Ovis aries (sheep): 101118500 Help Entry 101118500         CDS       T03117                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism oas  Ovis aries (sheep) Pathway oas04020   Calcium signaling pathway oas04024   cAMP signaling pathway oas04260   Cardiac muscle contraction oas04261   Adrenergic signaling in cardiomyocytes oas04371   Apelin signaling pathway oas04713   Circadian entrainment oas04911   Insulin secretion oas04921   Oxytocin signaling pathway oas04972   Pancreatic secretion oas05020   Prion disease oas05022   Pathways of neurodegeneration - multiple diseases oas05410   Hypertrophic cardiomyopathy oas05412   Arrhythmogenic right ventricular cardiomyopathy oas05414   Dilated cardiomyopathy oas05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:oas00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     101118500 (RYR2)    04020 Calcium signaling pathway     101118500 (RYR2)    04024 cAMP signaling pathway     101118500 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     101118500 (RYR2)    04921 Oxytocin signaling pathway     101118500 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     101118500 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     101118500 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     101118500 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     101118500 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     101118500 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     101118500 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     101118500 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     101118500 (RYR2)    05414 Dilated cardiomyopathy     101118500 (RYR2)    05415 Diabetic cardiomyopathy     101118500 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:oas04040]     101118500 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:oas04990]     101118500 (RYR2) Ion channels [BR:oas04040]  Voltage-gated cation channels   Ryanodine receptor    101118500 (RYR2) Domain-containing proteins not elsewhere classified [BR:oas04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    101118500 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 FYDLN_acid Motif Other DBs NCBI-GeneID:  101118500 NCBI-ProteinID:  XP_060262726 LinkDB All DBs Position 25:9036513..9847488 Genome browser AA seq 4928 aa AA seqDB search MRRREHFIRLVKFTLFSFLCGLFLCSMQTAQGGGHRTLLYGHAILLRHSYSGMYLCCLST SRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLS YGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHLDECLTVPSGEHGEE QRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKSLL LMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHINTGLWLTYQ SVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIRSTVFLFNRFIRGLDA LSKKVKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMI NLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGSL DWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLC SLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYY ELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSG CIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFS AGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTV SLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQH PCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEEKVKKMKLPKNYQLTSG YKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPY ALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSGTGERFRIFRAEKTYA VKAGRWYFEFEAITSGDMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWHQGNEHYGRS WQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRL NFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDG TIDSSPCLKVTQKSFGSQNSSTDIMFYRLSMPIECAEVFSKTAAGGIPGTGLFGPKNDLE DYDVDSDFEVLMKTAHGHLVPDRGDKDKEATKPEFNNHKDYAQEKPSRLKQRFLLRRTKP DYSTSHSARLTEDVLADERDDYDYLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDT GFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESLSPGQGRNNNGLEIGCVVDAAS GLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEH KNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCVEPLQFMSLHIPEE NRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMP GLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLFPDEKKKHGLPGIGLST SLRPRMQFSSPSFVSINTEGYQYSPEFPLDILKAKTIQMLTEAVKEGSLHARDPVGGTTE FLFVPLIKLFYTLLIMGVFHNEDLKHVLQLIEPSVFKEAASPEEESEVAEKEPFVEDSKL EGAAEEENKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAK LQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKSECPCPEEIRDQ LLDFHEDLMTHCGIELDEDRSLDGNNDLTIRGRLLSLVEKVTYLKKKQAEKPVESDSKKS STLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVED TINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVM VNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMR GSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEG ERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLSAMEEAIKIAE DPSRDGPSPTTGSSRTPDTEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAAKGE AIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRV YGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLF AGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFD VPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQK KYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPE KLEYFINKYAEHAHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPI KESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHGYSPRAIDMSNVTLSR DLHAMAEMMAENYHNIWAKKKKLELEAKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKF LQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFVFEVQHVPKKLF MSTDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI YSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVDLAESGIRYTQMPHVMEVILP MLCSYMSRWWEHGPENNPGRTEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKSEARGDMSEAELLILDEFT TLARDLYAFYPLLIRFVDYNRAKWLKEPNQEAEDLFRMVAEVFIYWSKSHNFKREEQNFV VQNEINNMSFLIMDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNI CAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTED TSDPEKTVERVLDIANVLFHLEQKSTCMRRRYYNLVEHPQRSKKAVWHKLLSKQRKRAVV ACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKR VDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQ RSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNST VQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQD DEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYY SGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFA HMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEM ILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAET DENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPF LGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNF CEDTIFEMQLAAQISESDLNERSANKEESEKEKPEEQGPRMGFFSIMTVKSALFALRYNI LTLMRMLSLKSLKKQVKKVKKMTVKDMITAFFTSYWSILMSLLHFVASVFRGFSRIIGSL LLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKTLEGALPSEDLTDLKELTEE SDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPEVQEKFQVTYLQSQQLSGL QEQKANEEEKEEKEESKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESA FWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSS ENARVSSLDSSSPRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVI FKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGE FYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSF LYLAWYMTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVY LYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEY EIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFD TVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFR KQYEDQLN NT seq 14787 nt NT seq  +upstreamnt  +downstreamnt atgagaagaagagagcattttatacgcttagttaaatttactcttttttcttttctttgc ggactctttctttgctctatgcagactgctcaaggtggtggccaccgaacgctcctctac ggccatgcaatactgctgcggcattcctacagtggcatgtatctgtgctgcctgtccacc tctcggtcttcaactgataagctggcttttgatgttggcttgcaagaggatacaacaggt gaagcttgttggtggaccatccatcctgcctctaagcagcgctcagaaggagaaaaagtg cgggttggagatgacctcatcttagtgagcgtgtcctctgaaaggtacctgcacttgtct tacggtaacggcagcttgcacgtggatgctgctttccagcagaccctctggagcgtggcg cccatcagctcaggaagtgaagcagcccaagggtatctgattggtggtgacgtcctcagg ttgcttcatggacacttggatgaatgcctcactgtcccctcaggagaacacggagaagag cagcggagaactgttcattacgaaggtggtgctgtatcggttcatgcacgttccctgtgg cgactagagacactaagagttgcgtggagtggaagccacataaggtggggacaacctttt cgactacgccatgtcacaacgggaaaatacttgagtctcatggaagacaaaagccttcta ctcatggacaaagaaaaagctgatgtcaaatcaactgcatttacgttccgatcttccaag gaaaaattggatgtaggagtgagaaaagaagttgatggcatgggaacctctgaaataaaa tatggagactcggtctgttatatacagcatatcaatacaggcttgtggctcacttaccag tctgtggatgtgaaatcggtgagaatgggatccatacaacgtaaggctattatgcatcat gaaggacacatggatgatggcctaaatttatccagatctcagcatgaagaatcacggaca gcacgtgtcatccggagcacagtcttcctttttaatagatttattaggggccttgatgct ctcagcaaaaaggtgaaggcttccacagtggacttacctatagagtctgtaagtctgagt ctgcaggaccttattggctacttccacccaccagatgagcatttagagcatgaagataag cagaacagattacgagctctgaagaataggcagaatctcttccaggaagagggaatgatc aaccttgtgcttgagtgtatagacaggctgcatgtgtatagcagtgctgcacacttcgct gatgttgctgggagagaagcaggggaatcttggaaatcgattctgaattctctgtatgag ttgctggcggcattaattagaggaaatcgtaaaaactgtgctcaattttctggctccctt gactggttaatcagccgactggaaagactggaagcttcttctggtattcttgaagtttta cactgtgtgttagtagaaagtccagaagctctaaatattattaaagaaggccatataaaa tccattatctcacttttagacaagcatggaagaaatcacaaggttctggatgtcctatgc tctctctgtgtttgccatggagtagcagtccgttctaaccagcatctcatctgtgacaat cttctgccaggaagagacctgttattgcagacccgccttgtgaaccatgtgagcagcatg agacccaatatttttctgggtgtcagtgaaggatctgcacagtataagaagtggtattat gagttgatggtggaccacactgagccattcgtgactgctgaagccactcacctgcgagtg ggctgggcttccacagaggggtactcaccctaccctggagggggtgaagagtggggtgga aatggtgtcggagatgacctcttctcctacggatttgatggccttcacctctggtcaggt tgtattgcccggactgtcagctcaccaaaccagcatctcttgagaactgatgatgtcatc agttgctgtttagatctaagtgccccaagcatctccttccgaattaatggacaacctgtt caaggcatgtttgagaatttcaacattgatggcctcttctttccagttgtcagtttctct gcaggaatcaaagtacgctttctgcttggggggagacatggagaatttaaattccttcct