Ovis aries (sheep): 101121261
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Entry
101121261 CDS
T03117
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
oas
Ovis aries (sheep)
Pathway
oas00310
Lysine degradation
oas01100
Metabolic pathways
oas05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
oas00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
101121261 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
101121261 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
oas03036
]
101121261 (DOT1L)
Enzymes [BR:
oas01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
101121261 (DOT1L)
Chromosome and associated proteins [BR:
oas03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
101121261 (DOT1L)
HMT complexes
Dot1-containing complex
101121261 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
101121261
NCBI-ProteinID:
XP_027825723
LinkDB
All DBs
Position
5:19128967..19180131
Genome browser
AA seq
1714 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVVFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVP
ESKAAVPADTPVDSGAEEEKAGTAAVKKPSPSKARKKKLNKKGRKMVGRKRGRPKKMSAT
NPERKPKKTQSALDLLHAQTVSRAASPLPQDAHRPPHSPFYQLPPSVQRPTPEQLLLAPT
PPALHRLLESFRIQYLQFLAYTKTPQYKATLQQLLDKEKEKNARLLGAAQQLFGHCQAQK
EESKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLEKGNRELRSQSLRLL
KARCEELKLDWSTLSLENLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDEALALQLRGKPEAEPGRLHLELDCARFSLPPFSSLSPELSMNGHAAGYELCSAL
GRPSPKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSSLALPDYTRLSPAKLVLRRHLS
QDHAASGKAAASELHPRAEHAKENGLPYQSPGITNGIKLSPQDPRPSSPTALQMGEKGPE
KGVKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKARSTPSPGPPA
RESSSTLEKQVAANTHGAGGNAAGSKSLALAPTGFAYSGSVAISGALAGSPAPLGPGAEP
PALDESSSSGSLFATVGSRSSTPQHPPLLTQPRTCGSASPAPQLCASPRLGALGPLPDSG
KGDLPCDASFSDPESEAKRRIVFTISAGASSAKQSPSSKHSPLPSGARGDGGQGHGPDSR
KRGRRKRASAGTPSLSSSVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAIS
SPESSLKSSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEPGSEDEPGSARIERKI
ATISLESKSPPKTLENAGGSLAGRKAPLASEPVNSSKWKSTFSPISDLGLAKAADSPLQA
ASALSHNSLFAFRPGLEEPSTADGKLATHSRKSFPGTLPGAGGLSPNSLPASGFALGGGL
AADLSLHSFSDGASLSHKAPEAAGLGAPLSFPGPRGKEGGAAESGPFANKRQLDGLGPKG
EGGLPTCGPPDKASTAHSKAGKGREREPDVKNGHNLFMAAAAAPPAGLLSGPGLAPAASS
AGGTAPSVQAHRPFLGAFAPGPQFALGPMSLQANLGPSVLQSLFSSVPAAGLVHVSTAAT
RLTNSHAMGSFSSGVAGGAVGGVFNHAVPPASAHPFGASFGSGAACRSTTLSLTPLQAVA
STPASSFQAPSSAEPRPPQPPPHLGRPPPGQPALHAPPHPNATLPPPPALLPANSEPVLL
QNLASLPANQAFLPAASAASLPPANASLSIKLASLPHKVSRPALTVHHQPLPGLALAQAA
PVNPQASSTGPPAVWVSLGMPPPYAARLAGVKPR
NT seq
5145 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgaggctcaagtcgcccgtgggggccgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcatgaaatcatcgagacc
atcagatgggtctgtgaggaaatcccggatctcaagctcgctatggagaattacgtttta
attgactacgataccaaaagctttgagagtatgcagaggctctgtgacaagtacaaccgg
gccatcgacagcatccaccagctgtggaagggcaccacacagcccatgaagctgaacaca
cggccgtccactgggctcctgcggcacatcctgcagcaggtctacaaccactcggtgacc
gaccctgagaagctcaacaactatgagcccttctccccagaggtgtatggggagacctcc
ttcgacctggtcgcccagatgatcgatgagatcaagatgaccgaagatgacctgttcgtg
gacctgggcagtggggtgggccaggtcgtgctgcaggttgccgcagccaccaactgcaaa
catcattatggtgtagagaaagctgacatcccagccaagtacgcggagacgatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggagagg
ggggacttcctctcggaggagtggagagaacggattgctaacacaagtgttgtatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgcaaacatg
aaggaaggtggcagaatcgtgtcctcgaagccctttgcgcctctgaacttcagaataaac
agtagaaacttgagtgacatcggcaccatcatgcgcgtcgtggagctgtcgccgctaaaa
ggctcggtgtcatggacggggaagccagtctcctactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctaaaaaatccaaaactcagggaggaacaagaggca
gctcggcgccggcagcagcgggagaacaagagcaacacaaccacacccaccaaggtgccc
gagagcaaggcagctgtgccggcagacacccccgtggactctggtgctgaggaggagaaa
gccgggacggccgctgtcaagaagccatctccctccaaggcccggaagaagaagctgaac
aagaagggccggaagatggtgggtcggaagcgtgggcgccccaagaagatgagtgccacc
aaccccgagcgcaagcccaagaagacccagagcgcactggacctgctgcacgcccagacc
