KEGG   Ovis aries (sheep): 101110074
Entry
101110074         CDS       T03117                                 
Symbol
PRKCA
Name
(RefSeq) protein kinase C alpha type isoform X1
  KO
K02677  classical protein kinase C alpha type [EC:2.7.11.13]
Organism
oas  Ovis aries (sheep)
Pathway
oas01521  EGFR tyrosine kinase inhibitor resistance
oas04010  MAPK signaling pathway
oas04012  ErbB signaling pathway
oas04014  Ras signaling pathway
oas04015  Rap1 signaling pathway
oas04020  Calcium signaling pathway
oas04066  HIF-1 signaling pathway
oas04070  Phosphatidylinositol signaling system
oas04071  Sphingolipid signaling pathway
oas04072  Phospholipase D signaling pathway
oas04082  Neuroactive ligand signaling
oas04150  mTOR signaling pathway
oas04151  PI3K-Akt signaling pathway
oas04261  Adrenergic signaling in cardiomyocytes
oas04270  Vascular smooth muscle contraction
oas04310  Wnt signaling pathway
oas04360  Axon guidance
oas04370  VEGF signaling pathway
oas04510  Focal adhesion
oas04517  IgSF CAM signaling
oas04540  Gap junction
oas04613  Neutrophil extracellular trap formation
oas04650  Natural killer cell mediated cytotoxicity
oas04664  Fc epsilon RI signaling pathway
oas04666  Fc gamma R-mediated phagocytosis
oas04670  Leukocyte transendothelial migration
oas04713  Circadian entrainment
oas04720  Long-term potentiation
oas04723  Retrograde endocannabinoid signaling
oas04724  Glutamatergic synapse
oas04725  Cholinergic synapse
oas04726  Serotonergic synapse
oas04727  GABAergic synapse
oas04728  Dopaminergic synapse
oas04730  Long-term depression
oas04750  Inflammatory mediator regulation of TRP channels
oas04911  Insulin secretion
oas04912  GnRH signaling pathway
oas04916  Melanogenesis
oas04918  Thyroid hormone synthesis
oas04919  Thyroid hormone signaling pathway
oas04921  Oxytocin signaling pathway
oas04925  Aldosterone synthesis and secretion
oas04926  Relaxin signaling pathway
oas04928  Parathyroid hormone synthesis, secretion and action
oas04929  GnRH secretion
oas04933  AGE-RAGE signaling pathway in diabetic complications
oas04935  Growth hormone synthesis, secretion and action
oas04960  Aldosterone-regulated sodium reabsorption
oas04961  Endocrine and other factor-regulated calcium reabsorption
oas04970  Salivary secretion
oas04971  Gastric acid secretion
oas04972  Pancreatic secretion
oas05017  Spinocerebellar ataxia
oas05022  Pathways of neurodegeneration - multiple diseases
oas05031  Amphetamine addiction
oas05032  Morphine addiction
oas05143  African trypanosomiasis
oas05146  Amoebiasis
oas05161  Hepatitis B
oas05163  Human cytomegalovirus infection
oas05164  Influenza A
oas05170  Human immunodeficiency virus 1 infection
oas05171  Coronavirus disease - COVID-19
oas05200  Pathways in cancer
oas05205  Proteoglycans in cancer
oas05206  MicroRNAs in cancer
oas05207  Chemical carcinogenesis - receptor activation
oas05214  Glioma
oas05223  Non-small cell lung cancer
oas05225  Hepatocellular carcinoma
oas05231  Choline metabolism in cancer
oas05415  Diabetic cardiomyopathy
oas05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:oas00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101110074 (PRKCA)
   04012 ErbB signaling pathway
    101110074 (PRKCA)
   04014 Ras signaling pathway
    101110074 (PRKCA)
   04015 Rap1 signaling pathway
    101110074 (PRKCA)
   04310 Wnt signaling pathway
    101110074 (PRKCA)
   04370 VEGF signaling pathway
    101110074 (PRKCA)
   04066 HIF-1 signaling pathway
    101110074 (PRKCA)
   04020 Calcium signaling pathway
    101110074 (PRKCA)
   04070 Phosphatidylinositol signaling system
    101110074 (PRKCA)
   04072 Phospholipase D signaling pathway
    101110074 (PRKCA)
