diseases
nvs05034  Alcoholism
nvs05160  Hepatitis C
nvs05161  Hepatitis B
nvs05200  Pathways in cancer
nvs05205  Proteoglycans in cancer
nvs05208  Chemical carcinogenesis - reactive oxygen species
nvs05210  Colorectal cancer
nvs05211  Renal cell carcinoma
nvs05212  Pancreatic cancer
nvs05213  Endometrial cancer
nvs05214  Glioma
nvs05215  Prostate cancer
nvs05216  Thyroid cancer
nvs05218  Melanoma
nvs05219  Bladder cancer
nvs05220  Chronic myeloid leukemia
nvs05221  Acute myeloid leukemia
nvs05223  Non-small cell lung cancer
nvs05224  Breast cancer
nvs05225  Hepatocellular carcinoma
nvs05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:nvs00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122905138 (BRAF)
   04012 ErbB signaling pathway
    122905138 (BRAF)
   04015 Rap1 signaling pathway
    122905138 (BRAF)
   04068 FoxO signaling pathway
    122905138 (BRAF)
   04024 cAMP signaling pathway
    122905138 (BRAF)
   04150 mTOR signaling pathway
    122905138 (BRAF)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122905138 (BRAF)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122905138 (BRAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    122905138 (BRAF)
   04062 Chemokine signaling pathway
    122905138 (BRAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122905138 (BRAF)
   04914 Progesterone-mediated oocyte maturation
    122905138 (BRAF)
   04928 Parathyroid hormone synthesis, secretion and action
    122905138 (BRAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    122905138 (BRAF)
  09156 Nervous system
   04726 Serotonergic synapse
    122905138 (BRAF)
   04720 Long-term potentiation
    122905138 (BRAF)
   04730 Long-term depression
    122905138 (BRAF)
   04722 Neurotrophin signaling pathway
    122905138 (BRAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122905138 (BRAF)
   05205 Proteoglycans in cancer
    122905138 (BRAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    122905138 (BRAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122905138 (BRAF)
   05212 Pancreatic cancer
    122905138 (BRAF)
   05225 Hepatocellular carcinoma
    122905138 (BRAF)
   05226 Gastric cancer
    122905138 (BRAF)
   05214 Glioma
    122905138 (BRAF)
   05216 Thyroid cancer
    122905138 (BRAF)
   05221 Acute myeloid leukemia
    122905138 (BRAF)
   05220 Chronic myeloid leukemia
    122905138 (BRAF)
   05218 Melanoma
    122905138 (BRAF)
   05211 Renal cell carcinoma
    122905138 (BRAF)
   05219 Bladder cancer
    122905138 (BRAF)
   05215 Prostate cancer
    122905138 (BRAF)
   05213 Endometrial cancer
    122905138 (BRAF)
   05224 Breast cancer
    122905138 (BRAF)
   05223 Non-small cell lung cancer
    122905138 (BRAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    122905138 (BRAF)
   05160 Hepatitis C
    122905138 (BRAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122905138 (BRAF)
   05022 Pathways of neurodegeneration - multiple diseases
    122905138 (BRAF)
  09165 Substance dependence
   05034 Alcoholism
    122905138 (BRAF)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    122905138 (BRAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122905138 (BRAF)
   01522 Endocrine resistance
    122905138 (BRAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:nvs01001]
    122905138 (BRAF)
Enzymes [BR:nvs01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     122905138 (BRAF)
