Ovis aries (sheep): 780515 Help Entry 780515            CDS       T03117                                  Symbol PKLR Name (RefSeq) pyruvate kinase PKLR isoform X1   KO K12406   pyruvate kinase isozymes R/L [EC:2.7.1.40] Organism oas  Ovis aries (sheep) Pathway oas00010   Glycolysis / Gluconeogenesis oas00620   Pyruvate metabolism oas01100   Metabolic pathways oas01200   Carbon metabolism oas01230   Biosynthesis of amino acids oas04910   Insulin signaling pathway oas04930   Type II diabetes mellitus oas04932   Non-alcoholic fatty liver disease oas04950   Maturity onset diabetes of the young Module oas_M00001   Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate oas_M00002   Glycolysis, core module involving three-carbon compounds Brite KEGG Orthology (KO) [BR:oas00001]  09100 Metabolism   09101 Carbohydrate metabolism    00010 Glycolysis / Gluconeogenesis     780515 (PKLR)    00620 Pyruvate metabolism     780515 (PKLR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     780515 (PKLR)  09160 Human Diseases   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     780515 (PKLR)    04950 Maturity onset diabetes of the young     780515 (PKLR)    04932 Non-alcoholic fatty liver disease     780515 (PKLR)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:oas04147]     780515 (PKLR) Enzymes [BR:oas01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.40  pyruvate kinase      780515 (PKLR) Exosome [BR:oas04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    780515 (PKLR) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK PK_C HpcH_HpaI IMPDH Neuregulin Motif Other DBs NCBI-GeneID:  780515 NCBI-ProteinID:  XP_027831917 LinkDB All DBs Position 1:complement(105458312..105466855) Genome browser AA seq 568 aa AA seqDB search MLPNWLWSWISKSQQDVVKSILIAAPGGPAGYLRWASVAQMTKELSISFFQRQQLPAAMA DTFLEHLCLLDIDSEPVVARSTSIIATIGPASRSVERLKEMIAAGMNIARLNFSHGSHEY HAESIANVREAVESFANSPLSYRPVAIALDTKGPEIRTGILQGGPASEVEIVKGSRVLVT VDPELRTRGDANTVWVDYPSIARVVPVGGRIYIDDGLISLVVKKIGPKGLETEVENGGVL GSRKGVNLPGIEVDLPGLSEQDVQDLRFGVEQGVDIIFASFVRKASDVAAVRAALGPEGQ GIKIVSKIENHEGVKKFDEILAVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKP VVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAR EAEAAMYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCGAGAIIVLTTTGRSAQLLSR YRPRAAVIAVTRSAQAARQAHLCRGVFPVLYREPPEDIWADDVDRRVQFGIDSGKLRGFL HSGDLVIVVTGWRPGSGYTNIMRVLTVT NT seq 1707 nt NT seq  +upstreamnt  +downstreamnt atgctccccaactggctctggtcatggatttctaagtcccaacaggatgtagtgaagtcc atcctgattgcagctccaggaggaccagcagggtacctgcggtgggctagtgtagcccag atgactaaggagctgagcatttccttcttccagcggcaacagctgccggccgctatggca gacaccttcctggaacatctgtgcctgctggacatcgactctgagcctgtggtcgctcgc agtaccagcatcatcgccacaatcgggccggcatctcgctccgtggagcgcctcaaggag atgatcgcggccgggatgaacatcgcgagactcaacttctcccacggctcccacgagtac catgctgagtccatcgctaacgtccgggaggcggtggagagctttgcaaattctccgctc agctaccgacccgtggccatcgccctggacaccaagggaccagagatacgcactgggatc ctgcaagggggcccggcgtcagaagtggagatagtgaagggctcccgggtgctggtgacc gtggatccagagctccggacgcgcggggacgcgaacaccgtgtgggtggactaccccagt atcgcccgagtcgtgccggtggggggccggatctacattgacgacgggctcatctcccta gtggtcaagaaaatcggtccaaaagggctagagaccgaagtggagaacggcggtgtcctg ggcagtcggaagggcgtgaacttgccgggcatcgaggtggacctgcccgggctgtccgag caagatgtccaggacctgcgcttcggggtggagcagggcgtggacatcatctttgcctct ttcgtgcggaaagccagcgacgtggctgccgtccgggctgctctggggccggaaggacag ggcatcaagatcgttagcaaaatcgagaaccacgagggcgtaaaaaagttcgatgaaatc ctggcagtgagcgacggcattatggtggcccggggtgacctgggcattgagatcccggcc gagaaggttttcctggctcagaagatgatgatcggccgttgcaacttggcgggaaagccc gttgtctgtgctacacagatgctggagagcatgatcactaagccccggccgactcgggca gagacgagtgatgtggccaacgccgttctggatggggcggactgtatcatgctgtcgggg gagactgccaaaggcagctttcctgtagaggctgtgaagatgcagcatgcgattgcccgg gaggcagaggctgccatgtaccaccggcagctctttgaggagctacgccgggcagcacca ctgagccgggatcccaccgaggtcaccgctattggtgctgtggaggctgccttcaagtgt ggtgctggtgccatcattgtgctgaccaccactggccgctcagcccagcttctgtctcgg taccgacctcgggcagcagtcattgccgtcacccgctctgctcaagctgcccgccaggcc cacctgtgccgaggagtctttcctgtgctctaccgtgaacctccagaggacatctgggcc gacgatgtggaccgccgggtccaatttggcatcgacagtggaaagctccgtggcttcctc cattctggggacctggtgattgtggtgacaggctggcgaccaggctctggctataccaac atcatgcgggtgctgaccgtaacctga

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