KEGG   Ornithorhynchus anatinus (platypus): 100084273
Entry
100084273         CDS       T01045                                 
Symbol
RYR2
Name
(RefSeq) LOW QUALITY PROTEIN: ryanodine receptor 2
  KO
K04962  ryanodine receptor 2
Organism
oaa  Ornithorhynchus anatinus (platypus)
Pathway
oaa04020  Calcium signaling pathway
oaa04024  cAMP signaling pathway
oaa04260  Cardiac muscle contraction
oaa04261  Adrenergic signaling in cardiomyocytes
oaa04371  Apelin signaling pathway
oaa04713  Circadian entrainment
oaa04911  Insulin secretion
oaa04921  Oxytocin signaling pathway
oaa04972  Pancreatic secretion
oaa05020  Prion disease
oaa05022  Pathways of neurodegeneration - multiple diseases
oaa05410  Hypertrophic cardiomyopathy
oaa05412  Arrhythmogenic right ventricular cardiomyopathy
oaa05414  Dilated cardiomyopathy
oaa05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:oaa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    100084273 (RYR2)
   04020 Calcium signaling pathway
    100084273 (RYR2)
   04024 cAMP signaling pathway
    100084273 (RYR2)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    100084273 (RYR2)
   04921 Oxytocin signaling pathway
    100084273 (RYR2)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    100084273 (RYR2)
   04261 Adrenergic signaling in cardiomyocytes
    100084273 (RYR2)
  09154 Digestive system
   04972 Pancreatic secretion
    100084273 (RYR2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    100084273 (RYR2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05020 Prion disease
    100084273 (RYR2)
   05022 Pathways of neurodegeneration - multiple diseases
    100084273 (RYR2)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    100084273 (RYR2)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    100084273 (RYR2)
   05414 Dilated cardiomyopathy
    100084273 (RYR2)
   05415 Diabetic cardiomyopathy
    100084273 (RYR2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:oaa04040]
    100084273 (RYR2)
   04990 Domain-containing proteins not elsewhere classified [BR:oaa04990]
    100084273 (RYR2)
Ion channels [BR:oaa04040]
 Voltage-gated cation channels
  Ryanodine receptor
   100084273 (RYR2)
Domain-containing proteins not elsewhere classified [BR:oaa04990]
 EF-hand domain-containing proteins
  Other EF-hand domain-containing proteins
   100084273 (RYR2)
SSDB
Motif
Pfam: RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8
Other DBs
NCBI-GeneID: 100084273
NCBI-ProteinID: XP_028903046
Ensembl: ENSOANG00000010281
LinkDB
Position
19:1800199..2033126
AA seq 4958 aa
MADEGEDEIQFLRTDDEVVLQCTTTIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDL
SICTFVLEQSLSVRALQEMLANTVEKAEGQVDLEKWKFMMKTAQGGGHRTLLYGHAILLR
HSYSGMYLSCLSTTRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLI
LVSVSSERYLHLSYGNGTLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMD
ECLTVPSGEHGEGQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHITT
GKYLSLMEDKSLLLMDKEKADVKSTAFCFRSSKEKLDLGMRKEVEGMGTSEIKYGDSVCF
IQHADTGLWLTYQSADAKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIRST
AFLFNRFLRGLEALSKKSKSSPVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRAL
KNRQNLFQEEGVISLVLECIDRLHVYSSAAHFADAAGPEAGDAWKSTLNSLYELLAALIR
GNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLD
KHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNVFLG
ISEGSAQYRKWYYELIVDHAEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDL
FSYGFDGLHLWSGCIARTVSSPNQHVLRTEDVVSCCLDLSAPSVSFRINGQPVQGMFENF
NVDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVENSGEYKQ
DQNSTRGVRDLLGPTASLPQAAFTPIPVDTSQVVLSPHLERIREKLAENIHELWVMNKVE
LGWQYGPVRDDNKRQHPCLVEFAKLPEQERNYNLQMSLETLKTLLALGCHVGISDERAEE
KVKKLKLPKNYQLSSGYKPAPMDLSFIKLTASQEAMVDKLAENAHNVWARDRIRQGWTYG
IQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHATRTEASS
GPGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDEHAFAFDG
FKAQRWHQGNEHYGRAWQAGDVVGCMVDMNERTLMFTLNGEILLDDSGSELAFKDFEVGQ
GFIPVCSLGLAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFL
QVPADHEHIEVTRIDGTGASSPCLRVTQKSFSSQKSSAEIMFYRLSMPIECAEAFSRTAG
LAGPGLFGPKSDPEDYDVDSDFEVLMKTAHGHLIPERADREKDAAKPEFNNHKDYAQEKP
SRLKQRFMLRRTKPDYSAGHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPANV
WVGWITSDFHQYDTVFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGENLSPGQGRN
NNGLEIGCVVDVATGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIK
NVMPLSAGLFKSEHKNPSPQCPPRLHVQFLTRVLWSRVPNRFLKVDVSRVSEHQGWLVQC
LEPLQFMSLHIPEENRSIDILELSEQEDLLKFHSHTLRLYSAVCALGNNRVAHALCSHVD
EQQLLYAIENKYMPGWLRAGYYDLLVDIHLSPYATARLMMNGEFIVPMTEETKSITLFPG
SGRKHGLPGIGLSTSLRPRMRTAAPGFVAVGHEGHQLSPEFPLDVLKAKTIRMLTEAVRE
GGLRARDPVGGTTEFLFVPLIKLFYTLLIMGVFHDGDLKHVLRLIEPGVFREAAAPDGGA
REDGDPGGDPGVGAEEMPQEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDD
FVAKLQDNQRFRYNEVMQALNMSAALTARKTREFRSPPQEQINMLLNFKDEKSECPCPEE
IRDQLLEFHEDLMMHCGIELDEDGGPEGSSDLTIRGRLLYLVEKVTYLKKKQAQRPVDGY
SRKPSTLQQLISETMVRWAQESVMEDPELVRAMFVLLHRQYDGIGGLARALPKTYTINGV
SVEDTVNLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETV
MEVMVNVLGGGEMKEIIFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLAS
PAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLLSCPLLVSKGYPDVGWN
PVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAI
KIAEDPSRDGPSPANGAGRTLEVEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAG
KGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFL
DRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCA
SLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPPMMQHLLRRL
VFDVPLLNEHSKMPLKLLMNHYERCWKYYCLPGGWGSFGTASEEELHLSRKLFWGIFDAL
SQKKYEQELFKLALPCLSAVGGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNIT
IPEKLEYFINKYAEHSHDKWSMEKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYR
WPIKESLKTMLAWGWRIERTREGDSMAFYNRTRRISQTSQVSVDAAHGYSPRAIDMSNVT
LSRDLHAMAEIMAENYHNIWAKKKKMELEAKVGGGNHPLLVPYDTLTAKEKAKDREKAQD
ILKFLQINGYTVSRGFKDLEMDTPSIEKRFAYSFLQQLIRYVDAAHQYILEFDGGSRSKG
EHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLSTGGHASNKEKEMVTSLFCKL
GVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGMESVKAALRAFLENAAKDLEKT
MENLKQGQFTHTRSQPKGVTQIINYTTVALLPMLSSLFEHIGQLQFGEDLILEDVQVSCY
RILSSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETSLNQHNPYSIYNTKTPRE
RAALNLPDSVEEMCPGVPTLEKLMEEIMELAESGVRYAQMPHVMEVILPMLCSYMSRWWE
YGPEGRPRPGPRPAEPCCTALRSDHMNTLLGNVLKIIHNNLGVDEGAWMKRLAVFSQPII
NKVKSQLLKTHFLPLMAKLKKKAATVVSDEDHLKAEARGDMSEAELLILDEFTTLARDLY
AFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINN
MSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNVCAPGDQE
LIALAKNRFSLKDTEDEVRDVIRSNLHLQGKMEDPAIRWQMALYKDLPHRTDGASDPEKT
VERVLDIANVLFHLDQKPTYMGRRYYSMVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAP
LYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGTEPPEEDEASRRVDPLHQL
ILLFSRTALTEKCKLEEDFLYMAYADIMAQSCHDEEDDSGEEEVKSFEEKEMEKQKLLYQ
QARLHERGAAEMVLQTISAGKGDTGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDV
GFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLC
EGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFS
KAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIEL
LKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLT
SSDAFKEYDPDSKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRF
HEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIER
VYFEISESSRTQWEKPQVKESKRQFVFDVVNEGGEKEKMELFVSFCEDTIFEMQLAAQIS
ESDLSERSASKEESEEEKPEEQEVGLGFFSVPTATSALLALRVHTLALVKALSVKSLKKQ
MKKAKKMTVRDLAAAFFVSYWTVSAGLLHFSSSVLRGFLRVLGGLLLGGGLVEGAKKIRV
SELLANMPDPTQDEVRGEGEEGDGKPAEAAPPAEDLTDLKELAEESDLLSDIFGLDLKRE
GGQYKLIPHNPNAGLSDLMSDPGPEEQEPLQEQKKAQGDKDEKEEMKSEPEKAEGEDGEK
EEKGRDEKGKQKLRQLHAHRYGEPETQESAFWKKIIAYQQKLLNYFARNFYNMRMLALFV
AFAINFILLFYKVSTSSATEGKEFSIPSVSEDTGLDSLDGPSHRIITVHFVLEESSGYME
PTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQ
WDRLAINTQSFPNNYWDKFVKRKVMDKYSEFYGRDRISELLGMDKAALDFSDAREKKKPK
KDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMG
FKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDMPDMKCDDM
LTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDA
FGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKD
ETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN
NT seq 14877 nt   +upstreamnt  +downstreamnt
atggccgacgagggagaggatgagatccagttcctgcggaccgatgatgaggtggttctc
cagtgcacgaccaccatccacaaggagcagcagaagctatgcctggcggcggagggcttt
gggaaccggctttgcttcctggagtccacgtccaattccaagaatgttcccccggatctg
tccatctgcaccttcgttctggaacagtctctgtcggtgcgggctctgcaggagatgctg
gccaacacggtggaaaaggcggaagggcaagttgatttggaaaaatggaaattcatgatg
aagactgctcaaggtgggggccatcggacgcttctctacgggcacgccatcttgctccgc
cattcctacagtggtatgtacctctcctgtctctccaccacgcggtcttccacggataag
ctggcgttcgacgtcgggctgcaggaagacacgacaggagaagcctgctggtggactatc
caccccgcctccaaacagcgatccgagggggaaaaggtgcgggtcggcgacgacctgatc
ctcgtcagcgtctcttccgagcggtacctgcacctgtcttacggcaacgggaccctgcac
gtggacgccgcctttcagcagaccctgtggagcgtggctcccatcagctccgggagcgaa
