KEGG   Ovis aries (sheep): 101116201
Entry
101116201         CDS       T03117                                 
Symbol
MAPK8
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
oas  Ovis aries (sheep)
Pathway
oas01522  Endocrine resistance
oas04010  MAPK signaling pathway
oas04012  ErbB signaling pathway
oas04014  Ras signaling pathway
oas04024  cAMP signaling pathway
oas04068  FoxO signaling pathway
oas04071  Sphingolipid signaling pathway
oas04137  Mitophagy - animal
oas04140  Autophagy - animal
oas04141  Protein processing in endoplasmic reticulum
oas04210  Apoptosis
oas04215  Apoptosis - multiple species
oas04217  Necroptosis
oas04310  Wnt signaling pathway
oas04380  Osteoclast differentiation
oas04510  Focal adhesion
oas04517  IgSF CAM signaling
oas04530  Tight junction
oas04620  Toll-like receptor signaling pathway
oas04621  NOD-like receptor signaling pathway
oas04622  RIG-I-like receptor signaling pathway
oas04625  C-type lectin receptor signaling pathway
oas04657  IL-17 signaling pathway
oas04658  Th1 and Th2 cell differentiation
oas04659  Th17 cell differentiation
oas04660  T cell receptor signaling pathway
oas04664  Fc epsilon RI signaling pathway
oas04668  TNF signaling pathway
oas04722  Neurotrophin signaling pathway
oas04723  Retrograde endocannabinoid signaling
oas04728  Dopaminergic synapse
oas04750  Inflammatory mediator regulation of TRP channels
oas04910  Insulin signaling pathway
oas04912  GnRH signaling pathway
oas04914  Progesterone-mediated oocyte maturation
oas04917  Prolactin signaling pathway
oas04920  Adipocytokine signaling pathway
oas04926  Relaxin signaling pathway
oas04930  Type II diabetes mellitus
oas04931  Insulin resistance
oas04932  Non-alcoholic fatty liver disease
oas04933  AGE-RAGE signaling pathway in diabetic complications
oas04935  Growth hormone synthesis, secretion and action
oas04936  Alcoholic liver disease
oas05010  Alzheimer disease
oas05012  Parkinson disease
oas05016  Huntington disease
oas05017  Spinocerebellar ataxia
oas05020  Prion disease
oas05022  Pathways of neurodegeneration - multiple diseases
oas05132  Salmonella infection
oas05133  Pertussis
oas05135  Yersinia infection
oas05142  Chagas disease
oas05145  Toxoplasmosis
oas05152  Tuberculosis
oas05161  Hepatitis B
oas05162  Measles
oas05166  Human T-cell leukemia virus 1 infection
oas05167  Kaposi sarcoma-associated herpesvirus infection
oas05169  Epstein-Barr virus infection
oas05170  Human immunodeficiency virus 1 infection
oas05171  Coronavirus disease - COVID-19
oas05200  Pathways in cancer
oas05208  Chemical carcinogenesis - reactive oxygen species
oas05210  Colorectal cancer
oas05212  Pancreatic cancer
oas05231  Choline metabolism in cancer
oas05415  Diabetic cardiomyopathy
oas05417  Lipid and atherosclerosis
oas05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:oas00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    101116201 (MAPK8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101116201 (MAPK8)
   04012 ErbB signaling pathway
    101116201 (MAPK8)
   04014 Ras signaling pathway
    101116201 (MAPK8)
   04310 Wnt signaling pathway
    101116201 (MAPK8)
   04668 TNF signaling pathway
    101116201 (MAPK8)
   04068 FoxO signaling pathway
    101116201 (MAPK8)
   04071 Sphingolipid signaling pathway
    101116201 (MAPK8)
   04024 cAMP signaling pathway
    101116201 (MAPK8)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    101116201 (MAPK8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101116201 (MAPK8)
   04137 Mitophagy - animal
    101116201 (MAPK8)
  09143 Cell growth and death
   04210 Apoptosis
    101116201 (MAPK8)
   04215 Apoptosis - multiple species
    101116201 (MAPK8)
   04217 Necroptosis
    101116201 (MAPK8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101116201 (MAPK8)
   04530 Tight junction
    101116201 (MAPK8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    101116201 (MAPK8)
   04621 NOD-like receptor signaling pathway
    101116201 (MAPK8)
   04622 RIG-I-like receptor signaling pathway
    101116201 (MAPK8)
   04625 C-type lectin receptor signaling pathway
    101116201 (MAPK8)
   04660 T cell receptor signaling pathway
    101116201 (MAPK8)
   04658 Th1 and Th2 cell differentiation
    101116201 (MAPK8)
   04659 Th17 cell differentiation
    101116201 (MAPK8)
   04657 IL-17 signaling pathway
    101116201 (MAPK8)
   04664 Fc epsilon RI signaling pathway
    101116201 (MAPK8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101116201 (MAPK8)
   04920 Adipocytokine signaling pathway
    101116201 (MAPK8)
