KEGG   Ovis aries (sheep): 443077
Entry
443077            CDS       T03117                                 
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase 3 isoform X1
  KO
K13242  nitric-oxide synthase, endothelial [EC:1.14.13.39]
Organism
oas  Ovis aries (sheep)
Pathway
oas00220  Arginine biosynthesis
oas00330  Arginine and proline metabolism
oas01100  Metabolic pathways
oas04020  Calcium signaling pathway
oas04022  cGMP-PKG signaling pathway
oas04066  HIF-1 signaling pathway
oas04071  Sphingolipid signaling pathway
oas04151  PI3K-Akt signaling pathway
oas04370  VEGF signaling pathway
oas04371  Apelin signaling pathway
oas04611  Platelet activation
oas04915  Estrogen signaling pathway
oas04921  Oxytocin signaling pathway
oas04926  Relaxin signaling pathway
oas04931  Insulin resistance
oas04933  AGE-RAGE signaling pathway in diabetic complications
oas05415  Diabetic cardiomyopathy
oas05417  Lipid and atherosclerosis
oas05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:oas00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    443077 (NOS3)
   00330 Arginine and proline metabolism
    443077 (NOS3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04370 VEGF signaling pathway
    443077 (NOS3)
   04371 Apelin signaling pathway
    443077 (NOS3)
   04066 HIF-1 signaling pathway
    443077 (NOS3)
   04020 Calcium signaling pathway
    443077 (NOS3)
   04071 Sphingolipid signaling pathway
    443077 (NOS3)
   04022 cGMP-PKG signaling pathway
    443077 (NOS3)
   04151 PI3K-Akt signaling pathway
    443077 (NOS3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    443077 (NOS3)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    443077 (NOS3)
   04921 Oxytocin signaling pathway
    443077 (NOS3)
   04926 Relaxin signaling pathway
    443077 (NOS3)
 09160 Human Diseases
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    443077 (NOS3)
   05418 Fluid shear stress and atherosclerosis
    443077 (NOS3)
   05415 Diabetic cardiomyopathy
    443077 (NOS3)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    443077 (NOS3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    443077 (NOS3)
Enzymes [BR:oas01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     443077 (NOS3)
SSDB
Motif
Pfam: NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1
Other DBs
NCBI-GeneID: 443077
NCBI-ProteinID: XP_027824803
LinkDB
Position
4:115195027..115213993
AA seq 1205 aa
MGNLKSVGQEPGPPCGLGLGLGFGLCGKQGPASPAPEPSWAPAPATPQAPDHSPAPSSPT
LTRPPEGPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLPRKLQTRPSQGPP
PAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVASTGTYHLRESELVFGAKQAW
RNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGR
GDFRIWNTQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWSPGNGRFDVLPLLLQAPDE
APELFVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYM
STEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIV
DHHAATVSFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYVLSPAFRYQPD
PWKGSAAKGAGITRKKTFKEVANAVKISASLMGTLMAKRVKATILYASETGRAQSYAQQL
GRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYN
SSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYP
HFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAKAAFQASCETFCVGEEAKA
AAQDIFSPKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRAT
ILVRLDTAGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPTESVAVEQLEKGSPG
GPPPSWVRDPRLPPCTLRQALTFFLDITSPPSPRLLRLLSTLAEEPSEQQELETLSQDPR
RYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSAHPGEVHLTVA
VLAYRTQDGLGPLHYGVCSTWLSQLKTGDPVPCFIRGAPSFRLPPDPYVPCILVGPGTGI
APFRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQERGVFGRVLTAFS
REPDSPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGGME
LDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGP
DTPGP