   04071 Sphingolipid signaling pathway
    101110074 (PRKCA)
   04151 PI3K-Akt signaling pathway
    101110074 (PRKCA)
   04150 mTOR signaling pathway
    101110074 (PRKCA)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    101110074 (PRKCA)
   04517 IgSF CAM signaling
    101110074 (PRKCA)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101110074 (PRKCA)
   04540 Gap junction
    101110074 (PRKCA)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    101110074 (PRKCA)
   04650 Natural killer cell mediated cytotoxicity
    101110074 (PRKCA)
   04664 Fc epsilon RI signaling pathway
    101110074 (PRKCA)
   04666 Fc gamma R-mediated phagocytosis
    101110074 (PRKCA)
   04670 Leukocyte transendothelial migration
    101110074 (PRKCA)
  09152 Endocrine system
   04911 Insulin secretion
    101110074 (PRKCA)
   04929 GnRH secretion
    101110074 (PRKCA)
   04912 GnRH signaling pathway
    101110074 (PRKCA)
   04921 Oxytocin signaling pathway
    101110074 (PRKCA)
   04926 Relaxin signaling pathway
    101110074 (PRKCA)
   04935 Growth hormone synthesis, secretion and action
    101110074 (PRKCA)
   04918 Thyroid hormone synthesis
    101110074 (PRKCA)
   04919 Thyroid hormone signaling pathway
    101110074 (PRKCA)
   04928 Parathyroid hormone synthesis, secretion and action
    101110074 (PRKCA)
   04916 Melanogenesis
    101110074 (PRKCA)
   04925 Aldosterone synthesis and secretion
    101110074 (PRKCA)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101110074 (PRKCA)
   04270 Vascular smooth muscle contraction
    101110074 (PRKCA)
  09154 Digestive system
   04970 Salivary secretion
    101110074 (PRKCA)
   04971 Gastric acid secretion
    101110074 (PRKCA)
   04972 Pancreatic secretion
    101110074 (PRKCA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101110074 (PRKCA)
   04961 Endocrine and other factor-regulated calcium reabsorption
    101110074 (PRKCA)
  09156 Nervous system
   04724 Glutamatergic synapse
    101110074 (PRKCA)
   04727 GABAergic synapse
    101110074 (PRKCA)
   04725 Cholinergic synapse
    101110074 (PRKCA)
   04728 Dopaminergic synapse
    101110074 (PRKCA)
   04726 Serotonergic synapse
    101110074 (PRKCA)
   04720 Long-term potentiation
    101110074 (PRKCA)
   04730 Long-term depression
    101110074 (PRKCA)
   04723 Retrograde endocannabinoid signaling
    101110074 (PRKCA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101110074 (PRKCA)
  09158 Development and regeneration
   04360 Axon guidance
    101110074 (PRKCA)
  09159 Environmental adaptation
   04713 Circadian entrainment
    101110074 (PRKCA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101110074 (PRKCA)
   05206 MicroRNAs in cancer
    101110074 (PRKCA)
   05205 Proteoglycans in cancer
    101110074 (PRKCA)
   05207 Chemical carcinogenesis - receptor activation
    101110074 (PRKCA)
   05231 Choline metabolism in cancer
    101110074 (PRKCA)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    101110074 (PRKCA)
   05214 Glioma
    101110074 (PRKCA)
   05223 Non-small cell lung cancer
    101110074 (PRKCA)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    101110074 (PRKCA)
   05161 Hepatitis B
    101110074 (PRKCA)
   05171 Coronavirus disease - COVID-19
    101110074 (PRKCA)
   05164 Influenza A
    101110074 (PRKCA)
   05163 Human cytomegalovirus infection
    101110074 (PRKCA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101110074 (PRKCA)
   05143 African trypanosomiasis
    101110074 (PRKCA)
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    101110074 (PRKCA)
   05022 Pathways of neurodegeneration - multiple diseases
    101110074 (PRKCA)
  09165 Substance dependence
   05031 Amphetamine addiction