gccgcccaaggatacctgatcggcggggacgtgctcaggctactgcacggccacatggat
gaatgtctgacggtgccctcgggggagcacggcgagggacagcggagaaccgtccattac
gaaggaggggctgtttctattcacgcccgttccctgtggaggctcgagaccctaagagtt
gcgtggagcggaagtcacatccggtgggggcagccgttcagactccggcatataaccaca
gggaagtacctgagcctcatggaagacaaaagcctcctgctcatggacaaggagaaggcc
gacgtcaagtccaccgccttttgcttccgctcttccaaggaaaagctggacctggggatg
aggaaggaagtggaggggatggggacgtcggaaatcaaatacggagactcggtctgcttc
atccagcacgcggacacgggcttgtggctcacctaccagtcggccgacgccaagtccgtg
aggatgggatccattcagcgcaaggcgatcatgcaccacgaaggtcacatggacgacggg
ctgaacctgtcccgctctcagcacgaggagtccaggaccgccagagtcatccgcagcacc
gccttcctgttcaatagattcctcaggggtctggaggcgctgagcaagaaatccaagtct
tcccccgtcgacctgcccatcgagtcggtcagcctgagcctgcaggacctgatcggctac
ttccaccctcccgacgagcacctggagcacgaggacaaacagaaccggctccgagcgctc
aagaaccgacagaacctctttcaggaagagggcgtgatcagcctggtcctggaatgcatc
gaccgactccacgtgtacagcagcgccgcccacttcgccgatgccgccggcccggaggcc
ggagacgcgtggaagtccactctcaactctctctacgagttgctcgcggctctgatcaga
ggaaatcgcaaaaattgcgctcagttctctggctccctcgactggctcatcagcagactg
gaacgactggaagcgtcctctggaattctcgaagttttgcactgtgtgttggtggaaagt
ccggaagctctgaatatcattaaagaggggcacattaaatccatcatctccctgttagac
aaacacggacgaaaccacaaggtcttggacgtcctctgctccctgtgtgtttgccacgga
gtggccgtccgctccaaccagcacctcatctgcgacaacctcctgccgggaagagacctc
ctcctgcagacccgcctcgtcaaccacgtcagcagcatgcggcccaatgtgttcctgggg
atcagcgaagggtccgcccagtatcggaagtggtactacgagctcatcgtggaccacgcg
gagcccttcgtcacggcggaggctacgcacctgcgggtcggctgggcctccacggagggc
tactccccctaccccggcggaggcgaggagtggggcggcaacggcgtcggcgatgacctc
ttctcctacggcttcgacggcctccacctgtggtcgggctgcatcgcccggacggtcagc
tcccccaaccagcacgtgctgcgcacggaggacgtggtcagctgctgcctggacctcagc
gcacccagcgtctccttccgcatcaacggacagcccgtgcaggggatgttcgagaacttc
aacgtcgacggcctcttcttcccggtcgtcagcttctccgccggcatcaaggtccgtttc
ctgctcgggggtcgtcacggagagtttaagttcctccccccgcctgggtacgccccttgc
ttcgaagcggtcttgcccaaggagaagctgaaggtggaaaacagcggcgaatacaagcag
gaccagaacagcacccgtggggttagagacctgctgggtcccaccgcctccctgccccaa
gccgccttcaccccgatccccgtggacaccagccaggttgttctgtccccgcacctggag
aggatccgagagaaactagcggaaaacatccacgagctttgggtgatgaataaagtggag
ctgggctggcagtatggaccggtgagagatgacaacaagaggcagcacccttgcctggtg
gagtttgccaaactgcccgagcaggagcgcaactacaacctgcagatgtcactggagacg
ctgaagaccctgctggcactggggtgccacgtcggaatctccgacgaacgggccgaagaa
aaggtgaagaagttgaaactgcccaagaactaccagctgtcaagcggctacaagccggcc
cccatggacctgagcttcatcaagctgacggcctcgcaggaagccatggtggacaagctg
gccgagaacgcccacaacgtgtgggcccgggaccgcattcggcagggctggacttacggc
atccagcaggacgtaaagaaccgaagaaaccctcgcctcgtcccctacgccctcctcgac
gaccggacgaagaagtccaacaaagacagcctccgggaggccgtgcggactctgctcggc
tacggttacaacctcgaggcccccgatcaggatcacgccacgaggacggaagcgtcgagc
ggccccggcgagaggttccggatcttccgggcggagaagacgtacgcggtgaaggcgggc
aggtggtacttcgagtttgaggcggtcacggccggggacatgagggtcggctggagcagg
ccgggctgccagcccgatcaagagctgggctcggacgaacacgccttcgccttcgacggc
ttcaaggcccagcgctggcaccagggcaacgagcactacgggcgggcgtggcaggcgggc
gacgtcgtgggctgcatggtggacatgaacgaacgcaccctgatgttcaccctgaacggc
