Ovis aries (sheep): 101106269 Help Entry 101106269         CDS       T03117                                  Symbol SYNE1 Name (RefSeq) nesprin-1 isoform X2   KO K19326   nesprin-1 Organism oas  Ovis aries (sheep) Pathway oas04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:oas00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     101106269 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:oas03036]     101106269 (SYNE1) Chromosome and associated proteins [BR:oas03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     101106269 (SYNE1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 SYNE1 CH KASH PBP_N Motif Other DBs NCBI-GeneID:  101106269 NCBI-ProteinID:  XP_014952960 LinkDB All DBs Position 8:complement(76909145..77401459) Genome browser AA seq 8832 aa AA seqDB search MASSRAASRSPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKSMYRGSPIKLVNINSTD IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQALSSSASSMDSMVSSETASPPSKRKVA TKIQGNAKKALLKWVQYTVTKQSGIEVKDFGRSWRSGVAFHSVIHAIRPELVDLEKVKGR PNRENLEEAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKQYPDVHSTGSDGQ EIDEILPSFPSFTNSIQILKREDRLILKEMKVWIEQFERDLTRAQMTDSSLQDKYQSFKH FRVQYEMKRKQIEHLLQPLHRDGKLSLDQALVKQAWDRVSSRLFDWHIQLDKSLPAPLGT IGAWLYRAEVALREEITIQQVHEETANTIQRKREQHKDLLQNTDAHKRAFHEIYRTRSVN GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGGR DSVELLLQNYISFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQ WRNLSVEVRSVRSMLEEVIANWDRYGNTVASLQAWLEDAEKMLNQSEHAKKDFFRNLPHW IQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYARADELDRMKKEY NDCVTVLSDFATEAHRKLSEPLEVSFINVKLLIQDLEDIEQRVPVMDAQYKMITKTAHLI TKEISQEEANEMFATMSGLKEQLTKVKDCYSPLLSESQQLLVPLEELEKQMTAFYDSLGK IDEIMTVLEHEAQSSPLFKQKHQELLACQESCKKAMTQIEKGSQSVQKFVTLSNVLKHFD QTKLQRKIADMHVAFQNMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRVAQEGLEEK GDPEDLLKRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQRGLQEAVRKLHKQWKDLQA EAPYHLLHLKIEVEKNRFLASVEECRAELDRETKLVPQEGSEKIIKEHRIFFSDKGPHHL CEKRLQLIEELCLKLPVRDAVRNTPETCHVTLKELRAAIDCTYVKLVGDPDKWKDYTSRI SEFSSWISAKETQLKGIKNETIDTANQGKVKRALEEIRSGITKKGETLSWLKSRLKILIE VSSEDEAQKQGDELAKLSSSFKALGTLLSEVEKMLSNFGDCVQYKEIVKSSLEELITGSK EVQEEAEKILDTENLFEAQQLLLHHQQKTKRINAKKKDVQQQIAQAQQGEGGLPGRVQEE LQKLESTLDSVEHSREKQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE SLSSELEQTKEFSKRTEGIAVQAENLVKEASEIPLGPKNKQLLQQQAKSIKEQVKKLEDT LEEDIKTMEMVKNKWDHFGTNFETLSIWITEKEKELNALETSSSAMDTQINQIKVMIKEI ESKISSITGLEEEAQSFAQFITTGESARIKAKLTQIRRYWEELREHAQSLQGIILGHLSQ QQKFEENLKKIQQSVSEFEDKLADPVKICSSATETYKVLQEHMDLCQALESLTSTVAALS VSARKVSNRDASIQEAATMQRSYEGLLGRAKERQTELEKLLACWQRLEKELSTFLTWLER CEAIASSPEADISADRVKVESELQSIQVLQNEVVSQASIYSNLLQLKESLFSVASKDDVK MMKLQLEQLDERWRDLPQIISKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE ISIVDHQAALTRHKDHVAEVESKKGELQSLQGHLAKLGALSRAEDLHLLQGKAEDCLQLF EEASQVVERRQHALSQLAKFLQSHASLSESLHQLRQTVEATHSMNKKQSDLLERDLNDAI RNVKTLESAAISLDGLLTKAQYHLKSGGSEQRTSCRATSDHLSVELERIQNLLGTKQSEA DALAVLKKAFRDQKEELLKSIEDIEERTDRERLKDLTRQALQQRLRVFNQLEDELNSHEH ELCWLKDKAKQIAQKDVAFAPEVDKEINRLEVTWDDTKKLIHENQGQCCGLIDLMREYQN LKSAITKVLESASNVIATKTTVKDQEDLKWALSKHEAAKNEMCNKQKDLDNFTSKGKQLL