Neogale vison (American mink): 122909912
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Entry
122909912 CDS
T08764
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
nvs
Neogale vison (American mink)
Pathway
nvs00310
Lysine degradation
nvs01100
Metabolic pathways
nvs05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
nvs00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
122909912 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
122909912 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
nvs03036
]
122909912 (DOT1L)
Enzymes [BR:
nvs01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
122909912 (DOT1L)
Chromosome and associated proteins [BR:
nvs03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
122909912 (DOT1L)
HMT complexes
Dot1-containing complex
122909912 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
122909912
NCBI-ProteinID:
XP_044110551
LinkDB
All DBs
Position
6:complement(223137239..223197058)
Genome browser
AA seq
1706 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSATTTPTKGP
ESKAAAPADAPTDSGAEEEKAGATTIKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSTA
NPERKPKKSQTALDLLHAQATPQTAAPSPQDAYKSPHSPFYQLPPSVQRHPPDQLLLAPT
PPALQKLLESFKIQYLQFLAYTKTAQYKASLQQLLDQEKEKNARLLGAAQQLFGHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLQKDNGELRTQSLRLL
KARCEELKLDWSTLSLENLLKEKQALRTQISEKQRHCLELQISIVELEKSQRRQELLQLK
SCVPPDDGLSAHLRGKGALGRELEAEPGRLHLDLDGPKFSLPHLSSASPELSMNGHAAGY
EVCGALSRPPSKQNTPQYLASPLDQDVVPCTPSHGGRPRLEKMAGLALPDYTRLSPAKLV
LRRHLSQDHAAGGKPAAGELHPRAEHAKENGLPYQSPGIANGIKLSPQDPRPSSPAALQM
TGERGSEKGVKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKVRST
PSPVSQTRESSSTLEKQMGANAHGGGSKSLAPAPTGFYTGSGTVSGVLAGSPAPLAPGAE
PGALDEVSSSGSLFAGMGSCSSAPQLPPLLPQSRGSGAASPAHPLCASPRLSSAAQGPLP
EANKGDLPSEAGVSDPEGEAKRRIVFTISAGGGAKQSPPGKPSPLPVGARGDSGQGHGPD
SRKRGRRKRAAAGTPSLSSSVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITA
ISSPESLKSSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEQGSEDEPGSARIERK
IATISLESKSPPKTLESGGGLTGRKPAPASEPANSSKWKSTFSPISDLGLAKCADSPLQA
SSALSQNSLFAFRPPLEEPGLADAKLAAHPRKGFPGALAGAGGLSPSSNPPNGFAFSGGL
TADLSLHSFSDGASLSHKVPETASLSGPLSFPTPRGKEGAAAEPGTFVNKRQLDGLSGPK
GREAGEPGLPACGPPEKASLTHSKPGKGRDRESDLKNGHNLFISAATVPPGGLLSGPGLA
TVASSTVSAAPSAQTHRPFLGTFAPGPQFALGPMSLQANLGSSVLQSLFSSVPAAAGLVH
VSSAATRLTNSHAMGSFSSGVAGGAVGGVFNHAVPPASAHPFGASVGSGVACRSGTLGLT
ARQAVAGAPASSFQAPPPPPQGQPALPAPPPPNAALPPAPALLPANSEPVLLQNLASLPA
NQAFLPASSAASLQPANASLSIKLASLPHKAPRPSFTVHHQPLPGLALAQAAPVIPQASS
TGPSAVWVSLGMPPPYAARLAGVKPR
NT seq
5121 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgaggctcaagtcgcccgtgggggccgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcacgaaatcatcgagacc
atccggtgggtctgtgaggagatcccggacctcaagctggccatggagaattacgttctc
atcgactacgacaccaaaagcttcgaaagcatgcagaggctctgtgacaagtacaaccgc
gccatcgacagcatccaccagctgtggaaggggaccacgcagcccatgaagctcaacacg
cggccgtccaacgggctcctgcggcacatcctgcagcaggtctacaaccactcggtcacg
gaccccgagaagctcaacaactacgagcccttctccccggaggtgtacggggagacctcc
ttcgacttggtcgctcagatgatcgacgagatcaagatgactgaggacgacctgtttgtg
gacctgggcagtggagtgggccaggtcgtgctacaggtcgccgcagccaccaactgtaag
catcactacggcgtggagaaagcggacatcccagccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggaaaga
ggcgacttcctctcagaagagtggagagagcggattgccaacacaagtgttatatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgccaacatg
aaggaaggtggcagaatcgtgtcctcgaagcccttcgcacctctgaactttagaataaac
agcagaaacttgagcgacatcggcaccatcatgcgggtcgtagagctctcgcccctgaag
ggctcagtgtcctggacggggaagccggtctcctactatctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaatccaaaactcagggaggagcaagaggca
gctcggcggcggcaacagcgggaaagcaagagcgccacaaccactcccaccaaggggcct
gagagcaaggctgccgcgcctgcggacgccccgacggattcgggggccgaggaagaaaaa
gctggggcaaccaccatcaaaaagccgtccccctccaaggcccggaaaaagaagctcaac
aagaaggggcggaagatggccggccggaagcgcgggcgccccaagaagatgagcactgcg
aaccccgagcgtaagcccaagaagagccaaaccgcactggacctcctgcacgcccaggcc
acgccgcagacggcagcgccctcgccgcaggacgcgtacaagtcacctcatagcccgttt
taccagctacctcccagcgtgcagcggcacccccccgaccagctgctgctggctcccacc
ccgcccgcactgcagaagctgctagagtccttcaagattcagtacttgcagttcttggcc
tacaccaagaccgcccagtataaggctagcctgcagcagctgctggaccaggagaaggag
aagaacgcccgcttgctgggcgccgcgcagcagctatttggccactgccaggcccagaag
gaggagatcaagaggctcttccagcagaagctggacgagctgggagtgaaggcgctgacc
tacaacgacctgatccaggcgcagaaggagatctcggcccacaaccagcagctgcgggag
cagacggagcagctgcagaaggacaacggggagctgaggacgcagagcctgcggctgctc
aaggctcggtgtgaggagctgaagctggactggtccacgctgtccctggagaacctgctg
aaggagaagcaggccctgaggacccagatctccgagaagcagaggcactgtctggagcta
cagatcagcatcgtggagctggagaagagccagcggcggcaggagctcctgcagctgaag
tcgtgcgtgccgcccgacgacggcctgtccgcacacctgcgtgggaagggcgccctgggc
cgggagctggaggctgagcccggccgtctgcacctcgacctggacggccccaagttctcg
ctgccgcacttgagcagcgccagcccggagctctccatgaacggccacgcggccggctac
gaggtgtgtggtgcgctgagccggcccccgtccaagcagaacacgccccagtacctggcc
tccccgctggaccaggacgtcgtgccctgtactcccagccacggtggccggccgcggctc
gagaagatggcgggcctggccttgcccgactacacccggctctccccggccaagctggtg
ctcaggcggcacctgagccaggaccatgcggccggcggcaagcctgcagccggcgagctg
cacccacgagcggagcacgccaaggagaacggccttccataccagagccctggcatcgcc
aacggtatcaagctgagccctcaggacccgcgaccgtcgtcccccgcggccttacagatg
acaggggagaggggcagcgagaagggtgtgaaggagcgcgcctacgccagcagcggggag
gccatcaccagcctgcccgtcagcatcccgctcagcaccgtgcagcccagcaaactgccc
