Ornithorhynchus anatinus (platypus): 100076776
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Entry
100076776 CDS
T01045
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
KO
K05859
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Organism
oaa
Ornithorhynchus anatinus (platypus)
Pathway
oaa00562
Inositol phosphate metabolism
oaa01100
Metabolic pathways
oaa01521
EGFR tyrosine kinase inhibitor resistance
oaa04012
ErbB signaling pathway
oaa04014
Ras signaling pathway
oaa04020
Calcium signaling pathway
oaa04062
Chemokine signaling pathway
oaa04064
NF-kappa B signaling pathway
oaa04066
HIF-1 signaling pathway
oaa04070
Phosphatidylinositol signaling system
oaa04072
Phospholipase D signaling pathway
oaa04360
Axon guidance
oaa04370
VEGF signaling pathway
oaa04380
Osteoclast differentiation
oaa04611
Platelet activation
oaa04613
Neutrophil extracellular trap formation
oaa04625
C-type lectin receptor signaling pathway
oaa04650
Natural killer cell mediated cytotoxicity
oaa04662
B cell receptor signaling pathway
oaa04664
Fc epsilon RI signaling pathway
oaa04666
Fc gamma R-mediated phagocytosis
oaa04670
Leukocyte transendothelial migration
oaa04722
Neurotrophin signaling pathway
oaa04750
Inflammatory mediator regulation of TRP channels
oaa04919
Thyroid hormone signaling pathway
oaa04933
AGE-RAGE signaling pathway in diabetic complications
oaa04935
Growth hormone synthesis, secretion and action
oaa05167
Kaposi sarcoma-associated herpesvirus infection
oaa05169
Epstein-Barr virus infection
oaa05170
Human immunodeficiency virus 1 infection
oaa05171
Coronavirus disease - COVID-19
oaa05200
Pathways in cancer
oaa05205
Proteoglycans in cancer
oaa05206
MicroRNAs in cancer
oaa05214
Glioma
oaa05223
Non-small cell lung cancer
oaa05225
Hepatocellular carcinoma
Module
oaa_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
oaa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
100076776 (PLCG2)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
100076776 (PLCG2)
04014 Ras signaling pathway
100076776 (PLCG2)
04370 VEGF signaling pathway
100076776 (PLCG2)
04064 NF-kappa B signaling pathway
100076776 (PLCG2)
04066 HIF-1 signaling pathway
100076776 (PLCG2)
04020 Calcium signaling pathway
100076776 (PLCG2)
04070 Phosphatidylinositol signaling system
100076776 (PLCG2)
04072 Phospholipase D signaling pathway
100076776 (PLCG2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
100076776 (PLCG2)
04613 Neutrophil extracellular trap formation
100076776 (PLCG2)
04625 C-type lectin receptor signaling pathway
100076776 (PLCG2)
04650 Natural killer cell mediated cytotoxicity
100076776 (PLCG2)
04662 B cell receptor signaling pathway
100076776 (PLCG2)
04664 Fc epsilon RI signaling pathway
100076776 (PLCG2)
04666 Fc gamma R-mediated phagocytosis
100076776 (PLCG2)
04670 Leukocyte transendothelial migration
100076776 (PLCG2)
04062 Chemokine signaling pathway
100076776 (PLCG2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
100076776 (PLCG2)
04919 Thyroid hormone signaling pathway
100076776 (PLCG2)
09156 Nervous system
04722 Neurotrophin signaling pathway
100076776 (PLCG2)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
100076776 (PLCG2)
09158 Development and regeneration
04360 Axon guidance
100076776 (PLCG2)
04380 Osteoclast differentiation
100076776 (PLCG2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100076776 (PLCG2)
