KEGG   Ornithorhynchus anatinus (platypus): 100074273
Entry
100074273         CDS       T01045                                 
Symbol
PIK3CD
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
oaa  Ornithorhynchus anatinus (platypus)
Pathway
oaa00562  Inositol phosphate metabolism
oaa01100  Metabolic pathways
oaa01521  EGFR tyrosine kinase inhibitor resistance
oaa01522  Endocrine resistance
oaa01524  Platinum drug resistance
oaa04012  ErbB signaling pathway
oaa04014  Ras signaling pathway
oaa04015  Rap1 signaling pathway
oaa04024  cAMP signaling pathway
oaa04062  Chemokine signaling pathway
oaa04066  HIF-1 signaling pathway
oaa04068  FoxO signaling pathway
oaa04070  Phosphatidylinositol signaling system
oaa04071  Sphingolipid signaling pathway
oaa04072  Phospholipase D signaling pathway
oaa04081  Hormone signaling
oaa04140  Autophagy - animal
oaa04150  mTOR signaling pathway
oaa04151  PI3K-Akt signaling pathway
oaa04152  AMPK signaling pathway
oaa04210  Apoptosis
oaa04211  Longevity regulating pathway
oaa04213  Longevity regulating pathway - multiple species
oaa04218  Cellular senescence
oaa04360  Axon guidance
oaa04370  VEGF signaling pathway
oaa04380  Osteoclast differentiation
oaa04510  Focal adhesion
oaa04550  Signaling pathways regulating pluripotency of stem cells
oaa04611  Platelet activation
oaa04613  Neutrophil extracellular trap formation
oaa04620  Toll-like receptor signaling pathway
oaa04625  C-type lectin receptor signaling pathway
oaa04630  JAK-STAT signaling pathway
oaa04650  Natural killer cell mediated cytotoxicity
oaa04660  T cell receptor signaling pathway
oaa04662  B cell receptor signaling pathway
oaa04664  Fc epsilon RI signaling pathway
oaa04666  Fc gamma R-mediated phagocytosis
oaa04668  TNF signaling pathway
oaa04670  Leukocyte transendothelial migration
oaa04722  Neurotrophin signaling pathway
oaa04725  Cholinergic synapse
oaa04750  Inflammatory mediator regulation of TRP channels
oaa04810  Regulation of actin cytoskeleton
oaa04910  Insulin signaling pathway
oaa04914  Progesterone-mediated oocyte maturation
oaa04915  Estrogen signaling pathway
oaa04917  Prolactin signaling pathway
oaa04919  Thyroid hormone signaling pathway
oaa04923  Regulation of lipolysis in adipocytes
oaa04926  Relaxin signaling pathway
oaa04929  GnRH secretion
oaa04930  Type II diabetes mellitus
oaa04931  Insulin resistance
oaa04932  Non-alcoholic fatty liver disease
oaa04933  AGE-RAGE signaling pathway in diabetic complications
oaa04935  Growth hormone synthesis, secretion and action
oaa04960  Aldosterone-regulated sodium reabsorption
oaa04973  Carbohydrate digestion and absorption
oaa05010  Alzheimer disease
oaa05017  Spinocerebellar ataxia
oaa05020  Prion disease
oaa05100  Bacterial invasion of epithelial cells
oaa05132  Salmonella infection
oaa05135  Yersinia infection
oaa05142  Chagas disease
oaa05146  Amoebiasis
oaa05160  Hepatitis C
oaa05161  Hepatitis B
oaa05162  Measles
oaa05163  Human cytomegalovirus infection
oaa05164  Influenza A
oaa05165  Human papillomavirus infection
oaa05166  Human T-cell leukemia virus 1 infection
oaa05167  Kaposi sarcoma-associated herpesvirus infection