SELKKIHSGDFIVVKTDLESTVDKWLDISEKIEESMDRLRVSLSIWDDVLTSKDEIDGWS NHSVPQMTESISNLNDSLRAEEFLKEFESEVKKKTLRLEELRSKVNDLKELTKNPETPPD LQFIEADLRQKLEHAKEITEEAKGTLKEFTTQSAQVEKFINDTATWLTKLEESLMNCAQT ETCEALKKVKDIQKELQSQQSNISTTQENLNSLCRKYHSVELGSLGSAMTGLIKRHEAVS QSCSKTQASLQDSLEKHFNESMQEFQEWFSGIKAAAKESSDRTGDSKVLEAKLHDLQNIL DSVSDGQSKLDAVTREGQTLYAHLSKQIVSSIQEQVTKANEEFQAFLKQCLKDKQALQDC ALELGSFEDQHRKLNLWIHEMEGRLSTENLGESKQHIPEKKNEVHKIEMFLGELLAARES LDKLSQRGQLLSEEGHGAGKESRLCSQLLTSYQNLLRMTKEKLRSCQVALQEHEALEEAL QSMWSWVKDMQDRLASAEGTVGSKDALERRLLQVQEILLMKGEGEVKLNMAIGKGEQALR SSNKEGQKMIQTQLQTLKDVWGNIMGSSIHAQSTLESVISQWNDYLEWKNQLEQWMESVD QKVEHPLQLQPGLKEKFSLLDHFQSIVSEAEDHAGALQRLTAKARELYQKTEDEAFTDTA QEELKTQFNDILTVSKEKMRKVEEIVKDHLVYLDAVQEFTDWLHSAKEELHRWSDMSGDS PATQKKLSKIKELMDSREIGASRLSRVESLAPAVKQNTTASGCELLHTEMQALRADWKQW EDSVFQTQTSLENLVSQMALSEQEFSGQVAQLEQALEQFSALLTSWTQQLALLEGKNTDK ELVECWQKGREILDALQKAEPQTENLKSQLNELCRFSGDLSTYSGKVSGLIKEYNCLCLQ ASKGCQNKEQILQQRFLRAFKDFQQWLVNAKITTAKCFDIPQNINEVSMSLQKIQEFFSE SENGQHKLNMMLSKGELLCTLLTKEKASSIQAKIATAKEDWKNFHSNLHQKESALENLKI QMKDFEVSAEPVQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEINCYEPQLRRL KEKAQQLWEGQAASRSFMHRVSQLSSQYLALSNVTKEKVSRLDRIVAEHNQFSLGIKDLQ DWMTDTVHMLDSYCHPTSDKSVLDSRMLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP EGVPAIQQQLASVKDMWASLLSAAIRCKSQLEGALSKWTSYQDDVRQFSSWMDGMEASLN ESERQHAELREKTAALGKAKLLNEEVLSHGSLLETIEVKGAGMTEHYVTQLEFQDLQERY RAIRERTKEAVTKSEKLVRLHQEYQRDLKAFEAWLEKEQEKLDRYSVLEGDAHTHETALR DLQELQVRCAEGQALLNSALHTREEVIPSGIPQTEDRALESLRQDWQAYQQRLSETRTQF NNVVNKLRLVEQKFQQVDEWLKTMEEKVNPRTGRQSSRAAKEMQLHQMKKWHEEITAYRD EVEEVGARAQEILDESHVSSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESELS LSSYSDWYSSTHKNFKNVAAKIDKVDKVMMGKKMKMLEGLLKDMEKGQSLLKSTREKGER ALKYLEDGEAETLRKEIHDHMEQLKELTGTVRKEHMTLEKGLHLTKEFSDKYKALTQWIA EYRDILHGPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLK DKIDQLQSDYQDLCSAAKEHVYSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLMET SSLETITQQLARHKAMMEEIAGFEDRLNDLKTKGDNLISQCADHLQAKLKQNVHAHLQGT KDSYSAICSTAQRVYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLKPSVNPPLSRAEAV KQVKHFRALQEQARTYLDLLCSMCDLSNSSVKTTAKDIQQTEQMIEQRLAQAQNLTQGWE EIKHMKAELWSYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQCKQASVTTIT EKVDELTKKQESPEHKEISHLNDQWLDLCLHSNNLCLQREEDLQRTRDYHDRMNVVEGFL EKFTTEWDNLARSDAESTAVHLEALKKLALALQERKKAIEDLKEQKQKMIEHLNLDDKEL VKEQTSHLEQRWFQLEDLVKRKIQVSITNLEELSVVRSRFQELMEWAEEQQPNIAEALKQ SPPPDMAQNLLMDHLAICSELEAKQMLLKSLTKDADRVMADLGLNERQIIQKALSDAQRH VSSLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQV KTCKSAQASLKTYQNEVTGLWAQGRELMKGVTEQEKSEVLGKLQELQSVYDTVLQKCSHR LQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNETAELHTQLAKYQHILEQSP EYENLLLSLQRTGQAILPTLNEVDHSYLDEKLHALPLQFNVIIDLAKDKFYKVQEAMLAR KEYASLIELTSQSLHDLEDQFSRMSQIPGHLSVEEALSLQDSWRALGGEVAGLTEAMDEL NQKKESFRSTGQPWQPDKMPQLVTLYHRLKRQTEQRVSFLEDTTSAYQEHERMCLQLEKQ LEAARMEQSKVNEETLPAEEKLKVYHSLAGSLQNSGILLKRVTRHLEDLVSHLDPAAYEK AKHQLQAWQEELKLLTSAIGVTVTECESRMVQSRDFQTELSRSLDWLRSVEAALSGPLCL DPNLRDIQEEIRKVQIHQEEVQSSLRIMNALSNKEQEKFMRAKELISADLQRTLAELSEL DGALQEALRTRQTTLTQIYSQCQRYYQVFQAANDWLEDAHEMLQLTGNGLDVESAEESLK SHMEFFSAEDQFHSNLEELQGLVANLDPLIKPTGKEDLAQKMASLEEKSQTIIQDSHAQL