05206 MicroRNAs in cancer
100076776 (PLCG2)
05205 Proteoglycans in cancer
100076776 (PLCG2)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
100076776 (PLCG2)
05214 Glioma
100076776 (PLCG2)
05223 Non-small cell lung cancer
100076776 (PLCG2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
100076776 (PLCG2)
05171 Coronavirus disease - COVID-19
100076776 (PLCG2)
05167 Kaposi sarcoma-associated herpesvirus infection
100076776 (PLCG2)
05169 Epstein-Barr virus infection
100076776 (PLCG2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
100076776 (PLCG2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100076776 (PLCG2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
oaa04131
]
100076776 (PLCG2)
Enzymes [BR:
oaa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
100076776 (PLCG2)
Membrane trafficking [BR:
oaa04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
100076776 (PLCG2)
Endocytosis
Macropinocytosis
Phospholipase C
100076776 (PLCG2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
EF-hand_PLCG2
C2
SH3_1
SH3_9
PH
EF-hand_PLCG1
SH2_1
PH_12
SH3_2
PH_14
EF-hand_like
Adhesin_E
Motif
Other DBs
NCBI-GeneID:
100076776
NCBI-ProteinID:
XP_028931366
Ensembl:
ENSOANG00000011330
UniProt:
F7GEP6
LinkDB
All DBs
Position
11:complement(49892294..50018287)
Genome browser
AA seq
1264 aa
AA seq
DB search
MATTIDCEALPEYEKSQIKRTLELGTVMTVFSLKKSSPERRTVQVIMETRQVAWSKTADK
IEGFLDLIEIKEIRPGKNAKDFERGKATRQKDDCCFTIFYGTQFVLNTLSLAADSKEDAL
KWLCGLKILTTEVKNASTPAITESWLRKQIYSVDQTRRNSISLREMKTILPLVNFKVGSA
KFLKDKFMEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VHLHDFQRFLHTEQQEQWAQDLSKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSKENS
IWDEKYDVVDVQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSDFPVILSIEEHCCVEQQRHMAKV
FKEVFGDALLVRPTEASADQLPSPTQLKEKIIIKHKKLGPRGDVDVNVEDKKEEKKQQGE
LYMWDSIDQKWYRHYCAIADEKLSFSDDIEQSAEEDTPKDVAQTDLHFGEKWFHKRMEKR
TSAEKLLQEYCAETGSKDGTFLVRESETYPNDYTLSFWRSGRVQHCRIRSIVEGGIMKYY
LTDNLMFSSIYDLIQHYREAHLRCAEFELRLTDPVPKPNPHESKPWYYDGLSRGEAEDML
MRIPRDGAFLIRKREGADSYAITFRAKGKVKHCRINQDGRHFVLGTSAYFESLVELVNYY
EKHALYRKMKLRYPVTQELLERYNTERDINSLYDLRMYVDPSEINPSTPQRTVKALYDYK
AKQEDELSFCRGALIHNVLKEAGGWWKGDYGGRLQQYFPANYVEDISTVDFEELEKQIIE
DNPLGSLCRGILDLHAYKVVKEPQGRNEKPFVFILDPKKPDDPPVVFATDRVEELFEWYQ
SIREITWKNTTVENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVET
KADTIVRQRANELLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGAQMVALNFQTADKYM
QMNHALFSLNGRTGYVLQPESMRNENYDPTPPESQRKMLMTLTVKVLGARHLPKLGRSIA
CPFVEVEICGAEYDNNKFKTTVVNDNGLNPVWAPTQEKVTFEIYDPTLAFLRFVVYEEDM
FSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCR
QLRRRQEELNNQLFLYDTHQNLRNANRDALVNEFNVNENQLQLYQERCDRRLREKRVSNS
KFYS
NT seq
3795 nt
NT seq
+upstream
nt +downstream
nt
atggccaccaccattgactgtgaagccctgcccgaatatgagaagagccagatcaagagg
accctcgaactggggacggttatgacggtgttcagcctcaaaaaatccagcccggagcgg
aggacggtccaggtcatcatggaaacaaggcaggtggcctggagcaagacagcggacaag
atcgaagggttcctggatctgatcgaaatcaaggaaatccgtccggggaagaacgcgaag
gacttcgagcgcgggaaagccacccgccagaaggatgactgctgcttcactatattctac
ggcacccagtttgttctcaacacactaagtttagcagctgattccaaagaggatgccttg
aagtggctctgcggcttgaagatcttaaccacggaagtcaagaacgcgtcgacgccggcg
attacagagagctggctaagaaagcagatttattctgtggatcaaaccaggagaaacagc
atcagcctccgagaaatgaagactatacttcccttagtaaacttcaaagtaggcagtgcc
aagttcctgaaggataagtttatggaaataggagctcacaaggacgaacttagctttgaa
