KEGG   Ovis aries (sheep): 101122126
Entry
101122126         CDS       T03117                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
oas  Ovis aries (sheep)
Pathway
oas00562  Inositol phosphate metabolism
oas01100  Metabolic pathways
oas01521  EGFR tyrosine kinase inhibitor resistance
oas04012  ErbB signaling pathway
oas04014  Ras signaling pathway
oas04020  Calcium signaling pathway
oas04062  Chemokine signaling pathway
oas04064  NF-kappa B signaling pathway
oas04066  HIF-1 signaling pathway
oas04070  Phosphatidylinositol signaling system
oas04072  Phospholipase D signaling pathway
oas04360  Axon guidance
oas04370  VEGF signaling pathway
oas04380  Osteoclast differentiation
oas04611  Platelet activation
oas04613  Neutrophil extracellular trap formation
oas04625  C-type lectin receptor signaling pathway
oas04650  Natural killer cell mediated cytotoxicity
oas04662  B cell receptor signaling pathway
oas04664  Fc epsilon RI signaling pathway
oas04666  Fc gamma R-mediated phagocytosis
oas04670  Leukocyte transendothelial migration
oas04722  Neurotrophin signaling pathway
oas04750  Inflammatory mediator regulation of TRP channels
oas04919  Thyroid hormone signaling pathway
oas04933  AGE-RAGE signaling pathway in diabetic complications
oas04935  Growth hormone synthesis, secretion and action
oas05167  Kaposi sarcoma-associated herpesvirus infection
oas05169  Epstein-Barr virus infection
oas05170  Human immunodeficiency virus 1 infection
oas05171  Coronavirus disease - COVID-19
oas05200  Pathways in cancer
oas05205  Proteoglycans in cancer
oas05206  MicroRNAs in cancer
oas05214  Glioma
oas05223  Non-small cell lung cancer
oas05225  Hepatocellular carcinoma
Module
oas_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:oas00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101122126 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101122126 (PLCG2)
   04014 Ras signaling pathway
    101122126 (PLCG2)
   04370 VEGF signaling pathway
    101122126 (PLCG2)
   04064 NF-kappa B signaling pathway
    101122126 (PLCG2)
   04066 HIF-1 signaling pathway
    101122126 (PLCG2)
   04020 Calcium signaling pathway
    101122126 (PLCG2)
   04070 Phosphatidylinositol signaling system
    101122126 (PLCG2)
   04072 Phospholipase D signaling pathway
    101122126 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101122126 (PLCG2)
   04613 Neutrophil extracellular trap formation
    101122126 (PLCG2)
   04625 C-type lectin receptor signaling pathway
    101122126 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    101122126 (PLCG2)
   04662 B cell receptor signaling pathway
    101122126 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    101122126 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    101122126 (PLCG2)
   04670 Leukocyte transendothelial migration
    101122126 (PLCG2)
   04062 Chemokine signaling pathway
    101122126 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    101122126 (PLCG2)
   04919 Thyroid hormone signaling pathway
    101122126 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    101122126 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101122126 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    101122126 (PLCG2)
   04380 Osteoclast differentiation
    101122126 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101122126 (PLCG2)