gtcagcatccccctggccagcgtggtgctgcccagccgcgccgagaaggtgagaagcacc
cccagccctgtgtcgcagacccgagagtcctcgtccacacttgaaaagcagatgggcgct
aatgcccacggcggtggaagcaaaagcctcgctccagctcctacaggcttctacacgggc
tccgggaccgtcagcggggtgctggcaggcagcccggcccccctcgctcccggagccgag
cccggcgccttggacgaggtctcgagctcaggaagcctgttcgccggcatggggtcctgt
agctccgccccgcagctcccgcccctgctcccgcagtcccgcggctccggtgcggcctcc
cctgcccatccgctctgcgccagcccgcggctcagcagcgctgcccagggcccgctgccc
gaggccaacaaaggggaccttccctccgaggctggcgtctcagaccccgagggcgaggcc
aagaggaggatcgtctttaccatctcggctggcggtggcgccaaacagtcacctcctggc
aaacccagccctttgcctgtgggcgcccgtggggacagcggccaaggccatgggccagac
agccgtaagcggggcaggaggaagcgggcggcagccgggacccccagcctgagctccagc
gtgtcgcccaagcgtcgggccctgccgtccgtcgccggcctcttcacacagtcttcgggg
tccccgctgaacctcaactcgatggtcagcaacattaaccagcctttggaaatcacggcc
atctcgtcccctgagagcctgaagagctcccctgtcccttaccaggacaacgaccagccg
cccgttctcaagaaggagaagcccttgagccagaccaacggggcccactactccccactg
acctcagacgaggagcagggctccgaggacgagccgggcagcgccagaattgagaggaaa
attgcaaccatctccttggaaagcaaatctcctccgaaaaccttggaaagcggtggcggc
ctgaccgggaggaagccggcgcctgccagcgagcccgccaacagcagcaagtggaaatcc
accttctcgcccatctccgacctcggcctggccaagtgcgccgacagcccgctgcaggcc
agctccgccctgagccagaactccctgttcgctttccggccgcccctggaggagcctggc
ctggccgacgccaagctggccgcccacccgaggaagggctttcccggtgccctggcgggg
gccgggggactcagccccagcagcaaccctcccaacggcttcgccttcagcgggggcctg
accgccgacctcagtttacacagcttcagcgatggtgcttctctctcccacaaggtcccg
gagacggccagcttgagcggccccttgagttttcccaccccgcggggcaaggagggcgcc
gccgcagagcctggcacgtttgtgaacaagaggcagctggacggactgagtggccccaag
ggcagagaggcgggcgagccaggcctcccggcatgtgggcccccggagaaggcctcgctg
acacacagcaagccgggcaagggccgggaccgcgagtccgacttgaagaacggccacaac
ctcttcatttctgccgccactgtgcctcccgggggccttcttagcggcccgggcctcgcc
acagtggcgtcctcgacggtcagcgcggctccctctgcccagacacaccgccccttcctg
ggcacctttgcccccggcccacagttcgccctgggtcccatgtccctgcaggccaacctg
ggctcgtctgtgctgcagtccctgttcagctccgtgccggccgccgccggcctggtgcat
gtctcgtccgccgcgaccagactgaccaactcgcacgccatgggcagcttctcctctggg
gtggcaggcggcgcagttggaggtgtctttaaccacgcggtgcctcccgcctccgctcat
ccgtttggagccagtgtcggcagcggggttgcgtgtcgcagcggcacgctgggcttaacc
gcgcggcaggcggtggctggcgcccccgcgtcttcctttcaggccccgcccccgcccccg
caggggcagcccgccctccccgcaccccctccccctaacgctgccttgcctcctgcccct
gcgctgctcccggctaactctgagcccgtgcttctgcagaacctcgcgtccctcccggct
aaccaggctttcttacccgcctcctctgccgcctctctgcagcctgctaacgcctctctg
tccatcaagctcgcctccctcccgcacaaggccccccgcccctccttcacggtgcaccac
cagcccctgcccgggctggccctggcccaggccgcgcccgtgatcccgcaggccagctcc
acggggccgtctgccgtgtgggtttcccttggcatgccgcctccgtatgccgcgcgcctt
gcgggggttaagccgagataa
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