Ovis canadensis (bighorn sheep): 138430002 Help Entry 138430002         CDS       T11679                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism ocan  Ovis canadensis (bighorn sheep) Pathway ocan04020   Calcium signaling pathway ocan04024   cAMP signaling pathway ocan04260   Cardiac muscle contraction ocan04261   Adrenergic signaling in cardiomyocytes ocan04371   Apelin signaling pathway ocan04713   Circadian entrainment ocan04911   Insulin secretion ocan04921   Oxytocin signaling pathway ocan04972   Pancreatic secretion ocan05020   Prion disease ocan05022   Pathways of neurodegeneration - multiple diseases ocan05410   Hypertrophic cardiomyopathy ocan05412   Arrhythmogenic right ventricular cardiomyopathy ocan05414   Dilated cardiomyopathy ocan05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:ocan00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     138430002 (RYR2)    04020 Calcium signaling pathway     138430002 (RYR2)    04024 cAMP signaling pathway     138430002 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     138430002 (RYR2)    04921 Oxytocin signaling pathway     138430002 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     138430002 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     138430002 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     138430002 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     138430002 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     138430002 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     138430002 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     138430002 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     138430002 (RYR2)    05414 Dilated cardiomyopathy     138430002 (RYR2)    05415 Diabetic cardiomyopathy     138430002 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ocan04040]     138430002 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:ocan04990]     138430002 (RYR2) Ion channels [BR:ocan04040]  Voltage-gated cation channels   Ryanodine receptor    138430002 (RYR2) Domain-containing proteins not elsewhere classified [BR:ocan04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    138430002 (RYR2) SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  138430002 NCBI-ProteinID:  XP_069427718 LinkDB All DBs Position 25:27417508..28227414 Genome browser AA seq 4970 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGKVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH LDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV CYIQHISTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEEK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFEAITSGDMRVGWSRPGCQPDQELGSDERAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRLNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDIMFYRLSMPIECAEVFSKTAAG GIPGTGLFGPKNDLEDYDVDSDFEVLMKTAHGHLVPDRGDKDKEATKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADERDDYDYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESLSPGQGR NNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ CVEPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLFP DEKKKHGLPGIGLSTSLRPRMQFSSPSFVSINTEGYQYSPEFPLDILKAKTIQMLTEAVK EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGVFHNEDLKHVLQLIEPSVFKEAASPEEE SEVVEKEPFVEDSKLEGAAEEENKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDRSLDGNNDLTIRGRLLSLVEKVTYLK KKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVR ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQML VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG NGLLSAMEEAIKIAEDPSRDGPSPTTGSSRTPDTEEEEDDTIHMGNAIMTFYAALIDLLG RCAPEMHLIHAAKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN FNPQPVDTSNITIPEKLEYFINKYAEHAHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY KLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHG YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELEAKGGGNHPLLVPYDTLTAK EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI LEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI YSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVDLAESGIRYTQMPHVMEVILP MLCSYMSRWWEHGPENNPGRAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKSEARGDMSEAELLILDEFT TLARDLYAFYPLLIRFVDYNRAKWLKEPNQEAEDLFRMVAEVFIYWSKSHNFKREEQNFV VQNEINNMSFLIMDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNI CAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTED TSDPEKTVERVLDIANVLFHLEQKSTCMRRRYYNLGSTVEHPQRSKKAVWHKLLSKQRKR AVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEG TKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEK EMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKM LDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTC DLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDV IDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMK LSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFF DMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENET LDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIE IMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTI FEMQLAAQISESDLNERSANKEESEKEKPEEQGPRMGFFSIMTVKSALFALRYNILTLMR MLSLKSLKKQVKKVKKMTVKDMITAFFTSYWSILMSLLHFVASVFRGFSRIIGSLLLGGS LVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKTLEGALPSEDLTDLKELTEESDLLS DIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPEVQEKFQEQKANEEEKEEKEESKS EPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFAR NFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENARVSSLDSSSPRIIAV HYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYI TEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAAL DFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSILGHYNNF FFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSE DGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVI LLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLAN YLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14913 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgagggcgaagatgagatccagttcctgcgaactgatgatgaagtg gtcctacagtgtaccgcaaccatccacaaagaacaacagaaactgtgtttggcggcagaa ggatttggcaacagactttgcttcttggagtccacttcgaattccaagaatgtccctcca