Ovis aries (sheep): 101111447
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Entry
101111447 CDS
T03117
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
oas
Ovis aries (sheep)
Pathway
oas05012
Parkinson disease
oas05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
oas00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
101111447 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
101111447 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
oas01001
]
101111447 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
oas04131
]
101111447 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
oas04147
]
101111447 (LRRK2)
Enzymes [BR:
oas01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
101111447 (LRRK2)
Protein kinases [BR:
oas01001
]
Serine/threonine kinases: TKL group
LRRK family
101111447 (LRRK2)
Membrane trafficking [BR:
oas04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
101111447 (LRRK2)
Exosome [BR:
oas04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
101111447 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
LRR_4
Roc
COR
Ras
LRR_14
LRR_9
Arf
WD40_2
WD40_CDC20-Fz
Ank_2
Beta-prop_EML_2
LRR_6
T2SSE
LRR_13
Beta-prop_RSE1_2nd
nSTAND3
Kdo
G-alpha
GTP_EFTU
AAA_22
AAA_16
Beta-prop_RIG_2nd
ABC_tran
PduV-EutP
Beta-prop_WDR19_1st
AAA_7
WD40_Prp19
MobB
NACHT
MMR_HSR1
Beta-prop_BBS7
TrwB_AAD_bind
AAA_29
cobW
FtsK_SpoIIIE
TniB
AAA_23
Arm
Motif
Other DBs
NCBI-GeneID:
101111447
NCBI-ProteinID:
XP_027823246
LinkDB
All DBs
Position
3:complement(146809153..147022487)
Genome browser
AA seq
2527 aa
AA seq
DB search
MASGSCQGCEEEDEESLKKLIVRLNNVQEGKQIETLVQILEDMLVFTYADHASKLFQDKN
VHVPLLIVLDSYMRVASVQQVGWSLLCKLIEICPNTMQSLMGPHDIGHDWEVLGVHQLIL
KMLTVHNASVNLTTVGLKALDLLLNSGKITLLILDEENDIFLLIFDAMRTFAASDEVQKL
GCKVLHVLFERVSEEQLTEFVENKDYMILLSALKNFEDEEEIVLHVLHCLHSLAIPCSNV
EVLMSGNVRCYNIVVEAMRAFPISEKIQEVSCCLLHRLTLGNFFNILVLNEVHVFVVKAV
QQYSENAVLQIAALSCLALLTETIFLNQDLEEKNENQENDDDEEDKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQKHMHSPEVAESGCKMLNHLFEESSTSLDTM
AAVVPKIITVMKSHETSLSVQLEALRAMLHFIVPGIPEEYREDTEYQHKLNMIEKQCFRN
DIHKLVLGALNRFIGNPGIQKCGLKVISSIIHFPDALEVLSLEGAIDSVLHTLQMYPDDQ
EIQCLGLSLIGCLITKKNLCVGTGHLLAKILISTLQRFKDIGEVQIKGFQTVLTILELSV
SFSKLLVDYSFDSVIFHQLSSSIMEQKDQQFLNLCCKCFAKLAVDNELKSVMLEKACDQN
NSIMVECLLLLGADANRAKEATPLICQVCEKASSPKLVELLLNSGSREQDVRKALTISIG
KGNSQIISLLLRRLALDLANSSICLGGFCMGKIDPSWLGPLFPDKTSYLRKETNIGSTLA
RMVLRYQMKSSVEEGAGSGSSGNFSEEIVDKFDEWTFIPESYVDSVFGQSDDLDSEGSEG
SFLVKKKSNSISVGEFYRDPALQRCSPNLQRHSSSLGPIFDHEDLIKRKRKIFSSDDSLR
ASKFQSHMKHSESMSSLPSEREYITSLDLSANELRDVDALSQNSCISGHLEHLEKLELHQ
NALTSFPQQLCETLKCLTHLDLHSNKFTSFPTYLLKMNCIASLDVSRNDIGPSVVLDPAV
KCPTLKQFNLSYNQISSLPENIGDVIEKLEQLILEGNKISEICSPLSLKELKILNLSKNH
ISSLSEDFLETCPKLEILSAKMNFLAAMPFLPSSITSLKLSQNRFTCVPEAILHLPHLRS
LDMSNNDIRYLPGPVHWRSLNLRELLFSHNQISILDLSEKACAWSRIEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLDLRSFPNEMGKLSKIWDLPLDELHLNFDFKHVGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKIKKSDLGMQGATVGIDVKDWPIQI
RGKGKKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVTDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREH
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGFPK
HPKGIISRRDVEKFLSKKKRFPKNYMAQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDHHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDNLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYQGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKTSLTRTLQHRIVLHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLIKKCLKENPQERPTSAQVFDILNSAELICLMRRISIPKSFTVECMVATNH
NSKNVRIWLGCGHTDKGQLSFLDLNTERYTSEEVTDSRILCLALVYLPVEKESWIVSGTQ
SGMLLVINTEDGRKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGNLAIFEDKTV
KCKGASPLKILNIGNVSTPLMCLSESVNLTEKNIMWGGCGTKVFSFSDDFTIQKLIETRT
NQRFSYASFCDSNIIAVVVDTALYVAKKNSPFVEVWDKKTEKLCELIDCVHFLKEELVRV
SKELKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRIIRIIHNFCDSVRVMMI
AQLGSLKNVMLVLGYNRKSAEGTQHQKEIQSCLSVWDVNLPHEVQNLEKHIEVRKELAEK
MRRISVE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagcggcagctgccaggggtgcgaggaggaggacgaggaatctctgaagaagttg
atagttaggctgaacaatgtccaggaaggaaaacagatagagacgctggttcaaatcctg
gaggatatgctggtgtttacatacgccgatcacgcctccaagttatttcaagacaaaaat
gtccacgtgcctctgttgatcgtcttggactcgtatatgagagtcgcaagtgtgcagcag
gtgggttggtcacttttatgcaaattaatagaaatctgtccaaatacaatgcaaagctta
atgggaccccatgatattggacatgattgggaagtccttggggttcaccaattgattctt
aaaatgctaacggttcataatgccagtgtcaacttgacaacagttggattgaaggcctta
gatcttctcctaaattcaggtaaaatcactttgctgatattggatgaagaaaatgatatt
ttcttgttaatcttcgatgccatgcgcacatttgcagccagtgatgaagtccagaaactt
ggatgtaaagttttacatgtgctgtttgagagagtttcagaggagcaactgactgaattt
gttgagaataaagattatatgatattgctcagtgcgttaaaaaactttgaagatgaagag
gaaattgtgcttcatgtattgcactgtttacattccttagcaattccttgtagtaatgtt
gaagtcctcatgagtggcaatgtcaggtgttataatattgtggtagaagccatgagagca
ttccctatcagtgaaaaaattcaagaagtgagttgctgcttgctccataggcttacatta
ggtaatttttttaatatcctggtgttaaatgaggtgcatgtgtttgtggtgaaagctgtg
cagcagtattcagagaatgcagtattacaaatcgcagcactcagctgtttagcactcctc
actgagaccattttcttaaatcaagacttagaggaaaagaatgagaatcaggagaatgat
gatgatgaagaagataaattgttttggctggaagcctgttacaaagcattaacttggcat
agaaagaacaagcatgtgcaggaggctgcctgttgggccctgaataatctccttatgtat
caaaacagtttacatgagaagattggagatgaagatggccagttcccagctcacagggaa
gtgatgctgtccatgctgatgcactcttcatcaaaagaagtcttccaggcatctgcaaat
gctttgtcaactctgttagaacaaaatgttaattttagaaagatcctgttgtcaaaagga
atatatctgaatgtattggagttgatgcagaagcatatgcattctcctgaagtggctgaa
agtggctgtaaaatgctaaatcatcttttcgaagaaagtagcacttccctggatacaatg
gcagcagtggtccccaaaataataacagtcatgaaaagccatgagacgtcattatcagtg
cagctggaagcacttcgagctatgttacattttatagttccaggcatcccagaagaatac
agggaagatactgaatatcagcacaagctaaatatgattgaaaagcagtgtttcaggaat
gatattcacaaattggtcctgggagctttgaacaggttcattggaaatcctgggattcag
aagtgtggattaaaagtaatatcatctataatacattttcctgatgcattagaggtatta
tccctggaaggtgctattgattcagtgcttcatacactgcagatgtatccagatgaccaa
gaaattcagtgtctgggtttaagtcttataggatgtttgattacaaagaagaatttatgc
