KEGG   Ornithorhynchus anatinus (platypus): 100082351
Entry
100082351         CDS       T01045                                 
Symbol
CHUK
Name
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit alpha
  KO
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
Organism
oaa  Ornithorhynchus anatinus (platypus)
Pathway
oaa01523  Antifolate resistance
oaa04010  MAPK signaling pathway
oaa04014  Ras signaling pathway
oaa04062  Chemokine signaling pathway
oaa04064  NF-kappa B signaling pathway
oaa04068  FoxO signaling pathway
oaa04150  mTOR signaling pathway
oaa04151  PI3K-Akt signaling pathway
oaa04210  Apoptosis
oaa04380  Osteoclast differentiation
oaa04519  Cadherin signaling
oaa04620  Toll-like receptor signaling pathway
oaa04621  NOD-like receptor signaling pathway
oaa04622  RIG-I-like receptor signaling pathway
oaa04623  Cytosolic DNA-sensing pathway
oaa04625  C-type lectin receptor signaling pathway
oaa04657  IL-17 signaling pathway
oaa04658  Th1 and Th2 cell differentiation
oaa04659  Th17 cell differentiation
oaa04660  T cell receptor signaling pathway
oaa04662  B cell receptor signaling pathway
oaa04668  TNF signaling pathway
oaa04920  Adipocytokine signaling pathway
oaa04936  Alcoholic liver disease
oaa05010  Alzheimer disease
oaa05132  Salmonella infection
oaa05135  Yersinia infection
oaa05142  Chagas disease
oaa05145  Toxoplasmosis
oaa05160  Hepatitis C
oaa05161  Hepatitis B
oaa05162  Measles
oaa05163  Human cytomegalovirus infection
oaa05164  Influenza A
oaa05165  Human papillomavirus infection
oaa05166  Human T-cell leukemia virus 1 infection
oaa05167  Kaposi sarcoma-associated herpesvirus infection
oaa05168  Herpes simplex virus 1 infection
oaa05169  Epstein-Barr virus infection
oaa05170  Human immunodeficiency virus 1 infection
oaa05171  Coronavirus disease
oaa05200  Pathways in cancer
oaa05208  Chemical carcinogenesis - reactive oxygen species
oaa05212  Pancreatic cancer
oaa05215  Prostate cancer
oaa05220  Chronic myeloid leukemia
oaa05221  Acute myeloid leukemia
oaa05222  Small cell lung cancer
oaa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
oaa05417  Lipid and atherosclerosis
oaa05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:oaa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100082351 (CHUK)
   04014 Ras signaling pathway
    100082351 (CHUK)
   04064 NF-kappa B signaling pathway
    100082351 (CHUK)
   04668 TNF signaling pathway
    100082351 (CHUK)
   04068 FoxO signaling pathway
    100082351 (CHUK)
   04151 PI3K-Akt signaling pathway
    100082351 (CHUK)
   04150 mTOR signaling pathway
    100082351 (CHUK)
  09133 Signaling molecules and interaction
   04519 Cadherin signaling
    100082351 (CHUK)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    100082351 (CHUK)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100082351 (CHUK)
   04621 NOD-like receptor signaling pathway
    100082351 (CHUK)
   04622 RIG-I-like receptor signaling pathway
    100082351 (CHUK)
   04623 Cytosolic DNA-sensing pathway
    100082351 (CHUK)
   04625 C-type lectin receptor signaling pathway
    100082351 (CHUK)
   04660 T cell receptor signaling pathway
    100082351 (CHUK)
   04658 Th1 and Th2 cell differentiation
    100082351 (CHUK)
   04659 Th17 cell differentiation
    100082351 (CHUK)
   04657 IL-17 signaling pathway
    100082351 (CHUK)
   04662 B cell receptor signaling pathway
    100082351 (CHUK)
   04062 Chemokine signaling pathway
    100082351 (CHUK)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    100082351 (CHUK)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100082351 (CHUK)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100082351 (CHUK)
   05208 Chemical carcinogenesis - reactive oxygen species
    100082351 (CHUK)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100082351 (CHUK)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    100082351 (CHUK)
   05221 Acute myeloid leukemia
    100082351 (CHUK)
   05220 Chronic myeloid leukemia
    100082351 (CHUK)
   05215 Prostate cancer
    100082351 (CHUK)
   05222 Small cell lung cancer
    100082351 (CHUK)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100082351 (CHUK)
   05170 Human immunodeficiency virus 1 infection
    100082351 (CHUK)
   05161 Hepatitis B
    100082351 (CHUK)
   05160 Hepatitis C
    100082351 (CHUK)
   05171 Coronavirus disease
    100082351 (CHUK)
   05164 Influenza A
    100082351 (CHUK)
   05162 Measles
    100082351 (CHUK)
   05168 Herpes simplex virus 1 infection
    100082351 (CHUK)
   05163 Human cytomegalovirus infection