gacctctccatctgcaccttcgtcctggagcagtccctgtctgtccgggccctgcaggag atgctggctaacactgtggaaaagtctgaagggaaggttgatgtggaaaaatggaaattc atgatgaagactgctcaaggtggtggccaccgaacactcctctacggccatgcaatactg ctgcggcattcctacagtggcatgtatctgtgctgcctgtccacctctcggtcttcaact gataagctggcttttgatgttggcttgcaagaggatacaacaggtgaagcttgttggtgg accatccatcctgcctctaagcagcgctcagaaggagaaaaagtgcgggttggagatgac ctcatcttagtgagcgtgtcctctgaaaggtacctgcacttgtcttacggtaacggcagc ttgcacgtggatgctgctttccagcagaccctctggagtgtggcgcccatcagctcagga agtgaagcagcccaagggtatctgattggtggtgacgtcctcaggttgcttcatggacac ttggatgaatgcctcactgtcccctcaggagaacacggagaagagcagcggagaactgtt cattacgaaggtggtgctgtatcggttcacgcacgttccctgtggcgactagagacacta agagttgcgtggagtggaagccacataaggtggggacaaccttttcgactacgccatgtc acaacgggaaaatacttgagtctcatggaagacaaaagccttctactcatggacaaagaa aaagctgatgtcaaatcaactgcatttacgttccgatcttccaaggaaaaattggatgta ggagtgagaaaagaagttgatggcatgggaacctctgaaataaaatatggagactcggtc tgttatatacagcatatcagtacaggcttgtggctcacttaccagtctgtggatgtgaaa tcggtgagaatgggatccatacaacgtaaggctattatgcatcatgaaggacacatggat gatggcctaaatttatccagatctcagcatgaagaatcacggacagcacgtgtcatccgg agcacagtcttcctttttaatagatttattaggggccttgatgctctcagcaaaaaggtg aaggcttccacagtggacttacctatagagtctgtaagtctgagtctgcaggaccttatt ggctacttccacccaccagatgagcatttagagcatgaagataagcagaacagattacga gctctgaagaataggcagaatctcttccaggaagagggaatgatcaaccttgtgctcgag tgtatagacaggctgcatgtgtatagcagtgctgcacacttcgctgatgttgctgggaga gaagcaggggaatcttggaaatcgattctgaattctctgtatgagttgctggcggcatta attagaggaaatcgtaaaaactgtgctcaattttctggctcccttgactggttaatcagc cgactggaaagactggaagcttcttctggtattcttgaagttttacactgtgtgttagta gaaagtccagaagctctaaatattattaaagaaggccatataaaatccattatctcactt ttagacaagcatggaagaaatcacaaggttctggatgtcctatgctctctctgtgtttgc catggagtagcagtccgttctaaccagcatctcatctgtgacaatcttctgccaggaaga gacctgttattgcagacacgccttgtgaaccatgtgagcagcatgagacccaatattttt ctgggtgtcagtgaaggatctgcacagtataagaagtggtattatgagttgatggtggac cacactgagccattcgtgactgctgaagccactcacctgcgagtgggctgggcttccaca gaggggtactcaccctaccctggagggggtgaagagtggggtggaaatggtgtcggagat gacctcttctcctacggatttgatggccttcacctctggtcaggttgtattgcccggact gtcagctcaccaaaccagcatctcttgagaactgatgatgtcatcagttgctgtttagat ctaagtgccccaagcatctccttccgaattaatggacaacctgttcaaggcatgtttgag aatttcaacattgatggcctcttctttccagttgtcagtttctctgcaggaatcaaagta cgctttctgcttggggggagacatggagaatttaaattccttcctccacctgggtatgct ccttgttatgaagctgttctgccaaaagagaagttgaaagtggagcacagccgagagtac aagcaagaaaggacttacacgcgggacctcctgggccccacggtttccctgacacaagct gccttcacaccaatcccagtggacaccagccagattgtgttgcctccccacctggagagg atacgagaaaaactggcagagaatatccatgagctctgggtgatgaataaaattgaactt ggctggcagtatggtccggttagagacgacaataagagacaacacccgtgtctggtggag ttctccaagctgcctgaacaggaacgcaattacaatttacagatgtcactcgagaccctg aagacgttgttggctttaggatgtcatgtgggtatatcagatgaacacgctgaagaaaag gtgaagaaaatgaagctgccgaagaattaccaactgacaagtggatacaagcctgcccca atggacctgagctttatcaaactcaccccatctcaggaggctatggtggacaagttggcg gaaaacgctcataacgtgtgggctcgggatcgaattcgacagggctggacctacggcatc caacaggatgtaaagaacagaagaaaccctcggcttgttccctatgcccttctagatgac