KEGG   Neogale vison (American mink): 122908712
Entry
122908712         CDS       T08764                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
nvs  Neogale vison (American mink)
Pathway
nvs00562  Inositol phosphate metabolism
nvs01100  Metabolic pathways
nvs01521  EGFR tyrosine kinase inhibitor resistance
nvs01522  Endocrine resistance
nvs01524  Platinum drug resistance
nvs04012  ErbB signaling pathway
nvs04014  Ras signaling pathway
nvs04015  Rap1 signaling pathway
nvs04024  cAMP signaling pathway
nvs04062  Chemokine signaling pathway
nvs04066  HIF-1 signaling pathway
nvs04068  FoxO signaling pathway
nvs04070  Phosphatidylinositol signaling system
nvs04071  Sphingolipid signaling pathway
nvs04072  Phospholipase D signaling pathway
nvs04081  Hormone signaling
nvs04140  Autophagy - animal
nvs04150  mTOR signaling pathway
nvs04151  PI3K-Akt signaling pathway
nvs04152  AMPK signaling pathway
nvs04210  Apoptosis
nvs04211  Longevity regulating pathway
nvs04213  Longevity regulating pathway - multiple species
nvs04218  Cellular senescence
nvs04360  Axon guidance
nvs04370  VEGF signaling pathway
nvs04380  Osteoclast differentiation
nvs04510  Focal adhesion
nvs04517  IgSF CAM signaling
nvs04518  Integrin signaling
nvs04550  Signaling pathways regulating pluripotency of stem cells
nvs04611  Platelet activation
nvs04613  Neutrophil extracellular trap formation
nvs04620  Toll-like receptor signaling pathway
nvs04625  C-type lectin receptor signaling pathway
nvs04630  JAK-STAT signaling pathway
nvs04650  Natural killer cell mediated cytotoxicity
nvs04660  T cell receptor signaling pathway
nvs04662  B cell receptor signaling pathway
nvs04664  Fc epsilon RI signaling pathway
nvs04666  Fc gamma R-mediated phagocytosis
nvs04668  TNF signaling pathway
nvs04670  Leukocyte transendothelial migration
nvs04722  Neurotrophin signaling pathway
nvs04725  Cholinergic synapse
nvs04750  Inflammatory mediator regulation of TRP channels
nvs04810  Regulation of actin cytoskeleton
nvs04910  Insulin signaling pathway
nvs04914  Progesterone-mediated oocyte maturation
nvs04915  Estrogen signaling pathway
nvs04917  Prolactin signaling pathway
nvs04919  Thyroid hormone signaling pathway
nvs04923  Regulation of lipolysis in adipocytes
nvs04926  Relaxin signaling pathway
nvs04929  GnRH secretion
nvs04930  Type II diabetes mellitus
nvs04931  Insulin resistance
nvs04932  Non-alcoholic fatty liver disease
nvs04933  AGE-RAGE signaling pathway in diabetic complications
nvs04935  Growth hormone synthesis, secretion and action
nvs04960  Aldosterone-regulated sodium reabsorption
nvs04973  Carbohydrate digestion and absorption
nvs05010  Alzheimer disease
nvs05017  Spinocerebellar ataxia
nvs05020  Prion disease
nvs05100  Bacterial invasion of epithelial cells
nvs05132  Salmonella infection
nvs05135  Yersinia infection
nvs05142  Chagas disease
nvs05146  Amoebiasis
nvs05160  Hepatitis C
nvs05161  Hepatitis B
nvs05162  Measles
nvs05163  Human cytomegalovirus infection
nvs05164  Influenza A
nvs05165  Human papillomavirus infection
nvs05166  Human T-cell leukemia virus 1 infection
nvs05167  Kaposi sarcoma-associated herpesvirus infection
nvs05168  Herpes simplex virus 1 infection
nvs05169  Epstein-Barr virus infection
nvs05170  Human immunodeficiency virus 1 infection
nvs05171  Coronavirus disease - COVID-19
nvs05200  Pathways in cancer
nvs05203  Viral carcinogenesis
nvs05205  Proteoglycans in cancer
nvs05206  MicroRNAs in cancer
nvs05207  Chemical carcinogenesis - receptor activation
nvs05208  Chemical carcinogenesis - reactive oxygen species
nvs05210  Colorectal cancer
nvs05211  Renal cell carcinoma
nvs05212  Pancreatic cancer
nvs05213  Endometrial cancer
nvs05214  Glioma
nvs05215  Prostate cancer
nvs05218  Melanoma
nvs05220  Chronic myeloid leukemia
nvs05221  Acute myeloid leukemia
nvs05222  Small cell lung cancer
nvs05223  Non-small cell lung cancer
nvs05224  Breast cancer
nvs05225  Hepatocellular carcinoma
nvs05226  Gastric cancer
nvs05230  Central carbon metabolism in cancer
nvs05231  Choline metabolism in cancer
nvs05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
nvs05415  Diabetic cardiomyopathy
nvs05417  Lipid and atherosclerosis
nvs05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:nvs00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    122908712 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    122908712 (PIK3CA)
   04014 Ras signaling pathway
    122908712 (PIK3CA)