ELLQRCAAQWQDYQKAREEVIELMNEAEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVIN SFHEKIVALEGEASELERTGNDASKAAISRSTTAVWQRWTRLRAVAQDQEKLLEDAVDEW TSFNNKVKKASEMIDQLQDKLPGSSAEKASKAELVTLLEYHDTFTLELERQQSALGMLRQ QALSMLQDGVTPSPGGEPPTVQEITAMQDRCLNMQEKVKKNGKMVKQELKEREVVETQIS SVKSWVQETKEYLGNPTIEIDAQLEELKILLTEAINHRQNVEKMAEEQKNKYLGLYTILP SELSLQLAEVALELGTIHDQIQDKVKEVEQSKTMSQEFSQQIQKIARDITTILTKLRAKT DNLVQAKTDQKVLGEELDGCHLKLMELDKAVQKFSEQNGQLGKPLAKKIGKLTELHQQTI RQAENQLSKLNQAASHLEEYNEMLELILRWIEKTKILVHGKIAWNSASQLREQYISHQTM LEESEDIHNDLEAMTEKLQYLDSVYHTEIMSQQVADLGRETEELRQVIKIRLQSLHDAAK DMKKFEAELRNLQVALEQAQTTLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVHAVQVC QSALRIPEDVVTSLPLCHAALHLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMQHLQE LIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTVKAKHA TMLLTVTEVEGLAEGTEDLAGELLPATSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSE ISSPPACRSPSPVANTDASVNQDIAYYQALSPERLQTDAAKVPPSTLPPQELYEPGLEPS ATAKLDDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIEMKLSESLEQ GRSPESQMAEHQSFPQALMDEILMLQEEISELQSALADELVSESPESEPAEQLALQSTLT VLAERMSTIKMKASGKRQLLEEKLNDQLEEQRQEQALHRYRCEADQLDHWLLSTKATLDI ALGSPKEPMDMEAQLVDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAVK LRTLKGSLLELQRALQDRQLHIQQGTAQEKEESDADLAATQSPGVQEWLAQARSTWTHQR QSSLQQQKELEQELAEQKSLLQSVASLGEEILTQHSAPEPSGGVGEKPDVLSQELGMEGE KSPAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDGQAQD KSAVTSLLDGLNQVFEEVSSQGGGTKKQSVDLERKLYDGVSATSTWLDDVEERLFVATAL LAEEPETCIFNQETLAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSL LDSVVNQRCHQMKERLQQILNFQNDLKVLVTSLADHKYIILQKLAKMFEQPVAEQIEAIQ QAEDGLKELDAGIIELKRRADKLQIEQPSMQELSKLQDMYDELLMTIGSRRSGLNQNLAL KSQYERALQDLADLLETGQEKTAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL FRKIISFAVPRETQFHTDLMAQASAVLKGAHKRGVELEYILETWSQLEKEHWELSRQLEV VEGSTPSVGLVEESEDRLIDRIALYQHLKSSLNEYQPKLYQVIDDGKRLLISVSCPDLES QLNQLGEHWLNDTNKVSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVT VPQELEMVRDHLNGFLEFSKEVDAKSTLKSSVLSTGNQLLRLKKVDTAALRSELSHIDGQ WNDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMTWISLMESVIQKDEENIKNSIGYKTIH EYLQKYKGFQIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAERLGAMNKSWQILQ GLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEERLKQQHRIGDQASVQNAMKDCQDL EDLIKAKEKEVEKIEQNGLALVQNKKEEVSGTVRSTLQELNQTWANLDHMVGQLKILLKS VLDQWSHHKVAFDEINSCLMEARYSLSRFCLLTGSLEAVQIQVDSLQNLQDDLEKQEKSL QKFGSVTSQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLRASKALLQLWQRYKDY FKQCAATVQQQEGRTNEFLKAATDKDIGDDEVATWIQDCNDLLKGLGPIQDSLVVLHELG GQLKQQVDASAASAIQSDWLSLKQQSHALEQALCKQQTVLQAGVLDYETFTKSLEALETW IVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMVPDLDRLNELGYRLPLNDKEI KRVQNLNRHWALISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY QHLLEQQRAHELFQAEMFSCQQILHSIIFDGQHLLEQGQVDDRDEFNLKLTLLSNQWQGV IRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSCLPVSGLGSVRIPLQQARALFDQV QFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEATLQAELAEIQEKWKSASVCLEEQKKK LAGLLQDWEKCENGIADSLEKLRTFKKRLSQPLPDHHEELHAEQMCCKELENAVGSWTDD LAQLTVLKKALCAYISADDISILNERMELLQRQWEELCHQLSLRRQQVSERLNEWAVFSE KNKELCEWLTQMESKVSQNGDILIEEMIEKLRKDYQEEIAVAQENKIQLQQMGERLARAS