    101110074 (PRKCA)
   05032 Morphine addiction
    101110074 (PRKCA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101110074 (PRKCA)
   05415 Diabetic cardiomyopathy
    101110074 (PRKCA)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101110074 (PRKCA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101110074 (PRKCA)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:oas01001]
    101110074 (PRKCA)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oas04131]
    101110074 (PRKCA)
Enzymes [BR:oas01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     101110074 (PRKCA)
Protein kinases [BR:oas01001]
 Serine/threonine kinases: AGC group
  PKC family [OT]
   101110074 (PRKCA)
Membrane trafficking [BR:oas04131]
 Endocytosis
  Lipid raft mediated endocytosis
   Caveolin-mediated endocytosis
    101110074 (PRKCA)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr C1_1 C2 Pkinase_C ABC1 C1_2
Other DBs
NCBI-GeneID: 101110074
NCBI-ProteinID: XP_060251884
LinkDB
Position
11:61845443..62134300
AA seq 688 aa
MADVFPAAEPAAPQDVANRFARKGALRQKNVHEVKNHRFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNETFTFKLKPSDKDRRL
SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVE
LRQKFEKAKLGPAGNKVTSPSEDRRQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSSFQTADRLYFVMEYV
NGGDLMYHIQQVGRFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPGKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVTFCTKMHWLQWASRPSCGKGAENFDKFFTRGQPVLTPPDQLV
IANIDQSDFEGFSYVNPQFVHPILQSAV
NT seq 2067 nt   +upstreamnt  +downstreamnt
atggctgacgtcttcccggccgccgagccggcggcgccgcaggacgtggccaaccgcttc
gcgcgcaaaggggcgctgaggcagaagaacgtgcacgaggtgaagaaccaccgcttcatc
gcgcgcttcttcaagcagcccaccttctgcagccactgcaccgacttcatctgggggttt
gggaaacaaggcttccagtgccaagtttgctgttttgtggttcacaagaggtgccatgaa
tttgttactttttcttgtccgggggcggataaaggacccgacacggatgacccgaggagc
aagcacaagttcaagatccacacgtatggcagccccaccttctgcgatcactgcgggtcc
ctgctctacggcctcatccaccaggggatgaagtgtgacacctgtgacatgaatgtgcac
aagcagtgtgtgatcaacgtgcccagcctctgtgggatggaccacacggagaagaggggc
cgcatctacctgaaggccgaggtgacggatgagaagctgcacgtcacagtacgagacgcg
aaaaacctaatccctatggatccgaatgggctttcagatccctatgtgaagctgaagctt
attcctgaccccaagaacgagagcaaacaaaaaaccaaaaccatccgctccacgttgaac
ccccagtggaatgagaccttcacgttcaaattaaaaccttctgataaagaccggcggctg
tccgtggagatctgggactgggatcgaactacacggaacgacttcatggggtccctttcc
tttggggtctcggagctgatgaagatgccggccagcggatggtacaagctgctgaaccaa
gaggagggtgagtactacaacgtgccgatccctgaaggcgacgaggaaggcaacgtggag
ctcaggcagaaattcgagaaagccaagcttggccctgccggcaacaaagtcaccagtccc
tccgaggacaggaggcagccttccaacaacctggacagggtgaagctaaccgacttcaac
ttcctcatggtgctgggcaaaggcagctttggcaaggtgatgctggccgaccggaagggg
accgaggagctgtacgccatcaagatcctgaagaaggacgtggtcatccaggacgacgac
gtggagtgcaccatggtggagaagcgggtgctggccctgctggacaagccgccgttcctg
acgcagctgcactccagcttccagacggcggaccggctctacttcgtcatggagtacgtc
aacggcggggacctcatgtaccacatccagcaggtcgggaggttcaaggagccgcaagca
gtgttctatgcagcagagatttccatcgggctgttcttccttcataaaagaggaatcatt
tatcgggacctgaagttagacaacgtcatgctggactcggaaggacacatcaagatcgcg
gacttcgggatgtgcaaggagcacatgatggacggcgtcacaaccaggaccttctgtggg
acccccgactacatcgccccagagataatcgcctatcagccgtatgggaagtccgtggac
tggtgggcctatggcgtcctgttgtacgagatgttggccgggcagcctccgttcgacggc
gaggacgaggatgagctgttccagtccatcatggagcacaacgtctcgtaccccaagtcc
ttgtccaaggaggccgtgtccatctgcaaagggctgatgaccaagcaccccgggaagcgg
ctgggctgcgggcccgagggcgagcgggatgtgcgggagcacgccttcttccggaggatc
gactgggagaagctggagaaccgtgagatccagccacccttcaagcccaaagtgactttc
tgcaccaaaatgcactggcttcagtgggcgtccaggccttcgtgcggcaaaggagcagag
aacttcgacaagttcttcacgcgagggcagcctgtcttgacgccgcccgaccagctggtc
atcgctaacatcgaccagtctgatttcgaaggcttctcgtacgtcaacccccagttcgtg
caccccatcctgcagagcgcggtatga

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