KEGG   Neogale vison (American mink): 122909192
Entry
122909192         CDS       T08764                                 
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
nvs  Neogale vison (American mink)
Pathway
nvs01521  EGFR tyrosine kinase inhibitor resistance
nvs01522  Endocrine resistance
nvs04010  MAPK signaling pathway
nvs04012  ErbB signaling pathway
nvs04014  Ras signaling pathway
nvs04015  Rap1 signaling pathway
nvs04022  cGMP-PKG signaling pathway
nvs04024  cAMP signaling pathway
nvs04062  Chemokine signaling pathway
nvs04068  FoxO signaling pathway
nvs04071  Sphingolipid signaling pathway
nvs04072  Phospholipase D signaling pathway
nvs04140  Autophagy - animal
nvs04150  mTOR signaling pathway
nvs04151  PI3K-Akt signaling pathway
nvs04210  Apoptosis
nvs04218  Cellular senescence
nvs04270  Vascular smooth muscle contraction
nvs04360  Axon guidance
nvs04370  VEGF signaling pathway
nvs04371  Apelin signaling pathway
nvs04510  Focal adhesion
nvs04540  Gap junction
nvs04550  Signaling pathways regulating pluripotency of stem cells
nvs04613  Neutrophil extracellular trap formation
nvs04625  C-type lectin receptor signaling pathway
nvs04630  JAK-STAT signaling pathway
nvs04650  Natural killer cell mediated cytotoxicity
nvs04660  T cell receptor signaling pathway
nvs04662  B cell receptor signaling pathway
nvs04664  Fc epsilon RI signaling pathway
nvs04666  Fc gamma R-mediated phagocytosis
nvs04720  Long-term potentiation
nvs04722  Neurotrophin signaling pathway
nvs04726  Serotonergic synapse
nvs04730  Long-term depression
nvs04810  Regulation of actin cytoskeleton
nvs04910  Insulin signaling pathway
nvs04912  GnRH signaling pathway
nvs04914  Progesterone-mediated oocyte maturation
nvs04915  Estrogen signaling pathway
nvs04916  Melanogenesis
nvs04917  Prolactin signaling pathway
nvs04919  Thyroid hormone signaling pathway
nvs04921  Oxytocin signaling pathway
nvs04926  Relaxin signaling pathway
nvs04928  Parathyroid hormone synthesis, secretion and action
nvs04929  GnRH secretion
nvs04935  Growth hormone synthesis, secretion and action
nvs05010  Alzheimer disease
nvs05022  Pathways of neurodegeneration - multiple diseases
nvs05034  Alcoholism
nvs05132  Salmonella infection
nvs05152  Tuberculosis
nvs05160  Hepatitis C
nvs05161  Hepatitis B
nvs05163  Human cytomegalovirus infection
nvs05164  Influenza A
nvs05165  Human papillomavirus infection
nvs05167  Kaposi sarcoma-associated herpesvirus infection
nvs05170  Human immunodeficiency virus 1 infection
nvs05200  Pathways in cancer
nvs05205  Proteoglycans in cancer
nvs05206  MicroRNAs in cancer
nvs05207  Chemical carcinogenesis - receptor activation
nvs05208  Chemical carcinogenesis - reactive oxygen species
nvs05210  Colorectal cancer
nvs05211  Renal cell carcinoma
nvs05212  Pancreatic cancer
nvs05213  Endometrial cancer
nvs05214  Glioma
nvs05215  Prostate cancer
nvs05218  Melanoma
nvs05219  Bladder cancer
nvs05220  Chronic myeloid leukemia
nvs05221  Acute myeloid leukemia
nvs05223  Non-small cell lung cancer
nvs05224  Breast cancer
nvs05225  Hepatocellular carcinoma
nvs05226  Gastric cancer
nvs05230  Central carbon metabolism in cancer
nvs05231  Choline metabolism in cancer
nvs05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:nvs00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122909192 (RAF1)
   04012 ErbB signaling pathway
    122909192 (RAF1)
   04014 Ras signaling pathway
    122909192 (RAF1)
   04015 Rap1 signaling pathway
    122909192 (RAF1)
   04370 VEGF signaling pathway
    122909192 (RAF1)
   04371 Apelin signaling pathway
    122909192 (RAF1)
   04630 JAK-STAT signaling pathway
    122909192 (RAF1)
   04068 FoxO signaling pathway
    122909192 (RAF1)
   04072 Phospholipase D signaling pathway
    122909192 (RAF1)
   04071 Sphingolipid signaling pathway
    122909192 (RAF1)
   04024 cAMP signaling pathway
    122909192 (RAF1)
   04022 cGMP-PKG signaling pathway
    122909192 (RAF1)
   04151 PI3K-Akt signaling pathway
    122909192 (RAF1)
   04150 mTOR signaling pathway
    122909192 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    122909192 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    122909192 (RAF1)
   04218 Cellular senescence
    122909192 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122909192 (RAF1)
   04540 Gap junction
    122909192 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    122909192 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122909192 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    122909192 (RAF1)
   04625 C-type lectin receptor signaling pathway
    122909192 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    122909192 (RAF1)
   04660 T cell receptor signaling pathway
    122909192 (RAF1)
   04662 B cell receptor signaling pathway
    122909192 (RAF1)
   04664 Fc epsilon RI signaling pathway
    122909192 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    122909192 (RAF1)
   04062 Chemokine signaling pathway
    122909192 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122909192 (RAF1)
   04929 GnRH secretion
    122909192 (RAF1)
   04912 GnRH signaling pathway
    122909192 (RAF1)
   04915 Estrogen signaling pathway
    122909192 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    122909192 (RAF1)
   04917 Prolactin signaling pathway
    122909192 (RAF1)