cagttccatttgttctataaaaaactcatgtttgaacaacaaaaatcaatccttgatgaa
ttcaaaaaggattcttcggtcttcatcctgggaaatacggaccggccggatgcctcagct
gtccaccttcatgacttccagaggtttctgcacactgaacagcaggaacaatgggcacag
gatctcagtaaagtccgggaacggatgacaaagtttattgacgacactatgagagaaacg
gctgagcctttcttatttgttgacgagttcctcacctaccttttttcaaaagaaaatagc
atctgggatgaaaagtacgatgtggtagatgttcaggatatgaacaatcctttatctcat
tattggatttcttcatcgcataacacgtacctcaccggggaccagctgcgaagcgaatct
tccccggaagcctatatcaggtgcctgcggatgggatgccgatgcatcgagttggactgc
tgggacggccctgatggaaagccaatcatctatcatggatggacgcggaccacgaagatc
aagttcgatgatgtggtacaggccatcaaagaccatgcttttgtgacctcagatttcccc
gtgatcctctccatcgaagagcactgttgtgtggagcagcagcgccacatggccaaggtg
ttcaaggaggtgtttggggatgccctcctcgtgcggccaaccgaggccagtgccgatcag
ttgccgtccccgacccagctgaaagagaaaatcatcatcaagcataaaaagctgggccca
agaggagatgtggatgtcaacgtagaagacaagaaagaagagaagaagcaacaaggggaa
ctgtacatgtgggattccatagatcagaaatggtatcggcattattgtgccatcgcagat
gagaagctttctttcagtgacgatatagagcagagcgcggaggaagataccccaaaggat
gtggcccagactgatctgcattttggcgaaaagtggtttcataagaggatggagaagagg
acaagtgctgagaagctgctccaggaatactgcgcggaaacggggagcaaagacggaacc
ttcctagtccgtgaaagtgaaacgtatcccaatgactacacgctgtcattctggagatcg
ggccgagtccagcactgccgcattcggtccatcgtagagggcggcatcatgaagtactac
ctgactgacaacctcatgttcagcagcatctacgacttgatccaacactatcgggaggcc
cacctgcggtgtgccgagttcgagctgcgcctgaccgatccggtgcccaaacctaacccg
catgaatctaaaccctggtactatgacggcctgagccgaggagaagctgaagacatgctg
atgcgaattccccgagatggagcctttctgattaggaagagagaaggggcagattcgtac
gccattacgttcagggcaaagggaaaggtgaagcactgccggattaatcaagacgggcgc
cattttgtgctgggaacttcagcctactttgaaagtttggtggagctggtaaactactat
gaaaagcacgcactctacagaaaaatgaagctgcgctatccagtgactcaggagctgctg
gagcgttataacacggaaagggatataaactcactttatgacctcaggatgtatgtggac
cctagtgagattaatccttcaacgcctcagagaactgtgaaggctttatatgactacaaa
gctaaacaagaagatgaactgagcttttgcaggggagccttgattcacaatgtcctgaag
gaagcaggaggctggtggaaaggggactatggtggacggcttcagcagtattttcccgca
aattatgttgaagacatatcaacagttgactttgaagagctcgaaaagcagattatcgaa
gacaatcctttagggtctctgtgcaggggcattctggacctccatgcctataaagttgtg
aaagaaccacaagggagaaatgaaaagccttttgtctttatcttggaccccaagaagccc
gatgaccctccagtcgtgtttgcgactgacagagtggaagaactgttcgagtggtatcaa
agcatccgagagatcacctggaagaatacaactgtggagaacaacatgaagtactgggag
aagaaccagtcaattgccatagaactgtccgacctggtcgtctactgcaaaccgactagc
aaaaccaaggataatttagaaaatcctgacttccgggaaatacgttcttttgtggaaact
aaggccgacaccatcgtcaggcagagggcaaatgagctcttgaaatacaatcaaaaggga
ctgacccgagtttaccctaaaggacaaagagttgactcctccaattacgacccctttcgt
ctgtggctctgcggtgctcagatggtggctttgaatttccaaactgcagacaaatacatg
cagatgaaccacgccctattctccctcaacgggcggaccggatacgtcctgcagcccgaa
agcatgagaaatgagaactatgacccgacgccaccggaatcgcagcgaaaaatgctcatg
acgctgacggtgaaggtccttggggctcgccacttacccaagctcggcagaagcatcgcc
tgcccatttgtagaggtggaaatctgcggggccgagtacgataacaataaattcaagaca
acggttgtgaatgataatggccttaatcccgtctgggctcccacacaggagaaagtgaca
tttgagatctacgatcccactttggcctttctgcgttttgtggtttatgaggaagatatg
ttcagtgatcccaacttccttgctcatgccacataccccatcaaaggaatcaaatcaggg
ttcaggtcagtccctctcaaaaatggttacagtgaggacatcgagctagcttccctgttg
gttttctgtgaaatgcgtccagttctggaaagcgaagaggagctctactcctcatgccgc
cagctccgaaggcggcaagaagaactgaacaaccagctcttcctctacgacacccaccaa
aacttgcgaaacgccaaccgagatgctctggtaaatgagttcaatgtaaatgagaatcag
ctgcagctgtatcaggagaggtgcgacaggagattaagggagaagagagtcagtaacagc
aagttctactcatag
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integrated database retrieval system