HESKASEIEYKLGKINDRWQHLLDLMAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESE LAKPIVYDSCDSEEIQKKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECD SIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDFSHFEDWLKISERTAAFPSS SGVLYTVAKEELKKFEAFQRQVHESLTQLELINKQYRRLARENRTDAAGSLKQMVHKGNQ RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIK QLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAVIEEELDELRRYCQEVFGRVDRYH KKLMRLPLPDDEHDLSDRELELDEAGALSDLRWRDTTDGVLSPQPSSNPSLSLAQPLRSE RSGRDTPASVDSIPLEWDHDYDLSRDLESAVSRTLPSEDEEGPEDKDFYLRGAVGLSDVV IPESPEAYVKLTESAIRNSSGDRGALESQIRQLGKALDDSHFQMQQTENIIHSKTPTGPE LDSGYRGYMKLLGECSGSIDSVKRLEHKLTEEEDHFPGFVNLNSTETQTAGVIDRWELIQ AEALSKELRMKQKPQRRQQLDSDLNSVLTWLRETEGDLEQLQRLQLSTDIQSIALQIQKL KELQKAVDQRKAIILSIHLCSSEFTQTGQEESQDLQDRLSQMNGRWDRVCSLLEEWRGLL QDALMQCQDFHEMSHSLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLKQIRHELLES QLKVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDMSSS QQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVNSPHSRSIKGGSD SSLSEPRPARSGRAFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFH PMLRYTNGPPPL NT seq 26499 nt NT seq  +upstreamnt  +downstreamnt atggcctcctccagggcagcctcccggtcccctcgggacatcgccaacgtgatgcagagg ctgcaagatgaacaagagatagtacaaaaacgtactttcacgaaatggatcaactctcat ctggccaagcggaaacccccgatggtggtagatgatctttttgaagacatgaaagatggt gtgaagctacttgctttgctggaagtcctgtctgggcagaaactgccatgtgaacaagga cgccggatgaagagaattcatgccgtggcaaacattggcacagcactgaagtttcttgaa ggaaggaagtccatgtacagaggatcaccgattaaattagtcaacattaactccactgat atagctgatggtcgaccctccattgttcttggattgatgtggaccattatcctgtatttc cagatcgaggagctgaccagcaacctgccccagctgcaggctctgtccagcagcgcatcc tccatggacagcatggtcagctctgagaccgccagccccccgagcaaacggaaggtggcc accaagatccaaggaaacgctaagaaggcgctactgaagtgggtccagtacacagtcacc aagcagagtggaatagaagtaaaagacttcggccggagttggagaagtggagtggccttt cattctgtcatccacgctattcggccggaactagtggacttggagaaggtgaaaggaagg cctaaccgagaaaacctggaggaggctttcaccattgctgaaacggaactggggatccca cggctcctggaccctgaagatgttgatgtggataaaccagatgagaagtctattatgacc tatgtagcccagtttctgaagcagtatcctgatgtccacagtacaggctctgatgggcaa gagattgatgaaatacttccaagtttcccatcttttacaaattctatccaaattcttaag agagaagacaggctaattttgaaggagatgaaagtttggatagaacaatttgaaagagat ttgacaagggcacagatgacagactcaagtttgcaggataaatatcagtcatttaagcac ttcagagttcaatatgaaatgaagaggaaacagattgaacacttattacaaccattacat agagacggtaaattgtcacttgaccaagcattggtaaaacaggcctgggatagagtgtcc tccaggctcttcgattggcatatacaacttgataagtctcttcctgctcctctgggcacc ataggggcctggctatacagagcagaggtggccctaagagaggaaataaccattcagcag gttcacgaggaaacagccaacacaatacaacggaaacgtgagcaacacaaggatctgctt caaaacacagatgcccacaaaagagcattccatgaaatctaccgaaccaggtctgtgaac gggatcccagtgccacctgatcaattagaggacatggctgagaggtttcattttgtttcc tccacatcagagctacacttaatgaaaatggaatttctggaattaaagtaccgtctgctc tcactgctggttcttgcagagtcaaagctgaagtcttggatcatcaagtatggggggaga gattcagtggagctacttctgcaaaactacatctcttttatagaaaatagcaagttcttt gaacaatatgaagtgacataccagatcttgaaacagacagctgagatgtatgtcaaagct gatggttcagtggaagaagctgagaatgtgatgaaattcatgaatgaaactactgcccag tggaggaacctctccgtggaagtcaggagcgtgcggagcatgctggaggaagtcatcgct aactgggaccgatacggcaataccgtggctagtcttcaggcttggcttgaggatgctgag