cgaactaagaaatccaataaggatagcctccgtgaggctgtacgcacactgctgggatat ggctacaacctggaggcacctgatcaagatcatgctgccagagctgaagtgtgcagcggc acaggagagaggttccgcatcttccgtgctgagaaaacgtatgctgtgaaggctggaagg tggtattttgaatttgaggcgatcacttctggagacatgcgagttggctggagcaggcca gggtgtcaacctgatcaggagcttggctcagatgaacgtgcctttgcttttgatggcttc aaggcccagcggtggcaccagggcaatgagcactatgggcgctcctggcaagctggcgat gttgtggggtgtatggttgacatgacagaacacaccatgatgttcacactgaatggcgaa atccttcttgatgattcaggttcagaactggctttcaaggactttgatgttggtgatgga ttcatacctgtgtgtagcctgggagtggctcaagtgggcaggctgaactttggaaaggat gtcagcaccttgaaatatttcaccatctgtggcttacaagagggctatgagccatttgcc gttaacacaaatagggatattaccatgtggctgagcaagaggcttcctcaatttctccaa gttccatcaaaccatgaacatattgaggtgaccagaatagatggcaccatagacagttcc ccatgtttaaaagtcactcagaagtcctttggctctcagaacagcagcacggatatcatg ttttatcgtctgagcatgcccatcgagtgtgcagaggtcttctccaagactgcagctgga gggatccctggcaccggcctctttgggcccaagaatgatctggaggattatgatgtggat tcagactttgaggttctcatgaagacagctcacggccatctggtgccagatcgaggagac aaagacaaagaagctacaaaaccagaatttaataaccacaaagattatgctcaggaaaaa ccctctcgtctgaaacagaggtttttgcttcgaagaacaaagccagattatagcaccagc cattctgcaagactcactgaagatgtccttgcagatgagagggatgactatgattacttg atgcaaacgtccacgtactattactcagtgagaatctttcctggacaagaacctgccaat gtctgggtgggctggatcacatctgatttccatcagtatgatacaggctttgacttggac agagttcgtacagtgaccgtgactctgggagatgaaaaaggaaaggtgcacgaaagcatc aaacgcagcaattgctacatggtgtgtgcgggtgagagcctgagcccggggcaaggacgc aacaacaatggcctggagattggctgcgtggtggatgctgccagtgggctgctcaccttc acggccaacggcaaggaactgagcacctattatcaggtggaaccaagcacaaaattattt cctgcagtttttgcacaagctacaagtcccaatgtttttcagtttgagttgggaagaata aagaatgtgatgcctctctcagcgggattattcaagagtgagcacaaaaatcctgtacca cagtgccccccacgcctccatgtgcagtttctctcacatgtcctgtggagcagaatgccc aaccagttcctgaaggtagatgtctctcgaataagtgaacgccagggctggctggtgcag tgcgtggagcctctgcagttcatgtctctccatatcccagaggagaacagatctgtggac atactggaactgacagagcaggaggaactgctgaaattccactaccacactctccggctc tactcggctgtctgcgcgctcgggaaccaccgggtggcccacgccttgtgcagccacgtg gacgagccgcagctgctctacgccatcgagaacaagtacatgcccggcttgctgcgcgcc ggctactacgacctgctgattgacatccacctcagctcctacgccaccgccaggctcatg atgaacaacgagttcatcgtccccatgaccgaggagacgaagagcatcaccctcttcccg gatgagaagaaaaagcacgggctcccgggcatcggcctcagcacctccctcaggccgcgg atgcagttttcctccccgagttttgtcagcattaataccgaaggttatcagtatagcccg gagttcccactggacatcctgaaggccaagaccatacagatgctgacagaagccgtgaaa gagggcagccttcacgcccgagaccccgttgggggcaccactgagttcctctttgtgcct ctcatcaagctgttctataccctgctcatcatgggtgtcttccacaacgaggacttgaaa cacgtcttgcagttgattgagcctagtgtgttcaaggaagccgccagccccgaggaggag agcgaggtggtggagaaggaaccctttgtggaagactccaagctggaaggagccgctgaa gaagaaaacaaagggggtaagaggcccaaggagggcctgctccaaatgaaactgccagag ccagtaaaattgcagatgtgcctgctacttcaatacctctgtgactgccaggtccggcac cggatagaagccattgtggccttttcagatgactttgtagccaagcttcaagacaatcaa cgattccgatataatgaagttatgcaagccttaaacatgtcagctgcactcacagccagg aaaacaaaggaattcagatccccgcctcaagaacagatcaatatgcttctcaattttaag gatgacaaaagtgaatgtccatgtcctgaagaaatccgagaccaactcttggattttcac gaagatttgatgacacactgtggaattgagctggatgaagataggtctctggacggaaac