   05206 MicroRNAs in cancer
    101122126 (PLCG2)
   05205 Proteoglycans in cancer
    101122126 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    101122126 (PLCG2)
   05214 Glioma
    101122126 (PLCG2)
   05223 Non-small cell lung cancer
    101122126 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    101122126 (PLCG2)
   05171 Coronavirus disease - COVID-19
    101122126 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101122126 (PLCG2)
   05169 Epstein-Barr virus infection
    101122126 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101122126 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101122126 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oas04131]
    101122126 (PLCG2)
Enzymes [BR:oas01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101122126 (PLCG2)
Membrane trafficking [BR:oas04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    101122126 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    101122126 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 PH SH3_9 PH_12 EF-hand_PLCG1 SH2_1 SH3_2 PH_14 GDPD EF-hand_like
Other DBs
NCBI-GeneID: 101122126
NCBI-ProteinID: XP_060254261
LinkDB
Position
14:7801268..7961445
AA seq 1274 aa
MANVDTLPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADKIEG
FLDIMEIKEIRPGKNSKDFERAKAVRQKEECCFTILYGTQFILSTLSLAADSKEDAAKWL
SGLKILHQEVMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSSAKFL
KDKFLEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFLLGNTDRPDASAVHL
HDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWD
EKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDCWDG
PDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARVFKE
VFGDLLLTKPKEASADQLPSPSQLRGKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELHM
WDPIDQKWTRHYCAIADAKLSFSDDIEQTVEEELPLDIPPTELHFGEKWFHKKVEKRTSA
EKLLQEYCAETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTMKYYLTD
NLMFTSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDMLMRV
PRDGAFLIRKREGTDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKH
ALYRKMKLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYRAK
QSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISPAEGEEADKQIIEDN
PLGSLCRGILNLNIYNVVKAPHGKNKKPFVFVLEPKKQGDPPVEFATDSVEELFEWFQSI
REITWKMDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKA
DSIVRQKPSDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQM
NHALFSLNGRTGYVLQPESMRAEKYDPMPPESQRKILMTLTVKVLGARHLPKPGRSIACP
FVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPSLAFLRFVVYEEDMFS
DPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQL
RRRQEELNNQLFLYDTHQSLRSANRDALVREFNVNENQLQLYQEKCNRRWVTPCSHCEVR
PGPGRRASLPFQKA
NT seq 3825 nt   +upstreamnt  +downstreamnt
atggccaacgtggacaccctcccggagtacgagaagagtcagatcaagcgggccctggag
ctgggcaccgtcatgaccgtgttcagcttccgcaagtccaccccggagcggaggaccgtc
caggtgatcatggagacgcggcaggtggcctggagcaagacggccgacaagatcgagggc
ttcctggacatcatggagataaaggagatccggccagggaagaactccaaggatttcgag
cgcgcgaaagcggtccgccagaaggaagagtgctgcttcaccatcctgtacggcacccag
tttatcctcagcacgctcagcctggcagccgactcgaaggaagatgcagctaagtggctg
tctggcttgaagatcttacaccaggaagtgatgagcgcatccacccccaccatcattgag
agctggctgagaaagcagatttattctgtggatcaaaccaggagaaacagcatcagcctc
cgggagttgaagaccatcttgcccctggtcaacttcaaagtgagcagtgccaagttcctc
aaagataagttcctggaaataggcgcacacaaagatgaactcagctttgaacagttccat