aaaatgctaaatcagtcagaacatgccaaaaaggattttttccgaaatttgcctcattgg atacagcagcacactgccatgaatgatgctggcaattttttaatcgaaacatgtgatgag atggtttcccgtgatctcaaacagcaattactattgctaaatgggcgatggagggagttg tttatggaagtcaagcaatatgctcgagctgatgagttggacagaatgaagaaagaatac aacgactgtgttactgtcttgtctgattttgcaactgaagcccacaggaaactttcagag cccttagaagtctcttttattaatgtcaagttattaattcaagacttggaggatattgaa cagagggtacctgtgatggatgctcagtataagatgataacaaagacagcgcacctcatt accaaagagatctctcaagaagaagctaatgaaatgtttgcaaccatgtctgggctcaaa gagcaactaaccaaggtcaaagactgttactccccactcctttctgagtctcaacagctg ttggtaccgttggaggaattggaaaagcagatgacagccttttatgactcacttgggaaa atcgatgaaattatgacagttcttgaacacgaggcacaatctagtcctctttttaaacag aaacatcaggaactgttggcttgtcaagaaagctgtaagaaagccatgactcaaattgag aaaggcagccagagtgttcagaagtttgtgaccttgagcaacgtgttaaagcattttgat cagacgaagctacagagaaagattgcagatatgcatgttgcttttcagaatatggtaaag aaaactggagattggaagaaacatgtggaaaccaacagccgcttgatgaagaagtttgag gagtctcgagccgagttggagaaggtgctcagggtcgctcaggagggcctggaggaaaag ggggacccggaagacttgctgaagagacacaccgagtttttcagtcagctggaccagagg gtgctcaatgctttcctgaaagcatgtgacgagctcactgacattctccctgagcaggag cagcggggcctgcaggaagccgtcagaaagctccacaaacagtggaaggatcttcaagca gaagctccatatcatttgcttcatctgaagattgaggtggagaagaacaggttcttagct tctgtggaagagtgcagagctgagctggaccgagagaccaagctggtgccccaggaaggc agcgaaaaaatcatcaaagagcacaggatcttcttcagtgacaagggccctcaccatctc tgtgagaaaaggttacagctcattgaagaactgtgtctgaaacttccagtccgggacgca gtccggaacacacctgagacctgtcacgtgaccctcaaggagctcagagctgctattgac tgcacctacgtgaagctggtgggagacccagacaagtggaaggactacacgagcagaatt tctgagttctcctcttggatatctgcaaaggagacccagttaaaggggattaagaatgag accattgatactgctaatcaaggaaaagttaaacgtgctctggaggagatcagaagtggt atcaccaaaaaaggggagactctcagctggctgaaatccaggcttaaaattctgattgaa gtctcttctgaggatgaagcccaaaagcaaggagatgagctggcaaaattatctagttct ttcaaggctctcgggactttgttgtcagaggttgaaaagatgttaagcaactttggagac tgtgtccagtacaaagaaatagtcaaaagttccctggaagagttaatcactggctctaaa gaagtccaggaggaagccgagaagatcttggacactgaaaatttgtttgaagcccaacaa ctactccttcatcaccagcaaaagacaaagaggatcaatgcaaagaagaaggacgtgcaa cagcagatcgcgcaggctcagcagggagaaggtgggctgcctgggcgagtccaagaggag ctgcagaagctggagagcaccctggacagcgtggagcacagtcgggagaaacaggagcgc cgtatccaggtcacattaagaaaatgggagagatttgaaacaaacaaagagacagtggtc agatacctttttcaaacaggttccagccatgaacgcttcttgagttttagcagtttggaa agcttatcttcagaactggaacagacaaaggagttttctaaacgaacagaaggtattgca gtccaggctgagaatcttgtgaaggaagcttcagagatcccacttgggcccaagaataag cagctgcttcagcagcaggccaagtcaatcaaggagcaagttaaaaaattagaagacacc cttgaagaagatattaaaaccatggaaatggtgaaaaacaagtgggatcattttggcact aactttgagaccctgtccatctggataactgagaaagaaaaagaactcaatgccttggag acgtcatcatctgccatggacacacaaatcaaccaaattaaggtcatgattaaggaaata gaaagtaagatcagcagcattacaggactagaagaagaagctcagtcttttgctcagttt 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cagcatttgctgtctgagatggagtcactcaagccaaaagtccacgcggtgcaggtctgt cagagcgcgctccggatccccgaggacgtggtcaccagccttccgctctgccacgcagct ctgcacctgcaggaggaggccagccggctccagcatacggccatccagcagtgcaacatc atgcaggaggctgtggtgcagtatgaacaatatgagcaagaaatgcagcacctccaggaa ctcatagaaggagctcacagagagattgaggataagcctgtggccaccagcaacatccag gaactgcaagcccagatttctcggcatgaggagctggctcagaaaattaagggctaccag