aacgatttaactattagaggacgcctgctgtccttggtagaaaaggtgacatatctgaag aagaagcaagctgaaaagccagttgagagtgactccaagaagtcatccactcttcagcag ttgatttctgagaccatggtccgatgggctcaagagtctgtaattgaagaccctgagttg gtgagggccatgtttgtattgctccatcgacagtatgatggcattgggggtctggtacgg gctctgccaaagacctacactataaatggtgtttctgtggaggataccatcaatctgctg gcatctcttggtcagattcgttctctgctaagtgtgagaatgggcaaagaggaagagaaa cttatgattcgtggattaggggatatcatgaacaataaagtgttttaccagcatcctaat ctcatgagggcgcttgggatgcacgagacagtgatggaggtcatggtgaatgtccttgga ggcggagagtccaaggaaatcacttttccgaagatggtggccaactgttgccgttttctc tgttacttctgtcgtataagtaggcagaatcagaaagctatgtttgatcatctcagttat ttactggaaaacagcagtgttggtcttgcctcaccagctatgagaggttcaacaccactg gatgtggcagcagcctcggtgatggataataatgaactagctttagctttgcgggagcca gatctggaaaaggtggttcgatatttggctggttgtggactgcagagttgccagatgcta gtgtcaaagggttatccagacattgggtggaatccagttgaaggagagagatatcttgac tttctcagatttgctgtcttctgtaatggggaaagcgtggaggagaacgcaaatgtcgtg gtgagattgctcatccggaggcctgagtgtttcggtcccgccctgaggggggaaggtggg aatggcctgctctcagccatggaagaagccataaaaatagctgaggatccctctagagat ggtccctcaccaactaccggatccagcaggacccctgatacagaagaggaagaggatgat accatccacatgggaaatgccatcatgaccttttatgcagctttgattgacctgttagga cgctgtgctcctgaaatgcatttgattcatgctgccaaaggagaagccatcagaatcagg tctattttgagatctctgattccattgggagatttggtgggagtaatcagcattgctttt cagatgcccacaatagccaaagatgggaatgtggtggagcctgacatgtctgcagggttt tgcccagatcacaaggcagccatggttttgttccttgacagggtctatggaattgaggtt caggatttcctcctccatcttctcgaggttggctttctgccagatctccgggctgctgct tctttagacacggctgctttgagtgctacagacatggccctggccctcaatcgctacctg tgcacagccgtgttacccttgttaacaaggtgtgctcctctttttgctggcactgagcac catgcttctctcattgactcattacttcacactgtgtacaggctttctaagggctgctcg cttaccaaagctcaacgggattccatagaagtgtgtttactctctatttgtggccaattg agaccttctatgatgcaacacttactcagaagattagtatttgatgtcccattattaaat gaacatgcaaagatgcctcttaagctgctgacaaatcattatgaaagatgctggaaatat tactgtctgcctggagggtggggcaactttggagctgcctcagaagaagaacttcattta tcaagaaagctgttctggggcatctttgatgccctgtctcaaaagaaatatgaacaagaa cttttcaaactggcactgccttgcctgagtgcagttgcgggagctttgcctccagactac atggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaac tttaatccacaacctgttgatacctcaaacattacaattcctgagaagttggaatacttc attaacaaatatgcagaacatgcacatgacaagtggtcaatggataagttggcaaatgga tggatttatggagaaatatattcagactcatctaaagttcaaccattaatgaagccatat aaactattatctgaaaaggaaaaagaaatttatcgctggccaatcaaagaatctttaaaa actatgctggcttggggatggagaattgaaaggacccgagagggagacagcatggccctt tataaccgtactcgtcgtatttctcagacaagtcaggtttctgtagatgccgcccatggg tacagcccacgagccattgacatgagcaatgtcacactatccagagatctgcacgctatg gcagaaatgatggctgaaaactaccataatatatgggcaaagaaaaagaaactggaacta gaggccaaaggaggtggaaaccatcccctgctggtaccttatgatacgctgacggccaaa gagaaagccaaggatagggaaaaagcacaggacatcctcaagttcctgcagatcaatggc tatgctgtgtccagagggttcaaagacctggaactggacacaccttctattgagaaacga tttgcctatagtttccttcagcaactcattcgctatgtagacgaggcccatcagtatatc ctggagtttgatggtggcagcagaagcaaaggagaacatttcccttatgaacaagaaatc aagttctttgctaaagtcgttcttcctttaattgatcagtatttcaaaaaccaccgttta tacttcttatctgcagcaagcagacctctctgttctggaggacatgcatcaaacaaagag aaagaaatggtgactagcctattctgcaaacttggagttcttgtcaggcataggatttca