gagatcctcttggacgactccggctccgagctggccttcaaggacttcgaggtcggccag
ggattcatacccgtgtgcagcctcgggctggcccaggtagggcggatgaacttcgggaag
gacgtgagcaccctgaagtatttcaccatctgcgggctgcaggaaggctacgagcccttc
gccgtcaacaccaacagggacatcaccatgtggctgagcaagaggctccctcagttcctt
caagtgccggccgaccacgagcacatcgaggtgacccggatcgacgggaccggggcgagc
tccccgtgtctgcgggtgacccagaagtcgttcagctcccagaagagcagcgcggagatc
atgttctaccggctgagcatgcccatcgagtgcgccgaggccttctccagaaccgcgggc
ctcgccggccccggcctcttcggccccaagagcgacccggaggactacgacgtggactcc
gacttcgaggtcctcatgaagacggcccacggccacctgatccccgagcgggccgaccgg
gagaaggacgccgccaagcccgagttcaacaaccacaaagactacgcccaggagaagccc
tcccggctgaagcagaggttcatgctgaggaggacgaagccggattacagtgccggccac
tcggcccggctcacggaggacgtgctggcggatgatcgggacgactacgatttcttgatg
cagacgtctacgtattactactcggtgcggattttcccgggtcaagagcccgccaacgtg
tgggtcggctggatcacttcggacttccaccagtacgacaccgtcttcgacctggacagg
gttcgcaccgtgacggtcaccctgggcgatgagaagggcaaggtgcacgagagcatcaag
cggagcaactgctacatggtgtgcgccggggagaacctgagtcccggccaggggcgcaac
aacaacggcctggagatcggctgcgtggtggacgtcgccaccggcctgctcaccttcacc
gctaacggcaaggagctcagcacctactaccaggtggagccgagtacgaaattatttccg
gccgttttcgcccaagccacgagccccaatgttttccagttcgagctggggaggatcaag
aacgtcatgccgctgtcggccggcctgttcaagagcgagcacaagaacccgagccctcag
tgcccgccccgcctccacgtccagttcctcacccgcgtgctgtggagccgcgtgcccaac
cggttcctcaaggtggacgtgtcccgcgtcagcgagcaccagggctggctggtccagtgc
ctggaaccgttgcagttcatgtcgctccacatcccggaggagaacaggtccatcgacatc
ctggagctgtcggagcaagaggacctgctgaagttccactcccacacgctccgcctctac
tcggccgtgtgcgccctgggcaacaaccgcgtggcccacgccctgtgcagccacgtggac
gagcagcagctcctctacgccatcgagaacaagtacatgcccggctggctgcgggccggc
tactacgacctgctggtggacatccacctgagcccctacgccacggcgcggctcatgatg
aacggcgagttcatcgtccccatgacggaggagaccaagagcatcacgctcttccccggg
tccggccgaaagcacggcctcccgggcatcgggctgagtacctcgctgcggccccggatg
cggacggccgcccccggcttcgtcgccgtgggccacgagggccaccagctgagccccgag
ttcccgctggacgtgctgaaggccaagaccatccggatgctgacggaggcggtgagggag
ggcgggctcagggcccgggaccccgtcggcgggaccacggagttcctcttcgtgccgctc
atcaagctcttctacacgctgctcatcatgggcgtgttccacgacggggacctcaaacac
gtcctgcggctcatcgagcccggggtcttccgcgaggcggccgccccggacgggggcgcc
cgggaggacggggaccccggcggggacccgggcgtcggggccgaggagatgccgcaggaa
ggactgctccagatgaagcttcccgagcccgtcaagttgcagatgtgccttctgctgcag
tacctctgcgactgccaggtccgccaccggatcgaagccatcgtcgccttctcggacgac
ttcgtggccaagctgcaggacaaccagcgcttccgctacaacgaggtcatgcaggccctg
aacatgtcggccgccctgacggcccggaagacccgggaattccggtctccccctcaggag
cagatcaacatgctcctgaattttaaggacgagaaaagcgagtgcccttgccccgaagaa
atcagggaccagctcttggaattccacgaagatctgatgatgcactgtggaatcgaactg
gatgaggacggcggcccggaggggagcagcgacctcaccatcaggggccgcctgctctac
ctggtggagaaggtcacctacctcaagaagaaacaagcccagagacccgtggacggctac
tccaggaagccctccacgctgcagcagctgatctcggagacgatggtgcgctgggcccag
gagtcggtgatggaggacccggagctggtgcgggccatgttcgtcctgctccaccgccag
tacgacggcatcgggggcctggcccgggcgctccccaagacctacaccatcaacggcgtc
tccgtggaggacaccgtcaacctcctggcctccctggggcagatccgctccctcctcagc
