Neogale vison (American mink): 122917753 Help Entry 122917753         CDS       T08764                                  Symbol JAK2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism nvs  Neogale vison (American mink) Pathway nvs01521   EGFR tyrosine kinase inhibitor resistance nvs04062   Chemokine signaling pathway nvs04081   Hormone signaling nvs04148   Efferocytosis nvs04151   PI3K-Akt signaling pathway nvs04217   Necroptosis nvs04550   Signaling pathways regulating pluripotency of stem cells nvs04630   JAK-STAT signaling pathway nvs04658   Th1 and Th2 cell differentiation nvs04659   Th17 cell differentiation nvs04725   Cholinergic synapse nvs04917   Prolactin signaling pathway nvs04920   Adipocytokine signaling pathway nvs04933   AGE-RAGE signaling pathway in diabetic complications nvs04935   Growth hormone synthesis, secretion and action nvs05140   Leishmaniasis nvs05145   Toxoplasmosis nvs05152   Tuberculosis nvs05161   Hepatitis B nvs05164   Influenza A nvs05167   Kaposi sarcoma-associated herpesvirus infection nvs05168   Herpes simplex virus 1 infection nvs05200   Pathways in cancer nvs05207   Chemical carcinogenesis - receptor activation nvs05235   PD-L1 expression and PD-1 checkpoint pathway in cancer nvs05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:nvs00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     122917753 (JAK2)    04151 PI3K-Akt signaling pathway     122917753 (JAK2)   09133 Signaling molecules and interaction    04081 Hormone signaling     122917753 (JAK2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     122917753 (JAK2)   09143 Cell growth and death    04217 Necroptosis     122917753 (JAK2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     122917753 (JAK2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     122917753 (JAK2)    04659 Th17 cell differentiation     122917753 (JAK2)    04062 Chemokine signaling pathway     122917753 (JAK2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     122917753 (JAK2)    04917 Prolactin signaling pathway     122917753 (JAK2)    04935 Growth hormone synthesis, secretion and action     122917753 (JAK2)   09156 Nervous system    04725 Cholinergic synapse     122917753 (JAK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     122917753 (JAK2)    05207 Chemical carcinogenesis - receptor activation     122917753 (JAK2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     122917753 (JAK2)   09172 Infectious disease: viral    05161 Hepatitis B     122917753 (JAK2)    05164 Influenza A     122917753 (JAK2)    05168 Herpes simplex virus 1 infection     122917753 (JAK2)    05167 Kaposi sarcoma-associated herpesvirus infection     122917753 (JAK2)   09171 Infectious disease: bacterial    05152 Tuberculosis     122917753 (JAK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     122917753 (JAK2)    05140 Leishmaniasis     122917753 (JAK2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     122917753 (JAK2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     122917753 (JAK2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     122917753 (JAK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:nvs01001]     122917753 (JAK2) Enzymes [BR:nvs01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      122917753 (JAK2) Protein kinases [BR:nvs01001]  Non-receptor tyrosine kinases   JAK family [OT]    122917753 (JAK2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl SH2 ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M Motif Other DBs NCBI-GeneID:  122917753 NCBI-ProteinID:  XP_044121927 LinkDB All DBs Position 9:96464515..96592109 Genome browser AA seq 1130 aa AA seqDB search MACLTMTEMEGTSVSPVHQNGDIPGNANPVKQIDPLLQVYLYHSLEKAEGEYLKFPTGEY VAEEICVAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPY WYCNGSNRTYRYGISRGAEAPLLDDFVMAYLFAQWRHDFLHGWIKIPVTHETQEECLGMA VLDMMRLAKEKDQTPLDIYSSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIEQFSH CKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSRGK HKESETLTEQDLQLYCDFPDIIDVTIKQASQEGSNESRIVTIHKQDGKNLEIELSSLKEA LSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPILMDFAISKLKKAGNQTGL YVLRCSPKDFNKYFLTFAVERENAIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNCYQ METVRSDSIIFQFTKCCPPKLKDKSNLLVFRTSGISDVPISPTLQRHNNVNQMVFHKIRN EDLMFNESLGQGTFTKIFKGIRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMS QLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWAMH FLEEKALVHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPE CIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTELAN LINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPT QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEIL KSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICK GMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYA PESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELL KNNGRLPRPDGCPDEIYLIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG NT seq 3393 nt NT seq  +upstreamnt  +downstreamnt atggcttgccttacaatgacagaaatggaaggaacatccgtatctcctgtacatcagaat ggtgatattcctggaaatgctaatccggtgaagcaaatagatccactcctacaagtgtat ctttatcattctcttgagaaagctgaaggagagtatctgaagtttccaactggggagtat gttgcagaagaaatttgtgttgctgcgtctaaagcttgtggaatcacacctgtgtatcac agtatgtttgctttaatgagtgaaacagaaaggatttggtatccgcccaaccatgtcttc catatagatgaatcaaccaggcacaatgtactctacagaataagattttactttccttac tggtattgtaacggcagcaacagaacctatcggtatgggatatctcgaggtgctgaagct cctcttcttgacgactttgtcatggcctacctttttgctcagtggcggcatgatttttta catggatggataaaaatacccgtgactcatgaaacacaagaagaatgtcttggaatggct gtgttagatatgatgagactagccaaagagaaagatcagaccccattggacatctatagc tctatcagctacaagacattcttaccaaaatgtgttcgagcaaagatccaagactatcat attttgacaaggaaacgaataaggtacagatttcgcagatttattgagcagttcagccat tgcaaagccactgccagaaacttgaaactcaagtatcttataaatctggaaactcttcag tctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttcaggtgag gagatttttgcaaccattataataactggaaacggtggaattcagtggtcaagagggaaa cataaagaaagtgagacactgacagaacaggatttacagttatattgtgacttccctgat attattgatgttactattaagcaagcaagccaagaaggctcaaatgaaagtagaattgta actatacataagcaagatggtaaaaatctggaaattgaacttagctcattaaaagaagct ttatcctttgtgtcattaattgatggctattatagattaactgcagatgcacatcattac ctctgtaaagaagtagcacctccaatggtccttgaaaatatacaaagcaactgtcatggc ccaattttaatggattttgccatcagtaaactgaagaaagcaggtaatcagactggactc tatgtacttcgatgcagtcctaaggactttaataagtattttctgacttttgctgttgag cgagaaaatgccattgaatataagcactgtttgattacaaagaatgagaatggagaatac aacctcagtgggaccaagaagaacttcagtaaccttaaagatcttttgaattgctaccag atggaaactgttcgctcagacagtataattttccagtttactaaatgttgtcccccaaag ttgaaagataaatcaaaccttctagtcttcagaaccagtggcatttctgatgttcccata tcaccaacattacagaggcataataatgtgaaccaaatggtgtttcacaaaatcagaaat gaagatttgatgtttaatgaaagccttggccaaggcacttttacaaaaatttttaaaggt ataaggagagaagtaggagattatggtcaactgcatgaaacagaagttcttttaaaagtt ctggataaagctcacagaaactattccgagtctttctttgaagcagcaagcatgatgagc cagctttctcacaagcatctagttttaaattatggagtgtgtgtctgtggggaggagaat attctggttcaagagtttgtaaaatttggatcattagatacatatctgaaaaagaataaa aattctataaatatattatggaaacttgaagtggctaaacagttggcatgggccatgcat tttctagaagaaaaagcacttgttcatgggaatgtgtgtgccaaaaatattctgcttatc agagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcctggcatt agtattacagttttgccaaaggacattcttcaggagagaataccatgggtaccacctgaa tgcattgaaaatcctaaaaatctaaatttggcaacagacaaatggagttttggtaccact ttgtgggaaatctgcagtggaggagataaacctctgagtgctttggattctcaaagaaag ctacagttttatgaagataggcaccagcttcctgcaccaaagtggacagaattagcaaat cttattaataattgtatggattatgaaccagatttcagaccttctttccgagccatcata agagatcttaatagtttgtttactccagattatgaactattaacagaaaatgacatgtta ccaaatatgagaataggtgccctagggttttctggtgcttttgaagaccgagaccctaca caatttgaagagagacacttgaaatttctacagcaacttggaaagggtaattttggcagc gtggagatgtgccggtatgaccccctgcaggacaacactggggaggtggtggctgtgaag aagctccagcacagtactgaggagcacctgagagactttgagagggagattgaaatcctg aaatccctgcagcatgacaacattgtgaagtacaagggagtgtgctacagtgctggtcgg cgtaatctaagattaattatggaatatttaccatatggaagtttacgagactatctccaa aaacataaagaacggatagatcataaaaaacttctgcagtatacatctcagatatgcaag ggcatggagtatcttggtacaaaaagatatatccacagggatctggcaacaaggaatata ttggtggaaaatgaaaacagggtaaaaattggagattttgggttaaccaaagtcttgcca caagacaaagaatactacaaagtgaaagaacctggtgaaagtcccatattctggtatgct ccagaatcactgacagagagcaagttttctgtggcttcagatgtttggagctttggagtg gttctctatgaacttttcacgtatattgagaagagtaaaagtcccccagcggaatttatg cgcatgattggcaatgacaaacaaggacagatgattgtgtttcatttgatagaactcctg aagaataatggaagattaccaagaccagatggatgcccagatgagatttatttgatcatg acggaatgctggaacaataatgtcaatcaacgcccctcttttagagacctagctcttcga gttgatcaaataagggacaacatggctggatga

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