ctatttgggaatgatgcaacatcaattgtcaactgtcttcatattttgggtcagactttg gatgcaaggactgtgatgaagactggcctggagagtgttaaaagtgcgctcagagccttc ctggacaatgccgcagaggatctggagaagacgatggagaatcttaagcagggccagttc acccacacccgaaaccaacccaaaggtgttactcagattatcaattataccacggtggca ctgttgccaatgctgtcatcattatttgagcatattggccagcatcaatttggagaagat ctaatattggaagatgtacaggtgtcatgttatagaattctgactagcttgtatgctttg ggaaccagcaagagtatttatgtggaaaggcaacgttctgcattgggagaatgtctggct gcttttgctggtgcctttcctgtagcatttttggaaactcacctggacaagcacaatatt tactccatctacaatacaaagtcttcgagagagagagcagctcttaatttgcctactaat gtggaagatgtttgtccaaatataccgtctttggagaagctcatggaagaaattgtggac ttggctgagtccggtattcgctacacacagatgccgcacgtgatggaagttatcctgccc atgctttgtagctacatgtctcgttggtgggagcatggacctgagaataatccgggaagg gctgagatgtgctgtactgctctgaactcagagcacatgaacacactgctgggcaatatc ctgaaaatcatatataataacttgggtattgatgagggagcctggatgaagaggttagca gtgttttcccagcctattataaataaagtgaaacctcagcttttgaaaactcatttcttg ccattaatggagaagctcaagaaaaaggcagcgatggtggtatcagaagaggaccatctg aaatctgaggccaggggagatatgtctgaagccgaacttctcatcctagatgagttcacc accctggccagagatctctatgccttctatccactcctgattagatttgtggactataac agggcaaagtggctgaaagagcctaaccaagaagcagaagatcttttccgcatggttgct gaggtgtttatctactggtcaaaatcccataatttcaaaagggaggaacagaacttcgtg gtgcagaatgaaatcaataatatgtctttccttattatggacaccaaatcaaagatgtca aaggcagctgtttctgatcaggaaaggaagaaaatgaagcgcaaaggggaccgatattcc atgcagacatctcttattgtggctgctctgaagcggttactgcccattgggttgaacatc tgtgcccctggggaccaggagctcattgctctggccaaaaatcgctttagtctgaaagac actgaggatgaagttcgagatataatccgcagtaatattcacttacaaggcaagttggag gatcctgctattagatggcaaatggctctttacaaagacttacccaataggacagaagac acttcagatcctgagaagacagtggaacgggtcttggatatagcaaatgtactttttcat cttgaacagaaatctacatgtatgcgccggagatattacaatctgggaagtacagttgag catcctcagagatcgaaaaaggccgtgtggcacaaactgctctctaagcagaggaaacgt gccgtggttgcctgcttccggatggctcctttatataatctgccgaggcatcgggctgtc aatctctttcttcagggatatgaaaagtcttggattgaaacagaagaacattactttgaa gataaattgatagaagacttagcgaaacctggagcagaacctccagaagaagatgaagga actaagagggttgatcctcttcatcagctgatccttctgtttagtcgaacagctttaacg gagaaatgcaaactggaggaagattttttatatatggcttatgcagatattatggcaaag agttgtcatgatgaggaagatgatgatggggaagaggaagtgaagagttttgaagaaaaa gaaatggaaaagcaaaagcttctataccaacaagccaggctgcacgaccgcggtgctgct gagatggtgctgcagaccatcagtgccagcaaaggtgaaactggacccatggtggctgct actttgaaacttggaattgctatcttaaatggaggaaactctacagtacagcagaaaatg cttgactacctcaaggagaaaaaggacgtgggcttctttcagagcctggctggcctgatg cagtcatgcagcgtcctcgacctaaatgcatttgagcggcaaaacaaagctgaaggactt gggatggtgactgaggaaggatcaggagaaaaggttctgcaggatgacgaattcacctgt gacctcttccgcttcttgcaactgctttgtgagggacacaactcagattttcaaaattat ctgagaactcagactggcaataatacaactgtcaacataatcatctctactgtagactac cttctgagagttcaggaatcaattagtgatttctattggtattactctgggaaagatgtc attgatgagcaaggacaaaggaatttctctaaagctattcaagtggcaaaacaagtcttt aacactcttacagagtacattcagggtccttgcactggaaaccagcagagtttggctcac agcaggctctgggatgctgtggtgggttttcttcatgtatttgcccacatgcagatgaag ctgtctcaggactccagtcaaattgagctactaaaagaattgatggatcttcagaaggac atggtggtcatgttgctgtccatgttggaaggcaatgttgttaatggcaccattggcaaa