KEGG   Ovis aries (sheep): 443076
Entry
443076            CDS       T03117                                 
Symbol
MET
Name
(RefSeq) hepatocyte growth factor receptor precursor
  KO
K05099  proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
Organism
oas  Ovis aries (sheep)
Pathway
oas01521  EGFR tyrosine kinase inhibitor resistance
oas04010  MAPK signaling pathway
oas04014  Ras signaling pathway
oas04015  Rap1 signaling pathway
oas04020  Calcium signaling pathway
oas04151  PI3K-Akt signaling pathway
oas04360  Axon guidance
oas04510  Focal adhesion
oas04520  Adherens junction
oas05100  Bacterial invasion of epithelial cells
oas05144  Malaria
oas05200  Pathways in cancer
oas05202  Transcriptional misregulation in cancer
oas05205  Proteoglycans in cancer
oas05206  MicroRNAs in cancer
oas05208  Chemical carcinogenesis - reactive oxygen species
oas05211  Renal cell carcinoma
oas05218  Melanoma
oas05223  Non-small cell lung cancer
oas05225  Hepatocellular carcinoma
oas05226  Gastric cancer
oas05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:oas00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    443076 (MET)
   04014 Ras signaling pathway
    443076 (MET)
   04015 Rap1 signaling pathway
    443076 (MET)
   04020 Calcium signaling pathway
    443076 (MET)
   04151 PI3K-Akt signaling pathway
    443076 (MET)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    443076 (MET)
   04520 Adherens junction
    443076 (MET)
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    443076 (MET)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    443076 (MET)
   05202 Transcriptional misregulation in cancer
    443076 (MET)
   05206 MicroRNAs in cancer
    443076 (MET)
   05205 Proteoglycans in cancer
    443076 (MET)
   05208 Chemical carcinogenesis - reactive oxygen species
    443076 (MET)
   05230 Central carbon metabolism in cancer
    443076 (MET)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    443076 (MET)
   05226 Gastric cancer
    443076 (MET)
   05218 Melanoma
    443076 (MET)
   05211 Renal cell carcinoma
    443076 (MET)
   05223 Non-small cell lung cancer
    443076 (MET)
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    443076 (MET)
  09174 Infectious disease: parasitic
   05144 Malaria
    443076 (MET)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    443076 (MET)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:oas01001]
    443076 (MET)
Enzymes [BR:oas01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     443076 (MET)
Protein kinases [BR:oas01001]
 Receptor tyrosine kinases (RTK)
  MET family
   443076 (MET)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr TIG Pkinase Sema PSI Kinase-like Pkinase_fungal Linker_histone
Other DBs
NCBI-GeneID: 443076
NCBI-ProteinID: NP_001104541
UniProt: Q09YI9
LinkDB
Position
4:complement(53094867..53211758)
AA seq 1384 aa
MKAPAVLAPGILVLLFTFVQKSNGECKEALVKSRMNVNMQYQLPNFTAETSIRNVVLHKH