ccgcctgggtatgctccttgttatgaagctgttctgccaaaagagaagttgaaagtggag cacagccgagagtacaagcaagaaaggacttacacgcgggacctcctgggccccacggtt tccctgacacaagctgccttcacaccaatcccagtggacaccagccagattgtgttgcct ccccacctggagaggatacgagaaaaactggcagagaatatccatgagctctgggtgatg aataaaattgaacttggctggcagtatggtccggttagagacgacaataagagacagcac ccgtgtctggtggagttctccaagctgcctgaacaggaacgcaattacaatttacagatg tcactcgagaccctgaagacgttgttggctttaggatgtcatgtgggtatatcagatgaa cacgctgaagaaaaggtgaagaaaatgaagctgccaaagaattaccaactgacaagtgga tacaagcctgccccgatggacctgagctttatcaaactcaccccatctcaggaggctatg gtggacaagttggcggaaaacgctcataacgtgtgggctcgggatcgaattcgacagggc tggacctacggcatccaacaggatgtaaagaacagaagaaaccctcggcttgttccctat gcccttctagatgaccgaactaagaaatccaataaggatagcctccgtgaggctgtacgc acacttctgggatatggctacaacctagaggcacctgatcaagatcatgctgccagagct gaagtgtgcagcggcacaggagagaggttccgcatcttccgtgctgagaaaacgtatgct gtgaaggctggaaggtggtattttgaatttgaggcgatcacttctggagacatgcgagtt ggctggagcaggccagggtgtcaacctgatcaggagcttggctcagatgaacgtgccttt gcttttgatggcttcaaggcccagcggtggcaccagggcaatgagcactatgggcgctcc tggcaagctggcgatgttgtgggctgtatggttgacatgacagagcacaccatgatgttc acactgaatggcgaaatccttcttgatgattcaggttcagaactggctttcaaggacttt gatgttggtgatggattcatacctgtgtgtagcctgggagtggctcaagtgggcaggctg aactttggaaaggatgtcagcaccttgaaatatttcaccatctgtggcttacaagagggc tatgagccatttgccgttaacacaaatagggatattaccatgtggctgagcaagaggctt cctcaatttctccaagttccatcaaaccatgaacatattgaggtgaccagaatagatggc accatagacagttccccatgtttaaaagtcactcagaagtcctttggctctcagaacagc agcacggatatcatgttttatcgtctgagcatgcccatcgagtgtgcagaggtcttctcc aagactgcagctggagggatccctggcaccggcctctttgggcccaagaatgatctggag gattatgatgtggattcagactttgaggttctcatgaagaccgctcacggccatctggtg ccagatcgaggagacaaagacaaagaagctacaaaaccagagtttaataaccacaaagat tatgctcaggaaaaaccctctcgtctgaaacagaggtttttgcttcgaagaacaaagcca gattatagcaccagccattctgcaagactcactgaagatgtccttgcagatgagagggat gactatgattacttgatgcaaacgtccacgtactattactcagtgagaatctttcctgga caagaacctgccaatgtctgggtgggctggatcacatctgatttccatcagtatgataca ggctttgacttggacagagttcgtacagtgaccgtgactctgggagatgaaaaaggaaag gtgcacgaaagcatcaaacgcagcaattgctacatggtgtgtgcgggtgagagcctgagc ccggggcaaggacgcaacaacaatggcctggagattggctgcgtggtggatgctgccagt gggctgctcaccttcacggccaacggcaaggaactgagcacctattatcaggtggaacca agcacaaaattatttcctgcagtttttgcacaagctacaagtcccaatgtttttcagttt gagttgggaagaataaagaatgtgatgcctctctcagcgggattattcaagagtgagcac aaaaatcctgtaccacagtgccccccacgcctccatgtgcagtttctctcacatgtcctg tggagcagaatgcccaaccagttcctgaaggtagatgtctctcgaataagtgaacgccag ggctggctggtgcagtgcgtggagcctctgcagttcatgtctctccatatcccagaggag aacagatctgtggacatactggaactgacagagcaggaggaactgctgaaattccactac cacactctccggctctactcggctgtctgcgcgctcgggaaccaccgcgtggcccatgcc ttgtgcagccacgtggacgagccgcagctgctctacgccatcgagaacaagtacatgccc ggcttgctgcgcgccggctactacgacctgctgattgacatccacctcagctcctacgcc accgccaggctcatgatgaacaatgagttcatcgtccccatgaccgaggagacgaagagc atcaccctcttcccggatgagaagaaaaagcacgggctcccgggcatcggcctcagcacc tccctcaggccgcggatgcagttttcctccccgagttttgtcagcattaataccgaaggt tatcagtatagcccggagttcccactggacatcctgaaggccaagaccatacagatgctg acagaagccgtgaaagagggcagccttcacgcccgagaccccgttgggggcaccactgag ttcctcttcgtgcctctcatcaagctgttctataccctgctcatcatgggtgtcttccac aacgaggacttgaaacacgtcttgcagttgattgagcctagtgtgttcaaggaagccgcc