cagatggtggatatgctcgtggaatcttccaacaacgtggagatgattctcaagtttttt gacatgttcttaaagctcaaggacttgacgtcttctgatactttcaaagagtatgacccc gatggtaagggagttatttccaagagggactttcacaaagccatggagagccataaacac tacacccagtccgagactgagtttctcctgtcctgtgcagagacagatgaaaatgaaacc ctggactatgaagaatttgtcaaacggttccacgagcctgccaaggacattggcttcaat gtggcagtgcttctgacaaacctctctgaacacatgcccaatgacacccggctgcagact tttctggaattggccgagagtgtgctcaattacttccagcccttcctgggccgcatcgag atcatgggcagtgccaagcgcatcgagagggtttattttgaaatcagtgagtccagccga acccagtgggagaagccccaggtcaaggaatccaaaaggcaatttatatttgacgtggtc aatgaagggggagagaaagagaagatggagctcttcgtgaacttctgcgaggataccatc tttgagatgcagctggcggctcagatatcagagtcagatctgaatgagaggtcagcgaac aaagaggagagtgagaaggagaagccggaggagcagggtccgaggatgggtttcttttcc atcatgacggtcaagtccgccctgtttgccctcaggtacaatatcttgacccttatgcgg atgctcagcctgaaaagcttgaagaagcaggtgaagaaggtgaagaagatgacagtgaag gacatgatcacagccttctttacatcctactggagtattttgatgagcctcctgcacttt gtagccagcgttttcagaggcttctctcgcatcatcggcagcctcctgctgggaggaagc ctggtcgaaggtgcaaagaagatcaaagtggcggagctcttggccaacatgccagacccc acgcaagatgaggttcgaggagacggggaggagggggagaggaaaaccctggaaggggcc ctgccctctgaagatctgacggacttgaaggaactgacagaggagagtgacctgctttcc gatatctttggcttggacctgaagcgagaaggggggcagtacaaactgattcctcacaat cccaatgctggcctgagtgacctcatgagcaaccccgtccctatcccagaggtgcaagaa aagttccaggaacagaaggcaaacgaagaagaaaaggaagaaaaagaagaaagcaaatct gaacccgagaaagctgaaggagaagacggagaaaaagaagaaaaagccaaagaagacaag ggtaaacaaaaactgaggcagctccacacacacagatacggagagccagaagttcctgag tcagcattctggaagaaaatcatagcctatcaacagaaacttctaaactattttgctcgc aacttctacaatatgagaatgttagccttatttgtcgcatttgcgatcaatttcatcttg ctcttttataaggtctccacttcttctgtggttgaaggaaaggaactacccactcgcagt tcaagtgaaaatgccagagttagcagcttggacagcagctcgcctagaatcattgcagtg cactatgtgctggaggagagcagtggctacatggagcccacactgcggatattagccatt ctgcacaccgtcatctctttcttctgcatcattggatactactgcttgaaagtcccactg gttatttttaagcgagaaaaggaagtagctcgaaaattggaatttgatgggctttatatt acagaacagccttcagaagatgatattaaaggccagtgggatagactcgtaatcaacaca cagtcatttcccaacaactactgggacaaatttgttaaaagaaaggttatggataaatat ggagagttctatggccgagacagaatcagcgagttacttggcatggacaaagctgccttg gacttcagtgatgcccgggaaaagaagaagccaaagaaagacagctccctgtcagctgta ctgaactctattgatgtgaagtatcagatgtggaaactaggagtcgttttcactgacaac tccttcctctaccttgcctggtatatgaccatgtccattcttggacactacaacaacttt ttctttgctgctcatcttctggacattgctatgggattcaagacgttaagaaccatcttg tcatcagtaactcacaatggcaaacagctcgtattaactgttggcttattggctgttgtt gtatacctatatactgtcgtggcattcaattttttccgaaaattctacaataaaagtgaa gatggcgatacaccagacatgaagtgtgatgacatgctaacatgctatatgttccacatg tatgttggagtacgtgccggagggggtatcggtgatgaaattgaagatccggcaggtgat gagtatgagatatatcgaatcatctttgacatcaccttcttcttttttgtgattgtcatt ctcttggccataatacaaggtttaatcatcgatgcttttggggaactaagagaccaacag gaacaggtcaaagaagacatggagaccaagtgcttcatctgtgggataggcaatgattac tttgacaccgtgccacatggctttgaaacccacactttacaggaacacaacttggccaat tatctgttttttctgatgtatctcataaacaaagatgaaacggagcacacaggacaggaa tcttatgtttggaagatgtatcaagaaaggtgctgggaatttttcccagccggagactgt ttccggaaacagtatgaagaccagctaaattaa

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