    100082351 (CHUK)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100082351 (CHUK)
   05169 Epstein-Barr virus infection
    100082351 (CHUK)
   05165 Human papillomavirus infection
    100082351 (CHUK)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100082351 (CHUK)
   05135 Yersinia infection
    100082351 (CHUK)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100082351 (CHUK)
   05142 Chagas disease
    100082351 (CHUK)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100082351 (CHUK)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100082351 (CHUK)
   05418 Fluid shear stress and atherosclerosis
    100082351 (CHUK)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    100082351 (CHUK)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    100082351 (CHUK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:oaa01001]
    100082351 (CHUK)
Enzymes [BR:oaa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     100082351 (CHUK)
Protein kinases [BR:oaa01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   100082351 (CHUK)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase UBL_IKK PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo TBK1_ULD YrbL-PhoP_reg M1AP_N APH
Other DBs
NCBI-GeneID: 100082351
NCBI-ProteinID: XP_028936882
Ensembl: ENSOANG00000002485
UniProt: A0A6I8PEK0
LinkDB
Position
16:37049878..37088886
AA seq 745 aa
MERPPGLRPPVSGPWEMRERLGTGGFGNVSLYQHRDLGDKIAIKACRQELSAKNKDRWCH
EIQIMKKLNHPNVVTACDVPEEMNFLVNDVPLLAMEYCSGGDLRKLLNKTENCCGLKESQ
ILSLLSDIGSGIQYLHENRIIHRDLKPENIVLQNVDGKVIHKIIDLGYAKDLDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFEGIVGYRPFLHHLQPFMWHEKIKKKDPK
HIFASEEMSGEVRFSSHLPQPNSLCRLIVEPMENWLQLMLNWDPQQRGGGIDSSTKQPRC
FLLMDQILHLKIVHILNMTSAKIISFLLLPDESLHSLQSRIEQETGISTGTQELLLEMGI
SLDPRKPASQCVIDGVRGWDSYMVYLFDKSKIVYEGPFASRSLSDCVNYIVQDSKIQLPI
TQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTMISASQQLKAKL
QFFHQSIQLDLDKYSDQMAYGISSEKMLKAWKEMEEKAIHCAQAGDIGYLDEQIMTLHTE
IVELQRSPYARRQGDVMETLEQKAIDLYKQLKHRSPDHSYSDSTEMVKIIVQTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALNNIKEADNTVMLMQGKRQREIWHLLKIACTQ
SSARSLVGSSLEGAVPPPTPAWLPASATGTVPHPFSSLVTPKDGENFTQMIEENLNYLGC
FSTIIREAKEEQGNSMMSLDWSWLK
NT seq 2238 nt   +upstreamnt  +downstreamnt
atggagcggcccccggggctgcggccgcccgtcagcggcccgtgggagatgcgggaacgg
ctgggcaccggcggcttcggaaacgtcagcctctaccagcaccgggacctcggcgataag
atagcgattaaagcttgccgccaggagctaagtgcgaagaacaaagaccggtggtgccat
gaaatccagatcatgaagaaactgaaccaccctaacgttgtaacggcctgtgacgttcct
gaggagatgaactttctagttaacgatgtccccctccttgcgatggagtactgctcagga
ggggacctgagaaagctccttaacaagacagaaaattgctgtggacttaaagagagccaa
atactttctctactcagcgatatagggtctgggattcagtatttgcatgaaaacagaatt
atccaccgagatctaaagcctgaaaacatcgtcctccagaacgttgatgggaaggtaatt
cacaaaataatcgacttgggatatgccaaagaccttgatcaaggaagtctgtgtacatct
tttgtggggactctgcaatatctggcccctgaactatttgagaataagccttacacagcc
accgtggattattggagctttggaacaatggtgtttgaaggaattgtgggctacagacct
tttctgcatcacctgcagccatttatgtggcatgagaaaattaagaagaaagatcccaag
cacatatttgccagtgaagagatgtcgggagaagtgcggttcagtagccatttacctcag
cccaacagcctctgccgcctaatagtggagccaatggaaaactggttacagttgatgctg
aactgggatcctcagcaaagagggggagggatcgatagcagcacgaagcagccgaggtgt
tttctattaatggatcaaattctgcacttgaagattgtacacatcctaaatatgacttct
gcaaagatcatttcttttctgttgctgccagacgaaagcctccattccttacagtcacgc
atcgagcaggaaacgggaataagtactgggacccaagaactactcttggagatgggaatt
tccttggatcccaggaaacctgcttctcagtgtgtgatagatggagtaaggggctgggat
agctacatggtttatttattcgataaaagcaagatcgtctacgaggggccgtttgcttcc
agaagtttatccgactgcgtcaattacatcgtacaggacagcaaaatccaactgccgatc
acgcagctccggaaagtgtgggccgaagcggtccattacgtgtctggactgaaagaagat
tacagtagactctttcagggtcagagagcagctatgttgagtcttctccgctataacgct
aacttaacaaaaatgaagaacaccatgatctcggcatctcagcaactgaaagctaaactg
cagttttttcatcagagcattcaacttgacctggataaatacagtgatcagatggcttat
gggatatcctcggaaaaaatgctgaaagcctggaaggaaatggaagaaaaagctatccac
tgtgcacaggccggtgatattggctacttggatgagcagatcatgacccttcacaccgaa
atcgtggagctccaaagaagtccatatgcgaggcggcaaggagacgtaatggagactctg
gagcaaaaagctattgatttatacaagcaactaaagcatagatctccagatcactcgtac
agcgacagcacggagatggtgaagatcattgtgcagactgtgcagagccaggaccgagtt
ctcaaggagctctttggacacttgagcaaactgttgggctgcaagcagaagatcatcgat
ctcctccccaaggtcgaagtggctctcaataacatcaaggaggctgataacactgtcatg
ctaatgcagggcaaacggcagagggaaatctggcatctgttgaagattgcttgtactcag
agttctgctcgctcccttgtaggatccagtctcgaaggcgcagtcccgcctcctaccccg
gcgtggctgcccgcaagtgccacgggaaccgtgccccatcctttttcttctctggtgact
cctaaagatggggaaaactttacacagatgatagaggaaaacctgaattatctcggctgc
tttagcactatcatccgggaggccaaagaggagcagggcaatagtatgatgagtcttgat
tggagttggctgaagtaa

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