NT seq 3618 nt   +upstreamnt  +downstreamnt
atgggcaacctgaagagtgtgggccaggagcccgggcccccctgtggcctggggctgggg
ctgggttttgggctatgcggcaagcagggcccggcctccccagcacctgagcccagctgg
gcccccgcacctgccaccccgcaagcgccagaccacagcccagctcccagcagccccacg
ctgacccggcctccggaggggcccaagttccctcgcgtgaagaactgggagctggggagc
atcacctacgacaccctgtgcgcacagtcccagcaggacgggccctgcacccccagacgc
tgcctcggctccctggtgttgccccggaaactgcagactcggccctcccaaggacctccg
cccgctgagcagctgctgagccaggccagggacttcatcaaccagtactacagctccatt
aagaggagcggctcccaggctcatgaggagcggcttcaggaggtggaggccgaggtggca
tccacgggcacctaccacctccgagagagcgagctggtgttcggggccaagcaggcctgg
cgcaacgcgccccgctgcgtgggccgcatccagtgggggaagctgcaggtgttcgatgcc
cgggactgcagctcagcacaggagatgttcacctacatctgcaaccacatcaagtacgcc
accaaccgtggcaaccttcgctcggccatcacagtgttcccgcagcgcgccccgggccgc
ggagacttccggatctggaacacccagctggtgcgctacgcaggctacagacagcaggac
ggctctgtgcgtggggacccggccaacgtggagatcacggagctctgcatccagcacggc
tggtcccccggaaacggccgcttcgacgtgctgcccctgctgctccaggccccagatgag
gctccagagctctttgttctgccccccgagctggtcctcgaagtgcccctggagcacccc
acactggagtggttcgcggccctgggcctgcgctggtatgccctcccggccgtgtcaaac
atgctgctggaaatcgggggtctggagttccctgcggcccccttcagcggctggtacatg
agcacggagattggcacgcggaacctgtgtgaccctcaccgctacaacatcctggaggat
gtggctgtctgcatggacctcgacacgcggaccacctcgtccctgtggaaggacaaggcg
gccgtggagatcaacctggctgtgctgcacagctttcagctcgccaaggtgaccatcgtg
gaccaccacgccgccacagtgtccttcatgaagcacctggaaaacgagcagaaggcccgg
gggggctgccccgccgactgggcctggatcgtgccccccatctcgggcagcctcacgccc
gtcttccaccaggagatggtcaattacgtcctgtcccctgccttccgctaccagccagac
ccctggaaggggagcgcggccaagggcgccggcatcaccaggaagaagacctttaaggaa
gtggccaacgcggtgaagatctctgcctcactcatgggcaccctgatggccaagcgagtg
aaagcaaccatcctgtacgcctctgagaccggccgggcccagagctatgctcagcagctg
gggaggctcttccggaaggcctttgacccccgggtcctgtgcatggacgagtatgacgtg
gtgtccctggagcacgaggcgctggtgctggtggtgaccagcacctttgggaatggcgat
cccccggagaatggagagagttttgcagctgccctgatggagatgtcggggccctacaac
agctccccgaggccggaacagcacaagagttacaagatccgcttcaacagtgtctcctgc
tccgacccgctggtgtcctcctggcggcggaagagaaaggagtccagcaacacagacagc
gcaggagccctggggaccctcaggttctgtgtgtttggactgggctcccgggcgtatccc
cacttctgcgccttcgcgcgtgcggtggacacccggctggaagagctgggaggggagcgg
ctgctgcagctgggccagggcgacgagctctgcggccaggaggaggccttccgtggctgg
gcaaaggcggccttccaggcctcctgcgagacgttctgcgtcggggaggaggccaaggcc
gccgcccaggacatcttcagccccaaacggagctggaaacgccagaggtaccggctgagc
acccaggccgagggcctccagctgctgccaggcctgatccacgtgcacagacggaagatg
tttcaggccacagtcctctcagtggaaaacctgcaaagcagcaagtccacccgggccacc
atcctggtgcgcctggacactgcaggccaggaggggctgcagtaccagccaggggaccac
ataggcatctgcccgcccaaccggccgggcctcgtggaggcgctgctgagccgcgtggag
gacccaccgccgcccaccgagtctgtggctgtggagcagctggagaagggcagcccaggc
ggccctcctcccagctgggtgcgggacccgcggctgcccccgtgcacgctgcgccaggct
ctcaccttcttcctggacatcacctccccgcccagcccccggcttctccgactgctcagc
accctggctgaagaacccagcgaacagcaggagctcgagaccctcagtcaggacccccgg
cgctacgaggagtggaagtggttccgctgccccacgctgctggaggtgctggagcagttc
ccgtccgtggcactgcccgccccactgctcctcacccagctgcccctgctgcagccccgg
tactactccgtcagctcggcccccagcgcccaccccggagaggtccacctcacggtggct
gtgctggcgtacaggacccaagatgggctgggccccctacactacggggtctgctccacg
tggctgagccaactcaagactggagacccagtgccctgcttcatcaggggggctccctct
ttccggctgccgcctgacccctacgtgccctgcatcctcgtgggccccggcactggcatc
gcccccttccggggattttggcaggagcggctgcacgacattgagagcaaagggctgcag
cccgcccccatgaccctggtgttcggctgccggtgctcccaactcgaccatctctaccgc
gacgaggtgcaggacgcccaggagcgcggggtgtttggccgcgtcctcaccgccttctcc
cgggaacctgacagccccaagacctacgtacaggacatcctgagaaccgagctggctgcc
gaggtgcaccgcgtgctgtgcctcgagcggggccacatgtttgtctgcggcgacgtcact
atggcaaccagcgtcctgcagacggtgcagcgcatcttggcgacagagggcggcatggag
ctggacgaggcgggcgacgtcatcggcgtgctgcgggatcagcaacgctatcacgaggac
atttttggcctcacgctgcgcacccaggaagtgacaagccgcatacgtacccagagcttt
tccctgcaggagcggcatctgcggggcgcggtgccctgggccttcgacccgccaggccca
gacacccccggcccctga

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