Ovis aries (sheep): 101114822
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Entry
101114822 CDS
T03117
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit isoform X1
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
oas
Ovis aries (sheep)
Pathway
oas00270
Cysteine and methionine metabolism
oas00480
Glutathione metabolism
oas01100
Metabolic pathways
oas01240
Biosynthesis of cofactors
oas04216
Ferroptosis
Module
oas_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
oas00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
101114822 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
101114822 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
101114822 (GCLC)
Enzymes [BR:
oas01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
101114822 (GCLC)
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GFIT
Motif
Pfam:
GCS
GCS2
SANT_DAMP1_like
Motif
Other DBs
NCBI-GeneID:
101114822
NCBI-ProteinID:
XP_014958129
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Position
20:7157378..7202454
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AA seq
638 aa
AA seq
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MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
EKKKAQLVLSGEELLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRKEATSLLGEGQALCTITSFPRLGCPGFTLPEFQPSPVEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVAINVPIFKDKNTPAPFIETFPEDEEAAKASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNHYRISKSRYDSIDSYLSECGEKYNDIDLTKDKEIYEQLLQ
EGLDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
QELFYFRKDICKAGGNAVVDGCGKAAGRAEPAAEEYALMSIDTIINGKEGVFPGLIPVLN
SYLESMEVDVDTRCSILNYLRLIKKRASGELMTVAKWMREFIAKHPDYKQDSVITDQMNY
SLLLKCNQIANESCECPELLGPAFRKVRYSGSKSDSST
NT seq
1917 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccagggctcgccgctgagctgggaggagaccaagcgccacgccgac
cacgtgcggcggcacgggatcctccagttcctgcacatctaccacgcagtcaaggaccgg
cacaaggacgtgctcaagtggggcgatgaggtggagtacatgttggtgtcttttgatcat
gaaaagaaaaaagcccagctggtcctgtctggagaggaacttcttgaaactctgcaagaa
aagggggaaaggacgaacccaaaccatccgaccctttggagaccagaatacgggagctac
atgatcgaggggacacccgggcagccgtatggtgggaccatgtctgaattcaacacggtt
gaggacaacatgaggaaacggcgcaaagaggccacatctctcctgggggaaggccaggcc
ctctgcaccatcacttcctttcccagattaggctgccctgggttcacgctgcctgagttc
caacccagcccggtagaaggaggagcttccaagtccctcttctttcccgatgaagccatc
aacaagcacccgcgcttcagcacactcaccaggaacatccggcaccggaggggcgagaaa
gtggccatcaacgtgcccatctttaaggacaagaacaccccagctccatttatagagact
ttccctgaggacgaggaggccgcgaaggcctctaagcccgaccacatctacatggacgcc
atgggcttcgggatgggcaactgctgcctgcaggtaacgttccaagcctgcagcatatct
gaggccagatacctttatgatcagttggctaccatctgcccaattgtcatggctttgagc
gctgcgtcgcccttttaccgaggctatgtgtcagacattgactgtcgctggggcgtgatt
tccgcgtctgtagatgatagaactcgggaggagagaggactggagccactgaagaacaac
cactataggatcagtaagtcccgatacgactcaatagacagttacttatctgagtgcggt
gagaaatacaatgacatcgacctgacaaaagacaaagaaatctacgaacagctgttgcag
gagggcctcgaccacctgctggcccagcacgtggcgcatctcttcatcagagacccgctg
actctgtttgaagagaaaatccacctggatgatgccaacgagtccgaccactttgagaat
attcagtccacaaattggcagacaatgcgattcaagcctccacctccaaactctgacatt
gggtggagagtggaattccggcccatggaggttcagctgacggacttcgagaactctgcg
tatgtggtgttcgtggtgctgctcaccagggtgatcctgtcctacaaactggactttctc
atcccgctgtccaaggttgatgagaacatgaaggtcgcccagaagcgagatgccgtcctg
caggaactgttttatttcagaaaagacatttgcaaagcaggtggcaacgccgtggtggac
ggctgcggcaaggctgcgggcagggcggagccagcggccgaggagtacgcgctcatgtcc
atcgacaccatcatcaacggcaaggaaggcgtgttccccgggctgatccccgtcttgaac
tcctacctggagagcatggaggtggacgtggacaccaggtgcagcatcctgaactacctg
aggctcatcaagaagagggcatccggagaattaatgacagttgccaaatggatgagggag
tttatcgcaaagcatcccgactacaagcaggacagtgtaataactgaccagatgaactat
agccttcttctaaagtgtaatcaaatcgcaaatgaatcatgtgagtgcccagagttactc
ggaccagcgtttaggaaagtaaggtacagtggaagtaaaagcgactcttccacctag
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