Ornithorhynchus anatinus (platypus): 100088528
Help
Entry
100088528 CDS
T01045
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
oaa
Ornithorhynchus anatinus (platypus)
Pathway
oaa00310
Lysine degradation
oaa01100
Metabolic pathways
oaa05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
oaa00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
100088528 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
100088528 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
oaa03036
]
100088528 (DOT1L)
Enzymes [BR:
oaa01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
100088528 (DOT1L)
Chromosome and associated proteins [BR:
oaa03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
100088528 (DOT1L)
HMT complexes
Dot1-containing complex
100088528 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
CBP_CCPA
Motif
Other DBs
NCBI-GeneID:
100088528
NCBI-ProteinID:
XP_028913200
Ensembl:
ENSOANG00000010015
LinkDB
All DBs
Position
Unknown
AA seq
1559 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVQ
ENKVAVLLDCHMDSGAEEDKTGVATVKKPSPSKARKKKLSKKGRKMAGRKRGRPKKMNTA
NTERKPKKNQTALELLHAQTVSQTASSSPQDAYKSPHSPYYQLPPKVQRHSSNQLLVTPT
PPALQKLLDSFKIQYMQFMAYMKTPQYKANLQQLLEQEKEKNAQLLGTAQQLFIHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLKEQTKQLEKENSELRNQSLQLL
KARCEELKLDWSTLSLENLLKEKQALKNQISEKQKHCLELQISIVELEKSQRQQELLQLK
SYMPADETPSVHLRHKSHLNRELEPEHSRFQLELECAKFSLPHINGMSPELSMNGHAAPY
EIPSTLSRSSSKQNTPQYLTSHLDQEIVPCTPNHNSRQKVDRVASLSIPDYTRFSPAKIA
LRRHLNQDHAATGKAPASDLHQRAEHAKENGLSYQSPGISNGIKLSPQHVRPSSPSALQI
AAGEKNTEKVLKERAYASNGETITSLPISIPLSTVQPNKLPVSIPLSSVVLPSRVEKVRS
TPSPVHQTRDSTSTLEKQFGANSYNGLSSATGTKPFASATSGFSYSGSVAVGGTVSSSPA
QLNHVVEQTALDDPSNSGSLFNAVGSRSSTPQHPSLLMMQCRNSGPNSPAHQHPVSPRLP
GAAQGLPGALQHADPQKMFTEGHMGDLQSDWGFSDPESEAKRRIIFTISTNAGNLKQSPS
NKHSPLTASIRTDCGPAYMQDGKKRGRRKRSSSGHPSGLSPKRKPLPSVAGLFTPSSGSP
LNINSMVNNINQPLEITAISSPENSLKNSPVPYQDNDQPPVLKKEKPLIQTNGIYYSPLT
SDEEQGSEDERNSTRIERKIATISLESKSPPKSMENAGGSGSSGRKPGPTHESTNSSKWK
STFSPISDLHLAKTADSPGQAAPPLFAFRPPSEDAGPADGKLSVHPRKNLAGGSAGAGAL
SPNGFAYNGGLSADLSLHSFPDGASLSHKASEVTGLHSPLGFPSQRSRDVSVSETNPFLN
KRQLDGLGGLKGDEFGRAGGKSKEMSELGVHPSEKGPLQHSGKVGKGRDRDLEFKNGHNL
FIAAAAAPPGGLLNGRSLPTAGPSSGNSVSAVQTHHPFLNAVTAGSQFPLGPGTLPANLS
SVASSSVLQSLFNSVPTAASLVHVSSAATRLTNSHAMGSFSSGVTGGTVGGRQNVASQL
NT seq
4680 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggaactgaggctgaagtcgccggtgggagcggagcctgccgtatac
ccctggcccttgccggtctacgataaacaccacgatgctgctcatgagatcattgagacc
attcgatgggtctgtgaagaaatcccagatctcaaacttgccatggaaaattatgttctg
attgactatgataccaaaagctttgaaagcatgcagagactctgtgacaagtacaaccga
gccattgatagcatccatcagttgtggaaaggaaccacccagcccatgaaactgaacact
cgtccatccaatggacttctccggcatattttgcagcaagtgtataaccactcagtgacg
gacccagagaaactcaacaactatgagcctttttccccagaagtgtatggagagacttcg
tttgacttagtggcccagatgattgatgagattaaaatgacagaagatgatttgtttgtg
gacttgggcagtggagtgggtcaggtggtgcttcaggtggcggcagccaccaactgcaag
catcattatggtgtggagaaagctgatattccagccaagtatgccgagacaatggacaga
gagttcagaaagtggatgaaatggtatgggaaaaagcatgcagaatacacactggaaaga
ggtgacttcctctcggaagagtggcgagaacgaatagcaaatacaagtgttatttttgtg
aataattttgcctttggtcctgaggtggatcaccaactgaaagaacgatttgcaaacatg
aaggaaggtggcagaatcgtatcctcaaaaccttttgcacctctaaactttagaataaac
agtaggaacttgagtgatattggcactataatgagagttgtggagttatcaccactgaaa
gggtcggtttcatggactgggaaaccagtctcttactacttgcataccattgatcgaaca
atacttgaaaactatttttctagtctcaaaaatccaaagctcagggaggaacaagaggca
gctagacgccgacagcaaagagaaaacaagagtaatacgacaactccaacaaaggtccaa
gaaaacaaggtagctgttctcttggattgtcacatggattctggtgctgaagaagataaa
actggggtagcgactgtaaaaaagccatctccctccaaagcacgcaagaaaaagttaagc