gagcagatcgcctctttgaactccaagtgcaagatgctgaccgtgaaagccaagcacgcc accatgctgctgacggtgaccgaggtggaggggctggcggaggggacggaggacttggcc ggggagctcctccccgcgacctcggcccacccctctgtggtcatgatgactgcaggtcgc tgtcacactttgctgtcacctgtcactgaggagtctggggaggagggaaccaacagtgag atctcttctccgcctgcttgtcgctccccttcacctgtggctaatacagatgcctctgtt aaccaggacatcgcttattaccaagccttatctcctgagaggttacagaccgatgctgcc aaggttccccccagcacgttgccaccccaagagctctatgaaccaggcctggagccttct gctactgcgaagctggatgatttgcagcgctcttgggaaaccttaaagaatgtgatcagc gagaagcagcgcacactctatgaagccttggaacgccagcagaagtaccaggactccctc cagtccatctccacgaaaatggaggccatcgagatgaaactcagtgagagtctggagcag ggcaggagtcccgagagccagatggccgaacatcagtctttccctcaggctctgatggat gagattctcatgctccaagaggagatcagcgagctgcagtcggccctcgcggacgagctg gtgtccgagtccccggagtccgagccagcagagcagctggccctgcagtccacgctcacc gtcttggcggagcgaatgtccaccatcaagatgaaggcatccgggaaacggcaacttctg gaggagaaactcaacgatcagctggaggaacagagacaggagcaagccctgcacaggtat cgctgtgaagctgatcagctggaccactggctcttgagcacgaaggccactctggacatt gccctggggtcacccaaggagcccatggacatggaggcccagttagtggactgccagaat atgctggtggaaatagagcagaaggtggtggccttatcagagctctcggtccacaatgaa aacctgctgctggagggcaaggctcacacaaaggatgaggccgagcagctggcagtgaag ctgagaaccctcaaggggagcctcctggagctgcagagggcactgcaggaccggcagctc cacatccagcaggggacagcccaggagaaggaggagagcgatgctgatctggctgccact cagagccccggggttcaggaatggctggctcaagctcggagcacatggacccaccagcgg cagagcagcctccagcagcaaaaagagttggaacaggaattggcagagcagaagagcctc ctccagtcagtagccagccttggagaggaaattctaacgcaacactcagctccagagccc tctggtggtgttggcgaaaaacctgatgtgttatcccaggagttggggatggaaggggag aaatcacctgctgaagaccagatgagaatgaaatgggaaagcctacatcaagaatttagc accaagcagaaactacttcagaatgttctggagcaggaacaagagcaagtgctctacagc agaccaaatcggctcctgtctggcgtgccactgtacaaaggggacgggcaggcccaggat aaatctgcggtgacgtctttgctggatggattgaaccaggtcttcgaggaggtttcatcc cagggtggagggacaaagaagcagagcgttgacttggaacggaagctgtatgacggggtc tcggccacctctacctggctggatgatgtagaggaacggctctttgttgccacagccctt ctagcagaagaaccggaaacctgcatcttcaaccaagagactcttgccaaagatattaag gaaatgtctgaagaaatggataagaacaagaacttgttttcccaagcctttccggagaat ggtgataaccgagatgttattgaagacactttgggttgtctcttgggcaggttatctttg ctagactcagtagtaaatcagcgatgtcatcagatgaaggaaagacttcagcagatacta aatttccagaatgatctgaaggtgctcgttacatcactggctgaccacaagtacatcatt ctgcagaagctggcgaaaatgtttgaacaacctgtggcagagcaaatagaggcaatacag caggctgaagatgggctaaaggaattagatgcgggaatcattgagttaaaaaggcgtgct gacaagttgcagattgagcagccgtccatgcaagaactctccaaactccaggacatgtat gatgaactcttgatgactattggctcccggcggagtgggctgaaccaaaatcttgccctc aagagtcagtatgaaagagccttgcaggatctggctgacctactggaaacaggacaagaa aagacggcaggagaccagaaaattatcgtgtcttccaaagaggaaatccaacaactactt gataaacataaggaatactttcagggtctggaatctcacatgatcttgaccgaaaccctc ttcagaaagatcatcagctttgcagtcccaagggaaactcagttccacacggacctgatg gcgcaggcttccgccgtgctcaaaggggctcacaagaggggtgtggagctggaatacatc ctcgagacatggtcccaactggagaaggagcactgggagcttagccggcagctggaggtg gtggagggcagcaccccaagtgtgggtttggtggaggagagcgaagacaggcttatcgac cggatcgcactctaccagcatttgaaatccagccttaatgaataccagcccaaattatat caggtaatagatgatggaaaacgacttctgatatctgttagctgcccagatctggaaagc cagctaaatcaacttggagaacactggttaaatgataccaacaaagtgtctaaggaactt cacagactggaaacaatattgaaacactggaccagatatcaaagtgaatctgcagatcta