HIYLGAINYIYVLNDKDLQKVAEYKTGPVLEHPDCFPCQDCSHKANLSGGVWKDNINMAL
LVDTYYDDQLISCGSVHRGTCQRHVLPPNNTADIESEVHCMYSPQEDEETNQCPDCVVSA
LGTKVLLSEKERFINFFVGNTINSSYFPDHSLHSISVRRLKETQDGFKFLTDQSYIDVLP
ELQDSYPIKYVHAFESNHFIYFLTVQRETLDAQTFHTRIIRFCSADSGLHSYMEMPLECI
LTEKRRKRSTKQEVFNILQAAYVSKPGAQLARQIGANLNDDILYGVFAQSKPDSSEPMNR
SAVCAFPVKYVNEFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEVRNDEYRTE
FTTALPRIDLFMGQFNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGSLTPHVNF
PLDSHPVSPEVVVEHPLNQNGYTLVVTGKKITKIPLNGLGCEHFQSCSQCLSAPSFVQCG
WCHDKCVRLEECPSGRWTQETCLPTIYKVFPTSAPLEGGTTLTVCGWDFGFKRNNKFDLK
KTRVLLGNESCTLTLSESTTNMLKCTVGPATNEHFNMSIVISNSRGSVQYSMFSYVDPII
TSISPNYGPKTGGTLLTLTGKHLNSGNSRHISIGGKTCTLKSVSYSILECYTPAQSAPTE
FSVKLKIDLANREVNSFIYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSIIRMVINV
HEAGKNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGIHSKYFDLIYVHNP
VFKPFEKPVMISIGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIQSHSEAVLCTVPND
LLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIVGVVSVSIILLLLLGLFLWLKKRK
QIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNG
SCRQVQYPLTDLSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVH
FNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNV
LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMEYLASKK
FVHRDLAARNCMLDEKFTVKVADFGLARDVYDKEYYSVHNKTGAKLPVKWMALESLQTQK
FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKC
WHPKAELRPSFSELVSRIAAIFSAFIGEHYVHVNATYVNVRCVAPYPSLLSSQENVSGED
DDDT
NT seq 4155 nt   +upstreamnt  +downstreamnt
atgaaggcccctgctgtgctcgcacctggcattcttgtgcttctgtttaccttcgtgcag
aagagcaatggggagtgtaaagaggcactagtaaagtccaggatgaatgtgaacatgcaa
tatcagcttcctaacttcactgcagaaacatccatccggaatgttgttttgcacaaacat
cacatttacctcggtgccattaactacatttacgttttaaatgacaaagaccttcagaag
gttgctgagtacaagactgggcctgtgctggaacacccagattgtttcccatgtcaggac
tgcagccacaaagccaatttatcaggtggtgtttggaaagataacatcaacatggctctg
cttgttgacacgtactatgatgatcaactcattagctgtggcagtgtccacagagggacc
tgccagcggcacgtcctgccacccaacaatactgcagacatagagtcggaagtccactgc
atgtattctcctcaggaagacgaagagaccaaccagtgtcctgactgtgtggtgagtgcc
ctgggaaccaaagtcctactgtctgagaaggagcgattcatcaacttcttcgtgggcaat
accataaattcttcttactttccagatcattcattgcactcgatatcggtgagaaggcta
aaggaaacgcaagatggttttaagtttttgacagaccaatcctatattgatgttctacct
gagcttcaagattcctaccccattaagtatgtccacgcctttgaaagcaaccattttatt
tactttttgacagtccaacgggaaactctagatgctcagacttttcacacaaggataatc
aggttttgttccgcagactctggattgcattcatacatggaaatgcctctggagtgtatt
ctgacagaaaagagaagaaagagatccacaaagcaggaagtgtttaatattctccaagct
gcatatgtcagtaagcctggggctcagcttgctaggcaaataggtgccaacctgaatgat
gacattttgtacggggtgtttgcacaaagcaagccagattcctcagaaccaatgaatcgc
tctgctgtctgtgcattccctgtcaaatatgtcaatgagttcttcaacaagatcgtcaac
aaaaacaatgtgagatgtctccagcacttttatggccccaaccatgaacactgcttcaat
aggacacttttgagaaattcatcaggatgtgaagtgcgcaatgatgaatatcgaacagag
tttaccacagctttgccgcgcattgacttattcatgggccagttcaaccaagtcctctta
acatctatatccacctttatcaaaggagatctcaccatcgctaatctcgggacgtcagaa