oaa05168  Herpes simplex virus 1 infection
oaa05169  Epstein-Barr virus infection
oaa05170  Human immunodeficiency virus 1 infection
oaa05171  Coronavirus disease - COVID-19
oaa05200  Pathways in cancer
oaa05203  Viral carcinogenesis
oaa05205  Proteoglycans in cancer
oaa05206  MicroRNAs in cancer
oaa05207  Chemical carcinogenesis - receptor activation
oaa05208  Chemical carcinogenesis - reactive oxygen species
oaa05210  Colorectal cancer
oaa05211  Renal cell carcinoma
oaa05212  Pancreatic cancer
oaa05213  Endometrial cancer
oaa05214  Glioma
oaa05215  Prostate cancer
oaa05218  Melanoma
oaa05220  Chronic myeloid leukemia
oaa05221  Acute myeloid leukemia
oaa05222  Small cell lung cancer
oaa05223  Non-small cell lung cancer
oaa05224  Breast cancer
oaa05225  Hepatocellular carcinoma
oaa05226  Gastric cancer
oaa05230  Central carbon metabolism in cancer
oaa05231  Choline metabolism in cancer
oaa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
oaa05415  Diabetic cardiomyopathy
oaa05417  Lipid and atherosclerosis
oaa05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:oaa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100074273 (PIK3CD)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100074273 (PIK3CD)
   04014 Ras signaling pathway
    100074273 (PIK3CD)
   04015 Rap1 signaling pathway
    100074273 (PIK3CD)
   04370 VEGF signaling pathway
    100074273 (PIK3CD)
   04630 JAK-STAT signaling pathway
    100074273 (PIK3CD)
   04668 TNF signaling pathway
    100074273 (PIK3CD)
   04066 HIF-1 signaling pathway
    100074273 (PIK3CD)
   04068 FoxO signaling pathway
    100074273 (PIK3CD)
   04070 Phosphatidylinositol signaling system
    100074273 (PIK3CD)
   04072 Phospholipase D signaling pathway
    100074273 (PIK3CD)
   04071 Sphingolipid signaling pathway
    100074273 (PIK3CD)
   04024 cAMP signaling pathway
    100074273 (PIK3CD)
   04151 PI3K-Akt signaling pathway
    100074273 (PIK3CD)
   04152 AMPK signaling pathway
    100074273 (PIK3CD)
   04150 mTOR signaling pathway
    100074273 (PIK3CD)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100074273 (PIK3CD)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100074273 (PIK3CD)
  09143 Cell growth and death
   04210 Apoptosis
    100074273 (PIK3CD)
   04218 Cellular senescence
    100074273 (PIK3CD)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100074273 (PIK3CD)
   04550 Signaling pathways regulating pluripotency of stem cells
    100074273 (PIK3CD)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100074273 (PIK3CD)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100074273 (PIK3CD)
   04613 Neutrophil extracellular trap formation
    100074273 (PIK3CD)
   04620 Toll-like receptor signaling pathway
    100074273 (PIK3CD)
   04625 C-type lectin receptor signaling pathway
    100074273 (PIK3CD)
   04650 Natural killer cell mediated cytotoxicity
    100074273 (PIK3CD)
   04660 T cell receptor signaling pathway
    100074273 (PIK3CD)
   04662 B cell receptor signaling pathway
    100074273 (PIK3CD)
   04664 Fc epsilon RI signaling pathway
    100074273 (PIK3CD)
   04666 Fc gamma R-mediated phagocytosis