atccactggttacagtctgcaaaagacaggctagaattttggactcagcaatctgtgaca gtcccacaagaactggaaatggtccgtgatcacctgaatggttttctggagttttccaaa gaggtggatgccaagtccacactaaaatcgtctgttctgagcactggaaatcagcttctt cgattaaagaaagtggacacagctgccttgcgttctgagctgtcccacattgatggccag tggaatgacctgctgacaaatattccagccgtacaggaaaagcttcaccagctccagatg gataaactgccttctcgccacgccatttctgaagtcatgacttggatttctcttatggaa agtgttattcaaaaggatgaagagaatattaaaaattccatcggttacaagacaattcat gagtaccttcagaaatataagggttttcagattgacattaactgtaagcagctgactgtt gattttgtgaaccagtctgtgctacagatcagcagtcaggatgtggaaagtaaacgcagc gacaagactgattttgctgagcgacttggagcaatgaataaaagctggcaaatcctgcag ggtctggtcactgagaagattcagttgttggaaggcttattggaatcttggtcagagtat gaaaataacgtacagtgtctgaaaacatggtttgaaacccaggaagagagactgaaacaa cagcatcgcattggagaccaggcttcagttcagaacgcgatgaaagactgtcaggatctg gaagacttgattaaagcaaaagagaaagaggtagagaaaattgagcagaatggacttgct ttggttcagaacaagaaagaagaagtctctggcactgtcaggagcacgcttcaggagctc aaccaaacttgggcaaatttagaccacatggttggccaactcaagatcctgttgaaatct gtgcttgaccagtggagccaccataaagtggcatttgatgagataaacagttgcctcatg gaggcccgatactctctttctcgattctgtctgctcactggctctttagaagctgtgcaa attcaggtggacagtcttcagaatcttcaagatgatctagaaaaacaggaaaagagcttg cagaaatttggctctgtgaccagtcaacttttaaaagagtgtcacccacctgtgacagaa actcttacgaatacactaaaagaagtcaacatgagatggaataacttgctggaagagatt gccgagcagctgcgtgccagcaaggccctacttcagctttggcagagatacaaggactac ttcaaacagtgtgctgctacagttcaacaacaggagggacgaaccaacgagttcctgaag gcagccaccgacaaggacatcggtgatgatgaagttgccacctggatccaagattgcaat gacctcctcaaaggattggggccgattcaggattctcttgtagttcttcatgagctggga gggcaactcaagcaacaagtggatgcttcggcagcatcagccattcagtccgattggctc tctttgaagcaacaatcacatgccctagaacaggctctctgcaaacagcagactgtgtta caggctggcgttcttgactatgaaacctttaccaagagtttagaagctttggagacttgg atagtagaagctgaagaaatactacaagggcaggaccctagccactcatctgacctctcg accatccaggaaagaatggaggagctgaagggacagatgctgaaattcagcagcatggtc ccagatttagaccgtctgaatgagcttggatacaggctgcccctgaacgataaagaaatc aaaagggtgcagaatctgaatcggcactgggctctgatctcctcccagactacggaaaga ttcagtaagttacagtcatttttgttacaacatcagactttcttggaaaaatgtgaaaca tggatggaattcctagttcaaacggaacaaaagttagcagtagagatttcaggcaattat cagcatcttttggagcagcagagagcacatgagttgtttcaagcagagatgttcagctgt cagcagattttacactcaatcatttttgatggacagcaccttctagaacaaggtcaagtt gatgacagggatgagtttaacctgaaattgaccctcctcagtaatcagtggcagggggtg atccgccgggcccagcagaggcggggcatcatcgacagccagatccgccagtggcagcgc taccgggagatggcagaaaagctccgtaaatggctggtggaggtgtcctgtctgcccgtg agtggtctggggagtgtccggataccactgcagcaagcaagggccctctttgatcaagtg cagttcaaagaaaaagtgttcctgcggcaacaaggcagctacatcctcaccgtggaggct ggcaagcagcttctgctttcggctgacagcggggctgaggccaccctgcaggccgaactc gctgagatccaagagaaatggaagtcagcaagtgtgtgtctggaggagcagaagaaaaaa ctggccggcttgctgcaggactgggaaaaatgtgagaatggaatagctgattctctggag aaactacgaactttcaaaaagaggctttcccagcctctcccagatcatcatgaagagctc cacgcagagcagatgtgctgcaaggaattggaaaacgcagttgggagctggacagatgac ttggcacagctgacagtgctgaagaaggctctctgtgcttacatcagcgcagatgatatc tccatccttaacgaacgcatggagcttctgcagaggcagtgggaagaactatgccaccag ctctccttaaggcgacagcaagtaagtgagaggttgaatgagtgggccgtcttcagtgaa aagaacaaggagctttgcgaatggctgactcagatggaaagcaaggtttctcagaatgga gacattctcattgaagaaatgattgagaagctcaggaaggattatcaagaggaaattgca