Ornithorhynchus anatinus (platypus): 100091802
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Entry
100091802 CDS
T01045
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X1
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
oaa
Ornithorhynchus anatinus (platypus)
Pathway
oaa00790
Folate biosynthesis
oaa01100
Metabolic pathways
oaa01240
Biosynthesis of cofactors
oaa01523
Antifolate resistance
oaa04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
oaa00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
100091802 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
100091802 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
100091802 (FPGS)
Enzymes [BR:
oaa01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
100091802 (FPGS)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
100091802
NCBI-ProteinID:
XP_028917918
Ensembl:
ENSOANG00000008391
UniProt:
F6XLU7
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Position
4:complement(32058379..32075061)
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AA seq
585 aa
AA seq
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MKGLEPQLAPGRWLQVRSIGFEGTMHGRRLNPRPRGSEVAAFEDAVRTLNTLQTNAGYLE
QMKRERGDPQAQLEAMKQYLVRSGLQVEDLDQLNIIHVTGTKGKGSTCAFTERILRNYGL
KTGFYSSPHLVQVRERIRIDGQPISPEMFTKYFWRLYHRLEETKDASCASMPPYFRFLTI
LAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGISSLGIDHTSILGDTIEKIAWQK
GGIFKPGVPAFTVSQPERPLQVLKDRARCLPCPLYLCPNLDVLEEEEQVLGLGLAGDHQR
DNAALALQLARSWLQQHGHKGIGEPKVPRQGPRRILPSAPVFRPTLLMQQGLRDTEWLGR
TQVLQHGPLTWYLDGAHTTSSIQAGVRWFRQAALNQEKPNNGSEVRVLLFNASGDRDTAA
LLKLLQPCQFDYAVFCPNFAEVSTVGNADQQNFTVTLDHMLTRCLENQKQWNGLVEEKAG
LDPWLPGSPDPEGPLHGPLRLVPSSPRPLNSNSLVFSCISHALQWISQGRDPHFQPPAPR
GLHNHPVASSGAVLLKEATAIRVLVTGSLHLVGGVLKLLDQSLSQ
NT seq
1758 nt
NT seq
+upstream
nt +downstream
nt
atgaagggcttagagcctcagttggctccgggccggtggcttcaggtccggagcatcggg
tttgaagggacgatgcatggtagaagattgaatccccggccccgcgggagcgaggttgct
gcttttgaggatgccgtccggaccctcaacactctgcagaccaatgcgggctacctggag
cagatgaaacgggagcggggcgatccccaggctcaactggaggccatgaagcagtacctg
gtgcgaagcgggctgcaggtggaagacttggatcagctgaatatcatccatgtaactggg
accaagggcaagggctccacatgtgccttcaccgagcgcattctgcgcaactacggtcta
aagacgggattctatagctccccccacctggtgcaggtgcgggagcggatccgcatcgac
gggcagccgataagccccgagatgttcaccaaatacttctggcggctctaccaccggctg
gaggagaccaaggatgcaagctgtgccagcatgcctccttacttccgcttcctcaccatc
ctggccttccatgtattccttcaggagaaggtggatctggctgtggtggaggtgggcatc
gggggagcttatgattgtaccaacattatcaggaagccggtggtctgtggaatctcctct
ttgggcatcgatcacaccagcatcctgggggataccatcgagaagatcgcttggcagaag
gggggcatatttaagcctggagttcccgccttcaccgtgtcccaaccggagaggcccttg
caagtgctcaaggaccgagcccgctgcctcccgtgccccctctacctgtgccctaacctt
gatgttctggaggaagaggagcaggtgctgggtctggggctggcgggggaccaccagcgg
gacaatgcagccttggccctgcagctggcgcggagctggctgcagcagcatggacacaag
gggattggagagccgaaggtcccccggcagggccccaggcggatcctgccctcggcacct
gtgttccggcccaccctcttaatgcagcaggggttgcgcgacacagagtggctgggccgg
acccaagtgctgcaacacgggcccctcacctggtacctggacggggctcacaccaccagc
agcatccaggctggggttcgctggttccgccaggccgccctcaatcaggagaagccaaac
aacggctcggaggtgcgggtgctactgtttaacgcttcgggggaccgagacacggccgcg
ctgctgaaattgctacagccctgccagtttgactatgctgttttctgccccaactttgcc
gaggtgtcaactgtgggaaacgcagaccagcagaacttcaccgtgaccctggaccacatg
ttgactcgctgcttggagaaccagaaacagtggaatgggctggtggaggagaaagccggg
ctggacccctggctacctggaagtcccgaccccgagggcccccttcatggaccgctgagg
ctggtgccctcctctccccgcccgctcaactccaactccctggtcttcagctgcatctcc
cacgctctgcagtggatcagccagggccgggacccacatttccagcctcccgcgccccgg
gggctccacaaccaccccgtggccagcagcggggccgtcctcctcaaggaggccaccgcc
atccgcgtgctggtgaccggcagcctgcacctggtgggcggggtcctgaagctgctggac
cagtcgctgtcgcagtaa
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