    100074273 (PIK3CD)
   04670 Leukocyte transendothelial migration
    100074273 (PIK3CD)
   04062 Chemokine signaling pathway
    100074273 (PIK3CD)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100074273 (PIK3CD)
   04923 Regulation of lipolysis in adipocytes
    100074273 (PIK3CD)
   04929 GnRH secretion
    100074273 (PIK3CD)
   04915 Estrogen signaling pathway
    100074273 (PIK3CD)
   04914 Progesterone-mediated oocyte maturation
    100074273 (PIK3CD)
   04917 Prolactin signaling pathway
    100074273 (PIK3CD)
   04926 Relaxin signaling pathway
    100074273 (PIK3CD)
   04935 Growth hormone synthesis, secretion and action
    100074273 (PIK3CD)
   04919 Thyroid hormone signaling pathway
    100074273 (PIK3CD)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100074273 (PIK3CD)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100074273 (PIK3CD)
  09156 Nervous system
   04725 Cholinergic synapse
    100074273 (PIK3CD)
   04722 Neurotrophin signaling pathway
    100074273 (PIK3CD)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100074273 (PIK3CD)
  09158 Development and regeneration
   04360 Axon guidance
    100074273 (PIK3CD)
   04380 Osteoclast differentiation
    100074273 (PIK3CD)
  09149 Aging
   04211 Longevity regulating pathway
    100074273 (PIK3CD)
   04213 Longevity regulating pathway - multiple species
    100074273 (PIK3CD)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100074273 (PIK3CD)
   05206 MicroRNAs in cancer
    100074273 (PIK3CD)
   05205 Proteoglycans in cancer
    100074273 (PIK3CD)
   05207 Chemical carcinogenesis - receptor activation
    100074273 (PIK3CD)
   05208 Chemical carcinogenesis - reactive oxygen species
    100074273 (PIK3CD)
   05203 Viral carcinogenesis
    100074273 (PIK3CD)
   05230 Central carbon metabolism in cancer
    100074273 (PIK3CD)
   05231 Choline metabolism in cancer
    100074273 (PIK3CD)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100074273 (PIK3CD)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100074273 (PIK3CD)
   05212 Pancreatic cancer
    100074273 (PIK3CD)
   05225 Hepatocellular carcinoma
    100074273 (PIK3CD)
   05226 Gastric cancer
    100074273 (PIK3CD)
   05214 Glioma
    100074273 (PIK3CD)
   05221 Acute myeloid leukemia
    100074273 (PIK3CD)
   05220 Chronic myeloid leukemia
    100074273 (PIK3CD)
   05218 Melanoma
    100074273 (PIK3CD)
   05211 Renal cell carcinoma
    100074273 (PIK3CD)
   05215 Prostate cancer
    100074273 (PIK3CD)
   05213 Endometrial cancer
    100074273 (PIK3CD)
   05224 Breast cancer
    100074273 (PIK3CD)
   05222 Small cell lung cancer
    100074273 (PIK3CD)
   05223 Non-small cell lung cancer
    100074273 (PIK3CD)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100074273 (PIK3CD)
   05170 Human immunodeficiency virus 1 infection
    100074273 (PIK3CD)
   05161 Hepatitis B
    100074273 (PIK3CD)
   05160 Hepatitis C
    100074273 (PIK3CD)
   05171 Coronavirus disease - COVID-19
    100074273 (PIK3CD)
   05164 Influenza A
    100074273 (PIK3CD)
   05162 Measles
    100074273 (PIK3CD)
   05168 Herpes simplex virus 1 infection
    100074273 (PIK3CD)
