KEGG   Ornithorhynchus anatinus (platypus): 100080362
Entry
100080362         CDS       T01045                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
oaa  Ornithorhynchus anatinus (platypus)
Pathway
oaa01521  EGFR tyrosine kinase inhibitor resistance
oaa01522  Endocrine resistance
oaa04010  MAPK signaling pathway
oaa04012  ErbB signaling pathway
oaa04014  Ras signaling pathway
oaa04015  Rap1 signaling pathway
oaa04022  cGMP-PKG signaling pathway
oaa04024  cAMP signaling pathway
oaa04062  Chemokine signaling pathway
oaa04066  HIF-1 signaling pathway
oaa04068  FoxO signaling pathway
oaa04071  Sphingolipid signaling pathway
oaa04072  Phospholipase D signaling pathway
oaa04114  Oocyte meiosis
oaa04140  Autophagy - animal
oaa04148  Efferocytosis
oaa04150  mTOR signaling pathway
oaa04151  PI3K-Akt signaling pathway
oaa04210  Apoptosis
oaa04218  Cellular senescence
oaa04270  Vascular smooth muscle contraction
oaa04370  VEGF signaling pathway
oaa04371  Apelin signaling pathway
oaa04380  Osteoclast differentiation
oaa04510  Focal adhesion
oaa04517  IgSF CAM signaling
oaa04540  Gap junction
oaa04550  Signaling pathways regulating pluripotency of stem cells
oaa04613  Neutrophil extracellular trap formation
oaa04620  Toll-like receptor signaling pathway
oaa04650  Natural killer cell mediated cytotoxicity
oaa04660  T cell receptor signaling pathway
oaa04662  B cell receptor signaling pathway
oaa04664  Fc epsilon RI signaling pathway
oaa04666  Fc gamma R-mediated phagocytosis
oaa04668  TNF signaling pathway
oaa04720  Long-term potentiation
oaa04722  Neurotrophin signaling pathway
oaa04725  Cholinergic synapse
oaa04726  Serotonergic synapse
oaa04730  Long-term depression
oaa04810  Regulation of actin cytoskeleton
oaa04910  Insulin signaling pathway
oaa04912  GnRH signaling pathway
oaa04914  Progesterone-mediated oocyte maturation
oaa04915  Estrogen signaling pathway
oaa04916  Melanogenesis
oaa04917  Prolactin signaling pathway
oaa04919  Thyroid hormone signaling pathway
oaa04921  Oxytocin signaling pathway
oaa04926  Relaxin signaling pathway
oaa04928  Parathyroid hormone synthesis, secretion and action
oaa04929  GnRH secretion
oaa04934  Cushing syndrome
oaa04935  Growth hormone synthesis, secretion and action
oaa05010  Alzheimer disease
oaa05022  Pathways of neurodegeneration - multiple diseases
oaa05034  Alcoholism
oaa05132  Salmonella infection
oaa05135  Yersinia infection
oaa05160  Hepatitis C
oaa05161  Hepatitis B
oaa05163  Human cytomegalovirus infection
oaa05164  Influenza A
oaa05165  Human papillomavirus infection
oaa05166  Human T-cell leukemia virus 1 infection
oaa05167  Kaposi sarcoma-associated herpesvirus infection
oaa05170  Human immunodeficiency virus 1 infection
oaa05200  Pathways in cancer
oaa05205  Proteoglycans in cancer
oaa05206  MicroRNAs in cancer
oaa05207  Chemical carcinogenesis - receptor activation
oaa05208  Chemical carcinogenesis - reactive oxygen species
oaa05210  Colorectal cancer
oaa05211  Renal cell carcinoma
oaa05212  Pancreatic cancer
oaa05213  Endometrial cancer
oaa05214  Glioma
oaa05215  Prostate cancer
oaa05216  Thyroid cancer
oaa05218  Melanoma
oaa05219  Bladder cancer
oaa05220  Chronic myeloid leukemia
oaa05221  Acute myeloid leukemia
oaa05223  Non-small cell lung cancer
oaa05224  Breast cancer
oaa05225  Hepatocellular carcinoma
oaa05226  Gastric cancer
oaa05230  Central carbon metabolism in cancer
oaa05231  Choline metabolism in cancer
oaa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:oaa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100080362 (MAP2K1)
   04012 ErbB signaling pathway
    100080362 (MAP2K1)
   04014 Ras signaling pathway
    100080362 (MAP2K1)
   04015 Rap1 signaling pathway
    100080362 (MAP2K1)
   04370 VEGF signaling pathway
    100080362 (MAP2K1)
   04371 Apelin signaling pathway
    100080362 (MAP2K1)
   04668 TNF signaling pathway
    100080362 (MAP2K1)
   04066 HIF-1 signaling pathway
    100080362 (MAP2K1)
   04068 FoxO signaling pathway
    100080362 (MAP2K1)
   04072 Phospholipase D signaling pathway
    100080362 (MAP2K1)
   04071 Sphingolipid signaling pathway
    100080362 (MAP2K1)
   04024 cAMP signaling pathway
    100080362 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    100080362 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    100080362 (MAP2K1)
   04150 mTOR signaling pathway
    100080362 (MAP2K1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    100080362 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100080362 (MAP2K1)
   04148 Efferocytosis
    100080362 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    100080362 (MAP2K1)
   04210 Apoptosis
    100080362 (MAP2K1)
   04218 Cellular senescence
    100080362 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100080362 (MAP2K1)
   04540 Gap junction
    100080362 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    100080362 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100080362 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    100080362 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    100080362 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    100080362 (MAP2K1)
   04660 T cell receptor signaling pathway
    100080362 (MAP2K1)
   04662 B cell receptor signaling pathway
    100080362 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    100080362 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    100080362 (MAP2K1)
   04062 Chemokine signaling pathway