gttgcccaagagaacaaaatacagctccagcaaatgggagaacggctggcccgagccagc cacgaaagcaaagcgtctgagattgagtacaaacttggcaagatcaatgaccggtggcag cacctgctggacctcatggcagccagggtaaagaagctgaaggagactctggttgcagtc cagcagctggataagaacatgagcagtctgaggacgtggttagcccacatcgagtcagag ctggccaaacccatcgtctacgattcctgtgactcagaagaaatacagaaaaagcttaac gagcagcaggagcttcagagagacatcgagaagcacagcacgggcgtggcctctgtgctc aacctgtgcgaggtccttctccatgactgtgatgcttgcgctacagacgccgagtgcgat tccatccagcaggccactcgaaacctggaccgccgatggagaaacatctgtgccatgtcc atggaaaggaggctcaaaattgaagagacatggcgattgtggcagaagtttctggatgac ttttctcattttgaagattggctcaagatctcagaaaggacagctgcctttcccagctct tccggggtgctctatacagttgccaaggaggaactaaagaaatttgaggctttccagcga caggtccatgagagcctgacccagctggagctgatcaacaagcagtaccgccgcctggcc agagagaaccgcacagacgcggccggcagcctcaaacagatggttcacaaaggcaaccag agatgggacaacctgcagaagcgcgtcacctccatcctgcgcagactcaagcatttcatt ggccagcgggaggagtttgagacggcacgggacagcattctggtgtggctgacggagatg gatctgcagctcaccaacattgagcacttctctgagtgtgatgttcaagctaaaataaag cagctcaaggccttccagcaggaaatctcgttgaaccacaataagattgagcagataatc gcccaaggagaacagctgatagaaaagagtgagcccttggatgcagccgtcattgaggaa gagctggacgagctccgacgttactgtcaggaggtcttcgggcgcgtggacagataccat aagaaactgatgcgcctgcccctcccagatgatgagcacgacctctctgaccgggagctg gaactggatgaggctggagctctgtcggacctccgctggcgggacaccacggacggcgtg ctctccccgcagccttcctccaacccctccctctcactcgcccagcccctccggagcgag aggtctggacgagacacccccgccagtgtggactccatccccctggaatgggaccatgac tatgacctcagccgtgacctggagtccgccgtgtccagaactctgccatctgaggacgaa gagggcccagaagataaagatttctacctcaggggagctgttggcttatcagatgtagtg atccctgaaagtcccgaggcctatgttaaactcacagaaagtgcaatcagaaattcctct ggggaccgtggtgccttggagtcacagatccgacagctgggcaaagccttggatgacagc cactttcagatgcagcaaacggagaatatcatccatagcaaaacgcccacaggaccagag ctagactccggctacagaggctacatgaaactgctgggtgaatgcagcggcagcatagac tcagtgaaaagactggaacacaagctgaccgaggaagaggaccattttcctggctttgtt aacttgaatagcactgaaacccaaacagctggtgtgattgaccgctgggaacttatccag gcagaggccctgagcaaggagctgaggatgaaacagaagccccagaggaggcagcagttg gactctgatctgaatagcgttctgacctggctgcgggagacggagggtgacctggaacag cttcagcgcttgcagctcagcaccgacatccagtccatcgcactccaaatccagaagctg aaggagctccagaaagctgtggaccagcgcaaagccatcatcctctccatccatctgtgc agctctgagttcactcagactggccaggaggagagccaggatcttcaggatcgcttgtcc cagatgaacgggcggtgggaccgtgtgtgctccctgctggaggagtggcggggtcttctc caggatgcactcatgcaatgccaggattttcatgaaatgagtcacagtttgcttcttatg ctggagaacattgacagaaggaaaaatgaaattgtccccattgattctaaccttgatgca gaaatacttcaggaccatcacaaacagcttaagcaaataaggcatgagctgttggaatct caactcaaagtggcctcactgcaagacatgtcttgccaactgttggtgaatgctgaaggc acagactgtttagaagccaaagaaaaagtccacgtgattggaaatcgactcaaacttctc ttgaaggaggtcagtcgtcatatcaaggagctggagaagttattagacatgtcaagcagt cagcaggatctgtcttcctggtcttctgctgacgaactggacacctcgggatctgtgagt cctacctcaggaagaagcaccccaaacagacagaaaacgccacgaggcaaatgtagtctc tcacagcctggaccctctgtcaacagtccacatagcaggtccataaaaggtggctccgat tcctccctttctgagcctcggccagcccggtccggccgagccttcctgttcagagtcctc cgagcagctcttcctcttcagcttctcctgctgcttctcattgggctggcctgcctagtc ccgatgtcagaggaagactacagttgtgccctctccaacaattttgcccgatcattccac cccatgctcagatacacaaacggccctcctcctctctga

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