   05163 Human cytomegalovirus infection
    100074273 (PIK3CD)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100074273 (PIK3CD)
   05169 Epstein-Barr virus infection
    100074273 (PIK3CD)
   05165 Human papillomavirus infection
    100074273 (PIK3CD)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100074273 (PIK3CD)
   05135 Yersinia infection
    100074273 (PIK3CD)
   05100 Bacterial invasion of epithelial cells
    100074273 (PIK3CD)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100074273 (PIK3CD)
   05142 Chagas disease
    100074273 (PIK3CD)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100074273 (PIK3CD)
   05017 Spinocerebellar ataxia
    100074273 (PIK3CD)
   05020 Prion disease
    100074273 (PIK3CD)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100074273 (PIK3CD)
   05418 Fluid shear stress and atherosclerosis
    100074273 (PIK3CD)
   05415 Diabetic cardiomyopathy
    100074273 (PIK3CD)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100074273 (PIK3CD)
   04932 Non-alcoholic fatty liver disease
    100074273 (PIK3CD)
   04931 Insulin resistance
    100074273 (PIK3CD)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100074273 (PIK3CD)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100074273 (PIK3CD)
   01524 Platinum drug resistance
    100074273 (PIK3CD)
   01522 Endocrine resistance
    100074273 (PIK3CD)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oaa04131]
    100074273 (PIK3CD)
Enzymes [BR:oaa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100074273 (PIK3CD)
Membrane trafficking [BR:oaa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100074273 (PIK3CD)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2
Other DBs
NCBI-GeneID: 100074273
NCBI-ProteinID: XP_028921595
Ensembl: ENSOANG00000008173
LinkDB
Position
5:complement(68641117..68696820)
AA seq 1050 aa
MAPGVDCPMELWSKEENQVLVDFLLPTGVYLNFPVSRNANLSSIKEILWRQAKREPLFHM
LSDPEAYVFTCINQTAEQQELEDEQRRLCDIQPFLPFLRLVAREGDRAKKLINSQISLLI
GKGLHEFDSLRDPEVNDFRSKMRQFCEETAAQRQQLDWEAWMRYNFPLQLEPLAMARTSG
TSFLSKTILVVIKFEGSEESFTLQVSLRDVPLALIAVALKKKATVFRPPALERPEEYTLQ
VNGKYEYLYGNYPLYQFQYVCSCLHEGYTPHLTMVHSSSILAMRDEQSHGSAQGPKLRPK
PPPIPLKKPASVALWSLEQPFWVELVQGSKVNADERMKLVVQAGLFHGNEMLCKMVSSSE
VNVCSEPVWKQRLEFDINVCDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWAN
IMLFDYKDQLKSGECCLYMWSSVPDEKGELLNPTGTVRSNPNTESAAALVICIPEVAPHP
VYYPALERVSGGDCEEILELGKNGEHARSTEEEQQQLKEILDRKLSGELYEHEKDLVWKM
RHEIQEQFPEALARLLLVTKWNKHEDVAQMLFLLRSWPELPVLSALELLDFSFPDRHVGS
FAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALTNRKIGHFLFWHLRSE
MHVPSVALRFGLIMEAYCRGSNHHMKVLMKQGEALNKMKSLNDYVKVSSQKTPKPQAKEL
MHTCMRQETFLEALSNLQSPLNPSTLLADVCVEQCTFMDSKMKPLWIVYSNEEVTGSSSV
GIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLSTGDRTGLIEVVLRSDTI
ANIQLNKSNMAATAAFNKDALLNWLKSKNPGDALERAIEEFTLSCAGYCVATYVLGIGDR
HSDNIMIRETGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGRTNNSEKFE
RFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTDDEALKH
FRVKFNEALRESWKTKVNWLAHNVSKDNRQ
NT seq 3153 nt   +upstreamnt  +downstreamnt
atggcccccggggtcgattgccccatggagctctggtccaaggaggaaaaccaggtgctg
gtggatttcctgctgcccactggagtctacctgaactttcccgtctcccgcaatgccaac