    100080362 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100080362 (MAP2K1)
   04929 GnRH secretion
    100080362 (MAP2K1)
   04912 GnRH signaling pathway
    100080362 (MAP2K1)
   04915 Estrogen signaling pathway
    100080362 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    100080362 (MAP2K1)
   04917 Prolactin signaling pathway
    100080362 (MAP2K1)
   04921 Oxytocin signaling pathway
    100080362 (MAP2K1)
   04926 Relaxin signaling pathway
    100080362 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    100080362 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    100080362 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    100080362 (MAP2K1)
   04916 Melanogenesis
    100080362 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100080362 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    100080362 (MAP2K1)
   04726 Serotonergic synapse
    100080362 (MAP2K1)
   04720 Long-term potentiation
    100080362 (MAP2K1)
   04730 Long-term depression
    100080362 (MAP2K1)
   04722 Neurotrophin signaling pathway
    100080362 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100080362 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100080362 (MAP2K1)
   05206 MicroRNAs in cancer
    100080362 (MAP2K1)
   05205 Proteoglycans in cancer
    100080362 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    100080362 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    100080362 (MAP2K1)
   05230 Central carbon metabolism in cancer
    100080362 (MAP2K1)
   05231 Choline metabolism in cancer
    100080362 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100080362 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100080362 (MAP2K1)
   05212 Pancreatic cancer
    100080362 (MAP2K1)
   05225 Hepatocellular carcinoma
    100080362 (MAP2K1)
   05226 Gastric cancer
    100080362 (MAP2K1)
   05214 Glioma
    100080362 (MAP2K1)
   05216 Thyroid cancer
    100080362 (MAP2K1)
   05221 Acute myeloid leukemia
    100080362 (MAP2K1)
   05220 Chronic myeloid leukemia
    100080362 (MAP2K1)
   05218 Melanoma
    100080362 (MAP2K1)
   05211 Renal cell carcinoma
    100080362 (MAP2K1)
   05219 Bladder cancer
    100080362 (MAP2K1)
   05215 Prostate cancer
    100080362 (MAP2K1)
   05213 Endometrial cancer
    100080362 (MAP2K1)
   05224 Breast cancer
    100080362 (MAP2K1)
   05223 Non-small cell lung cancer
    100080362 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100080362 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    100080362 (MAP2K1)
   05161 Hepatitis B
    100080362 (MAP2K1)
   05160 Hepatitis C
    100080362 (MAP2K1)
   05164 Influenza A
    100080362 (MAP2K1)
   05163 Human cytomegalovirus infection
    100080362 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100080362 (MAP2K1)
   05165 Human papillomavirus infection
    100080362 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100080362 (MAP2K1)
   05135 Yersinia infection
    100080362 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100080362 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    100080362 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    100080362 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100080362 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100080362 (MAP2K1)
   01522 Endocrine resistance
    100080362 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:oaa01001]
    100080362 (MAP2K1)
Enzymes [BR:oaa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100080362 (MAP2K1)
Protein kinases [BR:oaa01001]
 Serine/threonine kinases: STE group
  STE7 family
   100080362 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 100080362
NCBI-ProteinID: XP_028921900
Ensembl: ENSOANG00000009750
LinkDB
Position
5:6521596..6594392
AA seq 395 aa
MPMPRKKPDPIQLNPTPDGAAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQ
KVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLIMARKLIHLEIKPAIRNQIIRELQVL
HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT
YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGT
HYSVQSDIWSMGLSLVEMAIGRYPIPPPDSKELELMFGCTVEGDASETSPRQRTPGRPIS
SYGLDNRPPMAIFELLDYIVNEPPPKLPNGVFSLEFQDFVNKCLIKNPAERADLKQLMVH
AFIKRAEAEDVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1188 nt   +upstreamnt  +downstreamnt
atgcccatgcccaggaagaagcccgaccccatccagctcaaccccaccccggacggggcc
gccgtcaacggcaccagctccgccgagaccaacctggaagcgctccagaagaagctggaa
gaactggagctggacgagcagcagcgcaaacgactggaggctttcctaacccagaaacag
aaagtcggggaactcaaggatgacgacttcgagaaaatcagcgagctgggagccgggaac
ggcggggtggtattcaaggtctcccacaagccctctgggctgatcatggccagaaagctc
atccacctagagatcaagccagccatccggaaccagatcatccgggagctgcaggtgctc
cacgaatgcaactccccttacatcgtgggcttctatggggccttctacagtgatggcgag
atcagcatctgcatggagcacatggacggcgggtccttggatcaggtcctgaagaaagcc
ggaagaattccagagcagattctgggcaaagttagcattgctgtaataaaaggtctaacg
tatctgagggagaaacataaaattatgcacagagacgtgaagccgtccaacatcttggtg
aactcccgcggtgagatcaagctctgcgacttcggggtcagcgggcagctgatcgactcc
atggccaactcctttgtgggcacgaggtcctacatgtcgccggagagactacaaggcact
cattattcagtgcagtcggacatctggagcatgggcttatccttggtggagatggctatt
ggcaggtacccgatccctcctcccgattccaaggagctggaactgatgttcggatgcacg
gtggagggagacgcttcagagacgtcgccccgacagcggaccccggggaggcccattagc
tcttacggcctggacaacagaccacccatggccatctttgaactgctggactatatcgtc
aacgagccgccgcccaagctgcccaatggagtcttcagtcttgagtttcaagattttgtg
aataaatgcctcatcaaaaacccggccgagagagccgacctgaagcaactcatggttcac
gctttcatcaagagagccgaggcggaagacgtggactttgcgggctggctgtgctccacc
ataggcctgaaccagcccagcacgcccacccacgccgccggagtgtaa

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