   04015 Rap1 signaling pathway
    122908712 (PIK3CA)
   04370 VEGF signaling pathway
    122908712 (PIK3CA)
   04630 JAK-STAT signaling pathway
    122908712 (PIK3CA)
   04668 TNF signaling pathway
    122908712 (PIK3CA)
   04066 HIF-1 signaling pathway
    122908712 (PIK3CA)
   04068 FoxO signaling pathway
    122908712 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    122908712 (PIK3CA)
   04072 Phospholipase D signaling pathway
    122908712 (PIK3CA)
   04071 Sphingolipid signaling pathway
    122908712 (PIK3CA)
   04024 cAMP signaling pathway
    122908712 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    122908712 (PIK3CA)
   04152 AMPK signaling pathway
    122908712 (PIK3CA)
   04150 mTOR signaling pathway
    122908712 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    122908712 (PIK3CA)
   04517 IgSF CAM signaling
    122908712 (PIK3CA)
   04518 Integrin signaling
    122908712 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    122908712 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    122908712 (PIK3CA)
   04218 Cellular senescence
    122908712 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122908712 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    122908712 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122908712 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122908712 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    122908712 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    122908712 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    122908712 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    122908712 (PIK3CA)
   04660 T cell receptor signaling pathway
    122908712 (PIK3CA)
   04662 B cell receptor signaling pathway
    122908712 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    122908712 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    122908712 (PIK3CA)
   04670 Leukocyte transendothelial migration
    122908712 (PIK3CA)
   04062 Chemokine signaling pathway
    122908712 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122908712 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    122908712 (PIK3CA)
   04929 GnRH secretion
    122908712 (PIK3CA)
   04915 Estrogen signaling pathway
    122908712 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    122908712 (PIK3CA)
   04917 Prolactin signaling pathway
    122908712 (PIK3CA)
   04926 Relaxin signaling pathway
    122908712 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    122908712 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    122908712 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    122908712 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    122908712 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    122908712 (PIK3CA)
   04722 Neurotrophin signaling pathway
    122908712 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    122908712 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    122908712 (PIK3CA)
   04380 Osteoclast differentiation
    122908712 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    122908712 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    122908712 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122908712 (PIK3CA)
   05206 MicroRNAs in cancer
    122908712 (PIK3CA)
   05205 Proteoglycans in cancer
    122908712 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    122908712 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    122908712 (PIK3CA)
   05203 Viral carcinogenesis
    122908712 (PIK3CA)
   05230 Central carbon metabolism in cancer
    122908712 (PIK3CA)
   05231 Choline metabolism in cancer
    122908712 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122908712 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122908712 (PIK3CA)
   05212 Pancreatic cancer
    122908712 (PIK3CA)
   05225 Hepatocellular carcinoma
    122908712 (PIK3CA)
   05226 Gastric cancer
    122908712 (PIK3CA)
   05214 Glioma
    122908712 (PIK3CA)
   05221 Acute myeloid leukemia
    122908712 (PIK3CA)
   05220 Chronic myeloid leukemia
    122908712 (PIK3CA)
   05218 Melanoma
    122908712 (PIK3CA)
   05211 Renal cell carcinoma
    122908712 (PIK3CA)
   05215 Prostate cancer
    122908712 (PIK3CA)
   05213 Endometrial cancer
    122908712 (PIK3CA)
   05224 Breast cancer
    122908712 (PIK3CA)
   05222 Small cell lung cancer
    122908712 (PIK3CA)
   05223 Non-small cell lung cancer