   04921 Oxytocin signaling pathway
    122909192 (RAF1)
   04926 Relaxin signaling pathway
    122909192 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    122909192 (RAF1)
   04919 Thyroid hormone signaling pathway
    122909192 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    122909192 (RAF1)
   04916 Melanogenesis
    122909192 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    122909192 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    122909192 (RAF1)
   04720 Long-term potentiation
    122909192 (RAF1)
   04730 Long-term depression
    122909192 (RAF1)
   04722 Neurotrophin signaling pathway
    122909192 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    122909192 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122909192 (RAF1)
   05206 MicroRNAs in cancer
    122909192 (RAF1)
   05205 Proteoglycans in cancer
    122909192 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    122909192 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    122909192 (RAF1)
   05230 Central carbon metabolism in cancer
    122909192 (RAF1)
   05231 Choline metabolism in cancer
    122909192 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122909192 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122909192 (RAF1)
   05212 Pancreatic cancer
    122909192 (RAF1)
   05225 Hepatocellular carcinoma
    122909192 (RAF1)
   05226 Gastric cancer
    122909192 (RAF1)
   05214 Glioma
    122909192 (RAF1)
   05221 Acute myeloid leukemia
    122909192 (RAF1)
   05220 Chronic myeloid leukemia
    122909192 (RAF1)
   05218 Melanoma
    122909192 (RAF1)
   05211 Renal cell carcinoma
    122909192 (RAF1)
   05219 Bladder cancer
    122909192 (RAF1)
   05215 Prostate cancer
    122909192 (RAF1)
   05213 Endometrial cancer
    122909192 (RAF1)
   05224 Breast cancer
    122909192 (RAF1)
   05223 Non-small cell lung cancer
    122909192 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    122909192 (RAF1)
   05161 Hepatitis B
    122909192 (RAF1)
   05160 Hepatitis C
    122909192 (RAF1)
   05164 Influenza A
    122909192 (RAF1)
   05163 Human cytomegalovirus infection
    122909192 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122909192 (RAF1)
   05165 Human papillomavirus infection
    122909192 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122909192 (RAF1)
   05152 Tuberculosis
    122909192 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122909192 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    122909192 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    122909192 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122909192 (RAF1)
   01522 Endocrine resistance
    122909192 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:nvs01001]
    122909192 (RAF1)
Enzymes [BR:nvs01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     122909192 (RAF1)
Protein kinases [BR:nvs01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   122909192 (RAF1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 122909192
NCBI-ProteinID: XP_044108900
UniProt: A0A8C7AUR1
LinkDB
Position
6:170259590..170345048
AA seq 648 aa
MEHIQGAWKTISNGFGFKDTVFDGPSCISPTIVQPFGFQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRIPVSSQHRYSTPHAFTF
NSSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1947 nt   +upstreamnt  +downstreamnt
atggagcacatacagggggcctggaagacgatcagcaacggttttggattcaaagacaca
gtgtttgacggccccagctgcatctcgcctacaatagttcagccatttggctttcagcgt
cgggcgtcagatgatggcaaacttacggactcgtctaagacaagcaacactattcgtgtt
ttcttgccaaacaagcaaagaacagtggtcaatgtgcgaaatggaatgagcttgcacgat
tgccttatgaaagcactcaaggtgaggggcctacagccggagtgctgtgctgtgttcaga
cttctccatgaacataaaggtaaaaaggcacgtttagattggaatactgatgctgcctcg
ttgattggagaagaacttcaagtagatttcctggatcacgttcccctcacaacacacaac
tttgcacggaagacctttctgaagcttgcgttctgtgacatctgtcagaagttcctgcta
aatggatttcgttgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagtt
cctactatgtgtgtggattggagtaatatcagacagctcttattgtttccaaattctact
attggtgatagtggggtcccagcactgccttctttgacgatgcgtcggatgcgagagtct
gtttcccggattcctgttagttcccagcacagatattccacaccccatgccttcacattc
aactcctccagcccttcctctgaaggttccctttcccagaggcagaggtccacgtccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgaggatgca
attcgaagccacagtgaatcagcctcaccttcagccttgtccagcagccctaacaatctg
agcccaacaggctggtcacagcccaaaacccctgtgccagcacagagagagcgggcacca
ggatctgggacccaggagaaaaacaaaattaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagcgaagtgatgctctccactcggattgggtcaggctccttt
ggaacggtgtataagggcaagtggcacggagatgttgcagtaaaaatcctaaaggttgtc
gaccccacaccagagcagttccaggccttcaggaacgaggtggctgtcctccgcaaaaca
cggcatgtgaacatcctgctcttcatggggtacatgacaaaggacaacttggcgattgtg
acccagtggtgtgaaggcagcagcctctacaaacacctgcatgtccaggagactaaattc
cagatgttccagttgattgacatcgcccgccagactgctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccacgaaggcctg
acggtgaaaattggagattttggtttggcaacagtaaagtcacgctggagtggttctcag
caagttgaacaacccactggctctgtcctgtggatggcccctgaggtgatccgaatgcag
gataacaacccgttcagcttccagtctgatgtctactcctacggcattgtgctctatgag
ctcatgacaggagagcttccttactcccacatcaataaccgtgatcagatcatcttcatg
gtgggccgagggtatgcctccccagacctcagtaagctatataagaactgccccaaagca
atgaagaggcttgtagccgactgtgtgaagaaggttaaggaagagaggcctctttttccc
cagatcctgtcttccatcgagctgctccaacattctctgccgaaaatcaaccggagtgct
tctgagccatccctgcaccgggcggcccacactgaggatatcaacgcctgcacactgact
acgtcccctagactgcctgtcttctag

DBGET integrated database retrieval system