gtccgcatggggaaggaggaggagaagctgatgatccggggattgggtgacatcatgaac
aacaaagtattttatcagcatcccaatctaatgcgcgccctgggaatgcacgaaaccgtg
atggaggtcatggtgaatgtcctcggcggaggcgagatgaaggaaatcatctttcccaag
atggtggccaactgttgtcggttcctttgctacttctgccgcataagccggcagaatcag
aaagccatgtttgatcacctcagctacctcctggaaaacagcagcgttggactcgcctcc
ccagccatgcgagggtcgaccccgctggacgtagcagccgcgtccgtgatggacaacaac
gagctggccttggcgttgcgggagcccgacctggagaaggtggtacgctacctggcgggc
tgtggattgctgagttgccccttgctggtatccaagggctacccggacgtcggctggaat
cccgtggaaggggagagatatctggacttcctccggttcgccgtcttctgcaacggggag
agcgtggaagagaacgccaacgtggtggtcagattgctcatccggcggcccgagtgtttt
ggcccagctctgagaggggaaggtggaaacgggctactggccgccatggaggaagccatc
aagatagccgaagacccttccagagacggaccctcgcccgccaatggagccggcagaacc
ctcgaggtagaagaggaagatgacaccatccacatgggaaatgccatcatgaccttctat
gcggcgttgatagacctcttaggacgttgtgccccagagatgcatttaatccacgccggg
aagggagaagctattaggatcaggtccattctgagatcgctaatccccttgggcgatttg
gtgggggtgatcagcatcgccttccagatgcccacgatagccaaagatgggaatgtggtg
gagccggacatgtccgcggggttttgcccagaccacaaggcagccatggttttgttcctt
gacagggtttatggcattgaggtccaagacttcctcctccacctccttgaggtcggcttt
ctgccggatctccgggccgctgcttcgttagacacggccgcgctgagcgccaccgacatg
gccctggccctgaaccgctacctgtgcacggccgtcctgccgctgctcacccgctgcgcc
tcgctcttcgccggcacggagcaccacgcctctctgatcgactcgctcttgcacaccgtc
taccgcctctccaaaggatgctccctcaccaaagcccagcgcgactccatcgaagtctgc
ctgctgtccatctgcggccagctgaggcctcccatgatgcaacatctgctgcggaggctg
gttttcgacgtccctttgctgaacgagcactccaagatgccgctcaagctgctgatgaac
cactacgagaggtgctggaaatactactgtctgcccggaggctggggcagcttcgggacg
gcgtctgaggaagagctccatctgtcccggaagttgttctggggcatctttgacgccctg
tctcagaagaaatacgagcaggagctgttcaagctggcactcccctgcctcagcgcagtg
gggggggcccttccgccggactatatggagtccaactacgtcagcatgatggagaagcag
tcatccatggattccgaggggaactttaacccccagcccgtcgacacctccaacatcacg
attcccgaaaagttggagtacttcattaataaatacgcagagcactcccacgacaagtgg
tccatggaaaagttggccaacggatggatttatggggaaatatactctgattcgtcgaag
gttcagccgttaatgaagccctacaaactcttgtctgagaaggagaaggaaatctaccgc
tggcccatcaaagagtccctgaagacgatgctggcctgggggtggcggatcgaaaggact
cgggaaggggacagcatggccttctacaaccggacccgccgcatttctcagacaagtcag
gtttccgtcgacgccgcccacggctacagcccgcgtgccattgatatgagcaacgtcacc
ctctccagagatcttcacgccatggcagaaataatggcagaaaattaccacaacatatgg
gcaaagaaaaagaaaatggaactggaggcgaaagttggcgggggaaaccacccgttgctg
gtgccctatgacaccctgaccgccaaggagaaagctaaggaccgcgagaaggcccaggat
atcctcaagttcctgcagatcaacggctatactgtgtccaggggtttcaaggatttggaa
atggacaccccatccatagaaaaacgcttcgcctacagcttcctgcagcaactcatcaga
tacgtggatgcggctcatcagtacattctggagtttgatgggggcagcaggagcaaggga
gagcattttccctacgaacaagaaatcaagttcttcgccaaagtcgtgcttcctctcatc
gatcagtatttcaaaaaccaccgcctctacttcctttctgccgcgagcaggccgctgagc
acggggggccacgcgtccaacaaggagaaggaaatggtgacaagcctgttctgcaaactt
ggagttcttgtcaggcataggatttcactgtttggaaacgatgccacgtcgattgtcaac
tgcctccatattctgggacagaccctggacgcgaggacggtgatgaagaccggcatggag
agcgtgaaggccgcgttgagggcgtttctggaaaatgccgccaaggatttggagaagacg
atggagaacctcaaacaaggccagttcacccacaccaggagtcagcccaagggcgtgacg