ctcagcagcatcaaggagatcctgtggcgccaagcgaagcgtgagccgctgttccacatg
ctcagcgaccccgaggcctatgtcttcacctgcatcaaccagacggcggagcagcaggag
ctggaggacgagcagcggcggctctgtgacatccagcccttcctgcccttcttgcgcctg
gtggcccgggagggcgaccgcgccaaaaagctcattaactcccagatcagcctcctcatt
ggcaaaggcctacacgagtttgactccctccgtgacccggaagtgaatgatttccgctcc
aagatgcgtcagttctgcgaggagacggcagcccagcggcaacagctggattgggaggcc
tggatgcggtacaacttccccctacagctggagcccctggccatggcccggacttccgga
acctcgttcctctccaagaccatcttggtcgtcatcaagttcgagggcagcgaggagagc
ttcaccctccaggtgtccctcagggacgtccctctggcgctgatagccgtcgccctcaag
aagaaggccacagtcttccgtccgccggccctggagcgacccgaggagtacaccctacag
gtgaacgggaagtacgagtacctgtatgggaactaccccctctaccagttccagtatgtc
tgcagctgcctgcacgagggatatacccctcacctgaccatggttcactcctcctccatc
ctcgccatgcgggacgagcagagccatggctctgcccagggccccaagctccgccccaag
ccgccccccatccccttgaagaagccggcctcagtggccctctggtccctggagcagccg
ttctgggtggagctggtccagggcagcaaggtgaacgcggacgagaggatgaagctggtg
gtccaggccggcctcttccatgggaatgaaatgctgtgtaagatggtgtcgagctcggag
gtgaatgtgtgctcggagcccgtgtggaagcagaggctggagttcgacatcaacgtctgc
gacctgccgcgcatggcgcggctctgcttcgccctctacgccgtcatcgagaaggccaag
aaggcccgctccaccaaaaagaagtccaagaaggccgactgccccatcgcttgggccaac
atcatgctgttcgactacaaggaccagctgaagtcgggggagtgctgtctgtacatgtgg
tcctctgtgccggatgagaagggagagttactgaaccccacgggcactgtgaggagtaac
cccaacaccgagagcgcggccgctctcgtcatctgcatccccgaggtggctccgcatccc
gtctactacccagccctggaaagggtgagcgggggtgattgtgaggagatcctggagctg
gggaagaacggggagcacgctcggtccaccgaggaggagcagcagcagttgaaggagatc
ctggaccggaagctgtccggggagctgtacgagcatgaaaaggacctggtgtggaagatg
cggcatgagatccaggagcagtttcccgaggcgctggcccgcctgctgctggtcaccaaa
tggaacaagcatgaggacgtggcccagatgctcttcctgctccgctcttggcctgagttg
ccagtcctgagtgccctggagctgctggatttcagcttcccagaccgccacgtgggctct
ttcgccatcaagtccctgcggaaacttacggacgatgagctgttccagtacctgctgcag
ctggtgcaggtgctcaagtacgagtcgtacctggactgcgagctgaccaagttcctcctg
gaccgggccttgaccaaccgcaagatcggccacttcctcttctggcatctccggtcggag
atgcacgtcccatcggtggccctgcgcttcgggctcatcatggaggcgtactgccgcggc
agcaaccaccacatgaaggtgctgatgaagcagggtgaggcgctcaacaaaatgaaatcg
ctgaacgactacgtcaaagtgagctcccagaagacccccaagccccaggccaaggagctg
atgcacacgtgcatgcggcaagagacgttcttggaggcgctttccaacctgcaatcccca
ctcaaccccagtaccttactggctgacgtctgcgtggagcagtgcaccttcatggactct
aagatgaagcccctgtggattgtatacagtaacgaggaggtgacagggagcagcagcgtg
ggcatcatctttaagaacggcgatgacctccggcaggacatgctgaccctgcagatgatc
cagctgatggacgtgttgtggaagcaagaggggctggatctgaggatgacaccctatggc
tgcctctccacgggtgaccggacggggctcatcgaagtggtgctgcgctcggataccatc
gccaacatccagctcaacaagagcaacatggccgccacagccgccttcaacaaagacgca
ctgctcaactggctcaagtccaagaacccaggggatgctctggagcgtgccattgaggag
ttcacactttcctgtgccggctattgtgtggccacctacgtgctgggcatcggggaccgg
cacagcgacaacatcatgatccgggagaccgggcagctgttccacattgattttggccac
ttcctggggaatttcaagaccaagtttggaatcaaccgggagcgtgtccccttcatcctc
acctacgactttgtgcacgtgatccagcaggggaggaccaacaacagcgagaagtttgaa
aggttccgcggttactgcgaacgggcctataccatcctgcgccgccacggcctgctcttc
ctccacctctttgcgctgatgcgggcggccggcctgcccgagctcagctgctccaaggac
atacagtatctcaaggactccttggctttgggaaagacggacgacgaggcactgaagcac
ttccgagtgaagttcaacgaagcgctgcgggagagctggaaaaccaaagtgaactggttg
gcccacaacgtctccaaagacaacaggcagtag

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