agccccgaggaggagagcgaggtggcggagaaggaaccctttgtggaagactccaagctg gaaggagccgctgaagaagaaaacaaagggggtaagaggcccaaggagggcctgctccaa atgaaactgccagagccagtaaaattgcagatgtgcctgctacttcaatacctctgtgac tgccaggtccggcaccggatagaagccattgtggccttttcagatgactttgtagccaag cttcaagacaatcaacgattccgatataatgaagttatgcaagccttaaacatgtcagct gcactcacagccaggaaaacaaaggaattcagatccccgcctcaagagcagatcaatatg cttctcaattttaaggatgacaaaagtgaatgtccgtgtcctgaagaaatccgagaccaa ctcttggattttcacgaagatttgatgacacactgtggaattgagctggatgaagatagg tctctggacggaaacaacgatttaactattagaggacgcctgctgtccttggtagaaaag gtgacatatctgaagaagaagcaagctgaaaagccagttgagagtgactccaagaagtca tccactcttcagcagttgatttctgagaccatggtccgatgggctcaagagtctgtaatt gaagaccctgagttggtgagggccatgtttgtattgctccatcgacagtatgatggcatt gggggtctggtacgggctctgccaaagacctacactataaatggtgtttctgtggaggat accatcaatctgctggcatctcttggtcagattcgttctctgctaagtgtgagaatgggc aaagaggaagagaaacttatgattcgtggattaggggatatcatgaacaataaagtgttt taccagcatccgaatctcatgagggctcttgggatgcacgagacagtgatggaggtcatg gtgaatgtccttggaggtggagagtccaaggaaatcacttttccgaagatggtggccaac tgttgccgttttctctgttacttctgtcgtataagtaggcagaatcagaaagctatgttt gatcatctcagttatttactggaaaacagcagtgttggtcttgcctcaccagctatgaga ggttcaacaccactggatgtggcagcagcctcggtgatggataataatgaactagcttta gctttgcgggagccagatctggaaaaggtggttcgatatttggctggttgtggactgcag agttgccagatgctagtatcaaagggttatccagacattggatggaatccagttgaagga gaaagatatcttgactttctcagatttgctgtcttctgtaatggggaaagcgtggaggag aacgcaaatgtcgtggtgagattgctcatccggaggcctgagtgtttcggtcccgccctg aggggggaaggtgggaatggcctgctctcagccatggaagaagccataaaaatagctgag gatccctctagagatggtccctcaccaactaccggatccagcaggacccctgatacagaa gaggaagaggatgataccatccacatgggaaatgccatcatgaccttttatgcagctttg attgacctgttaggacgctgtgctcctgaaatgcatttgattcatgctgccaaaggagaa gccatcagaatcaggtctattttgagatctctgattccactgggagatttggtgggagta atcagcattgcttttcagatgcccacaatagccaaagatggaaatgtggtggagcctgac atgtctgcggggttttgcccagatcacaaggcagccatggttttgttccttgacagggtc tatggaattgaggttcaggatttcctcctccatcttctcgaggttggctttctgccagat ctccgggctgctgcttctttagacacggctgctttgagtgctacagacatggccctggcc ctcaatcgctacctgtgcacagccgtgttacccttgttaacaaggtgtgctcctcttttt gctggcaccgagcaccatgcttctctcattgactcattacttcacactgtgtacaggctt tctaagggctgctcgcttaccaaagctcaacgggattccatagaagtgtgtttactctct atttgtggccaattgagaccttctatgatgcaacacttactcagaagattagtatttgat gtcccattattaaatgaacatgcaaagatgcctcttaagctgctgacaaatcattatgaa agatgctggaaatattactgtctgcctggagggtggggcaactttggagctgcctcagaa gaagaacttcatttatcaagaaagctgttctggggcatctttgatgccctgtctcaaaag aaatatgaacaagaacttttcaaactggcactgccttgcctgagtgcagttgcgggagct ttgcctccagactacatggagtcaaattatgtcagtatgatggaaaaacagtcatcaatg gattctgaagggaactttaatccacaacctgttgatacctcaaacattacaattcctgag aagttggaatacttcattaacaaatatgcagaacatgcacatgacaagtggtcaatggat aagttggcaaatggatggatttatggagaaatatattcagactcatctaaagttcaacca ttaatgaagccatataaactattatctgaaaaggaaaaagaaatttatcgctggccaatc aaagaatctttaaaaactatgctggcttggggatggagaattgaaaggacccgagaggga gacagcatggccctttataaccgtactcgtcgtatttctcagacaagtcaggtttctgta gatgccgcccatgggtacagcccacgagccattgacatgagcaatgtcacactctccaga gatctgcacgctatggcagaaatgatggctgaaaactaccataatatatgggcaaagaaa aagaaactggaactagaggccaaaggaggtggaaaccatcccctgctggtaccttatgat acgctgacggccaaagagaaagccaaggatagggaaaaagcacaggacatcctcaagttc ctgcagatcaatggctatgctgtgtccagagggttcaaagacctggaactggacacacct