Protein kinases [BR:nvs01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   122905138 (BRAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 C1_2 Pkinase_fungal
Other DBs
NCBI-GeneID: 122905138
NCBI-ProteinID: XP_044102657
UniProt: A0A8C7BW31
LinkDB
Position
4:complement(217993872..218173412)
AA seq 764 aa
MAALSGGGGGAEQGQALFNGDMEPEAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEA
LLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASTDTVTSS
SSSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKK
ALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFF
TLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQE
EASIAETALTSGSSPSAPPSDSTGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRS
SSAPNVHINTIEPVNIDDLIRDQGFRSDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQ
RERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVK
MLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHI
IETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR
WSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD
QIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK
IHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq 2295 nt   +upstreamnt  +downstreamnt
atggcggcgctgagcggcggcggcggcggcgcggagcagggccaggctctgttcaacggg
gatatggagcccgaggccggcgccggcgccgcggcctcttcggctgcggaccctgccatt
cccgaggaggtgtggaatatcaaacaaatgattaagttgacgcaggaacatatagaagcc
ctattggacaaatttggtggggagcataatccaccgtcaatatatctggaggcctatgaa
gaatacaccagcaagctagatgccctccaacagcgagaacaacagttattggaatccctg
gggaatggaactgatttttctgtttctagctctgcatcaacagacaccgttacatcttct
tcctcctctagcctttcagtgctaccttcatctctttcagtttttcaaaatcccacagat
gtatcacggagcaatccaaagtcaccacaaaaacctattgttagagtcttcctgcccaat
aaacagaggacagtggtacctgcaagatgtggagttacagtccgagacagtctaaagaaa
gctctgatgatgagaggtctaatcccagagtgctgtgctgtttacagaattcaggatgga
gagaagaaaccgattggctgggacactgatatttcctggctcactggagaggaactacat
gtagaagtgttggaaaatgtcccacttaccacacacaactttgtacggaaaacttttttc
accttagcgttttgtgacttttgtcgaaagctgcttttccagggttttcgctgtcaaaca
tgtggttataaatttcaccagcgttgtagtacagaggttccactgatgtgtgttaattat
gaccaacttgatttgctgtttgtctccaagttctttgaacaccacccaataccacaggag
gaggcctccatagcagagactgcccttacgtctggatcatccccttctgctcccccctcc
gattctactgggccccaaatcctcaccagtccgtctccttcaaaatccattccaattcca
cagcctttccgaccagcagatgaagatcatcgaaatcaatttggacaacgagaccggtcc
tcatcagctccaaatgtacatataaacacaatagaacctgtcaatattgatgacttgatt
agagaccaagggtttcgtagtgacggaggatcaaccacaggtttgtctgccacccctcct
gcctcattgcctggctcactcactaatgtgaaagcattacagaaatctccaggacctcag
cgggaaaggaaatcatcttcatcctcagaagacaggaatcgaatgaaaacacttggtaga
cgggattcaagtgatgattgggagattcctgatgggcagatcacagtgggacagagaatt
ggatccgggtcatttgggacagtctacaaaggaaagtggcatggtgatgtggcagtgaaa
atgttgaatgtgacagcacccacacctcagcagttacaggccttcaaaaatgaagtagga
gtactcaggaaaactcgacatgtgaatatcctacttttcatgggctattcaacaaagccc
caactagctattgttacccagtggtgtgagggctccagcttatatcaccatctccacatc
atcgagaccaaatttgagatgatcaagcttatagatattgcacggcagactgcacagggc
atggattacttacacgccaagtcaatcatccacagagacctcaagagtaataatattttt
cttcatgaagacctcacagtaaaaataggtgattttggtctagccacagtgaaatctcga
tggagtgggtcccatcagtttgaacagttgtctggatccattttgtggatggcaccagaa
gtgatccgaatgcaagataaaaacccatatagctttcagtcagatgtctatgcatttggg
attgttctatatgaattgatgaccggacagttaccttattcaaacatcaacaacagggac
cagataatttttatggttggacgaggatatctttctccagatctcagtaaggttcggagt
aactgtccaaaagccatgaagagattgatggcagagtgcctaaaaaagaaaagagatgag
aggccactctttccccaaattctcgcctctattgagctgctggcccgctcattgccaaaa
attcaccgcagtgcatcagaaccctccttgaatcgggctggcttccaaacagaggatttt
agtctatatgcttgtgcttctccaaaaacacccatccaggcagggggatatggagaattt
gcagccttcaagtag

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