ggtcgattcatgcaggttgtggtttctcgatcaggatcattaactcctcacgtgaatttt
ccgctggattcccaccctgtgtctccagaagtggttgtggagcacccgctaaaccagaat
ggctatacactggttgtcactgggaagaagatcaccaagatcccgctgaatggcctgggc
tgtgaacatttccagtcctgcagtcagtgcctctccgccccttcctttgtgcagtgtggc
tggtgccatgataaatgtgtgcgattggaggaatgccccagtggaaggtggactcaagag
acctgtctgccaacaatctacaaggtttttccaactagtgccccccttgaaggagggaca
acactgactgtttgtggctgggactttggattcaagaggaataataaatttgacttgaag
aaaaccagagttctccttggaaatgagagctgcaccttaaccttaagtgagagcacaaca
aacatgttgaaatgcacagttggtcctgcaacgaatgaacatttcaatatgtccatagtt
atttcaaacagtcgtgggtcagtacagtatagtatgttttcctatgtggatcctataata
acaagtatttctccaaattatggtccaaaaactggtggcactttacttacattaactgga
aagcacctaaacagtggaaattcaagacacatttcaattggtggaaaaacatgtacttta
aaaagtgtttcatatagtattctcgaatgttataccccagcccaaagtgctccaactgag
ttttctgttaaattgaaaattgacttagccaaccgagaggtgaacagcttcatttaccgg
gaagaccccattgtctatgaaatacatcccaccaaatcttttattagtggtgggagtaca
ataacaggtgttggaaaaaacctgaattcagttagtatcataaggatggtaataaatgtg
catgaagccggaaagaactttacagtggcatgtcaacatcgctctaattcagagataatc
tgctgtacaactccttcactacaacagctgaacctacaactccccctgaaaaccaaagcc
tttttcatgttagatgggatccattccaaatactttgatctcatttatgtacataatcct
gtgtttaagccttttgaaaagccagtgatgatctcaataggcaatgaaaatgtactggaa
attaagggaaatgatattgaccctgaagcagttaaaggggaggtgttaaaagttggaaat
aagagctgtgaaaatatacagtcacattctgaagctgtattatgtacggtccccaatgac
ctgctgaaattgaacagcgaactaaatatagagtggaagcaagcaatttcttcaactgtt
cttggaaaagtgatagttcaaccagatcagaatttcacaggattgattgttggtgttgtc
tcagtatcaataatactcttactgttactcgggcttttcctgtggctgaaaaaaaggaag
caaattaaagatctgggcagtgaattagttcgctatgatgcaagagtacacactccacat
ttggataggcttgtcagtgcccgaagtgtaagcccaactacagaaatggtttccaatgaa
tctgtagactaccgagctacttttccagaagaccagtttcctaattcatctcagaatggg
tcatgcagacaagtgcagtatcctctgacagatctatcccccatcttaactagtggggac
tctgatatatccagtccattactgcaaaataccgtccacatcgacctcagtgctctaaat
ccagagctggtccaggcagttcagcacgtagtaattgggccgagcagtctgattgtacat
ttcaatgaagtcataggaagaggacattttggttgtgtatatcatggaactttgttggac
aacgatgataagaaaattcactgtgctgtgaaatccttgaatagaatcactgacatagga
gaagtttcccaatttctgactgagggaatcatcatgaaagattttagtcatcccaatgtt
ctctcgcttttgggaatctgccttcgaagtgaggggtctccactggtggtcctaccatac
atgaaacacggggatcttcgaaatttcattagaaatgagactcataacccaactgtaaaa
gatcttattggctttggtcttcaagtagccaaaggcatggaatatcttgcaagcaaaaag
tttgtccacagagacttggctgcaagaaactgtatgctggatgaaaaattcaccgtcaag
gttgctgattttggtcttgccagagacgtgtatgataaggaatactatagcgtacacaac
aaaacaggtgcaaaactgccagtgaaatggatggctttagaaagcctgcagactcagaaa
tttaccaccaagtcagatgtgtggtcctttggcgtgctcctctgggaactgatgacaaga
ggagcaccaccttatcctgacgtcaacacctttgacataacagtttacttgttgcaagga
agaaggctcctacaacctgaatactgcccagatcccttgtatgaagtgatgctgaaatgc
tggcaccctaaagctgaattgcgcccatccttttctgaactggtctccaggatagccgcg
atattctccgctttcattggggagcactatgtccatgtgaatgctacttacgtgaacgtc
agatgtgttgccccatatccttctctgttgtcatcacaagagaatgtcagtggcgaggat
gatgatgacacatga

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