tctattgagaaacgatttgcctatagtttccttcagcaactcattcgctatgtagatgag gcccatcagtatatcctggagtttgtgtttgaagtgcaacatgtacctaaaaaactcttc atgtctacagatggtggcagcagaagcaaaggagaacatttcccttatgaacaagaaatc aagttctttgctaaagtcgttcttcctttaattgatcagtatttcaaaaaccaccgttta tacttcttatctgcagcaagcagacctctctgttctggaggacatgcatcaaacaaagag aaagaaatggtgactagcctattctgcaaacttggagttcttgtcaggcataggatttca ctatttgggaatgatgcaacatcaattgtcaactgtcttcatattttgggtcagactttg gatgcaaggactgtgatgaagactggcctggagagtgttaaaagtgcactcagagccttc ctggacaatgccgcagaggatctggagaagacgatggagaatcttaagcagggccagttc acacacacccgaaaccaacccaaaggtgttactcagattatcaattataccacggtggca ctgttgccaatgctgtcatcattatttgagcatattggccagcatcaattcggagaagat ctaatattggaagatgtacaggtgtcatgttatagaattctgactagcttgtatgctttg ggaaccagcaagagtatttatgtggaaaggcaacgttctgcattgggagaatgtctggct gcttttgctggtgcctttcctgtagcatttttggaaactcacctggacaagcacaatatt tactccatctacaatacaaagtcttcgagagagagagcagctcttaatttgcctactaat gtggaagatgtttgtccaaatataccgtctttggagaagctcatggaagaaattgtggac ttggctgagtccggtattcgctacacacagatgccacacgtgatggaagttatcctgccc atgctttgtagctacatgtctcgttggtgggagcatggacctgagaataatccgggaagg actgagatgtgctgtactgctctgaactcagagcacatgaacacactgctgggcaatatc ctgaaaatcatatataataacttgggtattgatgagggagcctggatgaagaggttagca gtgttttcccagcctattataaataaagtgaaacctcagcttttgaaaactcatttcttg ccattaatggagaagctcaagaaaaaggcagcgatggtggtatcagaagaggaccatctg aaatctgaggccaggggagatatgtctgaagccgaacttctcatcctagatgagttcacc accctggccagagatctctatgccttctatccactcctgattagatttgtggactataac agggcaaagtggctgaaagagcctaaccaagaagcagaagatcttttccgcatggttgct gaggtgtttatctactggtcaaaatcccataatttcaaaagggaggaacagaacttcgtg gtgcagaatgaaatcaacaatatgtctttccttattatggacaccaaatcaaagatgtca aaggcagctgtttctgatcaggaaaggaagaaaatgaagcgcaaaggggaccgatattcc atgcagacatctcttattgtggctgctctgaagcggttactgcccattgggttgaacatc tgtgcccctggggaccaggagctcattgctctggccaaaaatcgctttagtctgaaagac actgaggatgaagttcgagatataatccgcagtaatattcacttacaaggcaagttggag gatcctgctattagatggcaaatggctctttacaaagacttacccaataggacagaagac acttcagatcctgagaagacagtggaacgggtcttggatatagcaaatgtactttttcat cttgaacagaaatctacatgtatgcgccggagatattacaatctggttgagcatcctcag agatcgaaaaaggccgtgtggcacaaactgctctctaagcagaggaaacgtgccgtggtt gcctgcttccggatggctcctttatataatctgccgaggcatcgggctgtcaatctcttt cttcagggatatgaaaagtcttggattgaaacagaagaacattactttgaagataaattg atagaagacttagcgaaacctggagcagaacctccagaagaagatgaaggaactaagagg gttgatcctcttcatcagctgatccttctgtttagtcgaacagctttaacggagaaatgc aaactggaggaagattttttatatatggcttatgcagatattatggcaaagagttgtcat gatgaggaagatgatgatggggaagaggaagtgaagagttttgaagtcacaggatcccaa cgcagcaaggaaaaagaaatggaaaagcaaaagcttctataccaacaagccaggctgcac gaccgcggtgctgctgagatggtgctgcagaccatcagtgccagcaaaggtgaaactgga cccatggtggctgctactttgaaacttggaattgctatcttaaatggaggaaactctaca gtacagcagaaaatgcttgactacctcaaggagaaaaaggacgtgggcttctttcagagc ctggctggcctgatgcagtcatgcagcgtcctcgacctaaatgcatttgagcggcaaaac aaagctgaaggacttgggatggtgactgaggaaggatcaggagaaaaggttctgcaggat gacgaattcacctgtgacctcttccgcttcttgcaactgctttgtgagggacacaactca gattttcaaaattatctgagaactcagactggcaataatacaactgtcaacataatcatc tctactgtagactaccttctgagagttcaggaatcaattagtgatttctattggtattac tctgggaaagatgtcattgatgagcaaggacaaaggaatttctccaaagctattcaagtg gcaaaacaagtctttaacactctcacagagtacattcagggtccttgcactggcaaccag cagagtttggctcacagcaggctctgggatgctgtggtgggttttcttcatgtatttgcc