KEGG   Ovis aries (sheep): 100305131
Entry
100305131         CDS       T03117                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
oas  Ovis aries (sheep)
Pathway
oas01521  EGFR tyrosine kinase inhibitor resistance
oas01522  Endocrine resistance
oas04010  MAPK signaling pathway
oas04012  ErbB signaling pathway
oas04068  FoxO signaling pathway
oas04270  Vascular smooth muscle contraction
oas04650  Natural killer cell mediated cytotoxicity
oas04720  Long-term potentiation
oas04726  Serotonergic synapse
oas04730  Long-term depression
oas04810  Regulation of actin cytoskeleton
oas04910  Insulin signaling pathway
oas04914  Progesterone-mediated oocyte maturation
oas04928  Parathyroid hormone synthesis, secretion and action
oas05010  Alzheimer disease
oas05022  Pathways of neurodegeneration - multiple diseases
oas05034  Alcoholism
oas05160  Hepatitis C
oas05161  Hepatitis B
oas05200  Pathways in cancer
oas05205  Proteoglycans in cancer
oas05208  Chemical carcinogenesis - reactive oxygen species
oas05210  Colorectal cancer
oas05211  Renal cell carcinoma
oas05212  Pancreatic cancer
oas05213  Endometrial cancer
oas05214  Glioma
oas05215  Prostate cancer
oas05218  Melanoma
oas05219  Bladder cancer
oas05220  Chronic myeloid leukemia
oas05221  Acute myeloid leukemia
oas05223  Non-small cell lung cancer
oas05224  Breast cancer
oas05225  Hepatocellular carcinoma
oas05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:oas00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    100305131 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    100305131 (ARAF)
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    100305131 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    100305131 (ARAF)
   04720 Long-term potentiation
    100305131 (ARAF)
   04730 Long-term depression
    100305131 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100305131 (ARAF)
   05205 Proteoglycans in cancer
    100305131 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    100305131 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100305131 (ARAF)
   05212 Pancreatic cancer
    100305131 (ARAF)
   05225 Hepatocellular carcinoma
    100305131 (ARAF)
   05226 Gastric cancer
    100305131 (ARAF)
   05214 Glioma
    100305131 (ARAF)
   05221 Acute myeloid leukemia
    100305131 (ARAF)
   05220 Chronic myeloid leukemia
    100305131 (ARAF)
   05218 Melanoma
    100305131 (ARAF)
   05211 Renal cell carcinoma
    100305131 (ARAF)
   05219 Bladder cancer
    100305131 (ARAF)
   05215 Prostate cancer
    100305131 (ARAF)
   05213 Endometrial cancer
    100305131 (ARAF)
   05224 Breast cancer
    100305131 (ARAF)
   05223 Non-small cell lung cancer
    100305131 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    100305131 (ARAF)
   05160 Hepatitis C
    100305131 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100305131 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    100305131 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    100305131 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100305131 (ARAF)
   01522 Endocrine resistance
    100305131 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:oas01001]
    100305131 (ARAF)
Enzymes [BR:oas01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100305131 (ARAF)
Protein kinases [BR:oas01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   100305131 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 100305131
NCBI-ProteinID: NP_001159362
UniProt: A0A6P3CXM2
LinkDB
Position
X:complement(57261686..57272081)
AA seq 606 aa
MEPPRGPPANGAEPSRSVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSVQDLSGSSRQHEVPSNRPLNEPL
TPQSPSSCTQHRDPEHFSFPAQANTPLQRIRSTSTPNVHMVSTTAPMDSGLIQLTGQNFN
TDAAGNRGGGDGAPRGSPSPASVSSGRKSPHSKSPSEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgctaacggggccgagccctcccggtcagtgggcacc
gtcaaagtgtacctgcccaacaagcagcgcacggtggtgactgtccgggacggcatgagt
gtctatgactctctagacaaggccctcaaggtgcggggtctcaatcaagattgctgtgtg
gtttaccggctcatcaaggggcgaaagacagtcactgcctgggacacagccattgccccg
ctggatggcgaggagctcattgtggaggtcctcgaagacgtccccctgaccatgcacaat
tttgtacggaagacattcttcagcctggccttttgtgacttctgccttaagtttctgttc
catggtttccgctgccaaacctgtggatacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgtcgacatgagtaccaaccgccgacagttctaccacagtgtccaggat
ttgtccggaagctccagacagcacgaggttccctcaaaccgccccctgaatgagccgctc
acccctcagagtcccagctcctgcacccagcaccgcgaccccgagcacttctccttccct
gcccaggccaacacccccctccagcgcatccgctccacatccacccccaatgtccacatg
gtcagcaccacagcccccatggactccggcctcatccagctcactggccagaacttcaac
actgatgctgctgggaatagaggtggtggcgatggagccccccgggggagccccagccca
gccagcgtgtcctcgggaaggaagtccccacattccaagtccccatcagagcagcgggaa
cggaagtccttggctgatgacaagaagaaagtgaagaatttggggtaccgggactcgggc
tattactgggaggtgccacccagtgaggtgcagttgctgaagaggatcgggacgggctcg
tttggcacggtgtttcgcgggcggtggcatggcgatgtggccgtgaaggtgctcaaggtg
gcccaacccacagctgagcaggcccaggccttcaagaacgagatgcaggtgctcaggaag
acacgtcacgtcaacatcttgctgttcatgggcttcatgacccggccaggatttgccatc
atcacacagtggtgtgagggctccagtctctaccaccacctgcatgtggctgacacacgc
ttcgacatggtccagctcattgatgtggcccgccagactgctcagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacaacatcttcctgcacgagggg
ctcacggtgaagatcggggattttggcctggccacagtaaagacgcggtggagtggggcc
cagcccttggagcaaccctcaggctctgtgctatggatggcagctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcagatgtctacgcctatggggttgtgctctat
gagctcatgaccggctcactgccttacagccacattggcagccgagaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaattgccccaag
gccatgaggcgcctgctgtctgactgcctgaagttccagcgagaggagcggccccttttt
ccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgagcggagt
gcctccgaaccctccttgcaccgtacccaggctgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag

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