gtgggaactgggcatctgctggcaaaaattctgatttccaccctacaacgattcaaggat
attggtgaagtacagataaaaggatttcagacagtcttgacaatactggaattgtcagtg
tctttttccaagctactggtggattactcctttgattcagtaatattccatcaattgtct
tccagtatcatggagcaaaaggatcaacagtttctaaacctttgttgcaagtgctttgca
aaattggccgttgataatgagttaaaaagtgtgatgctggagaaagcatgtgatcagaat
aatagcatcatggttgaatgcctgcttctgttgggagcagatgccaatcgagcaaaagaa
gcaactcctttgatttgtcaggtatgtgagaaagcaagcagtcccaaactggtagaattg
ctactgaatagtggatctcgtgagcaggatgttcggaaagctctgacaatcagcattggg
aaaggcaacagccaaataatcagcttactcttgaggaggcttgccctggatctggccaat
agtagcatctgtcttggaggattttgtatgggaaaaattgacccttcctggcttggtcct
ttatttccagataagacatcttatttaagaaaagagacaaatataggatccaccctggca
aggatggtgctcagatatcagatgaaaagttctgtggaggaaggagctggctcaggcagc
agtgggaatttttctgaagaaattgttgataaatttgatgaatggaccttcattcccgag
tcttatgttgacagtgtgtttggtcaaagtgatgacctggatagtgaaggaagtgaaggc
tcatttcttgtgaaaaagaaatcaaattcaattagcgtaggagaattttaccgagatcct
gccttgcagcgttgctcaccaaatttgcaaagacattccagttcattgggacccattttt
gatcatgaagatttaataaagagaaaaagaaaaatattttcatcagatgattcactcaga
gcctcaaaattccagtcccatatgaagcattcagagagcatgtcttccctgccttctgag
agagaatatatcacatcgttagacctttcagcaaatgaactaagagatgttgatgccctg
agccagaactcctgtataagtggtcatctggagcatcttgaaaagctggagcttcaccag
aatgcactcacaagttttccacaacaactatgtgaaactctgaaatgtttaacacatttg
gatctgcatagtaataaatttacatcgtttcccacttacttgttgaaaatgaattgtatt
gctagccttgatgtctctcgaaatgacattggaccctcagtagttttggaccctgctgtg
aagtgcccgaccttgaaacagtttaacttgtcatataatcagatatcttctcttcctgag
aacattggtgatgtgatagagaaattggaacagctcattttagaaggaaataaaatatca
gaaatatgttctcctttgagcctgaaggaactgaagattttaaaccttagtaaaaaccac
atttcatctttatcagaggacttccttgagacttgtcctaaattggagattttaagtgcc
aaaatgaattttcttgctgctatgccttttttaccttcttctatcacaagcctaaaatta
tctcaaaacagattcacatgtgtcccagaagcaattttacatctcccacacctgcggtcc
ttagatatgagcaacaatgatattcgatatctaccaggtcctgtgcactggagatctctg
aacttaagggaactcttgtttagtcataatcagatcagtatcttggacttgagtgaaaaa
gcatgtgcgtggtctagaatagagaaactacatctttctcataataaactgaaagagatt
cctcctgagattggctgtcttgaaaatctgacatctcttgatgttagttacaacttggac
ctgagatcctttcccaatgaaatggggaaattaagcaaaatatgggatcttcctttggat
gaactgcatcttaattttgattttaaacatgtaggatgtaaagccaaagacatcataagg
tttcttcagcagcggttgaaaaaggctgtgccctataaccgaatgaaacttatgattgtg
ggaaatactgggagtggcaagaccaccttattgcagcaattaatgaaaatcaagaaatca
gatcttgggatgcaaggtgccacagttggcattgatgtgaaagactggcccatccaaata
agaggcaaagggaagaaagacctcattctgaatgtatgggattttgcaggtcgtgaggaa
ttctacagcactcatccccactttatgacccaacgagccttgtatcttgcggtctatgac
ctcagcaaaggacaagcagaagttgatgccatgaagccttggcttttcaatataaaggcc
cgtgcttcttcttctcctgtgattcttgttggtacacatttagatgttactgatgagaag
cagcgcaaagcctgtatcagtaaaattaccaaggaactcttgaacaaacgaggatttcct
gcaatacgagattaccactttgtgaatgccactgaggaatctgatgctttggcaaaactt
cggaaaaccatcatcaatgagagccttaatttcaagatccgagatcagcctgttgttggg
cagctgattccagactgctatgtagaacttgagaaaatcattttatcagagcgtaaaaat
gtgccaattgaatttcctgtaattgaccggaaacgattattacaacttgtgagagaacat
cagctgcagttagatgaaaatgagcttcctcatgcagttcactttctaaatgaatcaggg