cagatcatcaactacaccaccgtggccctcttgccgatgctgtcgtctctgttcgaacac
atcgggcagctgcagtttggagaggatttgatcctggaagatgttcaggtgtcttgttac
agaatcctgagtagcttgtatgccctgggtaccagcaagagtatctacgtggagaggcag
agatctgccctaggagaatgcctggcggcttttgccggggctttccccgtggcgtttttg
gaaaccagcctgaatcagcacaatccctactccatctacaacaccaagactccgcgggag
agggcggcgctgaacctgcccgacagcgtggaggagatgtgccccggcgtgcccacgctg
gagaagctgatggaggagatcatggagctggcggagtcgggggtgcgctacgcccagatg
cctcacgtgatggaggtgatcctgccgatgctgtgcagctacatgtcccgctggtgggag
tacgggcccgagggtcggccccggcccggcccccgcccggccgagccctgctgcaccgcc
ctccgctccgaccacatgaacaccctgctgggcaacgtcctcaagatcatccacaacaac
ctgggcgtcgacgagggggcttggatgaagaggctggccgtgttctcccagccgatcatc
aacaaggtcaagtcgcagctgctgaagacccacttcctgcccctgatggccaagctgaag
aagaaggccgccaccgtggtgtcggacgaagaccacctgaaggccgaggcccggggggac
atgtccgaagccgagctgctcatcctggacgagttcaccaccctggcccgggacctgtac
gccttctaccctctgctcatccgattcgtggactacaacagggcaaagtggctgaaggag
cccaaccccgaggccgaggagctgttccgcatggtggccgaagtcttcatctactggtcc
aagtcccacaatttcaaaagggaggagcagaactttgtggttcagaatgaaatcaacaac
atgtctttcctcattacggacaccaagtcgaagatgtcaaaggcggccgtttccgaccag
gagcggaagaaaatgaagcggaaaggggaccgctactccatgcagacctccttgattgtg
gcggccctgaagaggttgctccccattgggctgaatgtctgcgcccccggagaccaggaa
ttaatcgcgctggccaaaaaccgatttagcctgaaagacacggaggacgaagtccgagac
gtcatacgcagtaaccttcacctgcaaggcaagatggaagacccggcaatcaggtggcag
atggccctctacaaagacctgccgcaccggaccgatggagcctcggaccccgagaagacg
gtggagcgcgtgctggacatagccaacgtgctctttcacctggaccagaaaccgacttat
atgggccggagatattacagtatggtggagcatcctcagcgatcgaagaaggctgtgtgg
cataaactgctgtccaagcaaaggaagagggcggtggtggcctgcttccggatggccccg
ctgtacaacctgccgaggcaccgggccgtcaacctcttcctccagggctatgagaagtct
tggatcgaaaccgaagagcattactttgaagataagctgatcgaggatctggcgaagccg
ggcactgagccgcctgaggaggacgaggcctcccggagagtggacccgcttcaccagctc
atcctcctgttcagcaggactgcgctgacagagaagtgcaaactggaggaagatttcctg
tatatggcttatgctgatatcatggcccagagctgccacgacgaggaagacgacagtggc
gaagaggaagtcaagagttttgaagagaaagaaatggagaaacagaagcttctgtaccag
caagccagactgcacgaacgaggagccgccgagatggtgctgcagactatcagtgccggc
aaaggtgacacgggacccatggtggccgcgaccctgaagctcgggatcgccatcttgaat
ggagggaattccacggtccagcagaaaatgttggactacctcaaggagaagaaggacgta
ggcttcttccagagtctcgcaggtctcatgcagtcatgcagcgtcctggacctgaacgcg
ttcgagcggcagaacaaggcagaaggactgggcatggtcacggaagagggatcaggagaa
aaggtgctgcaggatgacgaattcacctgtgacctcttccgcttcctccagctgctgtgc
gaggggcacaactcagatttccagaattacctgcgcacgcagacaggaaacaacaccact
gtcaatatcatcatctctacggtggattacctcctgagggttcaggaatcaatcagcgac
ttctactggtattactccgggaaagatgtgattgatgaacaggggcagcggaatttctcc
aaagcaatccaagtggccaagcaggtcttcaataccctcacggaatacattcaggggccg
tgcaccgggaatcagcagagtttagcgcacagtcggctctgggatgcggtggttggcttc
cttcacgtcttcgcccacatgcagatgaagctgtctcaggactccagccagatcgagttg
ctgaaagaactgatggatctgcagaaggacatggtggttatgctgctgtccatgttggaa
ggcaacgtggtgaacggaacgatcgggaagcagatggtggacatgctggtggagtcctcc
aacaacgtggagatgatcctcaagttcttcgacatgttcctgaagctgaaggacctgacg