aagaaaggaaggaaaatggcgggcagaaagcgtgggcgccccaagaaaatgaacactgca
aacactgagcgcaagcccaagaagaaccaaaccgcactggagctcctacatgctcaaact
gtgtcccagacagcatcatcctctcctcaggatgcatacaagtcacctcatagcccatat
taccaactacctcctaaagtgcaacggcattcatctaatcagctgttggtgactcccacc
ccccctgcactacagaagctgctagactcctttaagattcagtacatgcaatttatggca
tacatgaaaactcctcaatataaggcaaacctacagcagttactggagcaagaaaaggaa
aaaaatgcccagctgctgggcaccgcacaacaactgttcatccattgccaggcccagaaa
gaggaaatcaagcgactatttcagcagaaactcgatgagttgggagttaaggcactgact
tacaatgacctgattcaagctcagaaagagatctccgctcataaccagcagttaaaggaa
caaaccaaacagctagagaaagagaacagtgaactcaggaaccagagcttacagctgctt
aaggctcgatgcgaagagctgaagctggattggtccaccctgtcgctggagaatttactg
aaggaaaagcaggccctgaagaatcaaatttcagaaaagcagaagcattgtttggagttg
cagatcagcatcgtggagctggagaagagtcaaaggcagcaggagctgttgcagctcaag
tcctacatgccagctgatgagacaccgtcggttcatctgcgccacaaaagccatttaaac
cgggagctcgaacccgagcacagccgattccaacttgagcttgagtgcgccaagttctct
ctgccccacatcaacggcatgagccccgaactgtccatgaatggccatgcggctccctat
gaaattcccagtacgttgagccggtcctcttccaagcagaacacccctcagtacctgacc
tcccacctggaccaagaaatcgtgccctgcactcctaaccacaacagcaggcagaaggtg
gaccgagtggccagcttatccatccccgactacacccggttttctccagccaagatagcc
ctacggagacacttgaatcaggatcatgcagccactgggaaagccccagctagtgacctg
caccagagagctgagcatgccaaagagaatggcctttcatatcagagccccgggatttca
aacggcataaaactgagtcctcagcacgttcggccttcttctccttctgctttacagatt
gcagcgggagagaagaacactgagaaggttttgaaagaaagagcctatgccagcaatgga
gaaacgatcaccagcttacccatcagtattcctctcagcacagtgcagcccaataaactc
cctgttagtatcccactgtccagtgtagtcctgcccagccgggttgagaaggtgagaagc
acacctagtccagttcatcagactcgagactctacttcaacacttgaaaaacagtttggt
gctaattcctataatggtctaagcagtgctactggaaccaagccctttgcttcggctacc
tcaggtttttcttattctggctcggtggcagtcgggggaactgtttccagcagcccggcc
cagcttaaccacgtcgttgagcagactgctctggatgacccgtccaattcggggagtctg
ttcaacgcagtaggctcccggagctccaccccacaacatccttctttgctcatgatgcag
tgccggaattctggtccgaactcccccgcccaccagcacccggtgagcccccggctcccc
ggggccgcccaggggctgcctggggcgttgcagcatgcagatcctcagaagatgttcact
gagggccacatgggagacctgcagtctgattggggcttttctgatcccgagagtgaagcc
aagagaagaattatctttaccatctctacaaatgcaggaaacctaaaacagtctccttcc
aacaagcacagtcccctaacggcaagcatccgaacggactgtgggccagcctatatgcag
gacggcaagaagagagggaggaggaagcggtcttccagcgggcaccccagcgggctgtct
cccaaacgcaaacccttaccgtccgtggcgggactctttactccgtcgtcaggctcaccc
ctcaacatcaactctatggtcaataacattaatcagcctttagagatcacagccatttcc
tccccggaaaactccctgaagaattctcctgttccctaccaggacaacgaccaaccgccg
gtgctgaaaaaggagaagccgctcatccagaccaatgggatttactattccccgctcacg
tctgatgaagaacagggatccgaagatgagcgcaacagcaccagaattgaaagaaaaatt
gccaccatctctttggaaagcaaatccccaccaaaatcaatggaaaatgcagggggcagc
ggttcgtcaggaaggaaaccgggaccgacccacgagagcacgaatagcagcaagtggaag
tccaccttctcacccatctccgatctccacctggccaagacggccgacagccccgggcag
gccgcaccacctctgttcgccttcaggccgccctcggaggacgctgggcctgccgacggc
aagctctcggtgcacccccggaaaaacttggccgggggctcggcgggggctggtgcgctc
agcccgaatggatttgcctacaatgggggcctgtcagccgatctgagtttacacagcttt
cctgatggtgcttctctctctcataaggctagcgaggtgacgggcttacattcccctctg
ggttttccatcccagcggagcagagacgtcagtgtctccgagacaaacccctttctgaac
aagcggcagctggatggcctggggggcttgaaaggggacgaatttggaagggcagggggc
aaaagcaaagagatgagtgagttgggggtgcatccatctgaaaaagggcccctgcagcac
agtggcaaggttgggaaaggacgggaccgtgacctggagtttaaaaatggccacaacctt
ttcatcgccgccgccgctgcccctcctgggggccttctcaatggcagaagccttcccacg
gctggcccctcttctggcaactcagtatctgccgtgcaaacgcaccatcctttcttaaac
gctgtcaccgctggatcccagttccccctgggccccgggaccctgccggccaacctcagt
tctgtggccagctcatcggtcttgcagtccttatttaattcagtgcccacagctgccagt
ttggtccacgtgtcatcggctgcaaccagactgacaaattctcatgctatgggaagcttc
tcttccggggtgacgggtggaacagttggaggtaggcagaacgtggcttctcagctctga
DBGET
integrated database retrieval system