gtccttcttcattttcaagacccagcactgcagttaagtgacttatattttgtagaaccc
aagtggctttgtaaagtcatggcacagattttgacagtgaaagtggaaggctttccaaaa
catcctaagggaattatttcacgcagagatgtggaaaaatttctttcaaagaaaaagaga
tttccaaagaactacatggcacagtactttaaactcctagaaaaattccagattgccttg
ccaattggagaagaatatttactggttccaagcagtttgtctgaccacaggcctgtaata
gagcttccccattgtgagaactctgaaattatcattcgactgtatgaaatgccttatttt
ccaatgggcttttggtcaagattaatcaatcggttgcttgaaatttcaccttacatgctt
tcaggaagagaacgagcacttcgcccaaatagaatgtactggcgacaaggcatttacttg
aattggtctcctgaagcttactgcttggtaggatctgaagttttagatcatcacccagag
agtttcttaaaaattacagttccctcttgtagaaaaggctgtattcttttgggccaagtt
gtggaccacattgattctctcatggaagagtggtttcctggattactggagattgatatt
tgcggtgaaggagaaactctgctgaagaaatgggcattatatagttttaatgatggtgaa
gagcatcaaaaaatattgcttgacaacttgatgaagaaagcagaagaaggagacctccta
gtaaatccagatcaaccaagactcacaattccaatatctcagattgctcctgatttgatt
ttggctgatctgcctagaaatattatgttgaataatgatgaattggaatttgaacaagct
ccagagtttctcttaggtgatggcagttttggatctgtttatcgagcagcctaccaagga
gaagaagtggctgtgaagatttttaataaacatacatcacttaggctgttaagacaagag
ctggtggtgctctgccacctccaccatcccagcttaatatctttgctggcagctgggatt
cgtcctcgaatgttggtgatggaattagcctccaagggttccctggaccgcctgcttcag
caagacaaaaccagtcttaccagaacactgcagcacagaattgtgctacatgtggccgat
ggcttgagatacctccattcggccatgattatataccgtgacttgaagccccacaatgtg
ttgcttttcaccttgtatcccaatgctgccatcatcgccaagattgcggactatgggatt
gctcagtactgctgtagaatggggataaaaacttcagagggcactccaggttttcgtgca
cctgaagttgctagaggaaatgttatttataaccaacaagctgatgtttattcatttggt
ttgctactttatgacattttgacaactggaggtagaatagcagagggtttgaagtttcca
aatgagtttgatgaattggcaatacaagggaaattacccgatccagttaaagaatatggt
tgtgccccatggcctatggttgagaagttaattaaaaaatgtttgaaagaaaatcctcaa
gaaagacccacttctgcccaggtctttgacattttgaattcagctgagttaatctgtctg
atgagacgtatatcaatacctaaaagctttactgttgaatgcatggttgctacgaatcat
aacagcaagaatgtgaggatttggctgggctgtgggcacactgacaaaggacagctctcg
tttcttgacttaaatacagaaagatacacttctgaggaagttactgatagtagaattctg
tgccttgccttggtgtatcttcctgttgaaaaggaaagttggattgtgtctggaacacag
tctggcatgctcctcgtcattaatactgaagatgggagaaagaggcatacccttgaaaag
atgactgattctgttacttgcttgtattgcaattccttttccaagcaaagcaagcaaaaa
aatttccttttagtgggaactgctgatggcaacttagcgatttttgaagataaaactgtt
aagtgtaaaggagcctctcctttgaagatactcaacataggaaatgtcagcactccactg
atgtgcttgagtgaatctgtgaacttaactgaaaaaaacattatgtggggaggatgtggt
acaaaagttttctcattttctgatgatttcaccattcagaaactcattgagaccaggaca
aatcagcgattttcttatgcatctttctgtgattccaacatcatagcagtggtggtagac
acggccctttatgttgctaagaaaaatagcccatttgtggaagtgtgggataagaagact
gaaaaactctgcgaactaatagactgtgtgcactttttaaaggaggaactggtccgagta
agcaaggaattgaaacacaaaatgtcttattctgggagagtgaagactctctgcctccag
aagaacactgctctctggataggaactggaggaggccatatcttactccttgatctttca
actcgtcgaattatacgtataattcacaacttttgtgattctgttagagtcatgatgatt
gcacagttaggaagccttaaaaatgtcatgctggttttggggtataaccggaaaagtgct
gaaggtacacaacaccaaaaagagatacaatcttgcttgtctgtttgggacgtcaatctt
ccacatgaagtgcaaaatttagaaaaacatattgaagtaagaaaagaattagctgaaaaa
atgagaagaatatctgttgaataa
DBGET
integrated database retrieval system