cacatgcagatgaagctgtctcaggactccagtcaaattgagctactaaaagaattgatg gatcttcagaaggacatggtggtcatgttgctgtccatgttggaaggcaatgttgttaat ggcaccattggcaaacagatggtggatatgctcgtggaatcttccaacaacgtggagatg attctcaagttttttgacatgttcttaaagctcaaggacttgacgtcttctgatactttc aaagagtatgaccccgatggtaagggagttatttccaagagggactttcacaaagccatg gagagccataaacactacacccagtccgagactgagtttctcctgtcctgtgcagagaca gatgaaaatgaaaccctggactatgaagaatttgtcaaacggttccacgagcctgccaag gacattggcttcaatgtggcagtgcttctgacaaacctctctgaacacatgcccaatgac acccggctgcagacttttctggaattggccgagagtgtgctcaattacttccagcccttc ctgggccgcatcgagatcatgggcagtgccaagcgcatcgagagggtgtattttgaaatc agtgagtccagccgaacccagtgggagaagccccaggtcaaggaatccaaaaggcaattt atatttgacgtggtcaatgaagggggagagaaagagaagatggagctcttcgtgaacttc tgcgaggataccatctttgagatgcagctggcggctcagatatcagagtcagatctgaat gagaggtcagcgaacaaagaggagagtgagaaggagaagccggaggagcagggtccgagg atgggtttcttttccatcatgacggtcaagtccgccctgtttgccctcaggtacaatatc ttgacccttatgcggatgctcagcctgaaaagcttgaagaagcaggtgaagaaggtgaag aagatgacagtgaaggacatgatcacagccttctttacatcctactggagtattttgatg agcctcctgcactttgtagccagcgttttcagaggcttctctcgcatcatcggcagcctc ctgctgggaggaagcctggtcgaaggtgcaaagaagatcaaagtggcggagctcttggcc aacatgccagaccccacgcaagatgaggttcgaggagacggggaggagggggagaggaaa accctggaaggggccctgccctctgaagatctgacggacttgaaggaactgacagaggag agtgacctgctttccgatatctttggcttggacctgaagcgagaaggggggcagtacaaa ctgattcctcacaatcccaatgctggcctgagtgacctcatgagcaaccccgtccctatc ccagaggtgcaagaaaagttccaggtaacttacctccagtcacagcagctctctggactt caggaacagaaggcaaacgaagaagaaaaggaagaaaaagaagagagcaaatctgaacct gagaaagctgaaggagaagacggagaaaaagaagaaaaagccaaagaagacaagggtaaa caaaaactgaggcagctccacacacacagatacggagagccagaagttcctgagtcagca ttctggaagaaaatcatagcctatcaacagaaacttctaaactattttgctcgcaacttc tacaatatgagaatgttagccttatttgtcgcatttgcgatcaatttcatcttgctcttt tataaggtctccacttcttctgtggttgaaggaaaggaactacccactcgcagttcaagt gaaaatgccagagttagcagcttggacagcagctcgcctagaatcatcgcagtgcactat gtgctggaggagagcagtggctacatggagcccacactgcggatattagccattctgcac accgtcatctctttcttctgcatcattggatactactgcttgaaagtcccactggttatt tttaagcgagaaaaggaagtagctcgaaaattggaatttgatgggctttatattacagaa cagccttcagaagatgatattaaaggccagtgggatagactcgtaatcaacacacagtca tttcccaacaactactgggacaaatttgttaaaagaaaggttatggataaatatggagag ttctatggccgagacagaatcagcgagttacttggcatggacaaagctgccttggacttc agtgatgcccgggaaaagaagaagccaaagaaagacagctccctgtcagctgtactgaac tctattgatgtgaagtatcagatgtggaaactaggagtcgttttcactgacaactccttc ctctaccttgcctggtatatgaccatgtccattcttggacactacaacaactttttcttt gctgctcatcttctggacattgctatgggattcaagacgttaagaaccatcttgtcatca gtaactcacaatggcaaacagctcgtattaactgttggcttattggctgttgttgtatac ctatatactgtcgtggcattcaattttttccgaaaattctacaataaaagtgaagatggc gatacaccagacatgaagtgtgatgacatgctaacgtgctatatgttccacatgtatgtt ggagtacgtgccggagggggtatcggtgatgaaattgaagatccggcaggtgatgagtat gagatatatcgaatcatctttgacatcaccttcttcttttttgtgattgtcattctcttg gccataatacaaggtttaatcatcgatgcttttggggaactaagagaccaacaggaacag gtcaaagaagacatggagaccaagtgcttcatctgtgggataggcaatgattactttgac accgtgccacatggctttgaaacccacactttacaggaacacaacttggccaattatctg ttttttctgatgtatctcataaacaaagatgaaacggagcacacaggacaggaatcttat gtttggaagatgtatcaagaaaggtgctgggaatttttcccagccggagactgtttccgg aaacagtatgaagaccagctaaattaa

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