    122908712 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    122908712 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    122908712 (PIK3CA)
   05161 Hepatitis B
    122908712 (PIK3CA)
   05160 Hepatitis C
    122908712 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    122908712 (PIK3CA)
   05164 Influenza A
    122908712 (PIK3CA)
   05162 Measles
    122908712 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    122908712 (PIK3CA)
   05163 Human cytomegalovirus infection
    122908712 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122908712 (PIK3CA)
   05169 Epstein-Barr virus infection
    122908712 (PIK3CA)
   05165 Human papillomavirus infection
    122908712 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122908712 (PIK3CA)
   05135 Yersinia infection
    122908712 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    122908712 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    122908712 (PIK3CA)
   05142 Chagas disease
    122908712 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122908712 (PIK3CA)
   05017 Spinocerebellar ataxia
    122908712 (PIK3CA)
   05020 Prion disease
    122908712 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122908712 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    122908712 (PIK3CA)
   05415 Diabetic cardiomyopathy
    122908712 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    122908712 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    122908712 (PIK3CA)
   04931 Insulin resistance
    122908712 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    122908712 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122908712 (PIK3CA)
   01524 Platinum drug resistance
    122908712 (PIK3CA)
   01522 Endocrine resistance
    122908712 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:nvs04131]
    122908712 (PIK3CA)
Enzymes [BR:nvs01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     122908712 (PIK3CA)
Membrane trafficking [BR:nvs04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    122908712 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 122908712
NCBI-ProteinID: XP_044107758
UniProt: A0A8C7BFI8
LinkDB
Position
6:102548531..102629483
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaagtaccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgagaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtggaatcttcaccagaactgccaaagcac
atatataataagttagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactagaagtatgttgctatcatctgaacaactcaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgagtac
ttccttgagaaatatcctctaagtcagtataagtacataagaagctgtataatgctcggg
aggatgcccaatttgatgctgatggctaaagaaagcctttattcccaactgccaatggac
tgtttcacaatgccttcatattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaatcctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
tatcatggaggagaacccttatgcgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctaaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattatacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaacaccatgcttagagttggagtttgactggttc
agcagtgtggtcaagttcccagatatgtcagtgattgaagagcacgccaactggtcggtg
tctcgagaagcaggatttagttattcccacgcaggactgagtaacagactagctagagac
aacgaattaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctatggagccacagacactattgtgtaact
atccctgaaattctacccaaactgcttctgtctgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtgaaagattggcctccaatcaaacctgaacaggctatggaa
cttttggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatacttaacagatgacaagctttctcagtacctaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggccttcttttggagtcctattgtcgtgcatgtgggatgtatttgaag
cacctaaataggcaagttgaggctatggaaaagctcattaacttaactgatatcctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcagatgcgg
cgaccagatttcatggatgctctccaaggttttctatctcctcttaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttgctctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctcacacttcaaataattcgcattatg
gaaaatatctggcaaaaccaaggtcttgatcttcgaatgttaccttatggttgtctgtca
attggtgactgtgtgggacttattgaggtggtgcgaaattctcacacgattatgcagatt
cagtgcaaaggtggcctgaaaggcgctctgcagtttaacagccacacactccaccagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctcttcacacgttca
tgtgctggatattgtgtcgctaccttcattctgggcattggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttctggatcac
aagaagaaaaaatttggttataaacgggaacgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaagctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgcgttgaactga

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