tcctcggacgcgttcaaggagtacgaccccgacagcaagggcgtcatctccaagcgggac
ttccacaaggccatggagagccacaagcactacacccagtcggagacggagttcctgctg
tcctgcgcggagacggacgagaacgagaccctggactacgaggagttcgtcaagcggttc
cacgagccggccaaggacatcggcttcaacgtggcggtcctgctgaccaacctgtcggag
cacatgcccaacgacacgcggctgcagacgttcctggagctggcggagagcgtgctcaac
tacttccagcccttcctgggccgcatcgagatcatgggcagcgccaagcgcatcgagcgg
gtctacttcgagatcagcgagtcgagccggacccagtgggagaagccgcaggtcaaggag
tcgaagcgccagttcgtcttcgacgtggtcaacgagggcggcgagaaggagaagatggag
ctgttcgtcagcttctgcgaggacaccatcttcgagatgcagctggccgcccagatctcc
gagtcggacctgagcgagcggtcggccagcaaggaggagagcgaggaggagaagccggag
gagcaggaggtcggcctgggcttcttctccgtccccacggcgacctcggccctgctggcc
ctgagggtccacacgctggccctcgtgaaggcgctgagtgtcaagagcctgaagaagcag
atgaagaaagccaagaagatgacggtgagggacctggcggccgccttcttcgtctcctac
tggaccgtctcggcgggcctcctgcacttctcctcgagcgtcctccgcggcttcctccgc
gtcctgggcggcctgctgctcgggggcggcctggtggagggggccaagaagatccgggtg
tccgagctgctggccaacatgccggaccccacgcaggacgaggtgcggggggagggcgag
gagggcgacgggaagccggcggaggcggccccgccggccgaggacctgacggacctgaag
gagctggcggaggagagcgacctgctctcggacatcttcggcctggatctgaagcgggag
ggaggccagtacaagctcatcccgcacaatcccaacgccggcctcagcgacctgatgagc
gatcccggccccgaggagcaggagcctctccaggaacagaagaaggcacaaggtgacaaa
gacgagaaagaagaaatgaaatccgagccagaaaaagcggagggcgaagacggagaaaag
gaagagaagggcagagatgagaagggcaagcaaaagctaaggcagcttcacgcgcacaga
tacggcgagcccgagactcaagaatcggccttctggaagaagataatcgcctaccaacag
aagcttctcaactatttcgctcgtaacttttacaacatgaggatgttggccttgtttgtg
gcattcgcgatcaacttcatcttgctcttctataaggtctccacctcctcggcgacggaa
gggaaggagttctccatcccgagcgtgagtgaagacactggcttggacagcctggacggc
ccctcccatcggatcatcaccgtccacttcgtcctggaggagagcagcggctacatggaa
cccaccctccgtatcctggccatccttcacacggtcatctccttcttctgcatcattggc
tactactgcctcaaagtgcccctggtgattttcaaacgggagaaggaagtggctcggaaa
ctggaattcgacgggctgtacatcaccgagcagccgtccgaggacgatatcaaagggcag
tgggaccggttggccatcaacacgcagtcatttcctaacaactactgggacaagttcgtt
aagagaaaggtcatggacaagtacagcgagttctacggacgcgaccgcatcagcgagctg
ctggggatggacaaggcggcgctcgatttcagcgacgcccgggaaaagaagaagcccaag
aaggacagctcgctctctgccgtgctgaattccattgatgtgaagtatcagatgtggaaa
ctcggcgttgtcttcaccgataactccttcctttacctggcctggtacatgaccatgtct
gtcctgggacactacaacaactttttcttcgctgcccacctcctggacatcgccatggga
ttcaaaaccctgcggaccatcctgtcatccgtgactcacaacggcaagcagctggtgtta
acggtgggcctgctggcggtggtcgtgtacttgtacaccgtggtggcgttcaacttcttc
cggaagttctacaacaagagcgaagacggcgatatgcccgacatgaaatgcgacgacatg
ctcacgtgctacatgttccacatgtatgtgggagtgcgtgctggcgggggcatcggcgat
gagatcgaagacccggcgggagacgaatatgagatctaccggataatcttcgacatcacc
ttcttcttctttgtgattgtcatcctgttggccatcatacaaggtttgattatcgatgca
tttggagaactgagagaccagcaggagcaggttaaagaagacatggagaccaaatgcttt
atctgcggcatcggcaacgactacttcgacacggtgccccacggcttcgaaacgcacacc
ttgcaggaacacaacctggccaattacctgttctttctgatgtatctcataaacaaagat
gagacggaacacacagggcaggagtcgtacgtgtggaagatgtaccaggagaggtgctgg
gagttcttcccagccggcgactgcttccgcaaacagtacgaagaccagctcaactga

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