gtgtcacgagcggcctcccccttgccgcaggacgcgcacaggccacctcacagcccattc
taccagctacctcccagcgtgcagcggcctacccctgaacagctgctgctggcacccacc
ccgcccgcgctgcacaggctgctagagtccttcaggattcagtatctacagttcctggca
tacacgaagacccctcagtacaaggccaccctgcagcagctgctggacaaggagaaggag
aagaatgcccggttgctaggcgcagcgcagcagctgtttggccactgccaagctcagaag
gaggagagcaagaggctcttccagcagaaactggacgagctgggagtgaaggcgctgacc
tacaacgacctgatccaagctcagaaggagatctcggctcacaaccagcagttgagggaa
cagacggagcagctagagaagggcaaccgggagctgaggagccagagcctgcggctgctc
aaggcacggtgtgaggagctgaagctggactggtccacgctgtccctggagaatctgctg
aaggagaagcaggccctgaagagccagatctcagagaagcagaggcactgcctggaactg
cagatcagcatcgtggagctggagaagagccagcggcagcaggagctgctccagctcaag
tcctgcgtgccgcctgatgaggcgctggccctgcagcttcgtgggaagccagaggccgag
cctggccggcttcacttggagctggactgcgcccgcttctccctgccgcccttcagcagc
ttgagccccgagctctccatgaatggccatgcggccggctatgagctctgcagcgcactg
ggtcggccctcacccaagcagaacaccccccagtacctggcctctccgctagaccaggag
gtcgtgccctgcacccctagccacagcggccggccacggctggagaagctatccagcctg
gccctgcctgactataccaggctatcccctgccaagctggtgctgcggcgccacctgagc
caggaccacgcggccagtggcaaggcagctgccagcgagctgcacccacgagccgagcat
gccaaggagaacggactcccttaccagagccctggcatcaccaacggcatcaagctgagc
ccacaagacccccgaccttcatcccccacggctttacagatgggagagaagggccctgag
aagggtgtgaaggagcgtgcctacgccagcagtggggaggccatcaccagcctgcccgtc
agcatcccgctgagcaccgtgcagcccagcaagctgcccgtcagcatccccctggccagc
gtggtgctgcccagccgcgccgagaaggcgagaagcacacccagccctgggccaccggcc
cgagagtcctcgtctacgctggagaagcaggtggctgctaacacccatggtgccgggggc
aacgctgctgggagcaagagcctcgccctggctcccacaggctttgcatacagcggctcg
gtggccatcagtggggccctggcaggcagcccagcaccccttggccctggagctgagccc
ccggccctggacgagtcctccagctctggaagcctctttgccactgtggggtcccgcagc
tccaccccgcagcacccacccctgctgacgcagccacgcacctgtggctcagcctcgcca
gccccccagctctgcgccagcccccggctaggcgccctgggcccgcttcccgactctggc
aaaggggacctgccctgtgacgccagcttctcagaccctgagagcgaagccaaaaggagg
atcgtctttaccatctcggcgggtgccagcagcgccaagcagtcaccttccagcaaacac
agccctctgccctcgggtgcccgcggggatggtggccagggccatggaccagatagccgc
aagcggggccggaggaagcgggcatcggcggggacccccagcctgagctcgagtgtgtcc
cccaagcgccgggccttgccatctgtcgctgggcttttcacgcagtcttcagggtccccc
ctgaatctcaactccatggtcagcaacatcaaccagcccctggagatcacggccatctcg
tcccctgagagctccctaaagagctcacccgtcccctaccaggacaatgaccaaccacct
gtgctcaagaaggagaagcccctgagccagaccaatggtgcccactactccccactgacc
tcggacgaggagccaggctctgaggatgagcccggcagtgccagaattgagagaaaaatt
gcaacaatctccttagaaagcaaatctccaccaaaaaccttggaaaatgcaggtggcagc
ctagcaggaaggaaggcaccgctggccagcgagccggtcaacagcagcaagtggaagtcc
accttctcacccatctccgacctgggcctggccaaggcagctgacagcccgctgcaggct
gcctccgctctgagccacaactccctgttcgctttccggcctggcctggaggagcccagt
acagccgatggcaagctggccacccactccaggaagagcttcccaggcaccctgccgggg
gcgggcgggctgagccccaatagccttcctgccagcggcttcgccctgggcgggggccta
gcagctgacctcagtttacacagcttcagtgatggtgcttctctctcccacaaggccccc
gaggcagctggcctgggtgcccccctgagcttccctggcccacggggcaaggagggtggc
gctgcagagtctggccccttcgcaaacaagcggcagctggacggactgggcccaaaaggc
gaggggggccttcccacatgcggacccccggacaaggcctctacagcgcatagcaaggca
ggcaagggccgtgagcgcgagcccgacgtcaagaacggccacaacctgttcatggctgct
gccgccgcgccccctgcaggcctcctcagcggcccaggtcttgccccagcggcatcctcg
gcaggtggcacagccccgtccgtgcaggcccaccgccccttcctgggcgccttcgcccct
gggccacagttcgcgctgggccccatgtcgctacaggccaacctgggcccgtctgtgctg
cagtccctgttcagttctgtgcccgccgccggcctggttcacgtctcgaccgccgccacc
agattgaccaactcgcacgccatgggcagcttctcctccggggtggccggcggcgcagtt
ggaggtgtctttaaccacgcggtgcctcccgcctccgcccatccgtttggagccagtttc
ggcagtggggctgcatgtcgcagcaccacgctgagcttaaccccgctgcaggcggtggcc
agcaccccggcctcttcctttcaggccccgtcctctgcggagccgaggccaccccaaccc
cctccgcacctgggccggccccctccggggcagcctgccctccacgcacccccccatcct
aacgccaccttgcctcctccccctgcgctgctcccagctaactctgagcccgtgcttctg
cagaacctcgcatccctccctgctaaccaagctttcttgcccgccgcctctgccgcctct
ctgccgcctgctaacgcctctctgtccatcaagctcgcctccctcccgcacaaggtgtcc
cggcccgccttgacggtgcaccaccagcccctgcctgggttggccctggcccaggccgcg
cccgtgaacccacaggccagctccacggggccgcccgccgtgtgggtttcccttggcatg
ccgcctccgtatgccgcgcgccttgcgggggttaagccgcgataa
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