ctcttctataaaaaacttatgtttgaacagcaaaaatcgatccttgatgaattcaaaaag
gattcttccgtgttcctcttgggcaacaccgaccggccggacgcctctgctgtccacttg
catgacttccagcggtttctcttgcatgaacagcaggagctttgggcccaggatctgaac
aaagtccgtgagcggatgacgaagtttattgacgacaccatgagggaaactgctgaaccc
ttcttgtttgtggatgagttcctcacgtacctgttttcccgggagaacagcatctgggac
gagaagtatgacgtggtggacatgcaggacatgaacaaccccttgtctcattactggatc
tcctcatctcacaacacgtacctcacgggggaccagctacggagcgagtcgtccacggag
gcctacatccgctgcctgcggatgggctgccgctgcatcgagctggactgctgggacggg
cccgacggcaagcccatcatctaccatggctggacgcggaccaccaagatcaagtttgac
gacgttgtgcaggccatcaaagaccatgcctttgtcacctccagcttccccgtgatcctg
tccatcgaggagcactgctgtgtggagcagcagcgccacatggccagggtgttcaaggag
gtgtttggagacctgctgctgaccaaacccaaggaggccagtgccgaccagctgccgtcg
cccagccagctgcgtgggaagatcatcatcaagcataagaagctgggcccccgcggtgac
gtggacgtcaacatggaggacaagaaggacgagcacaagcagcagggcgaactgcacatg
tgggaccccatcgaccagaaatggactcggcactactgtgccattgctgatgccaagctg
tccttcagcgatgacattgaacagactgtggaagaggagctgcccctggatatacccccc
acagagctgcattttggggagaagtggttccacaagaaggtggagaagaggacgagtgcc
gagaagctgctgcaggaatactgcgccgagacagggggcaaggatgggaccttcttggtg
cgggagagtgagaccttccccaacgactacaccctatccttctggcggtcgggccgcgtg
cagcactgccggatccgctccaccatggagggcgggaccatgaagtactacctgaccgac
aacctcatgttcaccagcatctacgccctcattcagcactaccgcgagacacacctgcgc
tgcgccgagttcgagctccggctgaccgaccccgtgcccaaccccaacccgcacgagtcc
aagccgtggtactacgatgggctgagccgcggagaagcggaggacatgctgatgagggtc
ccccgggacggggccttcctgatccggaagcgggaaggtactgactcctacgccatcacc
ttcagggccaggggcaaggtgaagcactgtcgtatcaaccgagacggccggcacttcgtg
ctgggcacctccgcctactttgagagcctcgtggagctggtcagctactacgagaaacac
gcgctctaccggaagatgaagctgcgctaccccgtgacccccgagctcctggagcgctac
aacatggaaagagatataaactccctctatgatgtcagcaggatgtatgtggatcccagt
gaaatcaatccttcaatgcctcagagaaccgtgaaagctctgtatgactacagagccaag
cagagtgatgagctgagcttttgccgcggtgccctcatccacaacgtctccaaggagccc
gggggctggtggaaaggagactatgggaccagaatccagcagtacttcccgtccaattac
gtcgaggacatttcaccagcagaaggggaggaggcggataagcagattattgaagacaat
cccttagggtccctttgcagaggaatcctgaatctcaacatctataatgttgttaaagcc
ccacatgggaagaacaagaagcctttcgtctttgtcttggagcccaagaagcagggagat
cctccggtagagtttgccacggacagcgtggaggagctgtttgagtggttccagagcatc
cgggagatcacctggaagatggacaccaaggagaacaacatgaagtactgggagaagaac
cagtccatcgccatcgagctctcagacctggtcgtctactgcaagccaaccagcaagacc
aaggacaacctcgaaaaccctgacttccgagaaatccgctccttcgtggagacgaaggct
gacagtatcgtcagacagaagcccagcgatctcctgaaatacaatcaaaagggcctgacc
cgtgtgtaccccaaaggacagcgggtggactcgtccaactacgaccccttccgcctctgg
ctgtgtggctcccagatggtggcgctcaatttccagactccagataagtacatgcagatg
aaccacgcgctcttctccctcaacgggcggacgggctacgtcctgcagcctgagagcatg
agggcggagaagtacgaccccatgccgcccgagtcccagaggaagatcctgatgaccctg
acggtcaaggtactgggggcccgtcatctccccaaacccggacgaagcatcgcgtgtccc
tttgtggaggtggagatatgcggagcggagtatgacaacaacaagttcaagacgacagtt
gtgaatgacaacggcctcagccctgtttgggccccaacgcaggagaaggtgacgtttgag
atctatgaccccagccttgcgtttctgcgctttgtggtttatgaggaagatatgttcagc
gatcccaacttcctggcccatgccacgtaccccattaaaggcataaagtcagggtttaga
tctgtgcctctgaagaacggctacagtgaagacattgagctggcgtccctcctggttttc
tgtgagatgcggccagtcctggagagcgaagaggagctgtattcctcctgccgccagctg
cggaggcggcaagaagaactgaacaaccagctcttcctgtacgacacccaccagagcctg
cgcagcgccaaccgcgatgccctggtcagagaattcaacgtcaacgagaaccagctgcag
ctgtaccaggagaagtgcaaccgcaggtgggtcaccccctgcagccactgtgaggtcagg
cctgggccagggcggagggcaagcctcccctttcagaaagcctga

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