Ornithorhynchus anatinus (platypus): 100078137
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Entry
100078137 CDS
T01045
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
oaa
Ornithorhynchus anatinus (platypus)
Pathway
oaa00270
Cysteine and methionine metabolism
oaa00480
Glutathione metabolism
oaa01100
Metabolic pathways
oaa01240
Biosynthesis of cofactors
oaa04216
Ferroptosis
Module
oaa_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
oaa00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
100078137 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
100078137 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
100078137 (GCLC)
Enzymes [BR:
oaa01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
100078137 (GCLC)
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GFIT
Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
100078137
NCBI-ProteinID:
XP_028915080
Ensembl:
ENSOANG00000002861
UniProt:
A0A6I8P9Q2
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Position
1:complement(71043445..71098844)
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AA seq
637 aa
AA seq
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MGLLSQGSPLSWEETKRYAHHVRRHGVLQFLHIYHTVKERHKDVLKWGDEVEYMLVSFDH
INKKVRLVLSGEEVLETLQAKGERANPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
QDNMRKRRLEASSVMKENEALCTITSFPRLGCPGFTVPEHKPTPTEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIESFPQDDEAAKAAKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNIYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLK
EGIDHLLAQHIAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
QGKFYFRKDICKGGNAVVDGYGAAQNGMETDTEEYTLMSIDTIINGKEGVFPGLIPILNS
YLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFVANHPDYKKDSVITDEMNYS
LILKCNQIADELTECPELLGSAFKKTKYNENKTGSSN
NT seq
1914 nt
NT seq
+upstream
nt +downstream
nt
atggggctgttgtcgcaggggtccccgctgagctgggaggagacgaagcgctacgcccac
catgtgcggcgccacggggtcctccagttcctgcacatctaccacaccgtcaaagagcga
cacaaggacgtgctcaagtggggcgacgaggtggaatacatgttagtctcttttgatcac
ataaacaagaaagtgcgcttggttctgtctggagaggaagtccttgagacactgcaagca
aaaggggaaagggcaaatccaaaccatcctactctttggagaccagagtatggaagttat
atgatagaagggacacctggacagccatacggaggaacaatgtctgaatttaatacagtt
caagacaacatgagaaaacgtcggctggaggcttcctcagtgatgaaagaaaatgaagct
ctctgcactattacatcatttcctagattaggctgccctgggttcacagttccagagcat
aaacctacaccaactgaaggaggtgcctcaaaatctctcttctttccagatgaagcaata
aacaagcaccccaggttcagtaccttgacaagaaatatccgacatcggagaggggaaaaa
gttgtgatcaatgtaccgatatttaaagacaagaatactccatctccatttatagaatca
tttcctcaggatgatgaagcagcaaaagctgctaaaccggaccatatttatatggatgct
atgggatttggaatgggcaattgctgccttcaggtgacattccaggcttgcagcatatct
gaagcccgatacctttatgatcaactagctactatctgcccaattgtaatggctttaagt
gctgcatctcctttctacagaggctatgtttcagatattgattgtcgctggggagtaata
tcagcatctgtagacgatagaacacgggaagagagaggattggagcctctgaagaacaac
atatataggatcagtaaatcacgttatgattcaatagacagttatttatctaaatgtgga
gagaaatacaatgacattgatctgacaattgataaagaaatttatgaacagctattgaaa
gaaggtattgatcatctcttggcgcaacacatcgcacatctctttattcgagatcctctg
actctttttgaggagaaaatacacctagatgatgcaaacgaatctgaccattttgagaat
attcagtcgacaaactggcagactatgagattcaagccccctcctccaaattcagatatt
ggctggagagtagaattccgacccatggaggttcagctaacagatttcgagaactctgcc
tatgtggtgtttgtagtgctgctaaccagagtgatcctttcatacaagctagattttctc
atccctttgtcaaaggtggatgaaaacatgaaagtggctcagaaacgagatgctgtatta
cagggaaagttttacttcaggaaagatatttgcaaaggtggcaatgctgtggtggatggc
tatggggcagcccagaatggcatggagacagacacagaagaatacaccttgatgagcata
gataccatcattaatgggaaggaaggtgtctttcctggtttaatcccaattctcaactcc
taccttgaaaacatggaagttgatgtggacaccagatgcagcatcctgaactacttgaag
ttaatcaaaaagagagcatcgggagaactcatgacagtcgctcgttggatgcgggagttt
gtggccaaccatccagactacaaaaaagatagtgttatcactgatgaaatgaactacagc
cttattttgaagtgcaaccaaattgcagacgaattaacagagtgcccagagctgctggga
tcggcatttaagaagacaaaatataatgagaacaaaaccggctcttcaaattag
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