   04912 GnRH signaling pathway
    101116201 (MAPK8)
   04914 Progesterone-mediated oocyte maturation
    101116201 (MAPK8)
   04917 Prolactin signaling pathway
    101116201 (MAPK8)
   04926 Relaxin signaling pathway
    101116201 (MAPK8)
   04935 Growth hormone synthesis, secretion and action
    101116201 (MAPK8)
  09156 Nervous system
   04728 Dopaminergic synapse
    101116201 (MAPK8)
   04723 Retrograde endocannabinoid signaling
    101116201 (MAPK8)
   04722 Neurotrophin signaling pathway
    101116201 (MAPK8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101116201 (MAPK8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101116201 (MAPK8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101116201 (MAPK8)
   05208 Chemical carcinogenesis - reactive oxygen species
    101116201 (MAPK8)
   05231 Choline metabolism in cancer
    101116201 (MAPK8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101116201 (MAPK8)
   05212 Pancreatic cancer
    101116201 (MAPK8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101116201 (MAPK8)
   05170 Human immunodeficiency virus 1 infection
    101116201 (MAPK8)
   05161 Hepatitis B
    101116201 (MAPK8)
   05171 Coronavirus disease - COVID-19
    101116201 (MAPK8)
   05162 Measles
    101116201 (MAPK8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101116201 (MAPK8)
   05169 Epstein-Barr virus infection
    101116201 (MAPK8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101116201 (MAPK8)
   05135 Yersinia infection
    101116201 (MAPK8)
   05133 Pertussis
    101116201 (MAPK8)
   05152 Tuberculosis
    101116201 (MAPK8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    101116201 (MAPK8)
   05142 Chagas disease
    101116201 (MAPK8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101116201 (MAPK8)
   05012 Parkinson disease
    101116201 (MAPK8)
   05016 Huntington disease
    101116201 (MAPK8)
   05017 Spinocerebellar ataxia
    101116201 (MAPK8)
   05020 Prion disease
    101116201 (MAPK8)
   05022 Pathways of neurodegeneration - multiple diseases
    101116201 (MAPK8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101116201 (MAPK8)
   05418 Fluid shear stress and atherosclerosis
    101116201 (MAPK8)
   05415 Diabetic cardiomyopathy
    101116201 (MAPK8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101116201 (MAPK8)
   04936 Alcoholic liver disease
    101116201 (MAPK8)
   04932 Non-alcoholic fatty liver disease
    101116201 (MAPK8)
   04931 Insulin resistance
    101116201 (MAPK8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101116201 (MAPK8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    101116201 (MAPK8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:oas01001]
    101116201 (MAPK8)
Enzymes [BR:oas01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     101116201 (MAPK8)
Protein kinases [BR:oas01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   101116201 (MAPK8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH
Other DBs
NCBI-GeneID: 101116201
NCBI-ProteinID: XP_027818128
UniProt: W5NTN9
LinkDB
Position
25:41698933..41797488
AA seq 427 aa
MSRSKRDSNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTVEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVTSGSQRPSSSSSANDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacagcaacttctacagtgtggagattggggactctacattc
acagtcctgaaacggtatcagaatttaaaacctataggttcaggagcccaaggaatagta
tgtgcagcttatgatgccattcttgaaagaaacgttgcaatcaagaagctaagtcggcca
tttcagaatcaaactcatgctaagcgtgcttacagagagctagttcttatgaaatgtgtc
aatcacaaaaatataattggccttttgaatgtttttacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcaaatctttgtcaagtgattcag
atggaactagatcatgaaagaatgtcctaccttctctaccagatgctgtgtggaatcaag
caccttcattctgctggaattattcatcgggacttaaagcccagtaatatagtagtaaaa
tcagactgcactttgaagattcttgactttggactggccaggactgcaggaactagtttt
atgatgacaccttacgtagtgactcgctactacagagcacctgaggtcatcctaggcatg
ggctacaaagaaaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacag
cttggaacaccatgtcctgaattcatgaagaaactacaaccaacagtaaggacttatgtt
gaaaacagacctaagtatgctggatatagctttgagaagctcttccctgatgtacttttc
ccagctgactcggaacacaacaaacttaaagccagtcaggcaagggatttgttatccaaa
atgctggtaattgatgcatctaaaaggatttctgtagatgaagctctccagcacccgtac
atcaatgtctggtatgatccttctgaagcggaagctccaccaccaaagatccctgacaag
cagctagatgaaagggagcacacagtggaggagtggaaagaattgatatacaaagaagtt
atggacttggaggaaagaaccaagaatggagttatacgggggcagccctctcctttaggt
gcagcagtgaccagtggctctcagcgtccgtcatcatcgtcgtctgccaatgatgtgtcc
tcaatgtcaacagatccgaccttggcctcggatacagacagcagtctagaagcgtcggct
gggcctctgggctgctgtagatga

DBGET integrated database retrieval system